CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000083742/1-1388 ------------------------------------------------------------ ENSRNOP00000030935/1-1391 ------------------------------------------------------------ ENSP00000295373/1-1386 ------------------------------------------------------------ ENSCPOP00000008219/1-1382 ------------------------------------------------------------ XP_004839517.1/1-1454 MALGRLRGRPGCSGDPVARETGTLSPGSKYARDQSEGTGAVRPQLGRRAAAIGEVPEGIS ENSMUSP00000083742/1-1388 ------------------------MSSSVRRKGKPGKGDGKGSSRGGRGGKGHMNKSHGG ENSRNOP00000030935/1-1391 ------------------------MSSSVRRKGKPGKGDGKGSSRGGRGGRGHVNKSHGG ENSP00000295373/1-1386 ------------------------MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGS ENSCPOP00000008219/1-1382 ------------------------MSSSVRRKGKPGKGGGKGASRGGRGSRSHTNKSHGA XP_004839517.1/1-1454 AVWTPQCWAPPPDSSPWKRVCEPEMSSSVRRKGKPGKGSGKGSSRGGRGSRSHVNQSHGA **************.***:******.:.* .:***. ENSMUSP00000083742/1-1388 GGGGGGSCGGGGG---GSRKASNRIWDDGDDFCVFTEPKRPSRPCDSNKSKGETRPKWKP ENSRNOP00000030935/1-1391 GGSGGGGCGGGGGGGSGSRKASNRIWDDGDDFCVFTESKRPSRPCDSNKSKGETRPKWKP ENSP00000295373/1-1386 GGGGGGGGGGGG----GNRKASSRIWDDGDDFCIFSESRRPSRPSNSNISKGESRPKWKP ENSCPOP00000008219/1-1382 GSGG----GGGG----GTRKASSRIWDDEDDFCIFGESKRSSRPSNSSLNKEEARTKWKP XP_004839517.1/1-1454 GGGGGGGGGGGG----GSRKASSRIWDDGDDFCIFSESRRSSRPSNNSMNKEEGSTKWKP *..* **** *.****.***** ****:* *.:*.***.:.. .* * .**** ENSMUSP00000083742/1-1388 KAKVPLQTLHMTSENQEKVKALLRDLQEQGADAGSERGTSGEEEDSEPQCG-EEQGWPAG ENSRNOP00000030935/1-1391 KAKVPLQTLHMTSENQEKVKALLRDLQEQGADAGSERGSSGEEEEDAPEGA-AEQSWSAG ENSP00000295373/1-1386 KAKVPLQTLHMTSENQEKVKALLRDLQEQDADAGSERGLSGEEEDDEPDCCNDERYWPAG ENSCPOP00000008219/1-1382 KAKVPLQTLCMTSENQEKVKALLRDLQEQDADAGSERGISIEEEDDEPDCCDEEQYWLAG XP_004839517.1/1-1454 KAKVALQTLHMTSENQEKVKALLRDLQEQDADAGSERGVSVEEEDDEPDCCDDKQYWLAG ****.**** *******************.******** * ***:. *: :: * ** ENSMUSP00000083742/1-1388 QEPIFLPDCSPWEYIGPEEVEPPVPECAVSPLAVQKLSRYGFHTEHCQLALRICDGDLGA ENSRNOP00000030935/1-1391 PEPTFLPDCRPWEYIGPEEVEPPLPEFTVSPLAVQKLSRYGFHTEHCQLALRICEGDLGA ENSP00000295373/1-1386 QEPSLVPDLDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGA ENSCPOP00000008219/1-1382 PELALVPDSDVLECVGSGPVQPWVPEVTVSPFAAQRLSRYGFHIERCQAALRICDGDLGA XP_004839517.1/1-1454 RELALVPDSDALACTGSGPVQPYIPEFLVSPFAAQRLSRYGFNIEHCQAALRICDGDLGA * ::** * *:* :** ***:*.*:******: *:** .**:*:**:** ENSMUSP00000083742/1-1388 ALEHLLRQCFSETFGERMALSEAAVYVSLNECVEQRQEETLALKSICGEKFIERIQNRVW ENSRNOP00000030935/1-1391 ALEHLLHQCFSETFGERMALSEAAVSVSLDECVEQRQEETLALKSICGEKFIERIQNRVW ENSP00000295373/1-1386 SLEHLLTQCFSETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVW ENSCPOP00000008219/1-1382 ALEHLLTQCFAETFGEKMKMSKAAGRVSLHECVEQRQEEALALKSICGEKFVERIQNRVW XP_004839517.1/1-1454 ALEHLLTQCFSETFGEKVKISKAAGRISLYECVEQRQEEALALKSICGEKFMERIQNRVW :***** ***:*****:: :*:*. :** **:******::**********:******** ENSMUSP00000083742/1-1388 TIGLELDYLTNKFCKSKQKESSKNVRDTSPETCKFYLKGNCKFGSKCKFKHEVPPHQMIG ENSRNOP00000030935/1-1391 TIGLELEYLTNKFCKSKQKESNKNVRDTSPETCKFYLKGNCKFGSKCKFKHEVPPHQIIG ENSP00000295373/1-1386 TIGLELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVG ENSCPOP00000008219/1-1382 TIGLELEYLTSKFCKSKQKES-KNVQDTSLETCRFYLKGNCKFGSRCKFKHEVPPNQIVG XP_004839517.1/1-1454 TIGLELEYLTSKFCKSKQKES-KNVQDTSFETCKFYLKGNCKFGSRCKFKHEVPPNQIVG ******:***.:* *** *** ***::.* * *:***********:*:*******:*::* ENSMUSP00000083742/1-1388 RAERNVNDPHLDADDDTTFMYELQIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEF ENSRNOP00000030935/1-1391 RTERNVNDPHLDAENDTTFLYELQIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEF ENSP00000295373/1-1386 RIERSVDDSHLNAIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEF ENSCPOP00000008219/1-1382 RAEKIVDDSHLNANEDVSFLYELEIRFPKDHKYPYQAPLVAFYSTNENLPLTCRLHISEF XP_004839517.1/1-1454 RAEKIVDDSHLNANEGVSFLYELEIRFPKDHKYPYQAPLVAFYSTNENLPLACRLHISEF * *: *:*.**:* :..:*:***:***.***********************:******** ENSMUSP00000083742/1-1388 LYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPVNVPPVPSETRISKPA ENSRNOP00000030935/1-1391 LYGKALEFAKTSEPVVYSLITLLEEESEIVKLLTHTQHKYSVPPINVPPAPSETRISKPA ENSP00000295373/1-1386 LYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINNPA ENSCPOP00000008219/1-1382 LYGRALTFAETSEPVVYSLITLLEEESEIVKLLTNTQHKYSVPPVNFLPAPSGTRINNPA XP_004839517.1/1-1454 LYGKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSVPPVNFLPVPSGTRMNNPA **.:** **:************************:*:**** **:*. *.** **:.:** ENSMUSP00000083742/1-1388 YRKPVVPSNTFLSNQMLEGERLSELEEDADEDEGPASIIVENESYVNLKKRSYKRYDRPA ENSRNOP00000030935/1-1391 YRKPVIPSNTFLSNQMLEGEGLSELEEDADEDEGPAPIVVENESYVNLKKRSYRRCDRPA ENSP00000295373/1-1386 CHKTVIPNNSFVSNQIPEVEKASE-SEESDEDDGPAPVIVENESYVNLKKKISKRYDWQA ENSCPOP00000008219/1-1382 CRKPAIPSNSSVSSQTPGVEKESEPEEEADEEEGPVPVIVENESYVNLKRKISKRYDWQA XP_004839517.1/1-1454 CRKPVIPSNSFVSSQIPEGKYQSEPEEEADEDEGPAPVIVENESYVNLKK-TSKRCDWQA :*..:*.*: :*.* : ** .*::**::**..::**********: :* * * ENSMUSP00000083742/1-1388 KSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGC ENSRNOP00000030935/1-1391 KSLFAENSKICRQFQMKQASRQFHAILQERQLLPAWEERETILKLLSKHQVVVISGMTGC ENSP00000295373/1-1386 KSVHAENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGC ENSCPOP00000008219/1-1382 KSVHAENSKICKQFQMKQASRQFQSVLQERQSLPAWEERENILKLLSKHQVVVISGMTGC XP_004839517.1/1-1454 KSVHAENSKICRQFQMKQASRQFQSVLQERQSLPAWEERETILKLLSKHQVVVISGMTGC **:.***.***:**:********:::***** ********.**:** ************* ENSMUSP00000083742/1-1388 GKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRL ENSRNOP00000030935/1-1391 GKTTQIPQFILDNSLNGPPERVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRL ENSP00000295373/1-1386 GKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRL ENSCPOP00000008219/1-1382 GKTTQIPQFILDDSLSGPPEKVANIICTQPRRISAISVAERVAKERAERVGLTVGYQIRL XP_004839517.1/1-1454 GKTTQIPQFILDDSLSGPPEKVANIICTQPRRISAVSVAERVAKERAERVGLTVGYQIRL ************:**.****:**************:************************ ENSMUSP00000083742/1-1388 ESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLL--LVLKDIVM ENSRNOP00000030935/1-1391 ESVKSSATRLLYCTTGVLLRRLEGDATLQGVTHIIVDEVHERTEESDFLL--LVLKDIVM ENSP00000295373/1-1386 ESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLL--LVLKDIVS ENSCPOP00000008219/1-1382 ESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHIIVDEVHERTEESDFLL--LVLKDIVL XP_004839517.1/1-1454 ESVKSSATRLLYCTTGVLLRRLEGDTALQGVTHVIVDEVHERTEERAQPAESQTSGGIAC *************************::****:*:*********** . .*. ENSMUSP00000083742/1-1388 QRATLQ-VILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSP ENSRNOP00000030935/1-1391 QRATLQ-VILMSATLDAGLFSKYFSYCPVITIPGRAFPVDQFFLEDALAVTRYVLQDGSP ENSP00000295373/1-1386 QRPGLQ-VILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDGSP ENSCPOP00000008219/1-1382 QRPNLQ-VILMSATLDAELFSEYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLHDGSP XP_004839517.1/1-1454 EGPKTEHVKWVNTFFPHQQPPHTYAHIPL-----------SFFL-------RYVLHEGSP : . : * :.: : .. : *: .*** ****::*** ENSMUSP00000083742/1-1388 YMRSMKQIAKEKLKARHNRTAQEEVEEDLRLSLHLQDEEESVKDTIPDQQLDFKQLLIRY ENSRNOP00000030935/1-1391 YMRSMKQIAKERLKARHNRTALEEVEEDLRLALHLQDEEESVKDTIPDQQLDFKQLLVRY ENSP00000295373/1-1386 YMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQD-QDSVKDAVPDQQLDFKQLLARY ENSCPOP00000008219/1-1382 YMRSMKQIAKEKLKARRNRTAFEEVEEDLRLSLHFQD-QDSVKDAVPDQQLDFKQLLARY XP_004839517.1/1-1454 YVRSMKQIAKEKLKARRNRTAFEEVEEDLRLSLHLQD-QDSAKDAVPDQQLDFKQLLVRY *:******:**:****:**** *********:**:** ::*.**::*********** ** ENSMUSP00000083742/1-1388 KGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHAYPPGAVLVFLPGLAEIKMLYEQL ENSRNOP00000030935/1-1391 KGVSKSVIKTMSVMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQL ENSP00000295373/1-1386 KGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQL ENSCPOP00000008219/1-1382 KGISKSVIKTMSMMDFEKVNLELIEALLEWIVDGKHSYPPGAVLVFLPGLAEIKMLYEQL XP_004839517.1/1-1454 KGISKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPGLAEIKMLYEQL **:*********:***********************:*****:***************** ENSMUSP00000083742/1-1388 QSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPMGVTKIIISTNIAETSITIDDVVY ENSRNOP00000030935/1-1391 QSNSLFNNRRSHRCVIHPLHSSLSSEEQQAVFVKPPLGVTKIIISTNIAETSITIDDVVY ENSP00000295373/1-1386 QSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVY ENSCPOP00000008219/1-1382 QSNCLFNNRRSNRCIIHPLHSSLSSEEQQAVFIKPPVGVTKIIISTNIAETSVTIDDVVY XP_004839517.1/1-1454 QSNSLFNNRRSNRCIIHPLHSSLSSEEQQAVFIKPPVGVTKIIISTNIAETSITIDDVVY ***.*******:**:*****************:*** ***************:******* ENSMUSP00000083742/1-1388 VIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLL ENSRNOP00000030935/1-1391 VIDSGKMKEKRYDAGKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLL ENSP00000295373/1-1386 VIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLL ENSCPOP00000008219/1-1382 VIDCGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLL XP_004839517.1/1-1454 VIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYTHQLL ***.**********.****************************************.**** ENSMUSP00000083742/1-1388 KQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHIDSLRASKVRLRDLGALT ENSRNOP00000030935/1-1391 KQQLPEIQRVPLEQLCLRIKILEMFSTHNLQSVFSRLIEPPHVDSLRASKVRLRDLGALT ENSP00000295373/1-1386 KQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALT ENSCPOP00000008219/1-1382 KQQLPEIQRVPLEQLCLRIKILDMFSTHSLQSVFSRLIEPPHTDSLRASKVRLRDLGALT XP_004839517.1/1-1454 KQQLPEIQRVPLEQLCLRIKILDMFSSHSLQSVFSRLIEPPHADSLRLSKIRLRDLGALT **********************:***:*.************* **** **:********* ENSMUSP00000083742/1-1388 PDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEA ENSRNOP00000030935/1-1391 PDEKLTPLGYHLASLPVDVRIGKLMLLGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEA ENSP00000295373/1-1386 PDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEA ENSCPOP00000008219/1-1382 PDEKLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEA XP_004839517.1/1-1454 QDEKLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDVKEEA **:**********************:**************************** **** ENSMUSP00000083742/1-1388 NQKKLEFAFANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFT ENSRNOP00000030935/1-1391 NQKKLEFAFANSDYLALLCAYKGWQLSTKESARASYNYCRQNFLSGRTLQEMASLKRQFT ENSP00000295373/1-1386 NQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFT ENSCPOP00000008219/1-1382 NQKKLEFAVANSDYLALLRAYKGWQLSTREGMHASYNYCRQNFLSGRALQEMASLKRQFT XP_004839517.1/1-1454 NQKKLEFAFANSDYLALLRAYKGWQLSTREGMHASYNYCRQNFLSGRILQEIASLKRQFT ********.********* *********:*. :************** ***:******** ENSMUSP00000083742/1-1388 ELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQ ENSRNOP00000030935/1-1391 ELLSDIGFVKEGLRAKEIEKRAQGGDGVLDATGEEANTNAENPKLISAVLCAALYPNVVQ ENSP00000295373/1-1386 ELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQ ENSCPOP00000008219/1-1382 ELLSDIGFVREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAVLCAALYPNVVQ XP_004839517.1/1-1454 ELLSDIGFAKEGLRAREIEKRAQGGDGVLDATGEEANSNGENPKLISAMLCAALYPNVVQ ********.:*****:*********************:*.********:*********** ENSMUSP00000083742/1-1388 VKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKI ENSRNOP00000030935/1-1391 VKTPEGKFQKTSSGVVRLQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKI ENSP00000295373/1-1386 VKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKI ENSCPOP00000008219/1-1382 VKTPEGKFQKTSTGAVRMQPKSTELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKI XP_004839517.1/1-1454 VKTPEGKFQKTSTGAVRMQPKSTELKFVTKNDGYVHIHPSSVNYQVRHFDSPYLLYHEKI **:*********:*.**:****:************************************* ENSMUSP00000083742/1-1388 KTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGAFVVSLDDGWIRFVAASHQVAELVKEL ENSRNOP00000030935/1-1391 KTSRVFIRDCSMVSVYPLVLFGGGQVSVQLQRGAFVVSLDDGWIRFVAASHQVAELVKEL ENSP00000295373/1-1386 KTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFVAASHQVAELVKEL ENSCPOP00000008219/1-1382 KTSRVFIRECSMVSVYPLVLFGGGQVNVQLQRGEFVVSLDDGWIRFAAASHQVAELVKEL XP_004839517.1/1-1454 KTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVISLDDGWIRFVAASHQVAELVKEL ********:*****************.****** **:*********.************* ENSMUSP00000083742/1-1388 RCELDQLLQDKIKNPSMDLCSCPRGSRIISMIVKLITTQ ENSRNOP00000030935/1-1391 RCELDQLLQDKIKNPSMDLCTCPRGSRIISMIVKLITTQ ENSP00000295373/1-1386 RCELDQLLQDKIKNPSIDLCTCPRGSRIISTIVKLVTTQ ENSCPOP00000008219/1-1382 RGELDQLLQDKIKNPSIDLCTCPRGSRIISTIVKLVTTQ XP_004839517.1/1-1454 RCELDQLLQDKIKNPSIDLCTCPRGSRIISMIVKLVTTQ * **************:***:********* ****:***