CLUSTAL W(1.81) multiple sequence alignment ENSP00000467556/1-1502 MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG ENSMUSP00000120649/1-1505 MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG ENSRNOP00000047081/1-1343 ------------------------------------------------------------ XP_004859265.1/1-1405 ------------------------------------------------------------ ENSCPOP00000008142/1-1387 -------------FQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLG ENSP00000467556/1-1502 KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD ENSMUSP00000120649/1-1505 KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD ENSRNOP00000047081/1-1343 ------------------------------------------------------------ XP_004859265.1/1-1405 ------------------MGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKDYVD ENSCPOP00000008142/1-1387 KSLQGRTDPIPIVVKYDVMGMGRMEMELDYAEDATERRRVLEVEKEDTEELRQKYKCYID ENSP00000467556/1-1502 KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS ENSMUSP00000120649/1-1505 KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS ENSRNOP00000047081/1-1343 -------------------------------------------QRLKDLKQREFARNVSS XP_004859265.1/1-1405 KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS ENSCPOP00000008142/1-1387 KEKAIAKALEDLRANFYCELCDKQYQKHQEFDNHINSYDHAHKQRLKDLKQREFARNVSS ***************** ENSP00000467556/1-1502 RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFKPTTVAVDEEGGEDDKDESATNSG ENSMUSP00000120649/1-1505 RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEDGGEEDKDESSTNSG ENSRNOP00000047081/1-1343 RSRKDEKKQEKALRRLHELAEQRKQAECAPGSGPMFRPTTVAVDEDGGEEDKDESSTNSG XP_004859265.1/1-1405 RSRKDEKKQEKALRRLHELAELRKQAECAPGSGPMFRPTTVAVDEDGGDEDKDESATNSA ENSCPOP00000008142/1-1387 RSRKDEKKQEKALRRLHELAELRKQAECAPGSGPMFRPTTVAVDEEAGDEDKDESATSSG ********************* **************:********:.*::*****:*.*. ENSP00000467556/1-1502 TGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQGISFGIKNNLGTPLQKLGV ENSMUSP00000120649/1-1505 ASAVSSCGFGADFSTDKGGSFTSVQITNTTGLSQAPGLASQGISFGIKNNLGPPLQKLGV ENSRNOP00000047081/1-1343 ASAISSCGFGSDFSTEKGGPFTSVQITNSTGLSQASGLASQGISFGIKNNLGPPLQKLGV XP_004859265.1/1-1405 SGAAAGCSLGPEFSTEKGGPFTTVAGTGSTGLPQASGPAAPSVSFGFKNNQGTPLQKLGV ENSCPOP00000008142/1-1387 SGAAAGCSLGPELSSEKGGPFTAVPGTSSTGPGQASGPASQGVSFGFKNNLGTPLQKLGV :.* :.*.:*.::*::***.**:* *.:** **.* *: .:***:*** *.******* ENSP00000467556/1-1502 SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPDEKSSDQGLQKVGDSDGSSNLDGKKE ENSMUSP00000120649/1-1505 SFSFAKKAPVKLESIASVFKDHAEEGSSEDGTKADEKSSDQGVQKVGDTDGTGNLDGKKE ENSRNOP00000047081/1-1343 SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKAEEKSSDQGVQKVGETDGGGNLDGKKE XP_004859265.1/1-1405 SFSFAKKAPVKLESIASVFKDHAEEGSSEEGTKPDEKGSDQGLQKAGDADGGGSTDGKKE ENSCPOP00000008142/1-1387 SFSFAKKAPVKLESIASVFKDHAEEGSSEEGTKPDEKGSDQGLQKVGDADLSGSTEGKKD **************************:**:***.:**.****:**.*::* .. :***: ENSP00000467556/1-1502 DEDPQDGGSLASTLSKLKRMKREEGAGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM ENSMUSP00000120649/1-1505 DEDPQDGGSLASTLSKLKRMKREEGTGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM ENSRNOP00000047081/1-1343 DEDPQDGGSLASTLSKLKRMKREEGTGATEPEYYHYIPPAHCKVKPNFPFLLFMRASEQM XP_004859265.1/1-1405 DEDPQDGAALASTLSKLKRMRREEGAGVVEPEYYHYIPPAHCKVKPHFPFLLFMRASEQM ENSCPOP00000008142/1-1387 DEDLQDGGALASTLSKLKRMRREEGTGTAEPEYYHYIPPAHCKVKPHFPFLLFMRASEQM *** ***.:***********:****:*..*****************:************* ENSP00000467556/1-1502 DGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKE---------TSMT ENSMUSP00000120649/1-1505 EGDHSAHSKSAPENRKSSSPKPQGCSKTAASPGAERTVSEASELQKE---------AAVA ENSRNOP00000047081/1-1343 EGDHRTHSKNAPENRKGSSPRPKGCSKAAASQGAEKTVSDVSEPQKE---------ATVV XP_004859265.1/1-1405 EGEASSHPKGTPDSKKSGSPKPKGCVRAAPSQAAEPGASERLEPPKEPKETKEATAVAGA ENSCPOP00000008142/1-1387 EGEANAHPKGTLDSKKSGSPKAKSSSRVAPSQAAEQDASNSLEPAKEPKESKEKEATTEA :*: :*.*.: :.:*..**:.:.. :.*.* .** .*: * ** .: . ENSP00000467556/1-1502 EPSEPGSKAEAKKALGGDVSDQSL-ESHSQKVSETQMCESNSSKETSL--ATPAGKESQE ENSMUSP00000120649/1-1505 GPSEPGGKTETKKGSGGGEDEQSV-ES-RE-TSESPMCESNPKDISQATPATKAGQ---- ENSRNOP00000047081/1-1343 GPSEPGGKTETKKCSGEGEGEQSV-ESLRE-SSESQMCESDPKEISQATPATKAGQ---- XP_004859265.1/1-1405 EPAQPRGKAEARKVPSGFPG-----EQGRP-VSEAQVRQPEPAKEPSAPGDSVAGRDSQG ENSCPOP00000008142/1-1387 EPTLPRGRAEARKAPAGNTGEQSAGEQGAPGSSEVQLREPAPAKEPHAPGTGTSGRDVQE *: * .::*::* . . *. ** : :. . . . :*: ENSP00000467556/1-1502 GPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKG ENSMUSP00000120649/1-1505 GPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDAKAKG ENSRNOP00000047081/1-1343 GPKHPTGPFFPVLSKDESTALQWPSELLIFTKAEPPISYSCNPLYFDFKLSRNKDAKAKG XP_004859265.1/1-1405 RPRHPTGPFFPVLSKDESTALQWPSELLIFTKAQPSVSYSCNPLYFDFKLSRNKDARAKG ENSCPOP00000008142/1-1387 GPRLPTGPFFPVLSKDESTALQWPSELLIFTRAEPSVSYSCNPLYFDFKLSRSKDARSRG *: ***************************:*:*.:***************.***:::* ENSP00000467556/1-1502 TEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPG ENSMUSP00000120649/1-1505 TEKPKDVAGSSKDHLQSLDPREPNKSQE-EEQDVVLSSEGRVDEPASGAACSSLNKQEPG ENSRNOP00000047081/1-1343 TEKPKDVGDSSKGHLQSPDPREPNKSKE-GEQSVVL-SEGRVDEPASGAACSSLTKQEPG XP_004859265.1/1-1405 AERAKDAGGPSREALPGPEASGPGGDKDAGEPQ-----------ADGGPPAAAAAPLAPA ENSCPOP00000008142/1-1387 AERAKDAAGPSRDTLLSTEAAGQSGDKDLGQPR-----------ADVGLAVAAPEGPEPG :*:.** ...*: * . :. . .:: . * . :. *. ENSP00000467556/1-1502 GSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK--SSKAESGE ENSMUSP00000120649/1-1505 GSHMSETEDTGRSHPSKKEPSGKSHRHKKKKKHKKSSKHKRKHKADTEEK--SSKAESGE ENSRNOP00000047081/1-1343 GSHASETEDTGRSHPNKKEPSGKSHRHKKKKKHKKSSKHKRRHKADMEEK--SSKAESGE XP_004859265.1/1-1405 REPEPEPQDTGQSLAGRKERRGRTHRHKKRKKHKKSGRHKRRHKADADEKGSGSRADPGD ENSCPOP00000008142/1-1387 GSHGPAPQDTVRSLGSRKERPGRAHRHKKKKKHKKSSKHKRRHKADPEEK--GSRTEPGE . . .:** :* .:** *::*****:******.:***:**** :** .*:::.*: ENSP00000467556/1-1502 KSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSS ENSMUSP00000120649/1-1505 KSKKRKKRKRKKNKSSAAADSERGPKSEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGNS ENSRNOP00000047081/1-1343 KSKKRKKRKRKKNKS-APADSERGPKPEPPGSGSPAPPRRRRRARDDSQRRSLPAEEGNS XP_004859265.1/1-1405 KSRKRKKRKRKK-KSGGAADSERGPKPEPPGSGSPAPPRRLRR-HDESQRRPLPAADESG ENSCPOP00000008142/1-1387 KAKKRKKRKRKK-KSTGGADSERGPKPEPPGSGSPPPPRRRR--QEESQRRPLPSTD--- *::********* ** . ********.********.**** * :::****.**: : ENSP00000467556/1-1502 GKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDA-SS ENSMUSP00000120649/1-1505 GKKDDGGGGSSCQDHSGRKHKGEPPTSSCQRRANTKHSSRSSHRSQPSSGDEDSDDA-SS ENSRNOP00000047081/1-1343 GKKDDGGAGSGSQDHSGRKHKGEPPASSCQRRTSAKHSSRSSHRSQPSSGDEDSDNASSS XP_004859265.1/1-1405 GGQRDAGGGA--QERGGRRQPGEPPATSCQRRASAPRTGNTHRHGRPSSGEEDSDGG-AA ENSCPOP00000008142/1-1387 --------------------RGEPPTTSCQHRANTPRTSNPRCHNQPSSGEDEESDGILS ** *.:***:*:.: ::... :.:****:::.... : ENSP00000467556/1-1502 HRLHQKSPSQYSEEEEE---------EDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDA ENSMUSP00000120649/1-1505 HRLHQKSPSQYSEEEEEEEEEEEEEDEDSGSEHSRSRSRSGHRHSSHRSSRRSYSSSSDA ENSRNOP00000047081/1-1343 HRPHQKSPSQYKEEEEEEEEEEEEEDEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDA XP_004859265.1/1-1405 RRPRQESPAQYSDEDDDDEEE-----EDSGSARSRSRSR-SRR----RSSRRSYSSSSAA ENSCPOP00000008142/1-1387 HRLHQESPSQY----------------NSGSARSRSHSR-GHRHSSHRSSRRSYSSSSAA :* :*:**:** :*** :***:** .:* *********** * ENSP00000467556/1-1502 SSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSS-DDDY ENSMUSP00000120649/1-1505 SSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYTSSKHRSKRHKYSSS-DDDY ENSRNOP00000047081/1-1343 SSDQSCYSRQHSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSS-DDDY XP_004859265.1/1-1405 SSDQSCYSRPRSYSDDSYSDYSERSRRHSKRSHGSDDSDYASPK----RRKYSSSEDDDY ENSCPOP00000008142/1-1387 SSDQSCYSRPRSYSDDSYSDYSDHSRRHPKRS-------YTSPKHRSKRRKYSSSEEDDY ********* :***********::****.*** *:*.* *:***** :*** ENSP00000467556/1-1502 SLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRS ENSMUSP00000120649/1-1505 SLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRS ENSRNOP00000047081/1-1343 SLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRS XP_004859265.1/1-1405 SLSGSPSRSRSRSRSRERSPTRSR----SSSHSRSQRRSRSTTAHSWQRSRSYSRDRSRS ENSCPOP00000008142/1-1387 SLS------------------HSRSRSLSSSQSRSQRRSRSTTAHSWQRSRSYSRDRSRS *** :.* *.*:***:************************ ENSP00000467556/1-1502 TRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRG ENSMUSP00000120649/1-1505 TRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFQSGRGEGPGKKEDGRG ENSRNOP00000047081/1-1343 TRSPSQRSGSRKGSWGHESPEERRSGRRDFIRSKIYRSQSPHYFRSGRGEGHGKKEDGRG XP_004859265.1/1-1405 TRSPSQRSGSRKGSWGHDSPENRRSSRRDFIRSKIYRSQSPHYFWSGRGDCPGKKDDSQG ENSCPOP00000008142/1-1387 TRSPSQRSGSRKGSWGHESPKNRRSGRRDFIRSKIYRSQSPHYFQSGRGDGVGKKDDGRG ************ ****:**::*:*.****************** ****: ***:*.:* ENSP00000467556/1-1502 DDSKATGPPSQNSNI-GTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQA ENSMUSP00000120649/1-1505 DDSKGAGLPSQNSNT-GTGRGSESDCSPEDKNSVTARLLLEKIQSRKVERKPNVCEEVLA ENSRNOP00000047081/1-1343 EDSKGAGLPSQNSNAGGTGRGSESDCSPEDKNSVTARLLLEKIQSRKVERKPNVCEEVLA XP_004859265.1/1-1405 DDSKASGPPSQNSST-GTGRGSESDCGPEDKNSVTARLLLEKVQSRKGERKPSMGEEVLA ENSCPOP00000008142/1-1387 DDSKGTGPP-QNSNT-SMGRGSESDCSPADKNSVTAKLLLEKVQSRKGERKPSVGEEVLA :***.:* * ***. . *****.**.* *******:*****:**** ****.: *** * ENSP00000467556/1-1502 TPNKAGPKLKDPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEESGLERGEEQEQ ENSMUSP00000120649/1-1505 TPNKAGLKYKNPPQGYFGPKLPPSLGNKPVLPMIGKLPATRKSNKKCEESGLERGEEQEH ENSRNOP00000047081/1-1343 TPNKAGLKYKNPPQGYFGPKLPPSLGNKPVLPMIGKLPATRKSNKKCEDSALERGEEQEH XP_004859265.1/1-1405 TPNKAGLKLKDPPQGYFGPKLPPSLGSKPVLPLIGKLPTTRKPNRKCEESGVEKGEEQDQ ENSCPOP00000008142/1-1387 TPNKAGLKLKDPPQGYFGPKLPPSLGSKPVLPLIGKLPATRKPNRKCEESGVERGEEQDQ ****** * *:***************.*****:*****:***.*:***:*.:*:****:: ENSP00000467556/1-1502 SETEEGPPGSSDALFGHQFPSEETTGPLLDPPPEESKSGEATADHPVAPLGTPAHSDCYP ENSMUSP00000120649/1-1505 SEPEEGSPRSSDAPFGHQF-SEEAAGPLSDPPPEEPKSEEATADHSVAPLGTPAHTDCYP ENSRNOP00000047081/1-1343 SEPEEGSPRSRDAPLGHQFSSEDTAGPLSDPPPEEPKSEEATADHSVAPLGTPAHTD-YP XP_004859265.1/1-1405 SETEEGPPGS-----GCQVPAEDTAGPLSELPPGEPTSKEATAAYPVAPLGAPAHSDCYP ENSCPOP00000008142/1-1387 SETEEGLPGS-----GRQFPTENTAGPLLDPPPEEPKSEEATADHPVAPLSTPAHSDCYP **.*** * * * *. :*:::*** : ** *..* **** :.****.:***:* ** ENSP00000467556/1-1502 GDPTISHNYLPDPSDGDTLESLDSSSQPGPVESSLLPIAPDLEHFPSYAPPSGDPSIEST ENSMUSP00000120649/1-1505 GDPAISHNYLPDPSDGDTLESLDSGSQPGPVESSLLPIAPDLEHFPNYAPPSGEPSIEST ENSRNOP00000047081/1-1343 GDPAISHNYLPDPSDGDALESLDSGSQPGPVESNLLPIAPDLEHFPSYAPPSGEPSIEST XP_004859265.1/1-1405 GDPASSHSYLPDPSNGDTLEPPESGSQPGPVDAGLLPAAPDLEHFPGYAPPSREPRGESP ENSCPOP00000008142/1-1387 GDPAGPHSYLPDPSDGDTLESLESSSQPGPMDAGLLPAAPDLEHFAGYAPPSGEPSIESA ***: .*.******:**:**. :*.*****:::.*** *******..***** :* **. ENSP00000467556/1-1502 DGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASAALAPATP ENSMUSP00000120649/1-1505 DGTEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATP ENSRNOP00000047081/1-1343 DGTEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASTALAPATP XP_004859265.1/1-1405 EGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQAKAFPASAALAPAAP ENSCPOP00000008142/1-1387 EGAEDASLAPLESQPITFTPEEMEKYSKLQQAAQQHIQQQLLAKQVKAFPASATLAPAAP :*:******************************************.******::****:* ENSP00000467556/1-1502 ALQPIHIQQPATASATSITTVQHAILQHH-AAAAAAAIGIHPHPHPQPLAQVHHIPQPHL ENSMUSP00000120649/1-1505 ALQPIHIQQPATASATSITTVQHAILQHH-AAAAAAAIGIHPHPHPQPLAQVHHIPQPHL ENSRNOP00000047081/1-1343 ALQPIHIQQPATASATSITTVQHAILQHH-AAAAAAAIGIHPHPHPQPLAQVHHIPQPHL XP_004859265.1/1-1405 ALQPIHIQQPAAASATSITTVQHAILQHHAAAAAAAAIGIHPHAHPQPLAQVHHIPQPHL ENSCPOP00000008142/1-1387 ALQPIHIQQPATASATSITTVQHAILQHH-AAAAAAAIG--------------------- ***********:***************** ********* ENSP00000467556/1-1502 TPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAA ENSMUSP00000120649/1-1505 TPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAA ENSRNOP00000047081/1-1343 TPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAA XP_004859265.1/1-1405 TPISLSHLTHSIIPGHPATFLASHPIHIIPASAIHPGPFTFHPVPHAALYPTLLAPRPAA ENSCPOP00000008142/1-1387 -------------------FLASHPIHIIPASAIHPGPFAFHPVPHAALYPTLLAPRPAT ********************:*******************: ENSP00000467556/1-1502 AAATALHLHPLLHPIFSGQDLQHPPSHGT ENSMUSP00000120649/1-1505 AAATALHLHPLLHPIFSGQDLQHPPSHGT ENSRNOP00000047081/1-1343 AAATALHLHPLLHPIFSGQDLQHPPSHGT XP_004859265.1/1-1405 AAATALHLHPLLHPIFSGQELQHPPSHGT ENSCPOP00000008142/1-1387 AAATALHLHPLLHPIFSGQDLQHPPSHGT *******************:*********