CLUSTAL W(1.81) multiple sequence alignment ENSP00000315914/1-1778 METRSSKTRRSLASRTNECQGTMWAPTSPPAGSSSPSQPTWKSSLYSSLAYSEAFHYSFA ENSCPOP00000007956/1-1654 -------------------SSTAW-----PSGSSSRRKRSWVSSELRSSLPSEVLRCSFA XP_004854332.1/1-1725 MEISTREARRSEESQYELTKSSQ---TSRLAGSISSNQISGKSSLPSSVALSEVLHYSFS ENSRNOP00000043711/1-465 MEPESKKELQSPASSFVMSSETMW-ESTPRQPESTSLSWSPRKSLRSLTVFTDYCQFGYP ENSMUSP00000122380/1-1741 MDSESKEEQQCTASSAVMSSLETQFLSVPHQLESASLSWSIRKSLHSSTVLMDDCHFGFP . . : . : .* : : .:. ENSP00000315914/1-1778 ARPRRLTQLALAQRPEPQLLRLRPSSLRTQDISHLLTGVFRNLYSAEVIGDEVSASLIKA ENSCPOP00000007956/1-1654 ARPRRLRALALPPHPEPQPLRPRPSSLLTQDISHLLTRVFRNLYSVEVIGEDVSASLIQA XP_004854332.1/1-1725 ARPRRVGSLAQQPHPEPQLLRPRPSSLRSQDISHLLTRVFRNLYSVEVIGEDVSASLIQA ENSRNOP00000043711/1-465 TRSLRAGFQELPPLPEPQTLRLRPASLRTQDISHLLARVFRNLYTAQVIGDDLSDSLIKA ENSMUSP00000122380/1-1741 TRSLRAGFHALPPLPEPQTLRLRPASLRTQEISHLLARVFRNLYTAQVIGDDLSDSLIKA :*. * **** ** **:** :*:*****: ******:.:***:::* ***:* ENSP00000315914/1-1778 RGSENERHEEFVDQLQQIRELYKQRLDEFEMLERHITQAQARAIAENERVMSQAGVQDLE ENSCPOP00000007956/1-1654 RGSENARHEEFVDQLQQIREHYKQRLDEVEMLERHITQARARALAETERAFNLVQTHVLE XP_004854332.1/1-1725 RGSENARHEEFVDQLQQVTHSAASRV-----------ASRVRTVPETRTASQDS------ ENSRNOP00000043711/1-465 RGSEDARHEEFLDQLQQARAIYKKRLDDVAMLEKHITQARARDIAETEHATKQGRLHVVE ENSMUSP00000122380/1-1741 RGSEDARHEEFLDQLQQARAIYKQRLDEAAMLERHIMQARARDIAETEHTTKQSRLQVVE ****: *****:***** .*: ::.* :.*.. . . ENSP00000315914/1-1778 SLVRLPPVKSVSRWCIDSELLRKHHLISPEDYYTDTVPFHSAPKGISLPGCSKLTFSCEK ENSCPOP00000007956/1-1654 TSTQLPAVKTVFRWFIDSELLQKHHLICPEDYYSDTVPFCSAPKGTFHPRYSKLTFSCEK XP_004854332.1/1-1725 -----APVKTVFRWCVDSELLQKHHLICPEDYYSNTVPFFSAPKGAFHPGCSELTFSYEK ENSRNOP00000043711/1-465 APVKLPPVKTVFRWCIDNELMQKHHLISTEDYYNDPLPFCPAPKRSPTPMYSKMTFSCEK ENSMUSP00000122380/1-1741 TPVKLPPVKTAFRWCLDSKLMRKHHLISTEDYYTDPVPFCPAPKDKSTLGCSKLTFSCEQ ..**:. ** :*.:*::*****..****.:.:** .*** *::*** *: ENSP00000315914/1-1778 RSVQKKELNKKLEDSCRKKLAEFEDELDHTVDSLTWNLTPKAKERTREPLKKASQPRNKN ENSCPOP00000007956/1-1654 RAIPKAELDKKLAVSCREKLPAFEDDFDHTVDSLTWDSTPAAKQRAREAIKKPSPPKNKK XP_004854332.1/1-1725 HSIPKA--DKKLPVSCREKLPAFADEFDYTVDSLTWDSTPEAKQKTKETAKKASPPKNKK ENSRNOP00000043711/1-465 RFTHKSDLERKAEEHCR-KLVEF-DDLEYTTDSL--RSVSKTKGKTKVTIKKASTPANKK ENSMUSP00000122380/1-1741 RFLRKSELDREAEEHCR-QLTEC-DDFEYTVDSL--GSISKAKERTTDSVKKTSRPKNKK : * ::: ** :* *::::*.*** . :* :: . **.* * **: ENSP00000315914/1-1778 WMNHLRVPQRELDRLLLARMESRNHFLKNPRFFPPNTRYGGKSLVFPPKKPAPIGEFQST ENSCPOP00000007956/1-1654 WMNHLRVSQRELDRRQLARMESRNHFLKNPRFLPPNTAHGGRSLIFPPKKPELTGEFPNG XP_004854332.1/1-1725 WMKHLRVPQRELERLQLAGMESRSHFLKNPRFFPPNTPHGGRSLIFPPKKPALIGKFSNG ENSRNOP00000043711/1-465 WMEHLQVPQRALDRRLLARMQNRNHYLKNPRFFPPNTPHGGKSLIVPSRKPERRGSL-SA ENSMUSP00000122380/1-1741 WMEHLQVPQRALDRRLLASMENRNHFLKNPRFFPPNTPHGGKSLIVPLSKPERRASL-NA **:**:*.** *:* ** *:.*.*:******:**** :**:**:.* ** ..: . ENSP00000315914/1-1778 EPEQSCADTPVFLAKPPIGFFTDYEIGPVYEMVIALQNTTTTSRYLRVLPPSTPYFALGL ENSCPOP00000007956/1-1654 EPEQSCANTPVFLPKPSIVFFTDYEVGLVYEMKITLQNTTASSRYLRVLPPSTPYFALGL XP_004854332.1/1-1725 EPEQSCANTPVFLAKPSTVFFTDYEIGPVYEMVITLQNTTATSRYLRVLPPSTPYFALGL ENSRNOP00000043711/1-465 KPEWRCV----------------------------------------------------- ENSMUSP00000122380/1-1741 EPEWSCTDAPVFLAKPSVGFFTDYEIGPVYEMVIALQNTTSTSRFLRVLPPSSPYFALGL :** *. ENSP00000315914/1-1778 GMFPGKGGMVAPGMTCQYIVQFFPDCLGDFDDFILVETQSAHTLLIPLQARRPPPVLTLS ENSCPOP00000007956/1-1654 GMFPGKGGMVAPGMTCQYTVQFIPDCLGDFDDFILVETQSDQKLLIPLQARRPPPVLTLS XP_004854332.1/1-1725 GMFPGRGGMVAPGMTCQYTVQFIPDCLGDFDDFILVETQSAHKLLIPLQARRPPPVLTLS ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 GMFPGKGGIVAPGMTCQYIVQFIPDCLGDFDDFILVETQSPHTLVIPLQARRPPPVLTLS ENSP00000315914/1-1778 PVLDCGYCLIGGVKMTRFICKNVGFSVGRFCIMPKTSWPPLSFKAIATVGFVEQPPFGIL ENSCPOP00000007956/1-1654 PVLDCGYCLIGGIKVTKFICKNVGFSTGKFYIMPKEIWPPISLRAAASTGFVGRPPFGIM XP_004854332.1/1-1725 PVLDCGYCLIGGIKMTKFICRNVGFSTGKFHIMLKESWPPISFRAAASTGFIGQPPFAVM ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 PVLDCGHCLIGGVKITKFICKNVGFSVGKFCIMPQKSWPPPSFRAVATTGFVEQPPFGVM ENSP00000315914/1-1778 PSVFELAPGHAILVEVLFSPKSLGKAEQTFIIMCDNCQIKELVTIGIGQLIALDLIYISG ENSCPOP00000007956/1-1654 PSRFELAPGDSVFLEVLFLPTSLGRTEQTFIILCDNCQIKELVIAGTGQLVALDLIYVSG XP_004854332.1/1-1725 PSVFELAPGLSVLLEVLFLPMSLGKAEQTFIIVCDNCQIKELVIVGTGQLIALDLIYISG ENSRNOP00000043711/1-465 ---------------------------------CSSRRI--------------------- ENSMUSP00000122380/1-1741 PSVFELAPGYAILLEVLFLPTGLGQAEETFIIVCDNCQIKEVVVVGTGQLVALDLIHISG *.. :* ENSP00000315914/1-1778 EKSQPDPGELTDLTAQHFIRFEPENLRSTARKQLIIRNATHVELAFYWQIMKPNLQPLMP ENSCPOP00000007956/1-1654 EKSQPDPGELTDLTAQYFIRFESENLQSTSRKQLIIRNSTHVELVFRWQIMKPNLKPLMP XP_004854332.1/1-1725 EKSQPDPGELTDLTAQYFIRFEPENLQSTSRKQLIIRNATHVELAFHWQIMRPNLQPLMP ENSRNOP00000043711/1-465 ------PGNVS------------------------------------------------- ENSMUSP00000122380/1-1741 GKNEPDPGELKDLTAQYFIRFEPENVQSTAKKQLIIRNATHVELAFHWQIMKPNLQPLMP **::. ENSP00000315914/1-1778 GETFSMDSIKCYPDKETAFSIMPRKGVLSPHTDHEFILSFSPHELRDFHSVLQMVLEEVP ENSCPOP00000007956/1-1654 GETYSLNSIKHHPDRETAFSIKPEKGVLGPHTDHEFILSFSPYELRGFHSVLQMVLEDIP XP_004854332.1/1-1725 GETYSVDSIKHHPDRETAFSIRPAKGVLSPHTDHEFILSFSPYELRSFHSVLQMVLEEVP ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 GETHSSDSIKCHPDRETAFSIIPEKGILESHSDQEFILSFSPYKLKCFHSVLQMVLEAVP ENSP00000315914/1-1778 EPVSSEAESLGHSSYSVDDVIVLEIEVKGSVEPFQVLLEPYALIIPGENYIGINVKKAFK ENSCPOP00000007956/1-1654 KPVSSEVENQADYLYSADDLIVLEVEVKGSAEPFQVLLEPYALIIPGENYIGVNVKKDFK XP_004854332.1/1-1725 EPLSAEVKNLGEYSHSVDDVIVLEIEVKGPAEPFQVLLEPYALIIPGENYIGVNVKKDFK ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 EPLSSGLENLGDYSYSVDDMIVLEIEVKGLAEPFQVLLEPYALIIPGENYIGITVKKDFK ENSP00000315914/1-1778 MWNNSKSPIRYLWGKISDCHIIEVEPGTGVIEPSEVGDFELNFTGGVPGPTSQDLLCEIE ENSCPOP00000007956/1-1654 MWNNSKSPIRYMWKKISDCHIIEVEPCTGVIEPNEVGNFELNFTGGVPGPASQDLLCEIR XP_004854332.1/1-1725 MWNNSKSPIRYKWGKISDCHIIEVEPCTGVIEPSEVGNFELNFTGGVPGPASQDLVCEIR ENSRNOP00000043711/1-465 --------------------------------------FRVNLD---------------- ENSMUSP00000122380/1-1741 MWNNSKSPIRYMWGKISHCHIIEVEPCTGVIEPNEVGDFELNLTGGVPGPTSQDLECEIK *.:*: ENSP00000315914/1-1778 DSPSPVVLHIEAVFKGPALIINVSALQFGLLRLGQKATNSIQIRNVSQLPATWRMKESPV ENSCPOP00000007956/1-1654 HSPSPVVLHIEAAFKGPALVVNISALQFGLLRLRQKARNSIQIQNVSQLPAVWHLRESPV XP_004854332.1/1-1725 DSPSPVVLHIEAAFKGPALVINVSALQFGLLCLGQKGRNTIQIQNISQLLATWHLRESPA ENSRNOP00000043711/1-465 -------------------------LVYG------------------------------- ENSMUSP00000122380/1-1741 DSPCPVVLHIEASFKGPALTIDVPALQFGLLRLGKKASISIQIRNVSQLSAVWHLKESPV * :* ENSP00000315914/1-1778 SLQERPEDVSPFDIEPSSGQLHSLGECRVDITLEALHCQHLETVLELEVENGAWSYLPVY ENSCPOP00000007956/1-1654 CLEERHESVSPFDIEPSSGQLQPLGECTVTVTLEAVHCQSLQTVLELEVENGDWSYVAVC XP_004854332.1/1-1725 CLEERHESVSSFNIEPSSGQLHPLGECSVTVTLEALHCQTLQTVLELEVENGDWSYLAVY ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 CLAERDEDVSPFDIEPFCGQLLPLGECRVTITLEASQCQRLQTVLELEVENGSGSYLPVY ENSP00000315914/1-1778 AEVQKPHVYLQSSQVEVRNLYLGVPTKTTITLINGTLLPTQFHWGKLLGHQAEFCMVTVS ENSCPOP00000007956/1-1654 AEIQEPHVYLQNSQVELSSLYLDVPTKSTLSLVNSTLLPTRFHWGKLLGNQAASCTVTVS XP_004854332.1/1-1725 AEIQEPRVYLHSSQVELSSLYLDVPTKSTVTLINSTLLPTRFHWGKLLGNQATFCTVTIS ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 AEVQQPHVYLKNSHLEFSNLYLGVSTKSRTTLVNGTLLPTRFHWGKLLGPQADLCTMTVS ENSP00000315914/1-1778 PKHGLLGPSEECQLKLELTAHTQEELTHLALPCHVSGMKKPLVLGISGKPQGLQVAITI- ENSCPOP00000007956/1-1654 PRRGLLGPSEEHQFVLEFTAHTQDKLTNLALPCYVSGMKKPLVLGISGKPQGLQVTVAI- XP_004854332.1/1-1725 PSRGLLGPSEERQLILEFTAHTQDELADLVLPCHVSGMKKPLALGISGKPQGLQVTIAI- ENSRNOP00000043711/1-465 ------GP---------------------------------------------------- ENSMUSP00000122380/1-1741 PTQGLLGPSEELQLTLELTTHTEEKLTNLVLLCHVSGMEKPLVLGISGKPLGLQVTISIV ** ENSP00000315914/1-1778 SKESSDCSTEQWPGHPKELRLDFGSAVPLRTRVTRQLILTNRSPIRTRFSLKFEYFGSPQ ENSCPOP00000007956/1-1654 SAEGSDSSAKQWPGHPEELHLDFGSMVPLRTCVNRQLILNNHSPVQTSFTLKFEYFGSSP XP_004854332.1/1-1725 SAPGSDSSTKQWPGHPEELHLDFGSMVPLRTRVNRQLIMTNHSPIKTPFTLKFEYFGSPQ ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 ESDGSTTSTTQ-----EELRLDFGSKVPLRTPVIRHIILTNCSPIQTPFTLTLEYFGSSQ ENSP00000315914/1-1778 NSLSKKTSLPNMPPALLKTVRMQEHLAKREQLDFMESMLSHGKGAAFFPHFSQGMLGPYQ ENSCPOP00000007956/1-1654 NSLSKRSSLSDLPPALLKTARMREHLAKREQLDFMENMLSHGKGAAFFPHVSQGKLRAYQ XP_004854332.1/1-1725 DSLNKRTSVPDLPPALLKTARMREHLAKREQLDFMENMLSHGKGAAFFSHISQGMLRAYQ ENSRNOP00000043711/1-465 QTLASQGSVPEES----------------------------------------GVLGSTS ENSMUSP00000122380/1-1741 DSLYKKTSVPDVPPALLKTARIQQHVAKKERLDFVESMLSHRKGAAFLPHISQGMLGAYQ ::* .: *:.: . * * . . ENSP00000315914/1-1778 QLCIDITGCANMWGEYWDNLICTVGDLLPEVIPVHMAAVGCPISSLRTTSYTIDQAQKEP ENSCPOP00000007956/1-1654 KLSIKITACANMWGEYWDSLVCMVGNLPPAVIPVHMAAVGCPISSLRTTYYTTDCLQKEP XP_004854332.1/1-1725 KLSIEITGCANMWGEYWDSLICMVGNLPPTVIPVHMAAVGCPISSLRTTYYTADCFQKEP ENSRNOP00000043711/1-465 GMAFD------------------------------------------------------- ENSMUSP00000122380/1-1741 ELCIDITGCANMWGEYWDELLCVVGDLPVTVIPVYMAVVGCPISSLRNTCYSVAPFQKEP :.:. ENSP00000315914/1-1778 AMRFGTQVSGGDTVTRTLRLNNSSPCDIRLDWETYVPEDKEDRLVELLVFYGPPFPLRDQ ENSCPOP00000007956/1-1654 VIRLGTHISGGDTIRRTIRLYNSSPCDIRLDWETYVPEDKADKLVELRVFYGPPFPLKDQ XP_004854332.1/1-1725 IIRLGTHISGGSTISRTLRLYNSSPCDIRLDWETYMPEDREGKLVELLVFYGPPFPLRDQ ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 ITRFGTQISGGDTVTRSLRLYNSSHCDIRLDWETYIPEEKADRLLELLVFYGPPFPLRDQ ENSP00000315914/1-1778 AGNELVCPDTPEGGCLLWSPGPSSSSEFSHETDSSVEGS-SSASNRVAQKLISVILQAHE ENSCPOP00000007956/1-1654 AGNEIVCPEKPKNSSLLGLLSPSSVSEVSHATAPLVEGQ-SSASDGATEHIISVILQEHE XP_004854332.1/1-1725 AGNELMCPEMPKSSSFFGPLSPSNVSESSHAAAPLVEGH-SSASNRATEHIISVILREHE ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 DGSEIVCPETSE-ASLPGSPCPSNVSVSSHTVPSTGSCSGGGGGTRAEEQIMSVILQRHE ENSP00000315914/1-1778 GVPSGHLYCISPKQVVVPAGGSSTIYISFTPMVLSPEILHKVECTGYALGFMSLDSKVER ENSCPOP00000007956/1-1654 GVPAHHLFSVSPKQMVVPAGGSSTICISFSPIVLIPDTLHKVACTGYILGYMSLDNKEER XP_004854332.1/1-1725 GVPADHLFSISPKQMVVPAGGNSTIYISFTPIVLGPETLHKVACTGYALGFMSLDDEEER ENSRNOP00000043711/1-465 -----------------PQGP--------------------------------------- ENSMUSP00000122380/1-1741 AVPAGHIYRISPKQLVIPAGDHRTIYISFTPTVLDPGVMHKVGYTGYALGFMSLDKETDR * * ENSP00000315914/1-1778 EIPGKRHRLQDFAVGPLKLDLHSYVRPAQLSVELDYGGSMEFQCQASDLIPEQPCSGVLS ENSCPOP00000007956/1-1654 DIPGQRHRLQDFAVGPLRLNLHGFVRRAQLSVELDDSSSVEFRCQASDLIPDQPCAGVLS XP_004854332.1/1-1725 DIPGRSHRRQDFAVGPLRLDLHSYVRHAKLNVELDDSSSMEFRCRASDLIPDQPCSGVLS ENSRNOP00000043711/1-465 -----------------RVRLFSAVR----------SRGVDPW----------------- ENSMUSP00000122380/1-1741 QIPGRMRRLQDFAVSPLRLDLNGHVRHAQLHVELDSSGYLEFWCQASDLIPQNPCSGVLS :: * . ** . :: ENSP00000315914/1-1778 ELVTTHHLKLTNTTEIPHYFRLMVSRPFSVSQDGASQDHRAPGPGQKQECEEETASADKQ ENSCPOP00000007956/1-1654 EQLTTQQLKLVNTTEIPQYFQLLVSRPFLVSQAAVSRGHR-AGSDQEQESEEEMAPVSRQ XP_004854332.1/1-1725 ELLTTRRLKLINSTEIPQYFRLLVSRPFLVSQDAFSWGHR-PGSGQEQEGEEETASVSRQ ENSRNOP00000043711/1-465 -------------------------EPVWASSGHPKWGGAGAG----------------- ENSMUSP00000122380/1-1741 DRITTRHLKLTNTTEILYDFQARVSRPFFISQGGASWDSRAP-----HQCEEGTASTGQW .*. *. . . . ENSP00000315914/1-1778 LVLQAQENMLVNVSFSLSLELLSYQKLPADQTLPGVDIQQSASGEREMVFTQNLLLEYTN ENSCPOP00000007956/1-1654 LVLHPQENMLVNVSFSLSLELISYQKLPADQMLPRVNIQQSSSGKKEMVFTQDLLLEFPN XP_004854332.1/1-1725 LVLDSQENMLVNVSFSLSLELLSYQKLPADQMLPRVDIQQSLSGEKKIVFTQDLLLEFTN ENSRNOP00000043711/1-465 ----------------------AYS----------------------------------- ENSMUSP00000122380/1-1741 LMIRPQDNMLVDVSFSLSLELLSYQKLSADQMLPGVDIQESENGERKMVFTQNLLLGFTN :*. ENSP00000315914/1-1778 QTTQVVPLRAVVAVPELQLSTSWVDFGTCFVSQQRVREVYLMNLSGCRSYWTMLMGVVSC ENSCPOP00000007956/1-1654 QTTQVVPLRAIVAVPELQLSTSWVDFGTCFVNQLRSREVDLLNLSGCRSYWAVLMG---- XP_004854332.1/1-1725 QTTQVVPLRAIVAVPELRLSTCWVDFGTCFVNQQWAREVNLLNLSGCQSYWTVLMG---- ENSRNOP00000043711/1-465 -----------------HVTLAW-----------------------YVDYFFLLL----- ENSMUSP00000122380/1-1741 QTVQEVPLRAFVTLPAPQLSTSWVDFGTCLVNQQHTRQIYLMNLSCCLSYWTVLLG---- ::: .* .*: :*: ENSP00000315914/1-1778 TSPRWWWKVCSVRSPAPCGSGAKAPMMRDTCCLTSPEAPPQPS--APGPSWRKNIAQGLG ENSCPOP00000007956/1-1654 -------MTCPS------------------------------------------------ XP_004854332.1/1-1725 -------QQEPDKKAKAFGVSPSSGLLEARPTNAPASSITLKVFFTPRSTELYESTLVVE ENSRNOP00000043711/1-465 ------------------------------------------------------------ ENSMUSP00000122380/1-1741 -------QEEPAREDHAFGVSPGSGLLEARATNAPPTSSPLQVFFNPRSSILYESTLVVE ENSP00000315914/1-1778 AALQHKDTDLGTWGPLGSSWNGRTPFHNGLSLGPHDMSSELT ENSCPOP00000007956/1-1654 ------------------------------------------ XP_004854332.1/1-1725 GMLGEKPCTLRLRG-QGSYDERYAAPH--------------- ENSRNOP00000043711/1-465 ------------------------------------------ ENSMUSP00000122380/1-1741 GVLSEKPCVLRLRG-LGSYDERYVKFHEF-------------