CLUSTAL W(1.81) multiple sequence alignment ENSP00000396078/1-1078 -------------------------------------------------------MDAAG ENSMUSP00000099071/1-1071 -------------------------------------------------------MDAAG ENSRNOP00000034571/1-1050 -------------------------------------------------------MDAAG ENSCPOP00000007958/1-941 ------------------------------------------------------------ XP_004851410.1/1-1210 MKQCHSSAEKQQTPKLDPLSPANEFSPRLPPTAVWLQPPKLSHLWQRLPGPSPAPREERG ENSP00000396078/1-1078 RGCHLLPLPAARGPA--------------------RAPAAAAAAAASPPGPCSGAACAPS ENSMUSP00000099071/1-1071 RGCHLLPLPAARGPA--------------------RAP--AASSALSPTGLCSGTTSASF ENSRNOP00000034571/1-1050 RGCHLLPLPAARGPA--------------------RAP--AASSALSPAGLCSGTASASS ENSCPOP00000007958/1-941 ------------------------------------------------------------ XP_004851410.1/1-1210 RQCCPGHRAGAHGAAWARTPPGSALERSSLGALLPRRPAALAPASLPSAGSPPAAARRPS ENSP00000396078/1-1078 AAAGAGAMN-----------------------------------------------PSSS ENSMUSP00000099071/1-1071 AAAGAVAMN-----------------------------------------------PSSS ENSRNOP00000034571/1-1050 AAAGAVAMN-----------------------------------------------PSSS ENSCPOP00000007958/1-941 ------------------------------------------------------------ XP_004851410.1/1-1210 QSAGEGPRRERGGGRRPVIGREGAERGVSHNARRGVAADGCCRKALPSRTSPRSRPPVPR ENSP00000396078/1-1078 AGEEKG------------ATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEP ENSMUSP00000099071/1-1071 AGEERG------------ATGGSSSSGSGAGSCCLGAEGGADPRGAGAAA---AAALEEP ENSRNOP00000034571/1-1050 AGEERG------------ATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAA---AAALEEP ENSCPOP00000007958/1-941 ------------------------------------------------------------ XP_004851410.1/1-1210 PGSPRGRPGSLAMNTSSAAAGEDPGATGGAGSCCLGAEGGVDPRGAGAAA--GAAALEEP ENSP00000396078/1-1078 AAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRAT ENSMUSP00000099071/1-1071 AAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRAT ENSRNOP00000034571/1-1050 AAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRAT ENSCPOP00000007958/1-941 ----------AMEEKVQRANWRSSTCCRKAISRAGLQHLAPAHPLSLPVANGPAKEPRAT XP_004851410.1/1-1210 AAAGPREKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRAT *:***:: .:*.... ******:***********.************** ENSP00000396078/1-1078 LDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLE ENSMUSP00000099071/1-1071 LDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLE ENSRNOP00000034571/1-1050 LDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLE ENSCPOP00000007958/1-941 LDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLE XP_004851410.1/1-1210 LDWSENAMNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLE *******:**************************************************** ENSP00000396078/1-1078 KINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISC ENSMUSP00000099071/1-1071 KINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISC ENSRNOP00000034571/1-1050 KINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISC ENSCPOP00000007958/1-941 KINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISC XP_004851410.1/1-1210 KINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISC ************************************************************ ENSP00000396078/1-1078 SWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSF ENSMUSP00000099071/1-1071 SWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSF ENSRNOP00000034571/1-1050 SWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSF ENSCPOP00000007958/1-941 SWCKQAFHNKVTCSCCITLRNPAPWEAHAAVIVPPTWIIKVKKPQSSLKASNRKKKRTSF XP_004851410.1/1-1210 SWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSF ************* :.:*.. *******************.************** ENSP00000396078/1-1078 KRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQV ENSMUSP00000099071/1-1071 KRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQV ENSRNOP00000034571/1-1050 KRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQV ENSCPOP00000007958/1-941 KRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQV XP_004851410.1/1-1210 KRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQV ******** ***.*********************************************** ENSP00000396078/1-1078 FDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGND ENSMUSP00000099071/1-1071 FDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGND ENSRNOP00000034571/1-1050 FDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGND ENSCPOP00000007958/1-941 FDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGND XP_004851410.1/1-1210 FDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGND *************:********************************************** ENSP00000396078/1-1078 LARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV ENSMUSP00000099071/1-1071 LARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV ENSRNOP00000034571/1-1050 LARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV ENSCPOP00000007958/1-941 LARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV XP_004851410.1/1-1210 LARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV ***************************:******************************** ENSP00000396078/1-1078 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV ENSMUSP00000099071/1-1071 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV ENSRNOP00000034571/1-1050 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV ENSCPOP00000007958/1-941 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV XP_004851410.1/1-1210 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLAKHVKV ******************************************************:***** ENSP00000396078/1-1078 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTM ENSMUSP00000099071/1-1071 VCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTM ENSRNOP00000034571/1-1050 VCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTM ENSCPOP00000007958/1-941 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTM XP_004851410.1/1-1210 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTM ************:*********************************************** ENSP00000396078/1-1078 ASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSK ENSMUSP00000099071/1-1071 ASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSK ENSRNOP00000034571/1-1050 ASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSK ENSCPOP00000007958/1-941 ASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSK XP_004851410.1/1-1210 ASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSK ************************************************************ ENSP00000396078/1-1078 RRTSMPLLNDIHQVQTADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGFHYDKEK ENSMUSP00000099071/1-1071 RRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGLHYDKDK ENSRNOP00000034571/1-1050 RRTSMPLLND---------------------PQSVPDRLRIRVNKISLQDYEGLHYDKEK ENSCPOP00000007958/1-941 RRTSMPLLND---------------------PQSVPDRLRIRVNKISLQDYEGFHYDKEK XP_004851410.1/1-1210 RRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGFHYEKEK ********** **********************:**:*:* ENSP00000396078/1-1078 LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQR ENSMUSP00000099071/1-1071 LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQR ENSRNOP00000034571/1-1050 LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISAQR ENSCPOP00000007958/1-941 LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQR XP_004851410.1/1-1210 LREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQR ***********************************************:*******:**** ENSP00000396078/1-1078 LSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLV ENSMUSP00000099071/1-1071 LSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLV ENSRNOP00000034571/1-1050 LSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLV ENSCPOP00000007958/1-941 LSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEIFILDPDTVVSQQAGTPPGMPDLV XP_004851410.1/1-1210 LSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEIFILDPDMVVSQQAGTPPGMPDLV *********************************:********* **** *********** ENSP00000396078/1-1078 VEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQA ENSMUSP00000099071/1-1071 VEQASGLSDWWNPALRKRMLSDS--GMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQA ENSRNOP00000034571/1-1050 VEQASGLSDWWNPALRKRMLSDS--GMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQA ENSCPOP00000007958/1-941 VEQASGLSDWWTPALQKRMLSDSGLGMITPHYDDADIKDLSHSRVLQSPVSSEDHAILQA XP_004851410.1/1-1210 VEQASGLSDWWNPALRKRMLSDSGLGMITPHYDDEDRKDLSHSRVLQSPVSSEDHAILQA ******:****.***:******* ***:*:*:* * **:******************** ENSP00000396078/1-1078 VIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSE ENSMUSP00000099071/1-1071 VLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSE ENSRNOP00000034571/1-1050 VITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELLDMADSE ENSCPOP00000007958/1-941 VIAGDLMKLMESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSE XP_004851410.1/1-1210 VIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSE *::******:**************.**************:**********:********* ENSP00000396078/1-1078 TGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNY ENSMUSP00000099071/1-1071 TGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNY ENSRNOP00000034571/1-1050 TGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNY ENSCPOP00000007958/1-941 TGETALHKAACQRNRAVCQLLVDAGASLRKTDAKGKTPQDRAQQAGDPELAAYLESRQNY XP_004851410.1/1-1210 TGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQDRAQQAGDPDLAAYLESRQNY *****************************:**:******:********:*********** ENSP00000396078/1-1078 KVIGHEDLETAV ENSMUSP00000099071/1-1071 KIIGHEDLETAV ENSRNOP00000034571/1-1050 KIIGHEDLETAV ENSCPOP00000007958/1-941 KVIGHEDLETAV XP_004851410.1/1-1210 KVIGHEDLETAV *:**********