CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000135086/1-1517 -----------MLCVAGAKLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL ENSRNOP00000001928/1-1506 --------------------QRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL ENSP00000353401/1-1516 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL XP_004840185.1/1-1433 MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL ENSCPOP00000007696/1-1193 --------------------QRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDL :*************************************** ENSMUSP00000135086/1-1517 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDVGQQLEIKVQRLH ENSRNOP00000001928/1-1506 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDLGQQLEIKVQRLH ENSP00000353401/1-1516 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH XP_004840185.1/1-1433 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH ENSCPOP00000007696/1-1193 RKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLH ******************************.****************:****::****** ENSMUSP00000135086/1-1517 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQ ENSRNOP00000001928/1-1506 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQ ENSP00000353401/1-1516 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQ XP_004840185.1/1-1433 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQ ENSCPOP00000007696/1-1193 DIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQ *********************************************.************** ENSMUSP00000135086/1-1517 NDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEI ENSRNOP00000001928/1-1506 NDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEI ENSP00000353401/1-1516 NDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEI XP_004840185.1/1-1433 NDFAEKERKLQETQMSTTSKLEEAEHKLHSLQTALEKTRTELFDLKTKYDEETTAKADEI ENSCPOP00000007696/1-1193 NDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEI ***************************:::****************************** ENSMUSP00000135086/1-1517 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE ENSRNOP00000001928/1-1506 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDV--AIEVLTRSSLE ENSP00000353401/1-1516 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE XP_004840185.1/1-1433 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE ENSCPOP00000007696/1-1193 EMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLE *********************************************** *********** ENSMUSP00000135086/1-1517 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQA ENSRNOP00000001928/1-1506 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQA ENSP00000353401/1-1516 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQA XP_004840185.1/1-1433 VELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSTKNSTLKQLEEKLKGQA ENSCPOP00000007696/1-1193 VELAAKEREIAQLVEDVQRLQTSLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQA *********************:********************.:**************** ENSMUSP00000135086/1-1517 DYEEVKKELNTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGS ENSRNOP00000001928/1-1506 DYEDVKKELTTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGS ENSP00000353401/1-1516 DYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGS XP_004840185.1/1-1433 DYEEVKKELNILKSMEFAPSEGAGTQEAAKPLEVLLLEKNRSLQSENAALRISNSDLSG- ENSCPOP00000007696/1-1193 DYEEVKKELNILKSMEFAPSEGTGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGS ***:*****. ***********:***:::*******************:********** ENSMUSP00000135086/1-1517 ARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPS ENSRNOP00000001928/1-1506 ARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPS ENSP00000353401/1-1516 ARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPS XP_004840185.1/1-1433 ------------------------------------------------------------ ENSCPOP00000007696/1-1193 ARRKGKDQPESRRPGPLPASPPPQLPRNTGEQASNTNGTHQFSPAGLSQDFFSSSLTSPS ENSMUSP00000135086/1-1517 LPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDV ENSRNOP00000001928/1-1506 LPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDV ENSP00000353401/1-1516 LPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDV XP_004840185.1/1-1433 -----------------------------------------PYSTNSISSPTPLQQSPDV ENSCPOP00000007696/1-1193 LPLASTGKFALNSLLQRQLMHSFYSKAMQEAGSTSMIFSTGPYSTNSISSPTPLQQSPDV ********* :******** ENSMUSP00000135086/1-1517 NGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI ENSRNOP00000001928/1-1506 NGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI ENSP00000353401/1-1516 NGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI XP_004840185.1/1-1433 NGMAPSPSQSESAGSVSEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI ENSCPOP00000007696/1-1193 NGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEI ***************:*****:************************************** ENSMUSP00000135086/1-1517 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR ENSRNOP00000001928/1-1506 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR ENSP00000353401/1-1516 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR XP_004840185.1/1-1433 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR ENSCPOP00000007696/1-1193 LARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRR ************************************************************ ENSMUSP00000135086/1-1517 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQTSSTSSSGNSDDAIRSI ENSRNOP00000001928/1-1506 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQASSTASSGNSDDAIRSI ENSP00000353401/1-1516 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSI XP_004840185.1/1-1433 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSTSSPGNSDDAIRSI ENSCPOP00000007696/1-1193 NGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQLSSASSSGNSDDAIRSI *****************************************.* **::..********** ENSMUSP00000135086/1-1517 LQQARREMEAQQAALDPALKPAPLSQPDLTILTPKHLSASPMSTVSTYPPLAISLKKTPA ENSRNOP00000001928/1-1506 LQQARREMEAQQAALDPALKPAPLSQPDLTILNPKLLSASPMSTVSTYPPLAISLKKTPA ENSP00000353401/1-1516 LQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSA XP_004840185.1/1-1433 LQQARREMEAQQAALEPALKPAPLSQPDVTLLAPKLLSASPMPTVSSYSPLTVSLKKTPS ENSCPOP00000007696/1-1193 LQQARREMEAQQAALDPALKPAPLAQPDLALLTPKLLSASPMPTVSSYSPLAISLKKTPS ***************:**** ***:*.*:::* ** **:***.***:*.**::****..: ENSMUSP00000135086/1-1517 APETSTAALPSAPALKKEAQDVPTLDPPGSADAAQGVLRPMKSELVRGSTWKDPWWSPIQ ENSRNOP00000001928/1-1506 APEASTSALPSAPALKKEAQDAPTLDPPGSADATPGVLRPVKNELVRGSTWKDPWWNPVQ ENSP00000353401/1-1516 APEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQ XP_004840185.1/1-1433 APEATASSLPNTPALKKEAQDVPVLDPQGMADAAQGVLRHVKSELGRGGGWKDHWWSPVQ ENSCPOP00000007696/1-1193 ASEASASALPNTPALKKEAQDMPTLDPQGTMDTAQGVLRHVKSELGRGGGWKDHWWSPAQ *.*: :::**..********* * *** * * : **** :*.*: *.. *** **.. * ENSMUSP00000135086/1-1517 PERRNLTSSEETKADETTASGKER-----AGSSQPRAERSQLQGPSASAEYWKEWPSAES ENSRNOP00000001928/1-1506 PERRNLTTSEETKADETNASGKEK-----TGSSQPRAERSQLQGPSATAEYWKEWPNAES ENSP00000353401/1-1516 PERRNAASSEEAKAEETGG-GKEKGSGGSGGGSQPRAERSQLQGPS-SSEYWKEWPSAES XP_004840185.1/1-1433 PERRNPTSSEETKGEEATG-GKEKG----SGASQPRAERSQLQGPS--SEYWKEWPNAES ENSCPOP00000007696/1-1193 PERRNPTSSEETKGEEATG-GKEKG----GGSNHPRAERSQLQGPS--SEYWKEWPNAES ***** ::***:*.:*: . ***: *..:************ :*******.*** ENSMUSP00000135086/1-1517 PYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIE ENSRNOP00000001928/1-1506 PYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIE ENSP00000353401/1-1516 PYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIE XP_004840185.1/1-1433 PYSQSSELSLTGASRSETPQNSPLPSSPIVSMTKPTKPSVPPLTPEQYEIYMYQEVDTIE ENSCPOP00000007696/1-1193 PYSQSSELSLTGASRSETPQNSPLPSSPILPMAKPTKPSVPPLTPEQYEIYMYQDVDTIE *****************************:.*:**:*************:****:***** ENSMUSP00000135086/1-1517 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN ENSRNOP00000001928/1-1506 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN ENSP00000353401/1-1516 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN XP_004840185.1/1-1433 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN ENSCPOP00000007696/1-1193 LTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLN ************************************************************ ENSMUSP00000135086/1-1517 GELGQGVLPVQGQQQGPVLHSVASLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESV ENSRNOP00000001928/1-1506 GELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESV ENSP00000353401/1-1516 GELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESV XP_004840185.1/1-1433 GELGQGVLPVQGQPQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESV ENSCPOP00000007696/1-1193 GELGQGVLPVQGQPQGPVLHSVTSLQDSLQQGCVSSESTPKTSASCSPAPESPMSSSESV ************* ********:****.******************************** ENSMUSP00000135086/1-1517 KSLTELVQQPCPAIETSKEGKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELD ENSRNOP00000001928/1-1506 KSLTELVQQPCPTIETSKEGKPPEPSDPPTSDSQPTTPLPLSGHSALSIQELVAMSPELD ENSP00000353401/1-1516 KSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELD XP_004840185.1/1-1433 KSLTELVQQPCPPIETSKDGKPPEPSDPPTLDSQPTTPLPLSGHSALSIQELVAMSPELD ENSCPOP00000007696/1-1193 KSLTELVQQPCPPIETGKDGKPPEPSDPPTLDSQPTTPLPLSGHSALSIQELVAMSPELD ************.**:.*:.*********: ***************************** ENSMUSP00000135086/1-1517 TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQL ENSRNOP00000001928/1-1506 TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQL ENSP00000353401/1-1516 TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQL XP_004840185.1/1-1433 TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQV ENSCPOP00000007696/1-1193 TYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQV ***********************************************************: ENSMUSP00000135086/1-1517 WLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKP ENSRNOP00000001928/1-1506 WLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKP ENSP00000353401/1-1516 WLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKP XP_004840185.1/1-1433 WLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPPVGIDYSQGASPQPQHQLKKP ENSCPOP00000007696/1-1193 WLNDPNNVEKLMDMKRMEKK---------------------------------------- ******************** ENSMUSP00000135086/1-1517 RVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEE ENSRNOP00000001928/1-1506 RVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEE ENSP00000353401/1-1516 RVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEE XP_004840185.1/1-1433 RVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEE ENSCPOP00000007696/1-1193 ------------------------------------------------------------ ENSMUSP00000135086/1-1517 IQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVE------A-----TDAEEPGGNIVAT ENSRNOP00000001928/1-1506 IQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVE------A-----ADTEEPGGNIVAT ENSP00000353401/1-1516 IQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGS-----ADTEEP------- XP_004840185.1/1-1433 IQAGSQGQAGASDSPSARSGRPAPSSEGDSCDGVEAAEGPGATVTATADAEEPGGPTAAT ENSCPOP00000007696/1-1193 ------------------------------------------------------------ ENSMUSP00000135086/1-1517 KSQGGLAEVAAAPADREEATQPAEKAKAQPLCSGTPGQDDGEDASRPRPLP-EGLADAPA ENSRNOP00000001928/1-1506 KSQGGPAEVTAAPADREEATQPAEKAKAQPLSSGTPGQDDGEDAGRSRPPP-EGLADAPA ENSP00000353401/1-1516 KSQGE--------AEREEVPRPAEQT--EPPPSGTPGPDDARDDDHE-----GGPVEGPG XP_004840185.1/1-1433 KSQGGPGT-----AEREERPPPPSGTPGTPVPDDAAAAEDAGRAGPPPPPPLEGPAELPA ENSCPOP00000007696/1-1193 ------------------------------------------------------------ ENSMUSP00000135086/1-1517 PVPSLAAPAAGEDAATSATAPATATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQ ENSRNOP00000001928/1-1506 PVPNLAAPAAGEDAATSATAPAMATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQ ENSP00000353401/1-1516 PLPSPASATATAAPAAPEDA---ATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQ XP_004840185.1/1-1433 PVPNPATAAAAATGEDAATSAA-ATRGPASPGTSAGTGTSTGTSAGGTAPAAARRPRSLQ ENSCPOP00000007696/1-1193 ------------------------------------------------------------ ENSMUSP00000135086/1-1517 SLFGLPEAAGAR---DNLVRKKKAANLNSIIHRLEKAASREEPIEWEF ENSRNOP00000001928/1-1506 SLFGLPEAAGAR---DNPVRKKKAANLNSIIHRLEKAASREEPIEWEF ENSP00000353401/1-1516 SLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF XP_004840185.1/1-1433 SLFGLPEAASTRDPHDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF ENSCPOP00000007696/1-1193 ------------------------------------------------