CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000007509/1-1531 MDSYFKAAVSDLDKLLDDFEQNPLEEQDYLQGVQNAYDSHSCSVSSELAPSQPAPLLPKD XP_004841657.1/1-1552 MDRYFKAAVSDLDKLLDDFEQNP-DEQDDCQGVPNAYDSKNCSVPSEVTPSQPPSVLPKD ENSP00000337159/1-1539 MDSYFKAAVSDLDKLLDDFEQNP-DEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKD ENSMUSP00000022217/1-1528 MDSYFKAAVSGLDKLLDDFEQNP-DKQDYL---PDAYAFNQCSVSSESASPQLA-LLSKD ENSRNOP00000017705/1-1547 MDSYFKAAVSDLDKLLDDFEQNP-EKQDYFQDVQDVYAFNQCSVSSELASPQLA-LLSKD ** *******.************ ::** :.* : ***.** :..* . :*.** ENSCPOP00000007509/1-1531 QQCAHGYASLETRRE-ADEISLSEGALKGLTSLPNEKNVTGLDLLSSVDAGTSDDIQPSY XP_004841657.1/1-1552 RQSAGGHGSSETCCE-AKESSLGEKALQGLTFAQNEKNVAGLDLLSSVDAGASHGVPSSY ENSP00000337159/1-1539 QECVNSCASSETSYG-TNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLY ENSMUSP00000022217/1-1528 QRCISTCASSEACCEDANETFLEGKIHEGLTSRPNEKNVAGLDLLSSVDASTSDEIQPSC ENSRNOP00000017705/1-1547 QRCISSHASSETCCE-ANETFLQGKIPEGLTSKQNEKNVAGLDLLSSVDASTSDEIQPSC :.. .* *: :.* * :*** *****:*********..:*. : . ENSCPOP00000007509/1-1531 MR-CSEPVCDLISDMGNLVHPTNSEEDIKQLLPDDFTSSAHS------------LTGLDS XP_004841657.1/1-1552 MR-CSKPVCDLISDTGSLARAANSEEDFKKLLPGDFKSSGDS------------LPGLDS ENSP00000337159/1-1539 MGRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADS------------LIGLDL ENSMUSP00000022217/1-1528 MRRCSKPVCDLISDMGNLVHATNSEEDIKQLLPDDPKSSADT------------LITLDS ENSRNOP00000017705/1-1547 MRRCSKPVCDLISDMGNLVHATSSEEDIKQLLPDDSKSPADTLITLDSSSVSEVLIGLDL * **:*:****** *.*.:.:.****:*:***.* .* ..: * ** ENSCPOP00000007509/1-1531 SAVSDTVSITSTDHENGPITKEQSNVISELDAREIGDTKELGIKADTVPSDSCKYNETEN XP_004841657.1/1-1552 SAVSDALSVPSADNGNGPVAEEQNDVSSDLQNKEGGGTEESVIKVETTLSDSCKYDGTEN ENSP00000337159/1-1539 SSVSDTPCVSSTDHDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTEN ENSMUSP00000022217/1-1528 SSVSEALTVSSVDCGSNAVREEQNNINAGIKNRDIS-IKELGVKVDMALFDSCKYNRTEN ENSRNOP00000017705/1-1547 SSVSDTLAVSSVDGGSQAVRKEQ-DTNAGVQSRDNSRIQESGAEVDMALSDSCKYSRTEN *:**:: :.*.* . .: ::* : : :. :: . :* :.: . ** :*. *** ENSCPOP00000007509/1-1531 LKDENISNQLDPADDSNITSVLTQQSSKICDTKEEIQHKSLPCELLKDGG---------- XP_004841657.1/1-1552 LKDEEIFSQLDPVVDSNVTSVLTEQSSRICDTKDNLQYKSPPGDLFKDGGCLGKQEVDLV ENSP00000337159/1-1539 LKDKKIFNQLESIVDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLV-------- ENSMUSP00000022217/1-1528 LKDKIISNELETV-DFDMPSVLMEQSSEMSNTKDNPQYKRLPCELLKDDGCL-------- ENSRNOP00000017705/1-1547 LKDKMISNELETV-DFGMPSVLTEQSSEMSNTKDSPQYQRLPCELLKDDGDL-------- ***: * .:*:. * .:.*.* .***.: .:*:. *:: * *:** * ENSCPOP00000007509/1-1531 -----LMVAAAPECLK-GDS--TSALPCKSPPESESLCLSGSNTRGENFKLPDYSCQEDR XP_004841657.1/1-1552 TEEVDIMVAPATECLKGGGG--TSALPCESLPKNESLYLSDSNSRDENFKLPDFSCQEDR ENSP00000337159/1-1539 KEEVDVAVITAAECLKEEGK--TSALTCS-LPKNEDLCLNDSNSRDENFKLPDFSFQEDK ENSMUSP00000022217/1-1528 AEEKVAVAVNNTECLEEGGGSNTIAMPCK-LPENEGISPSDPASKDENFKLPDFPLQENR ENSRNOP00000017705/1-1547 AEEKVGMAGNSTKCLEEGGN--IIAMPCK-LPKNEEISPNDPTSKDENFKLPDFSVQESR . .:**: . *:.*. *:.* : ... ::.*******:. **.: ENSCPOP00000007509/1-1531 TTVFIKQSAKEDLINLDLKD-NDAIHNSVSSVHVSSEDAPSSLSCFPVPGSLCSSFIESK XP_004841657.1/1-1552 TAMSIKQSAKDDSRNLDRKD-NDAIHNSPSALHISSEAALSSLSCVSVPGSLCSSVIDSK ENSP00000337159/1-1539 TV--IKQSAQEDSKSLDLKD-NDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESK ENSMUSP00000022217/1-1528 TSVFMKQTVKEDSRNLDLKDNNDIV-------HVSGDDVPPSLSCLSLSGSLCGSLIHNN ENSRNOP00000017705/1-1547 TAVFIKQTVAEDSVKSDLKDNNDVVQVSSSSLHVSSDGVSPSLSCLSLSGSLCGSLVDCN * :**:. :* . * ** ** : *:*.. . .****.. .**:*.*.:. : ENSCPOP00000007509/1-1531 AHGDCLPQQEPKDPIQDMGKVPEETQKCVVLDR----QTNLTQQEKCKNTLLQPVHEEKG XP_004841657.1/1-1552 AHGDCLPQQEPKDHIQHTGMVHEETRENAVLDREPVGQADLMKEEKCKNTLLQPEHEERR ENSP00000337159/1-1539 ARGDFLPQHEHKDNIQDAVTIHEEIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGME ENSMUSP00000022217/1-1528 EHSDILPPNESEGQNNDAVTIHEEIQKSDVLDG----ETDLSKKETCRSIFLQPVNEKKG ENSRNOP00000017705/1-1547 AHGDFLPSDESKGQNNDAVTAHEEIQKSAALDG----ETDLLKKEKQESMFLQPVNDKEG :.* ** .* :. :. ** :: .*. : :* ::*. .. :**. : ENSCPOP00000007509/1-1531 EGKVEPRQMEIGAEALGAHGLSSSPTAAESQLEFLGADATGCPAGCAGL--AFPDNDMDG XP_004841657.1/1-1552 EGKVEPEQMGIGAEALGAPGPPSSSTTAGSQLELLGAEAPGCQAGCAGL--TFLGSDMDE ENSP00000337159/1-1539 DRKIDPDQTVIRAESLD--GGDTSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDG ENSMUSP00000022217/1-1528 EGKVEVEEMVISGESLESPEDASSAAAAGSPVALSAASVPEAPGPCEGL--TFPSSDMDG ENSRNOP00000017705/1-1547 DGEVELEEMVISGEPLEYPEG-TNPAAAGSQMAPPTVSASEAPGQCEAL--TFSSGDMDG : ::: : * .*.* :..:.. * . .. . * .: :* ..*** ENSCPOP00000007509/1-1531 HDLDYFNIDEGMKSATLVSDAELDAFLTEQYLQTSNLIPFEENVNDSKSQMNLIDVKGLD XP_004841657.1/1-1552 QDLDYFNIDESMRNGTLVSDAELDAFLTEQYLQTSNLMSFEENVNDSKSRMNQIDMKDLG ENSP00000337159/1-1539 QDLDYFNIDEGAKSGPLISDAELDAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLD ENSMUSP00000022217/1-1528 QELDYFNIDESMRSGILISDAELDAFLKEQCLSNSNTMSAGENVNDSQLQMNQITMKGLH ENSRNOP00000017705/1-1547 QELDYFNIDESMRSGILVSDAELDAFLKEQSLQNSNTMSFGENASDSQLQMNQIDMKGLC ::********. :.. *:*********.** *..:* . **..**: :** * :*.* ENSCPOP00000007509/1-1531 DRDVSDIYFNAEAGATGGNDSINMICETVDKQNIIENSALYVQERSEILIEQGFLTSKSE XP_004841657.1/1-1552 DGNVSDIYCKVEAGATGESDGINMICETVDKQSPIDNSVLCVQERSTVPIEQGSLTSPAE ENSP00000337159/1-1539 DGNINNIYFNAEAGAIGESHGINIICEIVDKQNTIEN-GLSLGEKSTIPVQQGLPTSKSE ENSMUSP00000022217/1-1528 DENAGDIYFNAEAGAAGENGGV-GNCETSDKENT-ENNGLSIGEKGAIPTERELSACQPD ENSRNOP00000017705/1-1547 DENAGDRYFNAEAGAAGESGGV-VICETTDKENTVQNGGLSVGEKSAIPTERGLSASQPD * : .: * :.**** * . .: ** **:. :* * : *:. : :: :. .: ENSCPOP00000007509/1-1531 VTEELAVSDASSQSVHAGGARPKQFASLVPRGRVSKEPSKPGVPGTPEGEPSPVNAIMPS XP_004841657.1/1-1552 MPDELLGSDVSSQSVHVGGARPKQSSSLASRARVSKDLRKPDVPSAPEGEASLADAIAPP ENSP00000337159/1-1539 ITNQLSVSDINSQSV--GGARPKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPI ENSMUSP00000022217/1-1528 IRDELPVPSIKTQAV--GGARPKQLLSLPPGTRSSKELNKPDVVDVPESEPCTANATAVS ENSRNOP00000017705/1-1547 IRSEVPVPSINTQAV--GGARPKQLPSRPPGTSSSQGPSKPHVVGVPAGEPSTANAAAAP : .:: .. .:*:* ******* * . *: ** * .. .*.. .:: ENSCPOP00000007509/1-1531 QCPTDSAGDSQANFDSNYIDIESNFESGSSFPSAHEDSLPENTCKEGLVLGQKQPTWVPD XP_004841657.1/1-1552 PCPPDSAGDAQASFNSNYIDIESNLEGRSSFLTPNEDSLPENTCKEDMALGQKQPNWVPD ENSP00000337159/1-1539 TCAIDSTADPQVSFNSNYIDIESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPD ENSMUSP00000022217/1-1528 TCSADHIPDSQVSFNSNYIDIESNFEDGSSFVTANKDSLPENKRKESLVLGQKQPTWVPD ENSRNOP00000017705/1-1547 TRPADHTPDSQVSFNSNYIDIESNFEGGSSFVTANKDSLPENIRKEGLVLGQKQPTWVPD . * *.*..*:********* *. *** :.::**:*** **.:.******.**** ENSCPOP00000007509/1-1531 SEAPNCMHCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLPYLEKEARVCVICYETISKA XP_004841657.1/1-1552 SEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKSKLPYLEKEARVCVICYETINRA ENSP00000337159/1-1539 SEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVVCYETISKA ENSMUSP00000022217/1-1528 SEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVICYETINKA ENSRNOP00000017705/1-1547 SEAPNCMNCKVKFTFTKRRHHCRACGKVFCGVCCNRKCKLQYLEKEARVCVICYETINKA *******:*:***************************.** **********:*****.:* ENSCPOP00000007509/1-1531 QAFERMMSPTGSGPQAHHPGDGAAALLPRET-PTSVSSPTALPTSALRQPSIEGLGSREQ XP_004841657.1/1-1552 QAFERMMSPTGSSPQAHHPGDSAASPALQEPQPTSVPSPTALPTSALKQPSAEGLGSREQ ENSP00000337159/1-1539 QAFERMMSPTGSNLKSNHSDECTTVQPPQENQTSSIPSPATLPVSALKQPGVEGLCSKEQ ENSMUSP00000022217/1-1528 QAFERMMSPGGSCLKSNHSNECATDQPLQETQTSSTPSPTTLPISALKQPNVEGPCSKEQ ENSRNOP00000017705/1-1547 QAFERMMSPGGACLKSNHSNECVTAQPLQETQTSSIPSPTALPISALKQPNVEGPCSREQ ********* *: :::*..: .: :* .:* .**::** ***:**. ** *:** ENSCPOP00000007509/1-1531 KRVWFADGILPNGEVADTTKLSSGSKRCPEDCSPPFSDVPMMVNTVDPALFTTLQKPDDE XP_004841657.1/1-1552 KRVWFADGILPNGEVADTTKLSSGSKRCSEDCIPPLLAVPTMVNTVDPACSTTVEKPNNK ENSP00000337159/1-1539 KRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVNTVDHSHSTTVEKPNNE ENSMUSP00000022217/1-1528 KRVWFADGILPNGEVADTTKLSSGSKRCSDDFSPVLPDVPTMINKVDRTHSPTVEKPNNG ENSRNOP00000017705/1-1547 KRVWFADGILPNGEVADTTKLSSGSKRCSDDFSPVLPDAPTVINKVDHTPSPMVEKANNS ****************************.:* * .* :*.** : . ::*.:: ENSCPOP00000007509/1-1531 LRGSTGSKDFGSPVSHIPSVENQLASTGADGLSA--SATLADDVFAEIEAACSSPGVAGN XP_004841657.1/1-1552 LGDSSRNESIGSPVSHVPSVEKLPTDMGTVTLPSA-SLTLDDDVFAEIEAPSSSLGVTVN ENSP00000337159/1-1539 TGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVN ENSMUSP00000022217/1-1528 LGDIIRSEISQSPTCHTAPVERLPGNTGTEGLPMPGPFTLEDDVFVDSEEPSTPTVVPAN ENSRNOP00000017705/1-1547 VGDVLRSEITQSPICRAAPLEILPGSTGAEGLPTAGPFTLEDDVFVDSEEPSTPTVVPAN . .: ** .: ..:* . * *. . ** ****.: * ..:. * * ENSCPOP00000007509/1-1531 SVLPVAGVSDYRLLCYVDRHVASKVSLLPDDEDSLPPLLGTSGEQGSVPAVQAYPSPEQV XP_004841657.1/1-1552 SIFPVTGVSDYGLLCCVDKHVCSKISLLPDDEHGLPPLLGASGGQGSVPAVEEHPSPEQI ENSP00000337159/1-1539 SNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGSVPVVEEHPSHEQI ENSMUSP00000022217/1-1528 SGLPVASISDYRLLCSVAKCVCNNISLLPDDDIGLPPLLATSGEDGSVPVVQERPSHEQI ENSRNOP00000017705/1-1547 TGLPVASVSDYRLLCGVAKCVCNNISLLPDDDVGLPPLLATSGEDGSVPVVQEHPSHEQI : :*::.:*** *** : : *..::****:*: .***** :** .****.*: ** **: ENSCPOP00000007509/1-1531 HSLLQSEGFPPATFVLNANLLVNVRLIVYCSDKYWYFSTNGLHGLGQAEIIVLLLCLPNE XP_004841657.1/1-1552 SSLLQSEGSPPATFVLNANLLVNVRLILYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNE ENSP00000337159/1-1539 ILLLEGESFHPVTFVLNANLLVNVKFIFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNE ENSMUSP00000022217/1-1528 ILLLEGEGFPPATFVLNANLLVNVKLVLYSSEKYWYFSTNGLHGLGQAEIIVLLQCLPNE ENSRNOP00000017705/1-1547 ILLLESEGFPPATFVLNANLLVNVKLVFYSSDKYWYFSTNGLHGLGQAEIIILLLCLPNE **:.*. *.************:::.*.*:*******************:** ***** ENSCPOP00000007509/1-1531 DRVPKDIFRLFLTIYKDAHKGKYIENLDSITFTESFLSSKDHGGFLFIAPTIQTLDDLPL XP_004841657.1/1-1552 DTVPRDIFRLFLTMYKDALRGKYIEDLDSVAFTESFLGSKDHGGVLFITPTVQKLDDLPL ENSP00000337159/1-1539 DTIPKDIFRLFITIYKDALKGKYIENLDNITFTESFLSSKDHGGFLFITPTFQKLDDLSL ENSMUSP00000022217/1-1528 DTVPKDIFRLFITIYKDALKGKYIENLDNLTFTESFLNSKDHGGFLFITPTFQNLDGLPV ENSRNOP00000017705/1-1547 DTVPKDIFRLFITIYKDASKGKYVENLDNLTFTESFLSSKDHGGFLFITPTFQKLDDLPV * :*:******:*:**** :***:*:**.::******.******.***:**.*.**.*.: ENSCPOP00000007509/1-1531 PSSPFLCGILIQKPEIPWAKVFPIRLMLRLGVEYKAYPAPLTSVRGRKPLFGEIGHTIMN XP_004841657.1/1-1552 PSSPFLFGILIHKLEIPWAKVFPIRLMLRLGVEYKVYPAPLTSIRGRKPLFGEIGHTIMN ENSP00000337159/1-1539 PSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRGRKPLFGEIGHTIMN ENSMUSP00000022217/1-1528 PRSPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSVRGRKPLFGEIGHTIMN ENSRNOP00000017705/1-1547 PRSPFLCGILIHKLEIPWAKAFPMRLMLRLGAEYKAYPAPLTSVRGRRPLFGEIGHTIMN * .*** ****:* ******.**:*******.***.*******:***:************ ENSCPOP00000007509/1-1531 LLVDLRNYQYTLHNIDQLLIHMEMGKSSIKVPRKKYSDVMKVLNSSNEHVISIGASFSTE XP_004841657.1/1-1552 LLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSAD ENSP00000337159/1-1539 LLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSSNEHVISIGASFSTE ENSMUSP00000022217/1-1528 LLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVIHSSNEHVISIGASFSTE ENSRNOP00000017705/1-1547 LLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVLKVINSSNEHVISIGASFSTE ***************************.**:********:**::**************:: ENSCPOP00000007509/1-1531 ADSHLVCVQSDGTYHTQASSVPGHPRRVTGASFVVFSGALKPSSGFLAKSSIVEDGLMVQ XP_004841657.1/1-1552 ADSHLVCVQRAGTYHTQASSAPGHARRVTGASFVVFSGALKSSSGFLAKSSIVEDGLMVQ ENSP00000337159/1-1539 ADSHLVCIQNDGIYETQANSATGHPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQ ENSMUSP00000022217/1-1528 ADSHLVCVQSDGVYQTQANSATGQPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQ ENSRNOP00000017705/1-1547 ADSHLVCVQSDGVYQTQANSATGQPRKVTGASFVVFNGALKTSSGFLAKSSIVEDGLMVQ *******:* * *.***.*..*:.*:*********.****.****************** ENSCPOP00000007509/1-1531 ITPETMNGLRQALREQKDFRITCGKVDAGDLREYVDVCWVDTAEEGNRGVISPVDGISLQ XP_004841657.1/1-1552 ITPETMDGLRQALREQKDFKITCGRVDAIDLREYVDICWVDAEEKGNKGVISLVDGISLQ ENSP00000337159/1-1539 ITPETMNGLRLALREQKDFKITCGKVDAVDLREYVDICWVDAEEKGNKGVISSVDGISLQ ENSMUSP00000022217/1-1528 ITPETMEGLRLALREQKDFRIQCGKVDAVDLREYVDICWVDSEERKNKGVISSVDGMSVE ENSRNOP00000017705/1-1547 ITPETMDGLRLALREQKDFKIQCGKVDAVDLREYVDICWVDSEERKNKGVISSVDGMSLE ******:*** ********:* **:*** *******:****: *. *:**** ***:*:: ENSCPOP00000007509/1-1531 GFPSEKVKLEADFETDEKMVKCTEVFYFLKDWDLSVLSTHYQFAKEIAMACSAALCPHLK XP_004841657.1/1-1552 GFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLSVLSTHHQFAKEIAMACSAALCPHLK ENSP00000337159/1-1539 GFPSEKIKLEADFETDEKIVKCTEVFYFLKDQDLSILSTSYQFAKEIAMACSAALCPHLK ENSMUSP00000022217/1-1528 GFPSEKIKLETDFETEEKTVKCTEVFYFLKDQDISILSSSYQFAKEIAVACSAALCPHLR ENSRNOP00000017705/1-1547 GFPSEKIKLETDFETEEKTVKCTEVFCFLKDQDISLSSSSYQFAKEIATACSAALCPHLR ******:***:****:** ******* **** *:*: *: :******* **********: ENSCPOP00000007509/1-1531 TLKSDRVNRIGLRVSIDTDVVEFQAGSEGQLLPQHYLNALDSALIPVIHGGTSSSSLPLE XP_004841657.1/1-1552 TLKSSGVNRIGLRVSIDTDVVEFQAGSEGQLLPQHYLNALDSALIPVIHGAASSSSLPLE ENSP00000337159/1-1539 TLKSNGMNKIGLRVSIDTDMVEFQAGSEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLE ENSMUSP00000022217/1-1528 TLKSNRMNKIGLRVSIDTDMVEFQAGCEGQLLPQHYLNDLDSALIPVIHGGTSNSSLPLE ENSRNOP00000017705/1-1547 TLKSNRMNRIGLRVSVDTDMVEFQAGCEGQLLPQHYLNDLDSALIPVIHGGTSNSTVPLE ****. :*:******:***:******.*********** ***********.:*.*::*** ENSCPOP00000007509/1-1531 MELVFFILENLVS XP_004841657.1/1-1552 MELVLFILENLVE ENSP00000337159/1-1539 IELVFFIIEHLF- ENSMUSP00000022217/1-1528 IELAFFILENLSE ENSRNOP00000017705/1-1547 IELAFFILENLLE :**.:**:*:*