CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000063648/1-1243 MIMFLPVGRMSLGILILFLTGGNLVSAS-------EERQEPMHAVSVLSPEKSTDLSLPT ENSRNOP00000046981/1-1239 --MFLPLGRISLGILILFLTGGNLVSVS-------EEIQDRMHAVAVLSPKESTDLSLPT ENSP00000193391/1-1241 MIMFPLFGKISLGILIFVLIEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLAT ENSCPOP00000007499/1-1240 MIMFPLLGKISLGILILVLIEGNLPSLTVQTYLSLEDIQEPKPAVSFLLPKESTDSSLPA XP_004858066.1/1-1240 --MFPFWGKISLGILIFVLIEGNLPSLT-------GEIQEPKRAVSFLLPKEPTDFSLPA ** *::******:.* *:: * : : *: **:.* *::.** **.: ENSMUSP00000063648/1-1243 RKRQLLDATETGRRWLLRRRRSILFPNGVKICSSETVAEAVANHVKYFKARVCQEAIWEA ENSRNOP00000046981/1-1239 RKRQLLDATETGRRWPLRRRRSILFPNGVRICPSDTVAEAVANHVKYFKARVCQEAIWEA ENSP00000193391/1-1241 KKKQPLDRRETERQWLIRRRRSILFPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEA ENSCPOP00000007499/1-1240 KKQQLLSHREIEKRWLLRRRRSILFPNGVKICRNETVTEAVASHMKYFKLRVCQEAVWEA XP_004858066.1/1-1240 EKKQLLDHREAEKRWLLRRRRALLFPNGVKICPNETVTEAVANHVKYFKLRVCQEALWEA .*:* *. * ::* :****::******:** .::*:****.*:**** ******:*** ENSMUSP00000063648/1-1243 FRTFWDRLPGRDEYRHWMNLCEDGVTSVFEMGAHFSQSVEHRNLIMKKLAYTREAESSSC ENSRNOP00000046981/1-1239 FRTFWDRLPGREEYQYWMNLCEDGVTSVFEMGTQFSQSVEHRHLIMEKLTYTKEAESSSC ENSP00000193391/1-1241 FRTFWDRLPGREEYHYWMNLCEDGVTSIFEMGTNFSESVEHRSLIMKKLTYAKETVSS-- ENSCPOP00000007499/1-1240 FKTFWDRLPGSKEYHYWMNLCEDGITSIFEMGTNFSQSVEHRSLIMKKLVHTKEMVSR-- XP_004858066.1/1-1240 FKTFWDRLPGREEYRYWMNLCEDGITSIFEMGTIFSQSVEHRSLIMKKLIDTKEMVGR-- *:******** .**::********:**:****: **:***** ***:** ::* . ENSMUSP00000063648/1-1243 KDQSCGPELSFPVPIGETSTLTGAVSSASYPGL-----ASESSAASPQESISNEIENVTE ENSRNOP00000046981/1-1239 KDQACGPELSSPVPIGETSTLAGAVSSASYPGA-----ASERSAASPQESISNEIENVTE ENSP00000193391/1-1241 ------SELSSPVPVGDTSTLGDTTLSVPHPEVDAYEGASESSLERPEESISNEIENVIE ENSCPOP00000007499/1-1240 ------PELSSPIPTGEPSTLGGAVLSVPYPGMSSHEGASESSLQSPEESISNEIVNVIE XP_004858066.1/1-1240 ------RELSSPVPIGDTSTLGGAILSAPYPEVSSYEGASESSLQPPEESISNEIVNVIE *** *:* *:.*** .: *..:* *** * *:******* ** * ENSMUSP00000063648/1-1243 EPTQPAAEQIAEFSIQLLGKRYSEELRDPSSALYRLLVEEFISEVEKAFTGLPGYKGIRV ENSRNOP00000046981/1-1239 QPTPPAAEQIAEFSIQLLGKQYSEELRDPSSALYRLLVEEFISEVEKAFTGLPGYKGIHV ENSP00000193391/1-1241 EATKPAGEQIAEFSIHLLGKQYREELQDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRV ENSCPOP00000007499/1-1240 EPTKPAAEQIAEFSIHLLGKQYRQDLQDPSSSYHKNLIEEFISEVENAFTGLPGYKDIHV XP_004858066.1/1-1240 EPAKPAAEQIAEFSIHLLGKEYREELQDPASSHHKHLVEEFISEVEKAFTGLPGYKDIHI :.: **.********:****.* ::*:*.:* :: * ********:********* *:: ENSMUSP00000063648/1-1243 LEFRAPEEND--SGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVEMDDKPTAVYT ENSRNOP00000046981/1-1239 LDFRSPKENG--SGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTAVYT ENSP00000193391/1-1241 LEFRSPKEND--SGVDVYYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTVVYT ENSCPOP00000007499/1-1240 LEFRSPKENGSHSGIDVHYEVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTAVYT XP_004858066.1/1-1240 LEFRSPKEDG--SGIDVHYEVTLNGEAVSNTTWDLISLHSNKVENHGLVELDDRPTAVYT *:**:*:*:. **:**:* **:****:**********************:**:**.*** ENSMUSP00000063648/1-1243 ISNFRDYIAETLHQNFLMGNSSLNPDPKSLQLINVRGVLLPQTEDIVWNTQSSSLQVTTS ENSRNOP00000046981/1-1239 ISNFRDYIAETLHQNFLMGNSSLNPDPKSLQLINVRGVLLPQTEEIVWNTQSSSLQVTTS ENSP00000193391/1-1241 ISNFRDYIAETLQQNFLLGNSSLNPDPDSLQLINVRGVLRHQTEDLVWNTQSSSLQATPS ENSCPOP00000007499/1-1240 IGNFRDYIAETLHQNLLVGNSSLNPDPESLQLINVRGVLLPQSEDLVWNTQSSSLQVAPP XP_004858066.1/1-1240 IGNFRDYIAETLHQNFLVGNSSLNPDPDSLQLITVRGVLLPQSEDLVWNTQSSNLQATPQ *.**********:**:*:*********.*****.***** *:*::*******.**.:. ENSMUSP00000063648/1-1243 SILDNTLQAEWLSAD--TTTTTTTTISPFGFSSSSPSATGRELQSQSALRDVVSTSKLAS ENSRNOP00000046981/1-1239 SILDNTLQAEWLSADESITTTTTTTISPFGFSSGPPSATGRELHSESTLGDIVSTPKLAS ENSP00000193391/1-1241 SILDNTFQAAWPSAD----ESITSSIPPLDFSSGPPSATGRELWSESPLGDLVSTHKLAF ENSCPOP00000007499/1-1240 FILDSTLQGEWPSAD----EPATSNISPLDFSSGPSSTTDRELWPESPLADVVSTPKLAF XP_004858066.1/1-1240 SILDNTLQAEWPSAD----EPTTSNISPLDFSSDPPSTTGRELWSESPLGDLVSTPKLAS ***.*:*. * *** . *:.*.*:.***...*:*.*** .:*.* *:*** *** ENSMUSP00000063648/1-1243 PTKVVLSSLPEILGGSSLTLHSVTPAVLQPDLPVAPEGRTSGSFILEDGLASTEELED-T ENSRNOP00000046981/1-1239 PSKVVLSSSPEVLGGSSLTLHSVTPAVLQIDLPVAPEGRTSGSSILEDD--NTEESED-V ENSP00000193391/1-1241 PSKMGLSSSPEVLEVSSLTLHSVTPAVLQTGLPVASEERTSGSHLVEDGLANVEESEDFL ENSCPOP00000007499/1-1240 PSEVVLSSSPEDLGVSSLTLHPVTPAVFQTGLPMASEGRTSGSYLLENDIFTISDERDFK XP_004858066.1/1-1240 PFKVVLGSSPKVLEVSGLTLHSVTPAVLQNVLPVASEERTSGFHLLENGLANVEKSEDFL * :: *.* *: * *.****.*****:* **:*.* **** ::*:. . .. .* ENSMUSP00000063648/1-1243 SIDGLPSSPLIQPVPKETVPPMEDSD-TALLSTPHLTSSAIED-LTKDIGTPSGLESLAS ENSRNOP00000046981/1-1239 SIDVLPSSSLIQPVPKETVPPMEDSDMILLTSSPHLTSSVIED-LAKDITTPSGLDSLAS ENSP00000193391/1-1241 SIDSLPSSSFTQPVPKETIPSMEDSD-VSLTSSPYLTSSI-----------PFGLDSLTS ENSCPOP00000007499/1-1240 SVDPLPSSSFIQPVPKQTVPPVENSG-VSLTSSPEVTS-------------PFSSDSLAS XP_004858066.1/1-1240 SVDPLPSGSLIQRVPKQTIPPLEDSG-VSLTSSPDLISSVTLDLLAKEVTVPFGFDPLAS *:* ***..: * ***:*:*.:*:*. * *:* : * * . :.*:* ENSMUSP00000063648/1-1243 NISDQLEVIPWFPDTSVEKDFIFESGLGSGSGKDVDVIDWPWSETSLEKTTKPLSKSWSE ENSRNOP00000046981/1-1239 RVSDKLEVSPWFPDTSVEKEFIFESGLGSGSGKNVDVIDWPWSETSLEKTTEPLSKSWSE ENSP00000193391/1-1241 KVKDQLKVSPFLPDASMEKELIFDGGLGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLE ENSCPOP00000007499/1-1240 EVKDQLEASHLFLDTSIEKEFIFESGLGSGSGQKVDLISWPWSEISLKKSTEPLSRSWLE XP_004858066.1/1-1240 EVKDQLEASHLFPDMSMEKQFIFESGLGSGSGQKVDLISWTWSETSLEKSTEPLSKSWLE .:.*:*:. : * *:**::**:.*******:.**:* *.*** * :*:::***:.* * ENSMUSP00000063648/1-1243 EQDALLPTEGR-EKLHIDGRVDSTEQIIESSEHRYGDRPIHFIEEESHVRSTIPIFVESA ENSRNOP00000046981/1-1239 EQDTLLPTESI-EKLH----MYFTEQMIEPSAHRYGDGPIYFTEEESHVRSTIPVFAESA ENSP00000193391/1-1241 DDDSLLPAEIEDKKLVLVDKMDSTDQISKHSKYEHDDRSTHFPEEEPLSGPAVPIFADTA ENSCPOP00000007499/1-1240 DEDSLLPTEGIDEKVVVESKIDYTDPTIEHSKYKHDEKSTSFVVEESLVKPTVPIFAVSV XP_004858066.1/1-1240 DENSLLPPEGINEKLVIDNTMDYTDQIIEHSKYKHDEKSTKFAEEEPLVEPTVSILAVSV ::::***.* :*: : *: : * :.:.: . * **. .::.::. :. ENSMUSP00000063648/1-1243 TPPTSPIFSKHTSDVPDIDSYSLTKPPFLPVTIAIPASTKKTDEV---LKEDMVH-TESS ENSRNOP00000046981/1-1239 TQPTSLISSKHTSDVPDIDSYSVTKAPFLLATIANTASTKETDEVNTLLKKGMVQ-TEPS ENSP00000193391/1-1241 AESASLTLPKHISEVPGVDDYSVTKAPLILTSVAISASTDKSDQADAILREDMEQITESS ENSCPOP00000007499/1-1240 IHSTSLTFPKHTSEIPNVDYHSVTKAPFLLTA----ASSVITDETNTFLIKDVDQTTESS XP_004858066.1/1-1240 IHSTSPTFSKHTSEIPDVDYHTVTKAPFLLTA----TSSDKTNQVNTFLIKDREQTTESS .:* .** *::*.:* :::**.*:: .: :*: :::. * :. : **.* ENSMUSP00000063648/1-1243 SHKELDSEVPVSRPDMQPVWTMLPESDTVWTRTSSLGKLSRDTLASTPESTDRLWLKASM ENSRNOP00000046981/1-1239 SPKGLDSKISVARPDMQPVWTILPESDTVWARTSSLGKLSRDTLVSTPESADRLWLKASM ENSP00000193391/1-1241 NYEWFDSEVSMVKPDMQTLWTILPESERVWTRTSSLEKLSRDILASTPQSADRLWL--SV ENSCPOP00000007499/1-1240 SHEWSDSKSSSVKPDLQPVWTIFPESAIASARTSSQGISPRDSLASTPQSSDGLWLKTSM XP_004858066.1/1-1240 SHEWFDSKTSMVKPDLQPVWTIFPESDIASASTSSLGKLHRDSLASTPQSTDGLWLKTSM . : **: . :**:*.:**::*** . : *** ** *.***:*:* *** *: ENSMUSP00000063648/1-1243 TQSTELPSTTHSTQLEEEVIMAVQDISLELDQVGTDYYQSELTEEQHGKADSYVEMSTSV ENSRNOP00000046981/1-1239 TQPAELPPSTHSIQLEDEVIMAVQDISLELDQVGTDYYQPELTQEQNGKVDSYVEMPTHV ENSP00000193391/1-1241 TQSTKLPPTTISTLLEDEVIMGVQDISLELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSV ENSCPOP00000007499/1-1240 AQSTKLPPTTSSTFLEDEVIMGVQDISLELDRIGTDYYQPELIQEQNGKAGSYVEMFTSF XP_004858066.1/1-1240 TQSTRLPPTTSSTLLEDEVIKGVQDISLELDRVGTDYNQPELTREQNGKVGSYVEMFTNF :*.:.**.:* * **:*** .*********::**** *.* .**:**..***** * . ENSMUSP00000063648/1-1243 HYTEMPIVALPTKGG-VLSHTQTAGALVVFFSLRVTNMLFSEDLFNKNSLEYKALEQRFL ENSRNOP00000046981/1-1239 HYTEMPLVAQPTKGG-VLSRTQTAGALVVFFSLRVTNMLFSEDLFNKNSLEYKALEQRFL ENSP00000193391/1-1241 HSTEMVSVAWPTEGGDDLSYTQTSGALVVFFSLRVTNMMFSEDLFNKNSLEYKALEQRFL ENSCPOP00000007499/1-1240 HSTEMAILAQPTKGD-DLGHARIEGALVVFFSLRVTNMMFSEDLFNRNSLEYKALEQRFL XP_004858066.1/1-1240 HSTEMATVAQPTRGG-DLSHAQTAGALVVFFSLRVTNMLFSEDLFNKNSLEYKALEQRFL * *** :* **.*. *. :: **************:*******:************* ENSMUSP00000063648/1-1243 ELLVPYLQSNLSGFQNLEILSFRNGSIVVNSRVRFAESAPPNVNKAMYRILEDFCTTAYQ ENSRNOP00000046981/1-1239 ELLVPYLQSNLSGFQNLEILNFRNGSIVVNSRVKFAESVPPNVNNAIYMILEDFCTTAYQ ENSP00000193391/1-1241 ELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFANSVPPNVNNAVYMILEDFCTTAYN ENSCPOP00000007499/1-1240 ELLVPYLQSNLTGFQNLEILNFRNGSIVVNSRMKFAKSIPPDVNNAVYMILENFCTTAYQ XP_004858066.1/1-1240 ELLVPYLQSNLSGFQNLEILNFRNGSIVVNSRMKFTKSIPPNVNNAVYMILEDFCTTAYQ ***********:********.***********::*::* **:**:*:* ***:******: ENSMUSP00000063648/1-1243 TMNLDIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCKCYPGYLSVDELPCQS ENSRNOP00000046981/1-1239 TMNLDIDKYSLDVESGDDANPCKFQACNEFSECLVNPWSGEAKCKCHPGYLSVDELPCQS ENSP00000193391/1-1241 TMNLAIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCRCFPGYLSVEERPCQS ENSCPOP00000007499/1-1240 TMNLAIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAQCRCYPGYQSVDELPCQS XP_004858066.1/1-1240 TLNLAIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCRCYPGYLSVDELPCQS *:** ************:************************:*:*.*** **:* **** ENSMUSP00000063648/1-1243 LCDLQPDFCLNDGKCDIMPGHGAICRCRVGSNWWYRGQHCEEFVSEPFVIGITIASVVSF ENSRNOP00000046981/1-1239 VCDLQPDFCLNDGKCDVMPGHGAICRCRVGSNWWYRGQHCEEFVSEPFVIGITIASVVSL ENSP00000193391/1-1241 LCDLQPDFCLNDGKCDIMPGHGAICRCRVGENWWYRGKHCEEFVSEPVIIGITIASVVGL ENSCPOP00000007499/1-1240 LCDLQPDFCLNDGKCDILPGHGAICRCRVGENWWYRGEHCEEFVSEPLVIGITIASVVGI XP_004858066.1/1-1240 LCDLQPDFCLNNGKCDIMPGHGAICRCRVGENWWYRGEHCEEFVSEPLVIGITVASVVGL :**********:****::************.******:*********.:****:****.: ENSMUSP00000063648/1-1243 LLVASAVVFFLVKMLQAQNVRRERQRPTS---SSRHPDSLSSVENAMKYNPAYESHLAGC ENSRNOP00000046981/1-1239 LLVASAVVFFLAKMLQAQNVRRERQRP-----TNRQPDSLSSVENAMKYNPAYESRLAGC ENSP00000193391/1-1241 LVIFSAIIYFFIRTLQAHHDRSERESPFSG--SSRQPDSLSSIENAVKYNPVYESHRAGC ENSCPOP00000007499/1-1240 LFVCSIIIFFLVKTLQDAHVRRERKCMFSGCNFSRQPDSLSSMENAVKHNPAFDSHMAGC XP_004858066.1/1-1240 LLICSVVIFFLVKTLQAQHVRRERGRPFSG--FSRQPDSLSSMENAVKCNPVFDSHLAGY *.: * :::*: : ** : * ** .*:******:***:* **.::*: ** ENSMUSP00000063648/1-1243 ELYEKSYSQHPFYSSASEEVIGGLSREEIRQMYESSDLSKEEIQERMRILELYANDPEFA ENSRNOP00000046981/1-1239 EQYEKPYSQHPFYSSASEEVIGGLSREEIRQMYESSDLSKEEIQERMRILELYANDPEFA ENSP00000193391/1-1241 EKYEGPYPQHPFYSSASGDVIGGLSREEIRQMYESSELSREEIQERMRVLELYANDPEFA ENSCPOP00000007499/1-1240 EQYEEPYPQHPFCGSASEEVIGGLSREEIRQMYESSGLSKEEIQERMRILELYANDPEFA XP_004858066.1/1-1240 EQYEQPYPQHPFYGSACEEVIGGLSREEIRQMYESSGLSKEEIQERMRILELYVNDPEFA * ** .*.**** .**. :***************** **:********:****.****** ENSMUSP00000063648/1-1243 AFVREHQMEEL ENSRNOP00000046981/1-1239 AFVREHEMEEL ENSP00000193391/1-1241 AFVREQQVEEV ENSCPOP00000007499/1-1240 AFVREHQITVT XP_004858066.1/1-1240 AFVREHQMEEL *****:::