CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000008106/1-1398 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV ENSRNOP00000004600/1-1492 MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV ENSMUSP00000108203/1-1554 MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV ENSP00000364550/1-1560 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV XP_004873563.1/1-1378 MEPGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPA---------- ** *********************************************** ENSCPOP00000008106/1-1398 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV ENSRNOP00000004600/1-1492 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV ENSMUSP00000108203/1-1554 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV ENSP00000364550/1-1560 DNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVV XP_004873563.1/1-1378 ---------------------------------------------------------IVV *** ENSCPOP00000008106/1-1398 EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP ENSRNOP00000004600/1-1492 EEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP ENSMUSP00000108203/1-1554 EEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP ENSP00000364550/1-1560 EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP XP_004873563.1/1-1378 EEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP ******:***************************************************** ENSCPOP00000008106/1-1398 FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG ENSRNOP00000004600/1-1492 FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG ENSMUSP00000108203/1-1554 FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG ENSP00000364550/1-1560 FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG XP_004873563.1/1-1378 FDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYG ************************************************************ ENSCPOP00000008106/1-1398 AGPKMMGLGLMAKDKTLRKK-------DKEGPECPPTVVVKEESGGDMKVESTSPKTFLE ENSRNOP00000004600/1-1492 AGPKMMGLGLMAKDKNLRKKEPLFSPTDKEGPECPPTVGGKEELGGEWKMESASPKTFLE ENSMUSP00000108203/1-1554 AGPKMMGLGLMAKDKTLRKK-------DKEGPECPPTVVVKEELGGDVKMESTSPKTFLE ENSP00000364550/1-1560 AGPKMMGLGLMAKDKTLRKK-------DKEGPECPPTVVVKEELGGDVKVESTSPKTFLE XP_004873563.1/1-1378 AGPKMMGLGLMAKDKTLRKK-------DKEGPECPPTVVVKEESGGDVKVESTSPKAFLE ***************.**** *********** *** **: *:**:***:*** ENSCPOP00000008106/1-1398 SKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFC ENSRNOP00000004600/1-1492 GKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFC ENSMUSP00000108203/1-1554 GKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFC ENSP00000364550/1-1560 SKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFC XP_004873563.1/1-1378 SKEELSHSPEPCTKMTMRLRRNHSNAQFIESYICRMCSRGDEDDKLLLCDGCDDNYHIFC .*******************************:*************************** ENSCPOP00000008106/1-1398 LLPPLPELGTTLWDCSWVLFQECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPV ENSRNOP00000004600/1-1492 LLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPV ENSMUSP00000108203/1-1554 LLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPV ENSP00000364550/1-1560 LLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPV XP_004873563.1/1-1378 LLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPV *******: . :* *. :: *************************************** ENSCPOP00000008106/1-1398 HMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSG ENSRNOP00000004600/1-1492 HMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSG ENSMUSP00000108203/1-1554 HMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSG ENSP00000364550/1-1560 HMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSG XP_004873563.1/1-1378 HMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSG ************************************************************ ENSCPOP00000008106/1-1398 WNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKT ENSRNOP00000004600/1-1492 WNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKT ENSMUSP00000108203/1-1554 WNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKT ENSP00000364550/1-1560 WNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKT XP_004873563.1/1-1378 WNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKT ************************************************************ ENSCPOP00000008106/1-1398 WYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEF ENSRNOP00000004600/1-1492 WYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEF ENSMUSP00000108203/1-1554 WYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEF ENSP00000364550/1-1560 WYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEF XP_004873563.1/1-1378 WYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEF ************************************************************ ENSCPOP00000008106/1-1398 VITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAA ENSRNOP00000004600/1-1492 VITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAA ENSMUSP00000108203/1-1554 VITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAA ENSP00000364550/1-1560 VITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAA XP_004873563.1/1-1378 VITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAA ************************************************************ ENSCPOP00000008106/1-1398 CPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKVSGGRVP--RVKYLRLVQIEGDGRNQ ENSRNOP00000004600/1-1492 CPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEK---GVLPAGRQCIEHYRRLRRYCVFS ENSMUSP00000108203/1-1554 CPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEK---GITEAEREAFELLPDDERQCIKC ENSP00000364550/1-1560 CPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEK---GITEAEREAFELLPDDERQCIKC XP_004873563.1/1-1378 CPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEK---GITEAEREAFELLPDDERQCIKC ********************************** * * . ENSCPOP00000008106/1-1398 KMECSLSFWMMKTQQD-RLVYETGI-----------Y-SYSCSVATLVILIHKEIEIWNV ENSRNOP00000004600/1-1492 HEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRL-R-KALLEKVIPNLNL-IQIFLS ENSMUSP00000108203/1-1554 KTTCFLSALACYDCPD-GLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHK-LKVRAE ENSP00000364550/1-1560 KTTCFLSALACYDCPD-GLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHK-LKVRAE XP_004873563.1/1-1378 KTTCFLSALACYDCPD-GLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHK-LKVRAE : . * *. : : :: ::: ENSCPOP00000008106/1-1398 SLE--MLFLLIQMVQKQSHFNTFPISVCQMSESSYRHSTLLGFKLLVQAGMCM-----CI ENSRNOP00000004600/1-1492 FFPALTILIKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACV ENSMUSP00000108203/1-1554 SFD--TWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACV ENSP00000364550/1-1560 SFD--TWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEAEACV XP_004873563.1/1-1378 SFD--TWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACV : :::. : .. .. .:. : **. *. : . :** : *: *: ENSCPOP00000008106/1-1398 ETQ---VTDRWADIHRKTP---TMTEAEGYMCGMCRHCQQVDRLTDKQSMRAVAEGYMNV ENSRNOP00000004600/1-1492 SRALGLVSGQEAG---VAGVQMTLAELQDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTE ENSMUSP00000108203/1-1554 SRALGLVSGQEAGPDRVAGLQMTLAELRDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTE ENSP00000364550/1-1560 SRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVEAYQAE XP_004873563.1/1-1378 SRALGLVSGQEAGPHRVAGLQMTLAELRAFLDQMNNLPCAMHQIGDVKGILEQVEAYQAE . *:.: *. : *::* . :: * . :.:: * :.: .*.* ENSCPOP00000008106/1-1398 CS------------------------------------------LEEVE--LAAIHRKGC ENSRNOP00000004600/1-1492 AREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGT ENSMUSP00000108203/1-1554 AREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGT ENSP00000364550/1-1560 AREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGT XP_004873563.1/1-1378 AREALASLPSSPGLLQSLLEKGQQLGVEVPEVQQLQRQVEQARWLDEVKRTLAPSARRGT . *:**: **. *:* ENSCPOP00000008106/1-1398 EQI--------GPVARITSIHRA---------YADRYGGQAGLLF--RQKHPPATLEAII ENSRNOP00000004600/1-1492 LAIMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAII ENSMUSP00000108203/1-1554 LAIMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAII ENSP00000364550/1-1560 LAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAII XP_004873563.1/1-1378 LAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAII : ..** .::.:* *:*: :* * : ************* ENSCPOP00000008106/1-1398 REAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLE ENSRNOP00000004600/1-1492 HEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLE ENSMUSP00000108203/1-1554 HEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLE ENSP00000364550/1-1560 REAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLE XP_004873563.1/1-1378 REAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLE :*************:********************************************* ENSCPOP00000008106/1-1398 ELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLY ENSRNOP00000004600/1-1492 ELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLY ENSMUSP00000108203/1-1554 ELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLY ENSP00000364550/1-1560 ELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLY XP_004873563.1/1-1378 ELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLY ************************************************************ ENSCPOP00000008106/1-1398 KSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSTTASSATS ENSRNOP00000004600/1-1492 KSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASLTTNSSTAS ENSMUSP00000108203/1-1554 KSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTAS ENSP00000364550/1-1560 KSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTS XP_004873563.1/1-1378 KSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSTTASTATS ************************************************** :* *:::* ENSCPOP00000008106/1-1398 ICVCGQVPAGVGALQCDLCQDWFHGRCVSVPRLLNSPRPSPTSSPLLAWWEWDTKFLCPL ENSRNOP00000004600/1-1492 ICVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLTSSPLLAWWEWDTKFLCPL ENSMUSP00000108203/1-1554 ICVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLPSSPLLAWWEWDTKFLCPL ENSP00000364550/1-1560 ICVCGQVLAGAGALQCDLCQDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPL XP_004873563.1/1-1378 ICVCGQVPAGVGALQCDLCQDWFHGRCVSVPHLLNSPRPSPTSSPLLAWWEWDTKFLCPL ******* **.*****************:**:**.* *.. .****************** ENSCPOP00000008106/1-1398 CMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLG ENSRNOP00000004600/1-1492 CMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLG ENSMUSP00000108203/1-1554 CMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLG ENSP00000364550/1-1560 CMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLG XP_004873563.1/1-1378 CMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALLG ************************************************.****:****** ENSCPOP00000008106/1-1398 RLADLRQRLQAEPRPEEPPTYPSALAS--DSLREGSGKDMPKAQGLLENGDGVTSPEKV- ENSRNOP00000004600/1-1492 RLAELRQRLQAESKPEESLAYSSDAYTFKSPLAQPFRSILSSVQGLLENGDSVTSPEKVA ENSMUSP00000108203/1-1554 RLAELRQRLQAESKPEESLAYPSDGG-------EGTG-NMPKVQGLLENGDSVTSPEKVA ENSP00000364550/1-1560 RLAELRQRLQAEPRPEEPPNYPAAPAS--DPLREGSGKDMPKVQGLLENGDSVTSPEKVA XP_004873563.1/1-1378 RLAELRQRLQAEPRPEEPPTYPSALVS--DSLREGSGKDMPKAQGLLENGDGVTSPEKVT ***:********.:***. *.: : :...********.******* ENSCPOP00000008106/1-1398 -EEGSGKRDMELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQ ENSRNOP00000004600/1-1492 TEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQ ENSMUSP00000108203/1-1554 TEEGSGKRDLELLSSILPQLSGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQ ENSP00000364550/1-1560 PEEGSGKRDLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQ XP_004873563.1/1-1378 PEEGS---DLELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSI----- **** *:*****:****:********************************** ENSCPOP00000008106/1-1398 AGQPPDLQRIHALLELEKAERHGSRARGRALEKRRRRKVDRGGEGDDPAREELEPKRVRS ENSRNOP00000004600/1-1492 AGQPPDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRS ENSMUSP00000108203/1-1554 AGQPPDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRS ENSP00000364550/1-1560 AGQPPDLERIRTLLELEKAERHGSRARGRALERRRRRKVDRGGEGDDPAREELEPKRVRS XP_004873563.1/1-1378 ---PKSFDFYILTPRYSDLSSWG------------------------PAPGVPHPW---- * .:. . .. . * ** .* ENSCPOP00000008106/1-1398 ------------------------------------------------------------ ENSRNOP00000004600/1-1492 S----------------------------------------------------------- ENSMUSP00000108203/1-1554 SGPEAEEVQEEEELEEETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGSDTSAPFSTLT ENSP00000364550/1-1560 SGPEAEEVQEEEELEEETGGEGPPAPIPTTGSPSTQENQNGLEPAEGTTSGPSAPFSTLT XP_004873563.1/1-1378 ------------------------------------------------------------ ENSCPOP00000008106/1-1398 ---------------- ENSRNOP00000004600/1-1492 ---------------- ENSMUSP00000108203/1-1554 SRLLMSCPQQPSLQQL ENSP00000364550/1-1560 PRLHLPCPQQPPQQQL XP_004873563.1/1-1378 ----------------