CLUSTAL W(1.81) multiple sequence alignment XP_004859370.1/1-1379 -MRLRLLCVLLAAAASGARGWGYYGCDEELVGPLYARSLGASSYYGLFTTARFARLHGIS ENSCPOP00000007948/1-1339 KMRLRLLCVLLAAAASTARGWGYYGCDEELVGPLYARSLGASSSYGLFTTARFARLHGIS ENSP00000264638/1-1384 MMHLRLFCILLAA-VSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGIS ENSMUSP00000099398/1-1385 MMSLRLFSILLATVVSGAWGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGIS ENSRNOP00000027505/1-1381 MMSLRLFSILLAAVVSGAQGWGYYGCNEELVGPLYARSLGASSYYGLFTTARFARLHGIS * ***:.:***: .* * *******:**************** *.*:*:.********* XP_004859370.1/1-1379 GWSPHTRDSNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQQGH ENSCPOP00000007948/1-1339 GWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQQGH ENSP00000264638/1-1384 GWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGH ENSMUSP00000099398/1-1385 GWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQKGH ENSRNOP00000027505/1-1381 GWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLLYGDRVDSWTPFYQQGH ****: *.*********************:**************************:** XP_004859370.1/1-1379 NATFFGNVNESAVVRHDLHYHFTARYVRIVPLAWNPRGKIGLRLGLYGCPYKSDILYFDG ENSCPOP00000007948/1-1339 NATFFGNVNESAVVRHDLHFHFTARYVRIVPLAWNPRGKIGLRLGLYGCPYKSDVLYFDG ENSP00000264638/1-1384 NSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDG ENSMUSP00000099398/1-1385 NATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSSILYFDG ENSRNOP00000027505/1-1381 NATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLRLGIYGCPYTSNILYFDG *:*******:*********:******:******************:*****.:.:***** XP_004859370.1/1-1379 DDAISYRFPRGVSRSLWDVIAFSFKTEEKDGLLLHSEGAQGDYVTLELQGAHLLLHMSLG ENSCPOP00000007948/1-1339 DDAISYRFPRGVSRSLWDVIAFSFKTEEKDGLLLHSEGAQGDYVTLELQGAHLLLHMSLG ENSP00000264638/1-1384 DDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLG ENSMUSP00000099398/1-1385 DDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLG ENSRNOP00000027505/1-1381 DDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDYVTLELQGAHLLLHMSLG ******** **.*:*****:***************:**:*********:*********** XP_004859370.1/1-1379 SSPIQPRPGHTTVSAGGVLNDQHWHYVRLDRYGREANLTLDGYVQRFVLNGDFERLNLDS ENSCPOP00000007948/1-1339 SSPIQPRPGHTTVSAGGVLNDQHWHYVRLDRYGREANLTLDGYAQHFLLNGDFERLNLDT ENSP00000264638/1-1384 SSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDT ENSMUSP00000099398/1-1385 SSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGYAHHFVLNGDFERLNLEN ENSRNOP00000027505/1-1381 SSPIQPRPGHTTVSAGGVLNDLSWHYVRVDRYGREANLTLDGYVHRFVLNGDFERLNLEN ************** ****** *****:**:**:.*:*****.::*:**********:. XP_004859370.1/1-1379 EMFIGGLVGATQKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPV ENSCPOP00000007948/1-1339 EMFIGGLVGAAQKNLAYRHNFRGCIENIIFNRVNIADLAVRRHHRITFEGKVAFRCLDPV ENSP00000264638/1-1384 EMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPV ENSMUSP00000099398/1-1385 EIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVMRHSRITFEGNVAFRCLDPV ENSRNOP00000027505/1-1381 EIFIGGLVGAARKNLAYRHNFRGCIENVIYNRINIAEMAVQRHSRITFEGNVAFRCLDPV *:********::***************:*:**:***::** ** ******:********* XP_004859370.1/1-1379 PHPINFGGPHNYVQIPGFPRRGRLAVSFRFRTWDLTGLLLFSSLGDGLGHVELMLSDGQV ENSCPOP00000007948/1-1339 PHPINFGGPHNFIQVPGFPRRGRLAVSFRFRTWDLTGLLLYSSLGDGLGHVELMLSEGQV ENSP00000264638/1-1384 PHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQV ENSMUSP00000099398/1-1385 PHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSHLGDGLGHVELMLSEGQV ENSRNOP00000027505/1-1381 PHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELMLSEGQV ***********::*:*************************:* ********** **:*** XP_004859370.1/1-1379 NVSIAQAARKRLQFAAGYRLNDGFWHEVNFVAQENQAVISIDDVEGAEVRVSYPLLIRTG ENSCPOP00000007948/1-1339 NVSIAQTGRKRLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTG ENSP00000264638/1-1384 NVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTG ENSMUSP00000099398/1-1385 NVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTG ENSRNOP00000027505/1-1381 NVSIAQTGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTG ******:.**:************************:************************ XP_004859370.1/1-1379 TSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRRLGHYAEVLFDTCG ENSCPOP00000007948/1-1339 TSYFFGGCPKPASQWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRRLGYYAEVLFDTCG ENSP00000264638/1-1384 TSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCG ENSMUSP00000099398/1-1385 TSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCG ENSRNOP00000027505/1-1381 TSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVDGQLVNLTLVEFRKLGYFAEVLFDTCG *************:*.**************************** *:**.:********* XP_004859370.1/1-1379 ITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHQPLYKESCEAYRLSGKISGNFT ENSCPOP00000007948/1-1339 ITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHQPLYKESCEAYRLSGKTSGNFT ENSP00000264638/1-1384 ITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFT ENSMUSP00000099398/1-1385 ITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYT ENSRNOP00000027505/1-1381 ITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGVTCHEPLYKESCEAYRLSGKYSGNYT ********************************** *** *************** ***:* XP_004859370.1/1-1379 IDPDGSGPLKPFVVYCDIRGERQWARETETGGCALTMWGHGRRTLAFRSVQLGSLPVVPK ENSCPOP00000007948/1-1339 IDPDGSGPLKPFVVYCDIRENRAWTVVRHD-----RLW-------------------TTR ENSP00000264638/1-1384 IDPDGSGPLKPFVVYCDIRENRAWTVVRHD-----RLW-------------------TTR ENSMUSP00000099398/1-1385 IDPDGSGPLKPFVVYCDIRENRAWTVVRHD-----RLW-------------------TTR ENSRNOP00000027505/1-1381 IDPDGSGPLKPFVVYCDIRENRAWTVVRHD-----RLW-------------------TTR ******************* :* *: . :* ..: XP_004859370.1/1-1379 GDCAGESPPATSAVPEWREQWAGRRNRRPGSAWALSPTREPSVDGGAARQAVDNTRVRLQ ENSCPOP00000007948/1-1339 VSGSSMERPFLAAVQYWNASW----------------------------EEVSALANASQ ENSP00000264638/1-1384 VTGSSMERPFLGAIQYWNASW----------------------------EEVSALANASQ ENSMUSP00000099398/1-1385 VTGSSMDRPFLGAIQYWNASW----------------------------EEVSALANASQ ENSRNOP00000027505/1-1381 VTGSSMDRPFLGAIQYWNASW----------------------------EEVSALANASQ :. . * .*: *. .* : *. * XP_004859370.1/1-1379 HGAALLGGRAVLERIVGGGRSAGQRLAALRAVDRVLLLQLPAAQHGSFWIGRHEEQHFYW ENSCPOP00000007948/1-1339 HCEQWIEFSCYNSR----------------------LLNTAGGYPYSFWIGRHEEQHFYW ENSP00000264638/1-1384 HCEQWIEFSCYNSR----------------------LLNTAGGYPYSFWIGRNEEQHFYW ENSMUSP00000099398/1-1385 HCEQWIEFSCYNSR----------------------LLNTAGGYPYSFWIGRNEEQHFYW ENSRNOP00000027505/1-1381 HCEQWIEFSCYNSR----------------------LLNTAGGYPYSFWIGRNEEQHFYW * : . .* **: ... ******:******* XP_004859370.1/1-1379 GGSQPGIRRCACGLDHSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRS ENSCPOP00000007948/1-1339 GGSQPGIQRCACGLDHSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRS ENSP00000264638/1-1384 GGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRS ENSMUSP00000099398/1-1385 GGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVVGDTNRS ENSRNOP00000027505/1-1381 GGSQPGIQRCACGLDQSCIDPALHCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRS *******:*******:**:****:*****************************:****** XP_004859370.1/1-1379 NSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPAIRANHSLDVSFYFRTSAPSGVFLEN ENSCPOP00000007948/1-1339 NSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN ENSP00000264638/1-1384 TSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN ENSMUSP00000099398/1-1385 NSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN ENSRNOP00000027505/1-1381 SSEAQFFLRPLRCYGDRNSWNTISFRTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLEN .************************:********.************************* XP_004859370.1/1-1379 QAGLYGGWRRPYLRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFSDDEWHLVRAEINVK ENSCPOP00000007948/1-1339 QSGRYCQWRRPYLRVELNTSRDVVFAFDVGNGDENLTAHSEDLEFSDDEWHLVRAEINVK ENSP00000264638/1-1384 MGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVK ENSMUSP00000099398/1-1385 MGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVK ENSRNOP00000027505/1-1381 MGGPFCQWRRPYVRVELNTSRDVVFAFDIGNGDENLTVHSDDFEFNDDEWHLVRAEINVK .* : *****:***************:********.**:*:**.************** XP_004859370.1/1-1379 QARLRVDHRPWVVRPMPLQTYLWLEYDQPLHVGSAELKRRPFVGCLRAMRLNGVTLNLEG ENSCPOP00000007948/1-1339 QARLRVDHRPWVVRPMPPQTYLWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEG ENSP00000264638/1-1384 QARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEG ENSMUSP00000099398/1-1385 QARLRVDHRPWVLRPMPLQTYIWLVYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEG ENSRNOP00000027505/1-1381 QARLRVDHRPWVLRPMPLQTYIWLEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEG ************:**** ***:*: *****:***************************** XP_004859370.1/1-1379 RANASEGTSPNCTGRCAHPRFPCSHGGRCVEHYSYYTCDCDLTAFDGPYCNQDIGGFFEP ENSCPOP00000007948/1-1339 RANASEGTSPNCTGRCAHPRFPCSHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEP ENSP00000264638/1-1384 RANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEP ENSMUSP00000099398/1-1385 RANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFET ENSRNOP00000027505/1-1381 RANASEGTFPNCTGHCTHPRFPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFET ******** *****:*:***:** *******:*******************:*******. XP_004859370.1/1-1379 GTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYVPGYDSPGYVPGYHGPGYRRPDYPRP ENSCPOP00000007948/1-1339 GTWMRYNLQSALRSAAREFSHMLSRPVPGYE---------------------RLPDYPRP ENSP00000264638/1-1384 GTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRP ENSMUSP00000099398/1-1385 GTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYVPGYDTPGYVPGYHGPGYRLPEYPRP ENSRNOP00000027505/1-1381 GTWMRYNLQSALRSAAQEFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRP ****************:************** * *:**** XP_004859370.1/1-1379 GRPVPGYRGPVYNVTGEEVSFSFSTSVAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLG ENSCPOP00000007948/1-1339 GRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLG ENSP00000264638/1-1384 GRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLG ENSMUSP00000099398/1-1385 GRPVPGYRGPVYNVTGEEVSFSFSTNSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLG ENSRNOP00000027505/1-1381 GRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKEDGTLQLRYQLG *************************. *********************:*********** XP_004859370.1/1-1379 TSPYVYPLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYL ENSCPOP00000007948/1-1339 TSPYVYPLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYL ENSP00000264638/1-1384 TSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYL ENSMUSP00000099398/1-1385 TSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYL ENSRNOP00000027505/1-1381 TSPYVYQLTTRPVTDGQPHSVNITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYL ****** *************:*************************************** XP_004859370.1/1-1379 GRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRSPRPMTAELAEALRVQGEL ENSCPOP00000007948/1-1339 GRVMETGVIDPEIQRYNSPGFSGCLSGVRFNNVAPLKTHFRSPRPMTAELAEALRVQGEL ENSP00000264638/1-1384 GRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGEL ENSMUSP00000099398/1-1385 GRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGEL ENSRNOP00000027505/1-1381 GRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEAMRVQGEL *****************:***********************:***********:****** XP_004859370.1/1-1379 AESNCGAMPRLVSEVPPELDPWYLPPDFLYYHDDGWVAILLG------------------ ENSCPOP00000007948/1-1339 AESNCGAMPRLVAEVPPELDPWYLPPDFLYYHDDGWVAILLGFLVAFLLLGLVGMLVLFY ENSP00000264638/1-1384 SESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFY ENSMUSP00000099398/1-1385 SESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFY ENSRNOP00000027505/1-1381 SESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDDGWIAILLGFLVAFLLLGLVGMLVLFY :***********:*************** ****:**:***** XP_004859370.1/1-1379 -------CEWQT---------------------PNLTPGPVPDPGH-------------- ENSCPOP00000007948/1-1339 LQHHRYKGSYHTNEPKATHDYQPRSKTPLPTQGVARAPSPEASSTWGFSALPAP------ ENSP00000264638/1-1384 LQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAP ENSMUSP00000099398/1-1385 LQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQLPTPAPAPAPAPAS ENSRNOP00000027505/1-1381 LQNHRYKGSYHTNEPKATHDSHPGGKAPLPPSGPAQAPAPTPAPTQVPTPAPAP----AS .::* .* * . . XP_004859370.1/1-1379 ------------------- ENSCPOP00000007948/1-1339 ------------------- ENSP00000264638/1-1384 APGPRDQNLPQILEESRSE ENSMUSP00000099398/1-1385 GPGPRDQNLPQILEESRSE ENSRNOP00000027505/1-1381 GPGPRDQNLPQILEESRSE