CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000048238/1-1471 MPGPPASPPPPM-LLLLLLLTVGCARAAPLPQTGAGEV-PVVEVPSLFVILSVCSLLILI ENSRNOP00000050872/1-1531 MPGPPASSPLPMPLLLLLLLTVGSARAAPLPQTGAGDA-PVVEVPSLFVILSVCSLMVLI ENSP00000297293/1-1503 MPGPPALRRRLL-LLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILI ENSCPOP00000008448/1-1485 VLGKHTKYPKPL-IILLLGTTGNNAHPASLSQVGLYEA-PVTEVPSTFVILSVCSLMILI XP_004840525.1/1-1494 MPGP----PALL-LLVLLRLVVGYAGAAPLPQTG--EV-PVAEVPSTFVILSVCSLMILI : * : :::*: . * .*.*.*.* :. *..**.* ****.****::** ENSMUSP00000048238/1-1471 VLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSIQSPAEVFTLSVPNISLPAPS ENSRNOP00000050872/1-1531 VLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPS ENSP00000297293/1-1503 VLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPS ENSCPOP00000008448/1-1485 VLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPS XP_004840525.1/1-1494 VLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPS ***************************************:******************** ENSMUSP00000048238/1-1471 QFQASVEGLKSQVARHSLNYIQEIGSGWFGKVLLGETYTGTSVARVIVKELKVSASPKEQ ENSRNOP00000050872/1-1531 QFQSSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGETYTGTSVTRVIVKELKVSASPKEQ ENSP00000297293/1-1503 QFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQ ENSCPOP00000008448/1-1485 QFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASASPKEQ XP_004840525.1/1-1494 QFQPSVEGLKSQVARHNLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASASPKEQ ***.************.********.********** ******:********.**.**** ENSMUSP00000048238/1-1471 DTFLKSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRGDSQT ENSRNOP00000050872/1-1531 DTFLNSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRSESQT ENSP00000297293/1-1503 DTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQT ENSCPOP00000008448/1-1485 DTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRNEQEHVRGDSQT XP_004840525.1/1-1494 DVFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRGDSQT *.**:.***********:*****************************:.****:*.:*** ENSMUSP00000048238/1-1471 MLLQRMACEIAAGLAAMHKLHFLHSDLALRNCYLTSDLNVKVGDYGIGFSRYKEDYIETD ENSRNOP00000050872/1-1531 MLLQRMACEIAAGLAAMHKLHFLHSDLALRNCYLTSDLNVKVGDYGIGFSRYKEDYIETD ENSP00000297293/1-1503 MLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETD ENSCPOP00000008448/1-1485 MLLQRMACEIAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETD XP_004840525.1/1-1494 MLLQRMACEIAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETD *********:**********************:*************************** ENSMUSP00000048238/1-1471 DKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYANLSDLDVL ENSRNOP00000050872/1-1531 DKKIFPLRWTAPELVTSFQDRLLTADQTKYSNIW-------------------------- ENSP00000297293/1-1503 DKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVL ENSCPOP00000008448/1-1485 DKKIFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYANLSDLDVL XP_004840525.1/1-1494 DKKIFPLRWTAPELVTSFQDRLLTAEQTKYSNIWSLGVTLWELFNNAAQPYAKLSDLDVL ***:*********************:******** ENSMUSP00000048238/1-1471 NQVIRERDMKLPKPQLEQPYSDRWYEVLQFCWLPPDKRPAAEDVHRLLTYLRMQSQRDSE ENSRNOP00000050872/1-1531 ------------------------YEVLQFCWLSPDKRPAAEDVHRLLTYLRMQSQRDSE ENSP00000297293/1-1503 NQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSE ENSCPOP00000008448/1-1485 NQVIRERDTKLPKPQLEQPYSDRWYEVLQLCWRSPDKRPAAEDVHRLLTYLRMQSQRDPE XP_004840525.1/1-1494 NQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPDKRPAAEDVHRLLTYLRMQSQRDPE *****:** .*:****************:*****.* ENSMUSP00000048238/1-1471 VDFEQQWTALKPDTNSRDASSSAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWE ENSRNOP00000050872/1-1531 VDFEQQWTALKPNANSRDPSSSAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWE ENSP00000297293/1-1503 VDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWE ENSCPOP00000008448/1-1485 VDFEQQWNALKPNTNSRDTSSNAAFPILDHFTRDRLGREMEEVLTVTETSQGLSFEYVWE XP_004840525.1/1-1494 VDFEQQWNTLKPNTNSRDTSSNAAFPILDNFTRDRLGREVEEVLTVTETSQGLSFEYVWE *******.:***::****.*..*******:*:*******:******************** ENSMUSP00000048238/1-1471 AAKHDHFDEQGRGHPDEALSYSSMFFPVEVFENSLSDPGPGKQDDSGQEVPVRAPGVVPV ENSRNOP00000050872/1-1531 AAKHDHFDEQGRGHPDEALSYSSMFFPVEVFENSLSDPGPGKQDGSGQEGPLRAPGVVPV ENSP00000297293/1-1503 AAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPV ENSCPOP00000008448/1-1485 AAKHDHFDERSRGHPDEALSYSSVFFPVEVFESSLSDPGPGKQDDSGQEVPLRAPGVVPV XP_004840525.1/1-1494 AAKHDHFDARSRAHPDEALSYSSIFFPVEVFESSLSDPGPGKQDDSGQEVPLRAPGVVPV ******** :.*.* **.***:*:*:******.***********.***: *:*.****** ENSMUSP00000048238/1-1471 FDAHNLSVGSDYYIQLEEKSSSNLGLD-PPALLTTEVDKLERAGAEE------------- ENSRNOP00000050872/1-1531 FDAHNLSVGSDYYIQLEEKSSSSLGLEYPPALLTTEVDNPEKGGTDAPHLTAFKTLVSEE ENSP00000297293/1-1503 FDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEE ENSCPOP00000008448/1-1485 FDAHNLSVGSDYYIQLEEKSRSNLELDYPPALLTTEMDNPEKTGTEE------------- XP_004840525.1/1-1494 FDAHNLSVGSDYYIQLEEKTRSNLELDYPPTLLTTEMDNPETAGAEASRFIALRNPDLEG *******************: *.* *: **:****::*: * *.: ENSMUSP00000048238/1-1471 PRTEEDFFQSSAHPKEASSTEDSRATSIPGSPF-NLFSDLDKADDLPSHQKIFDLMELNG ENSRNOP00000050872/1-1531 PSAEEDFFQSSARPKEANSAEDSHAASIPGSPF-NIFSDLDKADDLPSHQKIFDLMELNG ENSP00000297293/1-1503 SSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNG ENSCPOP00000008448/1-1485 SSTDEDFFQSSTDPKDSSIAEDFHVTSGPESPFNNIFNDLEKTEDLPSHQNIFNLMELNG XP_004840525.1/1-1494 SSTDEDFFQSSTDPKDFSLAEDLHVTSGPESPFNNILNDLEKAEDLPSHQKIFDLMELNG . ::*******: **: . . * :.:* * *** *::.*::*::******:**:****** ENSMUSP00000048238/1-1471 VQADFKPAILSSSLDDPKD---TCQSDKEKPHKLLDQGPLCLSESLLHQDHFDPLSVQEL ENSRNOP00000050872/1-1531 VQADFKPAILSPSLDGPKD---TCQSEREKPH---DQDPLCFPESPVHQDCFDPLSVQEL ENSP00000297293/1-1503 VQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQEL ENSCPOP00000008448/1-1485 VPADFKPTTLGSGLEDPRKSRITCHSDREKPHKLFDHEPFCLSENLLHQDHFDSLNVQEL XP_004840525.1/1-1494 VPADFKAATLGSSLEDPRQSGITCHSDKEK---LFDHEPFCVSENLLRQDHLDPLNVQEL * ****.: *...*:.*:. * : ::** * *:*..:. ::** :*.*.**** ENSMUSP00000048238/1-1471 SENFLFLQEKNLLKGSLTTKEQVSDLQTELKNAGFTSALLESPQRGSESSELEFLENTLD ENSRNOP00000050872/1-1531 SENFLFLQEKNLLKGSLPGKGRVNDLQTELKDAGFISEMLESPRRGSVSSGLELLEHTLD ENSP00000297293/1-1503 SENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPG ENSCPOP00000008448/1-1485 SENFLFLQEKNLLKGSLSSKELINDLHTELKNAGFTEALMETSHRNSLDSELKFPEDTPS XP_004840525.1/1-1494 SENFLFLQEKNLLKGSLSSKQLINDLHTELKNAGFTEALLETACTNSLDSELEFVEDTPG *****************. * :.**:****:*** . ::*:. .* .: *:: *.. . ENSMUSP00000048238/1-1471 FPLSQGDTRGQ-NEGAGVRRHSGTSPQASP----------ALLTEEGSPTAPTDPILKPE ENSRNOP00000050872/1-1531 FPSSQENMSGQ-NKGTGGTPQGATSPQASP-------------LTEGSPNGPPDSVLKSG ENSP00000297293/1-1503 LSLLQENVSTK-GDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQG ENSCPOP00000008448/1-1485 SPLSQENTSTK-VEDAGVKV--TTQSTSAPSFLEIPTPPTSLTAKETLLGGPSEPLSKAG XP_004840525.1/1-1494 SPLPQENTSFKGGEDAGITLKATTQSASVSSSPEIQVPPTSLTAEEAPPGGSSDSLLRPG . * : : ..:. * . : * ..:.: ENSMUSP00000048238/1-1471 ETKSFR-DVRVPEDSICLELGPDPVTVGVEIPATDAKTLDGGNRPPDVTCQSKEALSLTN ENSRNOP00000050872/1-1531 ETKPFT-GVSVPENSVCLDLSPDPVTGPVEIPAADAKAPDGGDGPPEVTCQSKEALNPTK ENSP00000297293/1-1503 ETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTE ENSCPOP00000008448/1-1485 ESKPTGLDCSIPEDCPCQDPTPDSVTARTEFPSTDANTHIVDHRPPDRTHQNKEALKLTK XP_004840525.1/1-1494 VSKPTGLHCSVSEDCACQDPHPDSVTATTEIPSTNAKTHSMDNGPPDRTQQNGEALRPTK ::. :.*:. : **.** .*: :::*.: .. . : . :. *:* *: ENSMUSP00000048238/1-1471 RHPILVNDITA-QGSVESCLPESRQDLQNEPFSEDPLSVSSLEKHSEAAETLNQLNSKAA ENSRNOP00000050872/1-1531 RDPILENEITA-QGSMETCLPESGQDLQNQPFSEDPLSGSILEKNSEAVETLNQLNYKAA ENSP00000297293/1-1503 SDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDA ENSCPOP00000008448/1-1485 RDAALMDGILANQAST-----ESRQDLQNQPFSEDQHGGSLQKKNLEAIETLNQFNSKDA XP_004840525.1/1-1494 RDTALVDGFLASQANTGDSLPESRQDLQNQPFTEDQHGGSLQEKSLEAVETLNQLNSKDA .. * : : * : . * *:*:*:**:** . :* ** *****:* * * ENSMUSP00000048238/1-1471 PEDAALASALSSDSTSQDSLLEDSLSTPIPTSEQSVETPDSLDSVDVREALLESLGSHTP ENSRNOP00000050872/1-1531 PKDAALASALSSDSTSQDSLLEDSLSTPIPTSEQSVETPDSLDSVDVHAALLESLGSHTP ENSP00000297293/1-1503 AKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTP ENSCPOP00000008448/1-1485 TKDIGLASTLSSDSTSQDSLLEDSLSTAIPTSEQSVETPDSLDSVDVHEALLESLVSHTP XP_004840525.1/1-1494 TKDTGLASALSSDSTSQDSLLEDSLSTAVLTSEQSVETPDSLDSVDVHEVLLEALGSHTP .:: .*.*:*****************:.. :** *:******:****: .**::* **** ENSMUSP00000048238/1-1471 RKLLPPDKPADSGYETENLESPEWTLHPAPEGTADSDAAAAGDSGHSSLPPNPVIVISDA ENSRNOP00000050872/1-1531 QKLLPPDKPADSGYETENLESPEWTLHPAPEGTADSDTAAAGDSSHSSLPPNPVIVISDA ENSP00000297293/1-1503 QKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDA ENSCPOP00000008448/1-1485 QKLLPPDKPADSGYETENLESPEWTLHPAPEGTSDSDPATAGDLGQSSLPPNPVIVVSDA XP_004840525.1/1-1494 QKLLPPDKPADSGYETENLESPEWTLHPTPEGTSDSDSAAAGDPGHSSLPPNPGVVVPDA :**:************************:****:**:.*::** .:*.***** :*:.** ENSMUSP00000048238/1-1471 GDGHRGAEGPPQSFTLGPQSSYRDSAYFSDNDSEPDKKPEEVPGTSANALVLVKGQSPPE ENSRNOP00000050872/1-1531 GDGHRGAEGPPQSFSLGTQSSYRDSAYFSDNDSEPDKKPEEAPGTSASALVLVKDQLPPE ENSP00000297293/1-1503 GDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPE ENSCPOP00000008448/1-1485 ASGHRGAEGTSQTFASGSQSSYRDSAYFSDNDSEPDKKSEEVPGASTSALLLIKDQSQPE XP_004840525.1/1-1494 GDSHRVAEGASQTSAPVSQSSYRDSAYFSDNDSEPDKKSEEVPGASTSALV-TKDQLLPE ...** :* ..:: : .*.***************:*:.**.**:*..**: : * ** ENSMUSP00000048238/1-1471 SVVPEESS-DVREGCLEAPQDKPDQSRVSTLQNSCHSELQETLQPTPAD----------- ENSRNOP00000050872/1-1531 PVAPEDSPDDVREGCLEASQSKPEQSPASALQNSCHSELQETLQPTPADQSPASALQNSC ENSP00000297293/1-1503 PVLPEQSP-AAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTG----------- ENSCPOP00000008448/1-1485 SVIPEQSP-GAKDGCLEATKSQPNQSYPLILENPSNLQL-EMLEPAQTD----------- XP_004840525.1/1-1494 PVIPEQSP-GAEDGCLQAQKSQPDQSCPPVLQHPSHLPLGEMLEPAQA------------ .* **:*. ..:.**:* :.:*::* *.:... * :*: : ENSMUSP00000048238/1-1471 ------------------------------------------------------------ ENSRNOP00000050872/1-1531 HSELQETLQPTPADQSPASALQNSCHSELQETLQPTPADQSPASALQNSCHSELQETLQP ENSP00000297293/1-1503 ------------------------------------------------------------ ENSCPOP00000008448/1-1485 ------------------------------------------------------------ XP_004840525.1/1-1494 ------------------------------------------------------------ ENSMUSP00000048238/1-1471 -----------------------------ASRESCPVNDEASSPLSLLNSEPSSCDDLDT ENSRNOP00000050872/1-1531 TPADQSPASALQNSCHSELQETLQPTPAGASRETYPVDDEARGPLGLLNSEFSSCDDLET ENSP00000297293/1-1503 -----------------------------VPQQVHPTEDEASSPWSVLNAELSSGDDFET ENSCPOP00000008448/1-1485 -----------------------------VSRQTHPVEDEANSPLSLLNSELSSGDDFET XP_004840525.1/1-1494 -----------------------------VFQQRPPGEDEARSPLSLPISELSSGDHLEA . :: * :*** .* .: :* ** *.::: ENSMUSP00000048238/1-1471 QEDRPCTLASTGTNTNELLAYMSSTLDKSLPSHLESSKLKEPDIEGKYLGKLCVSGMLDL ENSRNOP00000050872/1-1531 QEDRPCTLASTGTNTNELLAYTGSTLDKSLPSHFEGPKLKEPDIEGKYLGKLCVSGMLDL ENSP00000297293/1-1503 QDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDL ENSCPOP00000008448/1-1485 QEDHPCTLTSTGTNTNELLAYTNAAIDKSFSSHSEGPKLKEPDIEGKYLGKLSVSGMLDL XP_004840525.1/1-1494 QEAHPCTLTSTGTNTNELLAHTSPAADKPFSGHPEGPKLKEPDIEGKYLGKLGVSGMLDL *: :****:***********: ..: **.:..* *..*************** ******* ENSMUSP00000048238/1-1471 SEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDTEHPVPIIVSN-DDGRHLRSLLKP ENSRNOP00000050872/1-1531 SEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDMEHPVPIIVSN-DDGRHLRSLLKP ENSP00000297293/1-1503 SEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSN-EDGRHLRSLLKP ENSCPOP00000008448/1-1485 SEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDTEHPVPVILSNEEDSRHLRSLLKP XP_004840525.1/1-1494 SEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDDAEHPVPVILSNEEDSRHLRSLLKP ***********************************: *****:*:** :*.********* ENSMUSP00000048238/1-1471 SAAE--AIEQLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHGPGPSSPAAS ENSRNOP00000050872/1-1531 SAAA--AIEQLPDDWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHGPGPSSPAAS ENSP00000297293/1-1503 TAAN--APDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPA ENSCPOP00000008448/1-1485 AAAATVAISQLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGEEAHHPGPSSSAPT XP_004840525.1/1-1494 AAAA-VAMDQLPEAWKKEKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHRPGPSSPAPT :** * . **: ***************************** ** ** *. *..*.: ENSMUSP00000048238/1-1471 SSSPYLGRCMNSESSTDEE-GGGFEWDDDFSPDPFMSKTTS-LLGSKPSLQTSKYFSPPP ENSRNOP00000050872/1-1531 TGSPYLSRCMNSESSTDEE-GGGFEWDDDFSPDPFMSKTTS-LLGSKPSLQTSKYFSPPP ENSP00000297293/1-1503 SGSPYLSRCINSESSTDEE-GGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPP ENSCPOP00000008448/1-1485 SDSPYLSRCINSESSTDEEAGGGFEWDDDFSPDPFMSKTTSSLLGSKPSLQPSKYFSPPP XP_004840525.1/1-1494 SGSPYLSKTLNSESSTDEE-GGGFEWDDDFSPDPFMSKTTSNLLGSKPSLQPSKYFSPPP :.****.: :********* ********************* **.******.******** ENSMUSP00000048238/1-1471 PARSAEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGDKD ENSRNOP00000050872/1-1531 PARSSEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGDKD ENSP00000297293/1-1503 PARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD ENSCPOP00000008448/1-1485 PARSTEQSWPHVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD XP_004840525.1/1-1494 PARSTEQSWPLVSPCSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD ****:***** :* ********************************:**