CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000065633/1-1182 MEAMSPQQDALGAQPGRSSSLTGMSRIAGGPGTKKKMKTLAERRRSAPSLILDKALQKRP ENSRNOP00000034071/1-1182 MEAMSPQQDALGAQPGRSSSLTGMSRIAGGPGTKKKMKTLAERRRSAPSLILDKALQKRP ENSCPOP00000007916/1-1127 ------------------------------------------------------------ ENSP00000260283/1-1191 MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP XP_004856583.1/1-1167 MEAMSPQQETLGGQPPRSSSLTGVSRLAGGPGTKKKMKTLAERRRSAPSLILDKALQKQP ENSMUSP00000065633/1-1182 STRDSHSASIDTCAFLSSFMCSSRTLLIDGPVELKRGLQRQERHLFLFNDLFVSAKIKYN ENSRNOP00000034071/1-1182 STRDSHSASIDTCAFLSSFMCSSRTLLIDGPVELKRGLQRQERHLFLFNDLFVSAKIKYN ENSCPOP00000007916/1-1127 --RESPSAGVDTCAFLSSFMCASRTLLIDGRVELKRGLQRQERHLFLFSDLLVVVKIKYN ENSP00000260283/1-1191 TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN XP_004856583.1/1-1167 ST--------------------SRTLLIDGRVELKRGLQRQERHLFLFNDLLLVVKIKYN .******* .****************.**:: .***** ENSMUSP00000065633/1-1182 NNFKIKNKIRLTDMWTASCVEEVGEGNMNAQKSFVLGWPTVNFVATFSSPEQKDKWLSLL ENSRNOP00000034071/1-1182 NNFKIKNKVKLADMWTASCVDEVGEGNTNALKSFVLGWPTVNFVATFSSPEQKDKWLSLL ENSCPOP00000007916/1-1127 NNFKIKNKIKLTDMWTASCVEEVGEGNTSAVKSFVLGWPTVNFVATFSSPEQKDKWLFLL ENSP00000260283/1-1191 NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL XP_004856583.1/1-1167 NNFKIKNKIKLTDMWTASCVDEVGEVNTSAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL ********::*:********:**** * .* ************************** ** ENSMUSP00000065633/1-1182 QRYIALEKEKDYPKSIPLKIFAKDIGNCAYFKTITVMNSDTASEVINMSLQMLGITGSER ENSRNOP00000034071/1-1182 QRYIALEKEKDYPKSIPLKIFAKDIGNCAYFKTISVMNSDTASEVINMSLQMLGITGSER ENSCPOP00000007916/1-1127 QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVTNSDTASEVINMSLRMLGVTGSER ENSP00000260283/1-1191 QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER XP_004856583.1/1-1167 QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLRMLGITGSER **** ************************* ***:* *****.******* ***:***** ENSMUSP00000065633/1-1182 DYQLWVNSGKEAAPYPLIGHEYPYGIKMSHLRDTALLTQGSRDSASPSQLQEPFLMEQLP ENSRNOP00000034071/1-1182 DYQLWVNSGKEAAPYPLIGHEYPYGIKMSHLRDTALLTQGSKDSASPSQLQEPFLMEQLP ENSCPOP00000007916/1-1127 DFQLWVNSGKEAAPYPLIGHEFPYGIKMSHLRDTALLTQGSKDSATLSSLQEPFLMEQLP ENSP00000260283/1-1191 DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP XP_004856583.1/1-1167 DYQLWVNSGKEAAPYPLIGHEYPYGIKMNHLRDTALLTQGSKDSASLSNLQEPFLMEQLP *:********* *********:******.****:**** **:**:: .*********** ENSMUSP00000065633/1-1182 REMQCQFILKPTRLATAQQLSDSSQKTFKRRRSIINWAFWRGSSTHLDNLPMSPTSPMPG ENSRNOP00000034071/1-1182 REMQCQFILKPTRLATAQQLSDSSHKTYKRRRSIINWAFWRGSSTHLDNLPVSPTSPMPG ENSCPOP00000007916/1-1127 REMQCQFILKPSHLAATQHLSDSGQKTVRRRRSIINWAFWRGSSTHLDNLPMSPTSPVPG ENSP00000260283/1-1191 REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG XP_004856583.1/1-1167 REMQCQFILKPSRLAATQHLNDSGQKTVRRRRSIINWAFWRGSSTHLDNLPVSPTSPIPG ***********::**::*:*.**.:** :********************** *****:** ENSMUSP00000065633/1-1182 QLFGVSLPDLCENDNLPKPILDMLSFLNQKGPLTKGIFRQSANMKSCRELKEKLNSGIEV ENSRNOP00000034071/1-1182 QLFGVSLPDICENDNLPKPILDMLSFLNQKGPLTKGIFRQSANMKSCRELKEKLNSGIEV ENSCPOP00000007916/1-1127 QLFGVSLQDICENDNLPKSVLDMLFFLNQKGPLTRGIFRQSANVKSCRELKEKLNSGAEV ENSP00000260283/1-1191 QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV XP_004856583.1/1-1167 QLFGVSLQDICENDNLPKSVLDMLFFLNQKGPLTRGIFRQSANVKSCRELKEKLNSGVEV ****:** ::********.:**** *********:********:************* ** ENSMUSP00000065633/1-1182 HLDCESIFVIASVLKD--FLRNIPESIFSSDLYDHWVCVMDQGNDEEKINIIQRLLDQLP ENSRNOP00000034071/1-1182 HLDCESIFVIASVLKD--FLRNIPESIFSSDLYDHWVCVMDQGNDEEKINTIQRLLDQLP ENSCPOP00000007916/1-1127 HLDCESIFVIASVLKKIIFAKNLDFFRVSLRFSDVFLQVMDQGNDEEKINAIQRLLDQLP ENSP00000260283/1-1191 HLDCESIFVIASVLKD--FLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLP XP_004856583.1/1-1167 HLDCESIFVIASVLKD--FLRNIPGSIFLSDIYDQWVCLMDQGNDEEKINTIQRLLDQLP ***************. * :*: . : * :: :*********** :******** ENSMUSP00000065633/1-1182 RANVVFLRYLFGVLHNIEQHSLSNQMTAFNLAVCIAPSILWPPASSSPELENEFTKKVSL ENSRNOP00000034071/1-1182 RANVVFLRYLFGVLHNIEQHSLSNQMTAFNLAVCIAPSILWPPASSSPELENEFTKKVSL ENSCPOP00000007916/1-1127 RANVILLRYLFGVLYNIEKNSSTNQMNAFNLAVCVTPSLIWPPTSSSPELEHEFTKKVSL ENSP00000260283/1-1191 RANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSL XP_004856583.1/1-1167 RANIILLRYLFGVLYNIEKNSSTNQMNAFNLAVCVTPSLIWPPTSSSPELEHEFTKKVSL ***:::********:***::* :***.*******::**::***:*******:******** ENSMUSP00000065633/1-1182 LIQFLIENCCRVFGEEIASLLGELSERSD-REHTPDITCFQMNDSSYDSLENELNEEADA ENSRNOP00000034071/1-1182 LIQFLIENCCRIFGEEITSLLGELSERSD-REHTPDTSCFQLNDSSYDSLENELNEDADA ENSCPOP00000007916/1-1127 LIQFLIENCCRIFGHEITSLFGEISVRCDTKENSSDTSCVQLNDSSYDSLENELNEDADA ENSP00000260283/1-1191 LIQFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDA XP_004856583.1/1-1167 LIQFLIENCCRIFGHEITSLFGEVSLRCDTKENSSDTSCVQLNDSSYDSLENELNEDVDA ********* *:**.**:**: *:* *.* :*::.* :*.*:**************:.** ENSMUSP00000065633/1-1182 PCSDLVKKLGQGSRSMDSVLTLSDYDLEQPEVEGLLTLSNFDLDQSKEEHIPIKPPLEPK ENSRNOP00000034071/1-1182 PCSDLVKRLGQGSRSMDSVLTLSDYDLEPPEAEGLLTLSNFDLDQSKEEHIRTKQPLETK ENSCPOP00000007916/1-1127 PCSDLVRKLGQGSRSMDSVLTLSDYDIDQPEVEGLLALSEFDLDRSKHQDIQVKRPAGSK ENSP00000260283/1-1191 PCSDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESK XP_004856583.1/1-1167 PCSDLVKKLGQGSRSMDSVLTLSDYDIDQPEVEGLLTLSDFDLDHSTDQDIHMKQPPGSK ******::******************:: **.****:**:*** :*..:.: * * .* ENSMUSP00000065633/1-1182 PVNVFVGYRKVSLGEHARAPAGPGTLSCLPVAAADAPKVLRRHRRSSEPSIDYLDTKLSY ENSRNOP00000034071/1-1182 PVSVFVAYRKVSLGEHTRAPDGPGTPSCLPATASDARKVFRRHRRSSEPSIDYLDAKLSY ENSCPOP00000007916/1-1127 QVKVLVVGRNAPLVERPGASSSVCTPSYRSTAAAEAPQSLRRHRRCSEPSIDPHDSKGSY ENSP00000260283/1-1191 PVNILV-YTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSY XP_004856583.1/1-1167 LVNVSVMNRKASLGEHAGASSSTCTPSYLSTAAADVPKSLRRHRRCSEPSIDYRDSKVSY *.: * : .* ::. *. . * * ..:*::. : :*****.****** *:* ** ENSMUSP00000065633/1-1182 LREFYQKKLRKSSCDAVLSRKDEDYLKQTQPQKKGDKVCLKQSSVTGTDVSKRNTANENI ENSRNOP00000034071/1-1182 LREFYQKKLRKSSCDAVLSRKDEDYLKQTQPQKKGDQRCFKQSSVTGTDVSKRNTANENI ENSCPOP00000007916/1-1127 LKGFYQKKLRKSSCDAILSQNDEDDPEQNQPLPEEDKTCLEQSLVTNTDPSRKNATNKNI ENSP00000260283/1-1191 LREFYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNT XP_004856583.1/1-1167 LREFHQKKLRKSSCDGILSQKDKDSLKQNQTLTKEGKIPLEQNLVTGTDISRKNTTSKNI *: *:**********.:**::*:* :*.*. : .: ::*. **.** *::*::.:* ENSMUSP00000065633/1-1182 KKKSLSGHEGTQVTLFTKSKPVPISVASYSHGSSQDHPRKQAFDADPCRFSPPHLTDAQK ENSRNOP00000034071/1-1182 KKKSLSGHEGIQETPFTKSKPVAISVASY--MSSQDHSWEQPFEADACRFSPPHIADAQK ENSCPOP00000007916/1-1127 KKSSLSATEGNHVKLSTKSRPVAISVAPYSHASPRDHSRSPHSDANTSGYTPTHIRDTLK ENSP00000260283/1-1191 KKKSLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALK XP_004856583.1/1-1167 KKKSLSGNEGNHVKLFTNSKPVAISVASYSHMSPQDHSGNQHSDANTSGYSPSHTADTLK **.***. ** : . .:*:**.****.* *.:**. . :.:.. ::*.* *: * ENSMUSP00000065633/1-1182 SSRVQHRRCSEPSIDDQNYKLSYLRGIYSMKQNKASCEAGLLHGEDDYLRRHKSLQIEGQ ENSRNOP00000034071/1-1182 SSRA-HRRCSEPSIDDQNYKLSYLRGVYSKKQSKTSCEAGLLHGEEDYLKRHKSLQMEGQ ENSCPOP00000007916/1-1127 SSRT-HRRCSEPSIDDQKCKLTYLRGIYSKKQHKSSCQTVLLQGEEDYLRRHKSLQMEGQ ENSP00000260283/1-1191 GPRT-HRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQ XP_004856583.1/1-1167 SSRT-HRRCSEPNIDDQNCKLTYLRGIYSKKQHKISCEAALLQGEEDYLRRHKSLQMEGQ ..*. *******.*:**: **:****:** ** * **:: **:**:***:******:*** ENSMUSP00000065633/1-1182 KLINQSLVMGIEVGK-SSSSHQSTEKVLPPRLNLCPRASYSSLSSPGSSPSGSSVSSQDS ENSRNOP00000034071/1-1182 KLINQSLVMGIEVGKSSSSTNQSTEKVLPPRLNLCPRASYSSLSSPGTSPSGSSVSSQDS ENSCPOP00000007916/1-1127 KLINQSLVMGIEVGR-SSATHQSAEKVLPPRLSLCPSSSSSSLSSPGTSPSGSSVSSQDS ENSP00000260283/1-1191 KLINQSLVMGIEVGK-SSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDS XP_004856583.1/1-1167 KLINQSLVMGIEVSK-SSATNQSTEKVLPPRLNLCPSTSSSSLSSPSTSPSGSSVSSQDS *************.: **:::*.:********.*** :* ******.:************ ENSMUSP00000065633/1-1182 AFSQISEHSVFTPTETSSPIDCTFQTQRKQEELSSDFDSPSRLSGMPGPSMGQASSHLAY ENSRNOP00000034071/1-1182 AFSQISEHSVFTPTETSSPIDCTFRAQRKQEELSSDCDSPSLVSGMPGPSTGQASSHLAY ENSCPOP00000007916/1-1127 AFSQISEHSVFTPTETSSPIDCTFQAQKRQENPSFSF-----ISKVPGPSIGQASSHLTY ENSP00000260283/1-1191 AFSQISEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAY XP_004856583.1/1-1167 AFSQISEHSMFTPTETSSPIDCTFQARKKEENLSSNVSTSSLYSKMPGPSVGQASSHLAY *********:**************:::::.*: * . * :**** ***.*: :* ENSMUSP00000065633/1-1182 LRKGTTEQPSQMHSVTLHPSAWLRSGLVTLKNWSLKKKTKAARPEDRKVCSLKEPLELPS ENSRNOP00000034071/1-1182 LRKGTTEQLPQMHSVTLHPSTWLRSGLVTLKNWSLKKKTKAARPEDRKDCSLKEPLELPA ENSCPOP00000007916/1-1127 MKKDTIEWHSQMHSVTLHPSAWLKNSVASLKNWSLKKKAKLTRPEEKKLNLLKGPLESPP ENSP00000260283/1-1191 TKKDTMEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPP XP_004856583.1/1-1167 TKKDTVEWHLQMHSGTLHPSTWLKNSVASLKNWSLKKKAKVARPEEKKINSLKGP----- :*.* * **** *****:**:..:.:*********:* :***:.* * * ENSMUSP00000065633/1-1182 CASGTPEADSLQESQDDL--QGDEGPG--QTACGFSSYACQDSEQHAGSPFHLAESRLKP ENSRNOP00000034071/1-1182 CAAGTPEADSLQESQEDIHLGVDEGAG--QTACGLSSYACQDSEQHASSPFCLAGSRLTL ENSCPOP00000007916/1-1127 HASDVSEASSLQQSEKGPPPTATEGPRTSHTARPWSSGSCQDSDRHCSSPFSLQESRLKF ENSP00000260283/1-1191 HASGVPEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKL XP_004856583.1/1-1167 YASDVPKANSLQEFQKDLPQRAADGLGAMQTAQLCSSASCQDSEKHCSSPFSLVESRLKL *:...:*.***: :.. :* ::* ** . ***::*..*** * ***. ENSMUSP00000065633/1-1182 CMKLYKGEESGGQYPCDNP--WEGASSSLETTEDTANPGAEPTTFAMTGT-----DI ENSRNOP00000034071/1-1182 GMKLHEGEESGGQYPCDNP--WEGAPSGLETSEDAANTGVEPATVCNDGDRH----- ENSCPOP00000007916/1-1127 CGKSYGGGETEGPC-CSGPLPWEKASSSPGTVNDMTSPDEEPTVVPDAGDKHLAKDI ENSP00000260283/1-1191 CMKSHEEIEPGSQS-SSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI XP_004856583.1/1-1167 SVKSYKGEETEGQC-CSGPLRWEKASSSSGTINDVASPDGGPTVVSDGEDKPLTKDI * : *. . .... ** *.:. * :* :... *:..