CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000008512/1-1195 MALSYDPAVNTAEEEAEEDAPAHGTALEAFGESEETRALFGRLQAVHGERRAREVAQERF XP_004861112.1/1-1216 ----------------MITVPVHGPF--------------------------------RG ENSP00000440671/1-1230 MALSDEPAAGGPEEEAEDETLAFGAALEAFGESAETRALLGRLREVHGGGAEREVALERF ENSMUSP00000099302/1-1196 MVLSNEPAASAAEEEVEDDALVRASALEAFGESAETRALLRSLPAVHRERASREVAEERF ENSRNOP00000051796/1-1192 MVLSNEPAASAAEEEVEDDALVRASTLEAFGESAETRALLRSLPAVHRERAAREVAEERF . . .. * ENSCPOP00000008512/1-1195 RVIMDKYQEQPHLLDPHLEWMVTSLLDIAQDKTSPGTLVHLAFKFLYIITKVRGYKIFLR XP_004861112.1/1-1216 PVIMDKYQEQPHLLDPHLEWMMTSLLDIVQDKTSPGTLVHLAFKFLYIITKVRGHKIFLR ENSP00000440671/1-1230 RVIMDKYQEQPHLLDPHLEWMMNLLLDIVQDQTSPASLVHLAFKFLYIITKVRGYKTFLR ENSMUSP00000099302/1-1196 RVIMDKYQEQPHLLDPHLEWMMNSLLDLVQDETSLPDLVHLAFKFLYIITKVRGYKVFLR ENSRNOP00000051796/1-1192 RVIMDKYQEQPHLLDPHLEWMMNSLLDIVQDETSLPDLVHLAFKFLYIITKVRGYKVFLR ********************:. ***:.**:** *****************:* *** ENSCPOP00000008512/1-1195 LFPHEVADVQPVLDMISEQNPTDHE----------------------------------T XP_004861112.1/1-1216 LFPHEVADVHPVLAMISDQNPTDPEGSSCRHLAWLVETADSGRKAGARLTPHGTSAGCPT ENSP00000440671/1-1230 LFPHEVADVEPVLDLVTIQNPKDHE----------------------------------A ENSMUSP00000099302/1-1196 LFPHEVANVQPVLDMFTGQNPKDHE----------------------------------T ENSRNOP00000051796/1-1192 LFPHEVADVQPVLDMFTGQNPKDHE----------------------------------T *******:*.*** :.: ***.* * : ENSCPOP00000008512/1-1195 WETRYMLLLWLSMTCLIPFDLSRLDGNLGAQAGQVQMPIMDRILQIAESYLLVSDKARDA XP_004861112.1/1-1216 WETRYMLLLWLSVTCLIPFDLSRFDGNRGAQPGQAQMPVMDRVLQIAESYLLVSDKARDA ENSP00000440671/1-1230 WETRYMLLLWLSVTCLIPFDFSRLDGNLLTQPGQARMSIMDRILQIAESYLIVSDKARDA ENSMUSP00000099302/1-1196 WETRYMLLLWLSVTCLIPFDFSRLDGNLSTQTGETRVPTMDRILQIAESYLVVSDKARDA ENSRNOP00000051796/1-1192 WETRYMLLLWLSVTCLIPFDFSRLDGNLPTQSGETRMPIMDRILQIAQSYLVVSDKARDA ************:*******:**:*** :*.*:.::. ***:****:***:******** ENSCPOP00000008512/1-1195 AAVLVSRFVTRPDVKQRKMAGFLDWSLSTLAHSSFHTIEGVIAMDGTLQALAQIFKHGKR XP_004861112.1/1-1216 AAVLVSKFITRPDVKERKMASFLDWSLSTLARSSFHAIDGVIAMDGTLQALAQIFKHGKR ENSP00000440671/1-1230 AAVLVSRFITRPDVKQSKMAEFLDWSLCNLARSSFQTMQGVITMDGTLQALAQIFKHGKR ENSMUSP00000099302/1-1196 AAVLVSKFITRPDVKQRKMASFLDWSLCTLAHSSFQTIEGVITMDGMLQALAQIFKHGKR ENSRNOP00000051796/1-1192 AAVLVSKFITRPDVKQRKMASFLDWSLCTLAHSSFQTIDGVITMDGMLQALAQIFKHGKR ******:*:******: *** ******..**:***::::***:*** ************* ENSCPOP00000008512/1-1195 EDCLPYATVVLQCLDNCRLPESNQTLLRKLGMKLVQRLGLTFLKPKVAAWRYQRGSRSLA XP_004861112.1/1-1216 EDCLPYATIVLQCLDSCRLPESNQTLLRKLGVKLVQRLGLTFLKPKVAAWRYQRGSRSLA ENSP00000440671/1-1230 EDCLPYAATVLRCLDGCRLPESNQTLLRKLGVKLVQRLGLTFLKPKVAAWRYQRGCRSLA ENSMUSP00000099302/1-1196 EDCLPYANTVLQCLDGCRLPESSHTSLRKLGVKLVQRLGLTFLKPKVATWRYQRGCRSLA ENSRNOP00000051796/1-1192 EDCLPYANTVLQCLDGCRLPESSHTLLRKLGVKLVQRLGLTFLKPKVATWRYQRGCRSLA ******* **:***.******.:* *****:****************:******.**** ENSCPOP00000008512/1-1195 ANLQLSAPSQSEQKLP--VATSDRDEDYDVPEGVESVIEQLLGGLKDRDTVVRWSAAKGI XP_004861112.1/1-1216 ANLQLCAPAQSEQKLP--VAPSDGDEDYHVPEGVESVIEQLLVGLKDRDTVVRWSAAKGI ENSP00000440671/1-1230 ANLQLLTQGQSEQKPL--ILTEDDDEDDDVPEGVERVIEQLLVGLKDKDTVVRWSAAKGI ENSMUSP00000099302/1-1196 ANLKLCAPGKSDQKLLSDSLTSDGDEDYDVPEGVETVIEQLLVGLKDKDTVVRWSAAKGI ENSRNOP00000051796/1-1192 ANLQLRAPGKSEQKLLSDSLTSDGDEDYDVPEGVETVIEQLLVGLKDKDTIVRWSAAKGI ***:* : .:*:** ..* *** .****** ****** ****:**:********* ENSCPOP00000008512/1-1195 GRMAGRLPQELADDVVGSVLDCLSFQETDKAWHGGCLALAELGRRGLLLPSRLPEVVTVI XP_004861112.1/1-1216 GRMAGRLPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLPEVVAVI ENSP00000440671/1-1230 GRMAGRLPRALADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLVDVVAVI ENSMUSP00000099302/1-1196 GRMAGRLPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLSEVVTVI ENSRNOP00000051796/1-1192 GRMAGRLPRELADDVVGSVLDCFSFQETDKAWHGGCLALAELGRRGLLLPSRLSEVVTVI ********: ************:****************************** :**:** ENSCPOP00000008512/1-1195 LRAVTYEEKRGACSVGANVRDAACYVCWAFARAYDPQELAPFVAALASALVVASVFDRNV XP_004861112.1/1-1216 LRAVTYEEKRGAFSVGANVRDAACYVCWAFARAYDPQELESFVAAIASALVIASVFDRNV ENSP00000440671/1-1230 LKALTYDEKRGACSVGTNVRDAACYVCWAFARAYEPQELKPFVTAISSALVIAAVFDRDI ENSMUSP00000099302/1-1196 LKALTYDEKRGACSVGANVRDAACYVCWAFARAYEPQELTPFVTAISSALVIAAVFDRNV ENSRNOP00000051796/1-1192 LKALTYDEKRGACSVGANVRDAACYVCWAFARAYEPQELTPFVTAISSALVIAAVFDRNV *:*:**:***** ***:*****************:**** .**:*::****:*:****:: ENSCPOP00000008512/1-1195 NCRRAASAAFQENVGRQGTFPHGIDIVTTADYFAVGNTANCFQVISVSIASFPEYTQPMI XP_004861112.1/1-1216 NCRRAASAAFQENVGRQGTFPHGIDIVTTADYFAVGNTANCFLSISVSIAGFPEYTQPMI ENSP00000440671/1-1230 NCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNRSNCFLVISVFIAGFPEYTQPMI ENSMUSP00000099302/1-1196 NCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNISNCFLIISVFIAGFQEYTKPMI ENSRNOP00000051796/1-1192 NCRRAASAAFQENVGRQGTFPHGIDILTTADYFAVGNISNCFLIISVFIAGFQEYTKPMI **************************:********** :*** *** **.* ***:*** ENSCPOP00000008512/1-1195 DHLLTMKVSHWDRVIRELSAKALHRLAPWAPEYFATHVLPALLSMTLSPDLHTRHGAILA XP_004861112.1/1-1216 DHLIAKKVSHWDGTIRELSAKALHKLAPQAPEYFATHVLPALLLMVPSPDLHTRHGAILA ENSP00000440671/1-1230 DHLVTMKISHWDGVIRELAARALHNLAQQAPEFSATQVFPRLLSMTLSPDLHMRHGSILA ENSMUSP00000099302/1-1196 DHLVSMKINHWDGAIRELSAKALHNLTPQVPEYIAMHVFPALLLMTQSPDLHTRHGAILA ENSRNOP00000051796/1-1192 DHLVSMKINHWDGAIRELSAKALHNLTSLVPEYMATHVFPALLLMTQSPDLHTRHGAILA ***:: *:.*** .****:*:***.*: .**: * :*:* ** *. ***** ***:*** ENSCPOP00000008512/1-1195 CAEVTYALCKLAAQKDRPITDYLDEKMVQGLRQIHQQLSDRHLYRGLGGELMRQAVCVLI XP_004861112.1/1-1216 CAEVTYALYKLAAQRGRPVTDYLDEKAVQGLKQIHQQLSGRHLYRGLGGQLMRQAVCVLI ENSP00000440671/1-1230 CAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMRQAVCVLI ENSMUSP00000099302/1-1196 CAEVTYALYKLATQSNRLVTDYLDEKAVQSLKQIHQQLCDRHLYRGLGGELMRQAVCILI ENSRNOP00000051796/1-1192 CAEVTYALYELAAQSNRLVTDYLDEKAVQSLKQIHQQLCDRHLYRGLGGELMRQAVCILI ****:*** :**:* .* :**:***: **.*:****** .*:*******:*******:** ENSCPOP00000008512/1-1195 EKLTLSRMPFKGDPVIDGWQWLIDDTLRNLHLVSSQSRQRIKDTAVSALAAVCSEYYQKE XP_004861112.1/1-1216 ENLSLSRMPFKGDPVIDAWQWVIDDTLRSLHLVSSQSRQQVKDSAVLALAALCSEYYQKE ENSP00000440671/1-1230 EKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKE ENSMUSP00000099302/1-1196 EKLSLSRMPFKGDATVEGWQWLINDTLRSLHLVSSHSRQQIKEVAVSALTALCSEYYVKE ENSRNOP00000051796/1-1192 EKLSLSRMPFKGDTVIEGWQWLINDTLRSLHLVSSHSREQIKEVAVSALAAVCNEYYKKE *:*:**:***:**..::.***:*:**** ***:**:**:::*: ** **:*:*.*** ** ENSCPOP00000008512/1-1195 PREASPAIQEVLIPRYLVELQSPEEMVRCGFASALGALPCFLLQGRLRQVLDGLSVVTR- XP_004861112.1/1-1216 PREASPAVQEVLIPRYLVELQSPEEMVRCGFASALGALPAFLLRGRLRQVLEGLSAVTR- ENSP00000440671/1-1230 PGEADPAIQEELITQYLAELRNPEEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTH- ENSMUSP00000099302/1-1196 PGEAGSSIAKELIPQYLAELQSPEEMARCGFSSALGALPGFLLRGHLQQVLSGLRRVTC- ENSRNOP00000051796/1-1192 PGEAGSTITEELIPQYLAELRSPEEMTRCGFSSALGALPCFLLRGHLQQVLSGLRRVTCT * **..:: : **.:**.**:.****.****: ****** ***:*:*:*** ** ** ENSCPOP00000008512/1-1195 TSSKDMGFAEARRDSLRAIARICQTVGVKAEAAPDEAVCRQNVAQVYTILLGCMGDYTTD XP_004861112.1/1-1216 ISPQDVGFTEARKDSLRAIARICQTVGVQVEAAPDEAVCRQNVAQVYTTLLACMGDYTTD ENSP00000440671/1-1230 TSPEDVSFAESRRDGLKAIARICQTVGVKA-GAPDEAVCGENVSQIYCALLGCMDDYTTD ENSMUSP00000099302/1-1196 ISPNDVSFAEARRDGLKAISRICQTVGVNTRGPPDEVICKENISEVYAALLGCMSDYTTD ENSRNOP00000051796/1-1192 TSPMDVSFAEARRDGLKAISRICQTVGVNTQGPPDEVICQENISEVYAALLGCMSDYTTD *. *:.*:*:*:*.*:**:********:. ..***.:* :*::::* **.**.***** ENSCPOP00000008512/1-1195 SRGDVGAWVREAAMTSLMDLTLLLAQTQPALIEAHVCEQVMCRVAQQASEKIDRLRAHAA XP_004861112.1/1-1216 SRGDMGAWVREAAMSSLMDLTLLLAQTQPALIEAHVCERIMCCLAQQASEKIDRFRAHAA ENSP00000440671/1-1230 SRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAA ENSMUSP00000099302/1-1196 SRGDVGAWVREAAMTSLMDLMLLLARTEPVLIEAHICERVMCCVAQQASEKIDRFRAHAA ENSRNOP00000051796/1-1192 SRGDVGAWVREASMTSLMDLMLLLAQTEPVLIEAHICERVMCCVAQQASEKIDRFRAHAA ****:*:***:*:*:***** ****:::* ***** **::** :**********:***** ENSCPOP00000008512/1-1195 HVFLTLLHFDSSPVPHVPHRKELEVLFPRSDVATVNWNAASQAFPRITQLLGLPTYRYHV XP_004861112.1/1-1216 HVLLTLLHFGSSPVPHVPHRRELEALLPRLDMTSVNWNAPSQAFPRITQLLGLPTYRYHV ENSP00000440671/1-1230 SVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHV ENSMUSP00000099302/1-1196 RVFLTLLHFDSPPIPHVPHRQELESLFPRSDVATVNWNAPSQAFPLITQLLGLPTYRYHV ENSRNOP00000051796/1-1192 RVFLTLLHFDSPPIPHVPHRKELESLFPRSDVATVNWNAPSQAFPLITQLLGLPTYRYHV *:******.*.*:****** *** *:** *:::***.*.***** ************** ENSCPOP00000008512/1-1195 LLGLAVSVGGLTKSTVKHSTQSFFEYMKGIQQDPQALGSFSETLLQVFEDNLLNDRVSVS XP_004861112.1/1-1216 LLGLAVSVGGLTESTVKYSTQSLFEYMKGIQQDAQALGSFSGTLLQVFEDNLLNDRVSVS ENSP00000440671/1-1230 LLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNERVSVP ENSMUSP00000099302/1-1196 LLGLAVSVGGLTESTVRHSTQSLFEYMKGIQKDAQVLQSFSETLLKVFEDNLLNDRVSVS ENSRNOP00000051796/1-1192 LLGLAVSVGGLTESTVRHSTQSLFEYMKGIQKDAQVLESFSETLLKVFEDNLLNDRVSVS ****.**:****:**:::****:********.*.*.* *** ***::*******:****. ENSCPOP00000008512/1-1195 LLKTLDQMLANGCLDIFTKEENHPFCVRLLALCKEEIKKSKDIQKLRSSIAV-------- XP_004861112.1/1-1216 LLKMLDQMLANGCFDIFTREENHPFCVKLLALCKEEIKKSKNTQKLRSSIAV-------- ENSP00000440671/1-1230 LLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVDFPSATLV ENSMUSP00000099302/1-1196 LLKMLDQLLANGCFDIFTAEENHPFCVKLLTLCKEEIKKSKDIQKLRSSIAV-------- ENSRNOP00000051796/1-1192 LLKMLDQLLANGCFDIFTAEENHPFCVKLLTLCKEEIKKSKDIQKLRSSIAV-------- *** **::*::**:**** **:***.*:**:***:***:**: *** *.*** ENSCPOP00000008512/1-1195 ------------------------------LCGMVQFCGDVRKKVLLQLMLLLCHPFPVI XP_004861112.1/1-1216 ------------------------------LCGMVQFCGDVRRKVLLQLMLLLCHPFPVI ENSP00000440671/1-1230 CVGTVQMYAHTHLRLGAPGPHCAHGSALPRFCEMVQFPGDVRRQALLQLCLLLCHRFPLI ENSMUSP00000099302/1-1196 ------------------------------LCGMVQFNGDVRKKILLQLFLLLGHPFPVI ENSRNOP00000051796/1-1192 ------------------------------LCGMVQFSGDVRKKVLLQLFLLLGHPFPVI :* **** ****:: **** *** * **:* ENSCPOP00000008512/1-1195 RKATASQVYEMVLTYSGVLSADVLDEVMAVLSDTAWDAELPVVREQRNHLCDLLGVPRPQ XP_004861112.1/1-1216 RKTTASQVYEMVLTYSGVVSTDVLDEVMAVLSDTVWDAELPVAREQRNRLCDLLGVPQPQ ENSP00000440671/1-1230 RKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQ ENSMUSP00000099302/1-1196 RKSTASQVYEMVLTYSDLVDAEVLDEVMSVLSDTAWDAELPVVREQRNRLCDLLGVPRPQ ENSRNOP00000051796/1-1192 RKSTASQVYEMVLTYSDLVDAEVLDEVMSVLSDTAWDSELPVVRGQRNHLCDLLGVPRPQ **:******* :****.::.::*****::*****.**:**.*.* ***:********:** ENSCPOP00000008512/1-1195 LVPK------------VIPASH----------------------- XP_004861112.1/1-1216 LVPKVTLWFPTCSLPPPVPALEATVAGAPLPSLTLGGSVSLHMVS ENSP00000440671/1-1230 LVPQ--------------PGAC----------------------- ENSMUSP00000099302/1-1196 LVPK------------PIPGS------------------------ ENSRNOP00000051796/1-1192 LVPK----------------------------------------- ***: