CLUSTAL W(1.81) multiple sequence alignment ENSP00000372635/1-1196 MMTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFK ENSCPOP00000007998/1-701 ---VMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFK XP_004834412.1/1-1194 -MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFK ENSMUSP00000091315/1-1197 -MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFK ENSRNOP00000067350/1-1203 -MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFK ********************************************************* ENSP00000372635/1-1196 NIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFL ENSCPOP00000007998/1-701 NIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFL XP_004834412.1/1-1194 NIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFL ENSMUSP00000091315/1-1197 NIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFL ENSRNOP00000067350/1-1203 NIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVRRQETVTDLAAAGKRLGISFL ***************************************:*************:****** ENSP00000372635/1-1196 EDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNM ENSCPOP00000007998/1-701 EDLTDRNFSNSPGPYVFCITEK-----------HEEPAITNGPRITNAFSIIETEN---- XP_004834412.1/1-1194 EDLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITTGPRITNAFSIIETENSNNM ENSMUSP00000091315/1-1197 EDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTNGPRITNAFSIIETENSNNM ENSRNOP00000067350/1-1203 EDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTNGPRITNAFSIIETENSNSM ***:************.***** *****:*.*************** ENSP00000372635/1-1196 FSPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVRE ENSCPOP00000007998/1-701 ------------------------------------------------------------ XP_004834412.1/1-1194 FSPLDLRASFKKVSDSMRTTSLCLERTDVCHEAEPVRTLAEHSYAVSSITEAYRSQPARE ENSMUSP00000091315/1-1197 FSPLDLRASFKKVSDSMRTASLCQERASVCHEVEPVRTLAEHSYAVSSITEAYRSQPPRE ENSRNOP00000067350/1-1203 FSPLDLRASFKKVSDAMRTTSLCQERASVCPEAEPVRTLAEHSYAVSSITEAYRSQPLRE ENSP00000372635/1-1196 HD-GSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSP ENSCPOP00000007998/1-701 ------------------------------------------------ITNPETNQ---- XP_004834412.1/1-1194 HD-SGSPGKTGKENGEALVAKPKTCRKPKTYSLPQDSDSATENIPPPPVTNPEINQERSP ENSMUSP00000091315/1-1197 QD-SSSSAKTGKETGDALATKAKPCRKPKPQT--QDSDSTTENMPLSLVTCPEVNQERSP ENSRNOP00000067350/1-1203 HDSSSSSGKTGKENGEALTTKAKPCRKPKTQT--QDSDSTTENMPLPLVTCPEVNQERSP :: * ** ENSP00000372635/1-1196 QPAAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLS ENSCPOP00000007998/1-701 ------------------------------------------------------------ XP_004834412.1/1-1194 QPAAILPHSKSPNNEGDVHFSKEDENQSSDIPVPPATEVPPLIYNCSCCSKSFDSSALLS ENSMUSP00000091315/1-1197 QPAPDLSHSEPPSNEGDIHFPREDENQPSDAPGPGAAEVPPLVYNCSCCSKSFDSSTLLS ENSRNOP00000067350/1-1203 QPAPILSHSEPPSSEGDVHFPREDENQPSETPGPPAAEVPPLVYNCSCCSKSFDSSTLLG ENSP00000372635/1-1196 AHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQN ENSCPOP00000007998/1-701 -------PTQEPLVCKYCNKQFTTLNRLDRHEQICMRS-------------KNYPTIGQN XP_004834412.1/1-1194 AHMQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSNHLPVPGGNQPFLENCPTIGQN ENSMUSP00000091315/1-1197 AHMQLHKPTQEPFVCKYCNKQFTTLNRLDRHEQICMRSSHVPIPGGNPPFLENYPTIGQD ENSRNOP00000067350/1-1203 AHMQLHKPTQDPFVCKYCNKQFTTLNRLDRHEQICMRSSHMPMPGGNQPFLENYPTIGQD ***:*:************************* :* *****: ENSP00000372635/1-1196 GGSFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRH ENSCPOP00000007998/1-701 GGSITGPEPLLSENRIGEFSSTGSTLPDADHMVKFVNGQMLYSCVVCKRSYVTLSSLRRH XP_004834412.1/1-1194 GSSITGPESLLSENRIGEFSSTGNTLPEAEHMIKFVNGQMLYSCVVCKRSYVTLSSLRRH ENSMUSP00000091315/1-1197 GTSFRSPESLGPENRIGELSSAGSALSDADHMVKFVNGQMLYSCIVCKRSYVTLSSLRRH ENSRNOP00000067350/1-1203 GGSFTSPDSLVPESRIGELSSAGSALSDADHMVKFVNGQMLYSCVVCKRSYVTLSSLRRH * *: .*:.* .*.****:**:*.:*.:::**:***********:*************** ENSP00000372635/1-1196 ANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSF ENSCPOP00000007998/1-701 ANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSF XP_004834412.1/1-1194 ANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSF ENSMUSP00000091315/1-1197 ANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSF ENSRNOP00000067350/1-1203 ANVHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSF ************************************************************ ENSP00000372635/1-1196 HAIDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNES ENSCPOP00000007998/1-701 HAIDHRLSISKKTANGGLKPTVYPYKLYRLLPMKCKRAPYKSYRNSSYENAQENTQINES XP_004834412.1/1-1194 HAIDHRLSISKKTANGGLKPTVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENRQINES ENSMUSP00000091315/1-1197 HAIDHRLSINKKTANGGLKPTVYPYKLYRLLPMRCKRAPYKSYRNSSYVSAQGSSQRGES ENSRNOP00000067350/1-1203 HAIDHRLSISKKTANGGLKPTVYPYKLYRLLPMRCKRAPYKSYRNSSYESAQGNRQRNES *********.**********:************:************** .*: . * .** ENSP00000372635/1-1196 APGTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEE ENSCPOP00000007998/1-701 TPGT-------------------------------------------------------- XP_004834412.1/1-1194 TPGTYVVQNPRSSELSALNFQDSVNVLTNSPAIPLEASACQDIRTSATVQNAEGTKWREE ENSMUSP00000091315/1-1197 APDTFIVPNLQSSEMPTLDFQDGRNTLPSSPAVPVETPSRQGAPTSARVKNAEGIKWRKQ ENSRNOP00000067350/1-1203 PPDTFVIPNLPSSEMPTLNFQDGRNSLTSSPAIPVETPSWQGTPTSAKVKNAEGLKWRKQ .*.* ENSP00000372635/1-1196 ALKMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIV ENSCPOP00000007998/1-701 -------------------------SDLQAGDGPVSSLSNGSENSASVISYSGSAPSVIV XP_004834412.1/1-1194 TMKIDLDNNFYSTEVSVSSTENAVSSDLQAGDVPVLSLGNGSENSASVISYSGSAPSVIV ENSMUSP00000091315/1-1197 AVKTNLVDNFDSTEVSVSSTGNTVSATLQTEPACVSSVGKGSEHSASVISYSGSVPSVIV ENSRNOP00000067350/1-1203 ALKTDLVD---SAEVSISSIGNSVSTTLQAEPVCVSS----GEHSASVISYSGSVPSVIV : *:: * * .*::*********.***** ENSP00000372635/1-1196 HSSQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKK ENSCPOP00000007998/1-701 HSSQFSSVIMHSNAVAAMASSSHRAPSEPAVSQFL-----------------PKSSKEKK XP_004834412.1/1-1194 HSSQFSSVIMHSNAVAAMASSSHRAPSDPAVSQPLKDDSKPETDKVGRFASRPKSTKEKK ENSMUSP00000091315/1-1197 HSSQFSSVIKHSNTIASLTNSNHKSPSQPVVSPSLIKDSKPETDKASKPASRPKSIKEKK ENSRNOP00000067350/1-1203 HSSQFSSVIKHSNAIACLANSNHQSPSQPVASPSLIKDSKPEADKASKLASRPKNSKEKK ********* ***::*.::.*.*:: *:*..* * **. **** ENSP00000372635/1-1196 KTTSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQ ENSCPOP00000007998/1-701 KTVPCNKTEIAEESKYVADPGGSLSKATNTAEETSKIETYIAKPALPGTSTNSNVAPLCQ XP_004834412.1/1-1194 KTIPCNKAEIPEESKYVADPGGSLNKATNTVEETSKIETYIAKPALPGTSTNSNVAPLCQ ENSMUSP00000091315/1-1197 KTAPSNRGEITEEAKYIADHGGSSGKTTN-AEETSKIETYIAKPALPGTSTNSNVAPLCQ ENSRNOP00000067350/1-1203 KTVPCNRGEITEEAKYVADLGGSSGKTTNVVEETSKIETYIAKPALPGTSTNSNVAPLCQ ** . .: **.**::*:** *** .*:** .***************************** ENSP00000372635/1-1196 ITVKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECME ENSCPOP00000007998/1-701 ITVKIGNEAIVKRHILGSKLFYKRGRRPKYQTQEETAPQVNDPETHRDSPL--------- XP_004834412.1/1-1194 ITVKIGNEAIVKRHILGSKLFYKRGRRPKYQTQEETVPQVSDPKTHGDSPLGVCQSECVE ENSMUSP00000091315/1-1197 ITVKIGNEAIVKRHILGSKLFYKRGRKPKYQMQEETLPRENDPETPGDSPLGLCQAECVE ENSRNOP00000067350/1-1203 ITVKIGNEAIVKRHILGSKLFYKRGRKPKYQMQEETLPRESDPETRGDSPLGLCQADCVE **************************:**** ***. *: .**:. **** ENSP00000372635/1-1196 MSEVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAEL ENSCPOP00000007998/1-701 ----------DDSTDKPWRPYYNYKPKKKSRQLRKMRKGNWRKEH--------------- XP_004834412.1/1-1194 MSEVFDDASDQDSTDKPWRPYYNYKPKKKSRQLRKMRKGNWRKEHGNKSPSNKCKYPAEL ENSMUSP00000091315/1-1197 MSEAFDEVSDQDSTDKPWRPYYNYKPKKKSKQLRKMRKVKWRKERRSRSPVGRCRYPAEL ENSRNOP00000067350/1-1203 MSEAFDEVSDQDSTDKPWRPYYNYKPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAEL :*******************:**:*:** :****: ENSP00000372635/1-1196 D---------------CAVGKAPQDKPF----EEEETKEMPKLQCELCDG--DKAVGAGN ENSCPOP00000007998/1-701 ------------------------------------------------------------ XP_004834412.1/1-1194 D---------------CAVGKPPPDKAF----EEEENKEMPKLQCELCDG--DKVSGAGN ENSMUSP00000091315/1-1197 D---------------RAEVKLPPDKAFEEEEEEEENKEMPKLQCELCDGCPDGAAGAGA ENSRNOP00000067350/1-1203 DRAEMGRRRYPAELDRCAEVKLPPDKAS----EEEENKEMPKLQCELCDG--DKAAGAGA ENSP00000372635/1-1196 QGRPHRHLTSRPYACELCAKQFQSPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHE ENSCPOP00000007998/1-701 ------------------------------------------------------------ XP_004834412.1/1-1194 LGRPHRHLTSKPYVCELCAKQFQSPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHE ENSMUSP00000091315/1-1197 EGKPHQHLTSKPYICELCAKQFQSSSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHE ENSRNOP00000067350/1-1203 EGKPHQHLTLKPYICELCAKQFQSSSTLKMHMRCHTGEKPYQCKTCGRRFSVQGNLQKHE ENSP00000372635/1-1196 RIHLGLKEFVCQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQRFLYLSTKRNHEQRHI ENSCPOP00000007998/1-701 ------------YCNKAFTLNETLKIHERIHTGEKRYHCQFCFQSFLYLSTKRNHEQRHI XP_004834412.1/1-1194 RIHLGVKEFICQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQSFLYLSTKRNHEQRHI ENSMUSP00000091315/1-1197 RIHLGVKEFICQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHI ENSRNOP00000067350/1-1203 RIHLGVKEFICQYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHV ******************************** ***********:**: ENSP00000372635/1-1196 REHNGKGYACFQCPKICKTAAALGMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGS ENSCPOP00000007998/1-701 REHNGKGFACFQCPKICKTAAALGMHQKKHLFKNP------------------------- XP_004834412.1/1-1194 REHNGKGFACFQCPKICKTAAALGMHQKKHLFKNPNQQEKIGDMCHENSNPLENQHFIDS ENSMUSP00000091315/1-1197 REHDGKGFACFQCPKICKTAAALRMHQKKHLYKTLPKQEETGDTCHENADLLESQLCTDS ENSRNOP00000067350/1-1203 REHDGKGFACFQCPKICKTAAALRMHQKKHLFKTLTKQEETDDLCHENSDLLESQPCTDS ***:***:*************** *******:*. ENSP00000372635/1-1196 EDNDQKDNIQTGVENVVL- ENSCPOP00000007998/1-701 ------------------- XP_004834412.1/1-1194 EDTDQKDNVKSIVENVL-- ENSMUSP00000091315/1-1197 EDSEQKDDIKAFAENVL-- ENSRNOP00000067350/1-1203 EDSDQKDDIKKPLLKMSFE