CLUSTAL W(1.81) multiple sequence alignment XP_004869001.1/1-1560 MEALFPKVQLQEASPGEAGGMASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQGSLPEN ENSCPOP00000008002/1-1567 --------------------MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQGSLPEN ENSP00000260983/1-1572 --------------------MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPEN ENSMUSP00000113283/1-1578 --------------------MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQNSMPEN ENSRNOP00000017761/1-1578 --------------------MASSAREHLLFVRRRNPQMRYTLSPENLQSLATQNSMPEN ********************************:*.*:*** XP_004869001.1/1-1560 MTLQRANSDTDLVTSESRSSLTASMYEYMLGQAQNLIIFWDIKEEVDPSDWIGLYHIDEN ENSCPOP00000008002/1-1567 MTLPRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDEN ENSP00000260983/1-1572 MTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDEN ENSMUSP00000113283/1-1578 MALQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDEN ENSRNOP00000017761/1-1578 MALQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDEN *:* ************************ ******************************* XP_004869001.1/1-1560 SPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK ENSCPOP00000008002/1-1567 SPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK ENSP00000260983/1-1572 SPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK ENSMUSP00000113283/1-1578 SPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK ENSRNOP00000017761/1-1578 SPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVK ************************************************************ XP_004869001.1/1-1560 NPAVMMGAEGMEDGVSGNLHSRKLVSFTLS-DLRAVGLKKGMFFNPDPYLKMSIQPGKKS ENSCPOP00000008002/1-1567 NPAVMMGAEGTEGGMSGSLHSRKLVSFTLSEDLRAVGLKKGMFFNPDPYLKMSIQPGKKS ENSP00000260983/1-1572 NPAVMMGAEGMEGGASGNLHSRKLVSFTLS-DLRAVGLKKGMFFNPDPYLKMSIQPGKKS ENSMUSP00000113283/1-1578 NPAVMMGAEGMEGGASGSLHSRKLVSFTLS-DLRAVGLKKGMFFNPDPYLKMSIQPGKKS ENSRNOP00000017761/1-1578 NPAVMMGAEGMEGCASGSLHSRKLVSFTLS-DLRAVGLKKGMFFNPDPYLKMSIQPGKKS ********** *. **.************ ***************************** XP_004869001.1/1-1560 SFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLG ENSCPOP00000008002/1-1567 SFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLG ENSP00000260983/1-1572 SFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLG ENSMUSP00000113283/1-1578 SFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLG ENSRNOP00000017761/1-1578 SFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLG ************************************************************ XP_004869001.1/1-1560 KLTIPVQRLLERQAIGDQMLSYSLGRRLPADHVSGYLQFKVEVTSSMHEDASPEAVGTIL ENSCPOP00000008002/1-1567 KLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSAHEDASPEAVGTIL ENSP00000260983/1-1572 KLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGTIL ENSMUSP00000113283/1-1578 KLTIPVQRLLERQA-GDQMLSYNLGRRLPADHVSGYLQFKVEVTSSAHEDASPEAVGTIL ENSRNOP00000017761/1-1578 KLTIPVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPSSAQEDASPEAVGTIL ************** *******.****************:***.** :************ XP_004869001.1/1-1560 GVSTVNGDLGSPSDDEDVPGSHQDSPGCANGPVSEDSAADGTPKHSLRTSCTLEIEAEEL ENSCPOP00000008002/1-1567 GVSTVNGDLGSPSDDEDMPGSHQDSPGCANGAVSEDSTADGTPKHSFRTSSTLEMDAEEL ENSP00000260983/1-1572 GVNSVNGDLGSPSDDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEEL ENSMUSP00000113283/1-1578 GVHTVNGDLGSPSDEEDMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTLEIDTEDL ENSRNOP00000017761/1-1578 GVHTVNGDLGSPSDDEDMPGSHHDSTICANGPVSEDSVADGTPKHSFRTSSTLEIDTEDL ** :**********:**:****:** *:**.*****.********:***.***:::*:* XP_004869001.1/1-1560 AATSSRASPPRGRQDSLNDYLDALEHGGPSRPG-------PMGASPKLRSSFPTDTRLSA ENSCPOP00000008002/1-1567 TSTSSRTSPPRGRQDSLNDYLDALEHDGPARPG-ATASERPMGASPKLRSSFPTDTRLSA ENSP00000260983/1-1572 TSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNA ENSMUSP00000113283/1-1578 ISTSSRNSPPRGRQDSLNDYLDAIEHNGPARPGAASSSERSMGASPKLRSSFPTDTRLNA ENSRNOP00000017761/1-1578 ISTSSRNSPPRGRQDSLNDYLDAIEHNGPSRPGTASSSERPMGASPKLRSSFPTDTRLNA :**** ****************:**.* :*** .*****************.* XP_004869001.1/1-1560 MLHIDSDEEDHEFPQDRGCPSSLEEDGGLIMFGRAA-----SPVSYSGLEAARPLDTGER ENSCPOP00000008002/1-1567 MLHIDSDEEDHELQQDLGYPSSLEEEGGLIMLSRPSRADEGSLTSQTKSEDTNLVDLEE- ENSP00000260983/1-1572 MLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLED-NPVENEE- ENSMUSP00000113283/1-1578 MLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMCSRASRIDDGSLTSQTKPEDDNPVENED- ENSRNOP00000017761/1-1578 MLHIDSDEEDHDFQQDLGYPSSLEEEGGLIMCSRTSRIDDGSLTSQTKPEDDNPVENED- ***********:: ** * ******:***** .*.: * .* : * . :: : XP_004869001.1/1-1560 PEAARHGDGHGDGDEALPGPVDG--SPDPAPEEGEAAGPESGPVAEPEPEPEPRGSEEAE ENSCPOP00000008002/1-1567 -HSVLEAVSQEDKPEDLPELADG--PLDAAPEDGEAAGPDSHPEVE-QGSTKLCGSQEAE ENSP00000260983/1-1572 -ASTHEAASFEDKPENLPELAESSLPAGPAPEEGE-GGPEPQPSAD-QGSAELCGSQEVD ENSMUSP00000113283/1-1578 -ASIHETASLEERLENLPEVADGSLPSSTAPDENE-ANLEPQPSAD-QGSTELCSSQEVD ENSRNOP00000017761/1-1578 -ASVHETASLEERPENLPEVEDGSLPSGTAPDENE-ASVEPQPSAD-QGSTELCSSQEVD : . . : * ** :. . ..**::.* .. :. * .: : ..: .*:*.: XP_004869001.1/1-1560 QPASGADPGTPNTSAGSRRAASEAESLDQGSEPSQVSSETEPSDPARTESASEASARLEG ENSCPOP00000008002/1-1567 QPASGADTGTPDTSGGSRRAISETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEG ENSP00000260983/1-1572 QPTSGADTGTSDASGGSRRAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEG ENSMUSP00000113283/1-1578 QPTSGADAGASDTSGGSRRAASETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEG ENSRNOP00000017761/1-1578 QPTSGTDAGASDTSVGSRRAASETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPEG **:**:*.*:.::* ***** **:**************************.****:* ** XP_004869001.1/1-1560 ESDPEGADSSCTESAATQLTSAHTRCSSPGSARFPGTPAFSSQEDDDGG----AAEPAA- ENSCPOP00000008002/1-1567 ESDLEGADSSCNDSVATQL-------SSLESARPPGTPAFSSQEDEDGACAAAAAEPPSR ENSP00000260983/1-1572 ESDLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGAC---AAEPTSS ENSMUSP00000113283/1-1578 ESDPEGADSSCNESVTTQLSSVETRCSSLESARFPETPAFSSQEEEDGAC---AAEPTSS ENSRNOP00000017761/1-1578 ESDLEGADSSCNESVTTQLSSVETRCSSLESARFPETPAFSSQEEEDGAC---AAEPTSS *** * *****.:*.:*** ** *** * ********::**. ****.: XP_004869001.1/1-1560 ----------CAPGA--LPAVQVPGARDDAG-------PESEERGAVWQRRPGLESPRGA ENSCPOP00000008002/1-1567 GP---GPEPACTPGTGMLPAVQVPEAQEDAG-------PEPKDLGEIWQRRAGLEGASAI ENSP00000260983/1-1572 GPAEGSQESVCTAGS--LPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAA ENSMUSP00000113283/1-1578 GPAEGSQESVCTPSS--LPAVQVPSREEEGSAAEAAALSEQGELGEVWQRRGSLEGAAAA ENSRNOP00000017761/1-1578 GPTEGSQESVCTPGS--LPAVQVPSREEEGSGAEATALSEQGELGEVWQRRGSLEGAAAA *:..: **.**** .::. .: : * :**** .**.. . XP_004869001.1/1-1560 E-----------YAGDEPGEDAGACEGASAQEEGAAGGAQANGHQPLRSLPSVRQDVSRY ENSCPOP00000008002/1-1567 ENESRSQALEEEEAQEDMGEDARACEGAAALEEGAAGGSPANGHQPLRSLPSVRQDVSRY ENSP00000260983/1-1572 A------ESPPQEEGS-AGEAQGTCEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRY ENSMUSP00000113283/1-1578 APAAAATDSQPQEDGD-AGDAQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVSRY ENSRNOP00000017761/1-1578 A-TAAATDSQPQEDGD-PGDTQGACEGATAQEEGATGGSQTNGHQPLRSLPSVRQDVSRY . *: :****:* ****:**: :******************* XP_004869001.1/1-1560 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR ENSCPOP00000008002/1-1567 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR ENSP00000260983/1-1572 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR ENSMUSP00000113283/1-1578 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR ENSRNOP00000017761/1-1578 QRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRR ************************************************************ XP_004869001.1/1-1560 YQSIRRTMTNERPEENTSAVDGAGEEADFHQASADFRRESVLPHSTSRSRLTLLLQSPPV ENSCPOP00000008002/1-1567 YQSIRRTMTNERPEESASAMDGAGEEVDFHQTSADFRRESVLPHSTSRSRLALLLQSPPV ENSP00000260983/1-1572 YQSIRRTMTNERPEENTNAIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPV ENSMUSP00000113283/1-1578 YQSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPPV ENSRNOP00000017761/1-1578 YQSIRRTMTNERPEENTSAIDGAGEEADFHQASADFRRENVLPHSTSRSRLTLLLQSPPV ***************.:.*:******.****:*******.:*********::******** XP_004869001.1/1-1560 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN ENSCPOP00000008002/1-1567 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN ENSP00000260983/1-1572 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN ENSMUSP00000113283/1-1578 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN ENSRNOP00000017761/1-1578 KFLISPEFFTVLHSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFAN ************************************************************ XP_004869001.1/1-1560 KQLDLPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALAHRQHLTRQRSHS ENSCPOP00000008002/1-1567 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALAHRQHLTRQRSHS ENSP00000260983/1-1572 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS ENSMUSP00000113283/1-1578 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS ENSRNOP00000017761/1-1578 KQLELPRGWEMKHDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHS ***:*******************************************.************ XP_004869001.1/1-1560 AGEVGEDSRHAGPPVLPRPSSTFSTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQ ENSCPOP00000008002/1-1567 AGEVGEDSRHAGPPVLPRPSSTFNTVNRPQYQDMVPSAYNDKIVAFLRQPNIFEILQERQ ENSP00000260983/1-1572 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQ ENSMUSP00000113283/1-1578 AGEVGEDSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNILEILQERQ ENSRNOP00000017761/1-1578 AGEVGEDSRHAGPPVLPRPASTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNILEILQERQ *******************:***.**.********* ***************:******* XP_004869001.1/1-1560 PDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ ENSCPOP00000008002/1-1567 PDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ ENSP00000260983/1-1572 PDLTRNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ ENSMUSP00000113283/1-1578 PDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ ENSRNOP00000017761/1-1578 PDLARNHSLREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQ ***:******************************************************** XP_004869001.1/1-1560 SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRR ENSCPOP00000008002/1-1567 SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRR ENSP00000260983/1-1572 SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRR ENSMUSP00000113283/1-1578 SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRR ENSRNOP00000017761/1-1578 SPRGSPVSSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRR ************************************************************ XP_004869001.1/1-1560 DHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFE ENSCPOP00000008002/1-1567 DHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFE ENSP00000260983/1-1572 DHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFE ENSMUSP00000113283/1-1578 DHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFE ENSRNOP00000017761/1-1578 DHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFE ************************************************************ XP_004869001.1/1-1560 YSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD ENSCPOP00000008002/1-1567 YSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD ENSP00000260983/1-1572 YSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD ENSMUSP00000113283/1-1578 YSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD ENSRNOP00000017761/1-1578 YSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCD ************************************************************ XP_004869001.1/1-1560 LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNK ENSCPOP00000008002/1-1567 LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNK ENSP00000260983/1-1572 LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNK ENSMUSP00000113283/1-1578 LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNK ENSRNOP00000017761/1-1578 LSDLEYLDEEFHQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNK ************************************************************ XP_004869001.1/1-1560 KEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWR ENSCPOP00000008002/1-1567 KEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWR ENSP00000260983/1-1572 KEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWR ENSMUSP00000113283/1-1578 KEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWR ENSRNOP00000017761/1-1578 KEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWR ********************************************************.*** XP_004869001.1/1-1560 SNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR ENSCPOP00000008002/1-1567 SNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR ENSP00000260983/1-1572 NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR ENSMUSP00000113283/1-1578 NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR ENSRNOP00000017761/1-1578 NNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRR .*********************************************************** XP_004869001.1/1-1560 FCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE ENSCPOP00000008002/1-1567 FCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE ENSP00000260983/1-1572 FCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE ENSMUSP00000113283/1-1578 FCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE ENSRNOP00000017761/1-1578 FCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE **************************************************