CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000007493/1-1555 SVLLKILQWYRKRFEVLLDTVVEEMGLIE-GGGIMDTEMSEDIDHNLTPTLDSMSYGMPN ENSMUSP00000101714/1-1549 MAEREVETGPRKRFEQKSDAVFDE--IVENC-GVMDTEMSEDTDHNLTPTLASMSYGMPN ENSRNOP00000016992/1-1550 MAEREVETGPRKRFEQKSDAVFDE--IVENC-GVMDTEMSEDTDHNLTPTLASMSYGMPS ENSP00000322915/1-1548 MAEREVESGPRKRFEQKSGAVFDE--IVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPN XP_004850978.1/1-1550 MAEREVESGPRKRFEQKSGAVFDE--IVENCGGIMDTEMSEDIDHNLTPTLDSMSYGMPN . :: ***** .:*.:* ::* *:******** ******** *******. ENSCPOP00000007493/1-1555 QTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKENLVSSVHTDDSLEVERRVT ENSMUSP00000101714/1-1549 QTGSENSLLDEDDYFLNSGDLAGIPVVSSDNEDEQDCSSKDNLVSSVHTDGSLEVERRAA ENSRNOP00000016992/1-1550 QTGSENSLLDEDDYFLNSGDLAGIPVVSSDNEDEQDFSSKDNLVSSAHTDGSLEIERRAS ENSP00000322915/1-1548 QTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKDNLVSSIHTDDSLEVERRVT XP_004850978.1/1-1550 QTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKENLVSSIHTDDSLEVERRVT ***************************.******** ***:***** ***.***:***.: ENSCPOP00000007493/1-1555 QNESDNENEIQIQNKLKKDFTKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYH ENSMUSP00000101714/1-1549 HQESDNENEIQIQNQLKKDFPKQFDQVSVFKSIRKDFCLVRENSKETFSGKEKNRDLTYH ENSRNOP00000016992/1-1550 HHESDNENEIQIQSQLKKDFPKQFDQVSVFKSIRKDFCLVRENSKETFSGKEKNRDLTYH ENSP00000322915/1-1548 QHESDNENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTY- XP_004850978.1/1-1550 QHESDNENEIQIQNKFKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYH ::***********.::****.****************.********************* ENSCPOP00000007493/1-1555 EHEKRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGS ENSMUSP00000101714/1-1549 EREKRLDKPHKGLDSRLKSSFFDKAANQVEETLHTHLPQNPETNFRDSSYPFASKESIGS ENSRNOP00000016992/1-1550 EREKRLDKPHKGLDSRLKSSFFDKAANQVEETLHTHLPQNPETNFRDSSYPFANKESIGS ENSP00000322915/1-1548 EREKRLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGS XP_004850978.1/1-1550 EREKQLDKPHKDLDSRLKSSFFDKAANQVEETLHTHLPQTPETNFRDSSYPFANKESIGS *:**:******.***************************.*************.****** ENSCPOP00000007493/1-1555 ELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEPENAQEYSHGQQQKTQEGELKI ENSMUSP00000101714/1-1549 ELGNSFASNIRIKEEPLDDEYDRAVAPQQGLLDRVKDEPDNAQEYSHGQQQKTQEGELKI ENSRNOP00000016992/1-1550 ELGNSFASNIRIKEEPLDDEYDKAVAPQQGLLDRVKDEPDNAQEYGHGQQQKTQEGELKI ENSP00000322915/1-1548 ELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEPDNAQEYSHGQQQKTQEGELKI XP_004850978.1/1-1550 ELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKIKDEPENAQEYSHGQQQKTQEGELKI **********************:*:********::****:*****.************** ENSCPOP00000007493/1-1555 SAVFSVSGSPLEAPQLTTGFQPSLASSGTNKMLPSVPATAVRVSCSGCKKILQKGQTAYQ ENSMUSP00000101714/1-1549 SAVFSVSGSPL-APQLTTGFQPSLASPGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQ ENSRNOP00000016992/1-1550 SAVFSVSGSPL-APQLTTGFQPSLASPGMNKMLPAVPATAIRVSCSGCKKILQKGQTAYQ ENSP00000322915/1-1548 SAVFSVSGSPL-APQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQ XP_004850978.1/1-1550 SAVFSVSGSPL-APQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQ *********** **************.* *****:*****:******************* ENSCPOP00000007493/1-1555 RKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKYSLNIQNFKNIEFLNTSGSKHF ENSMUSP00000101714/1-1549 RKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENSTTSKDF ENSRNOP00000016992/1-1550 RKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENSTTSKDF ENSP00000322915/1-1548 RKGSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDF XP_004850978.1/1-1550 RKGSTQLFCSTLCLTGYTVPSARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDF ********************.***************** ** ::. . :* *:: **.* ENSCPOP00000007493/1-1555 SCNRRSLGTYLLLSSLKITISRCSHCSLCSLCSQTVIIAFAVNAWKQNMCGNLCSFKCAL ENSMUSP00000101714/1-1549 -CSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNY--QNVVHKLCSDACFS ENSRNOP00000016992/1-1550 -CSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNY--QNVVHKLCSDACFS ENSP00000322915/1-1548 -CSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNY--QNVVHKLCSDACFS XP_004850978.1/1-1550 -CSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNY--QNVVHKLCSDACFS *.: .*.** * .. :**. * .: **:*.:..:* . ** **: :*** * ENSCPOP00000007493/1-1555 KYDECHSMDKNKKENPIGLCRSGSGQCHMLQIEGQSKKFCSSTCITAYKQKSAKITPCAL ENSMUSP00000101714/1-1549 KFRSANNLTMNCCENCGGYCYSGSGQCHVLQIEGQSKKFCSSMCVTSYKQKSAKITPCAL ENSRNOP00000016992/1-1550 KFRSANNLTMNCCENCGGYCYSGSGQCHVLQIEGQSKKFCSSMCVTSYKQKSAKITPCAL ENSP00000322915/1-1548 KFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCAL XP_004850978.1/1-1550 KFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSTCITAYKQKSAKITPCAL *: ..:.: * ** * * *******:************* *:*:************* ENSCPOP00000007493/1-1555 CKSLRSSAEMIENTSSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLA ENSMUSP00000101714/1-1549 CKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLA ENSRNOP00000016992/1-1550 CKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLA ENSP00000322915/1-1548 CKSLRSSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLA XP_004850978.1/1-1550 CKSLRSSSEMIENTSSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLA *******:******.********************************************* ENSCPOP00000007493/1-1555 MSDGSIRNFCSYSCVVAFQNLFNKPAGMNSSVVPLSQGQVIVSIPTGSTVSAGGGNTSAV ENSMUSP00000101714/1-1549 MSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSSASAGGGSTPAV ENSRNOP00000016992/1-1550 MSDGSIRNFCSYSCVLAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSSASAGGGSTPAA ENSP00000322915/1-1548 MSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGSTSAV XP_004850978.1/1-1550 MSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGNTSAV ***************:*********:**********************:.*****.*.*. ENSCPOP00000007493/1-1555 SPTSI-SSSAAAGLQRLAAQSQHIGFTRNVVKLRCQHCNRLFATKPELLDYKGKMFQFCG ENSMUSP00000101714/1-1549 SPTSI-NSSAAAGLQRLAAQSQHVGFARSVVKLRCQHCNRLFATKPELLDYKGKMFQFCG ENSRNOP00000016992/1-1550 SPTSVHSSSAAAGLQRLAAQSQHVGFARSVVKLRCQHCNRLFATKPELLDYKGKMFQFCG ENSP00000322915/1-1548 SPTSI-SSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCG XP_004850978.1/1-1550 SPTSI-SSSAAAGLQRLAAQSQHIGFTRNVVKLRCQHCNRLFATKPELLDYKGKMFQFCG ****: .****************:**:*.****:************************** ENSCPOP00000007493/1-1555 KNCSDEYKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLGKRWGSHC ENSMUSP00000101714/1-1549 KNCCDEYKKINNVMAMCEYCKIEKIIKETVRFSGADKSFCSEGCKLLYKHDLGKRWGSHC ENSRNOP00000016992/1-1550 KNCSDEYKKINNVMAMCEYCKIEKIIKETVRFSGADKSFCSEGCKLLYKHDLGKRWGSHC ENSP00000322915/1-1548 KNCSDEYKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHC XP_004850978.1/1-1550 KNCSDEYKKINNVMAMCEYCKIEKIVKETVRFSGADKTFCSEGCKLLYKHDLGKRWGSHC ***.*********************:***********:**************.****.** ENSCPOP00000007493/1-1555 KMCSYCLQ-SPKLVQNNLGGKLEDFCCEECMSKYTVLFYQMAKCDGCKRQGKLSESLKWR ENSMUSP00000101714/1-1549 KMCSYCLQTSPKLIQNNLGGKVEDFCCEECMSKYTVLFYQMAKCDGCKRQGKLSESLKWR ENSRNOP00000016992/1-1550 KMCSYCLQTSPKLIQNNLGGKVEDFCCEECMSKYTVLFYQMAKCDGCKRQGKLSESLKWR ENSP00000322915/1-1548 KMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAKCDACKRQGKLSESLKWR XP_004850978.1/1-1550 KMCSYCLQTSPKLIQNNLGGKLEDFCCEECMSKYTVLFYQMAKCDGCKRQGKLSESLKWR ******** ****:*******:*:*********************.************** ENSCPOP00000007493/1-1555 GEVKHFCNLLCILMFCNQQSVCDPPSQNSAATNISVVQAASTGPPSLRKDSTPVIANVVS ENSMUSP00000101714/1-1549 GDIKHFCNLLCILMFCHQQTVCDPPLQNNAVASISMVQAASAGPPSLRKDSTPVIANVVS ENSRNOP00000016992/1-1550 GDIKHFCNLLCILMFCHQQTVCDPPLQNNT-ASISMVQAASAGPPSLRKDSTPVIANVVS ENSP00000322915/1-1548 GEMKHFCNLLCILMFCNQQSVCDPPSQNNA-ANISMVQAASAGPPSLRKDSTPVIANVVS XP_004850978.1/1-1550 GEVKHFCNLLCILMFCNQQSVCDPPSQNNA-ASISMFQAASTGPPSLRKDSTPVIANVVS *::*************:**:***** **.: :.**:.****:****************** ENSCPOP00000007493/1-1555 LANAPAAQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPI ENSMUSP00000101714/1-1549 LASAPAAQPTANTNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPI ENSRNOP00000016992/1-1550 LASAPAAQPTANANSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPI ENSP00000322915/1-1548 LASAPAAQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPI XP_004850978.1/1-1550 LANAPAAQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPI **.*******.*:*********************************************** ENSCPOP00000007493/1-1555 TQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPM ENSMUSP00000101714/1-1549 TQTKATSCKPHTQNKECQT-DTPSEPQVMVVPVPVPVFVPIPLHLYTQYTPVPFGIPVPM ENSRNOP00000016992/1-1550 TQTKATSCKPHTQNKECQT-DTPSEPQVMVVPVPVPVFVPIPLHLYTQYTPVPFGIPVPM ENSP00000322915/1-1548 TQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPVPFGIPVPM XP_004850978.1/1-1550 TQTKATSCKPHTQNKECQTEDTPRQPQIIVVPIPVPVFVPVPLHLYTQYAPVPFGIPVPM ******************* *** :**::***:*******:********:********** ENSCPOP00000007493/1-1555 PVPMLVPSSMDNEDKIAESIDDIKEKVPTHPFEADLLEMAEMIAEDEEKEKTLSQGESQT ENSMUSP00000101714/1-1549 PVPMFIPSSMDNDEKATEGIEDIKEKLATHPFEADLLEMAEMIAEDEEKEKTLSQGESQT ENSRNOP00000016992/1-1550 PVPMFIPSSMNNEEKASEGIEDIKEKLATHPFEADLLEMAEMIAEDEEKEKTLSQGESQT ENSP00000322915/1-1548 PVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEK-KTLSQGESQT XP_004850978.1/1-1550 PVPMLVPSSMDNEDKVIESIDDIKEKLSTHPFEADLLEMAEMIAEDEEKEKTLSQGGSQT ****::****:.::* *.*:*****:.********************* ****** *** ENSCPOP00000007493/1-1555 SEQELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADVELKQFS ENSMUSP00000101714/1-1549 SEQELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQDADSELKPFS ENSRNOP00000016992/1-1550 SEQELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQDADSELKQFS ENSP00000322915/1-1548 SEHELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFS XP_004850978.1/1-1550 SEQELFLDTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADAELKQFS **:***********************************************:** *** ** ENSCPOP00000007493/1-1555 KGETEQDLEADYPSESFDPLNKGQGIQPRSRTRRRHRDGFPQPRRRGRKKSVVAVEPRSL ENSMUSP00000101714/1-1549 KGETEQDLEADFPSESFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSVVPVEPRSL ENSRNOP00000016992/1-1550 KGETEQDLEADFPSESFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSVVPVEPRSL ENSP00000322915/1-1548 KGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVAVEPRSL XP_004850978.1/1-1550 KGETEQDLEADYPSESFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIVGVEPRSL ***********:**:************.***********************:* ****** ENSCPOP00000007493/1-1555 IQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQLDVKCGVGELGSSSPSSDPLGSA ENSMUSP00000101714/1-1549 IQGALQGCSVSGMTLKYMYGVNAWKNWVQWKNAKDEQGDLKCGGGELASASPCSDSLGSA ENSRNOP00000016992/1-1550 IQGALQGCSVSGMTLKYMYGVNAWKNWVQWKNAKDEQGDLKCGGGEHASASPCSDSLGSA ENSP00000322915/1-1548 IQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGST XP_004850978.1/1-1550 IQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQVDIKCGGGEHASSSPCSDPLGSA ****:*****************************:** *:*** * .*:** **.***: ENSCPOP00000007493/1-1555 QDQPVSQESSEAGCRVRSVKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYL ENSMUSP00000101714/1-1549 QDHALSQESSEQGCKARSVKLKEDILSCTFSELSLGLCQFIQEVRRPNGEKYDPDSILYL ENSRNOP00000016992/1-1550 QDQALSQESSEQGCKVRSMKLKEDILSCTFSELSLGLCQFIQEVRRPNGEKYDPDSILYL ENSP00000322915/1-1548 QDHALSQESSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYL XP_004850978.1/1-1550 QDQAISQESSEAGSRVRSVKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYL **:.:****** *.:.**:***********:***************************** ENSCPOP00000007493/1-1555 CLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQ ENSMUSP00000101714/1-1549 CLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQ ENSRNOP00000016992/1-1550 CLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQ ENSP00000322915/1-1548 CLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQ XP_004850978.1/1-1550 CLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEEHLWECKQ ************************************************************ ENSCPOP00000007493/1-1555 LGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFF-PPL ENSMUSP00000101714/1-1549 LGAYSPIVLLNTLLFFNTKYFQLRNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFF-PPL ENSRNOP00000016992/1-1550 LGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPPP ENSP00000322915/1-1548 LGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFF-PPL XP_004850978.1/1-1550 LGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFF-PPL ***********************:******************************** ** ENSCPOP00000007493/1-1555 QKQEPEPDKLTIGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRND ENSMUSP00000101714/1-1549 QKPESEPDKVTIGKRKRNEDDEAPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRSD ENSRNOP00000016992/1-1550 QKQESEPDKLTIGKRKRNEDEEAPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRTD ENSP00000322915/1-1548 QKQESEPDKLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRND XP_004850978.1/1-1550 QKQESETDKLTTGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRND ** *.*.**:* ********:*.***********************************.* ENSCPOP00000007493/1-1555 VFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD ENSMUSP00000101714/1-1549 VFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDAELSD ENSRNOP00000016992/1-1550 VFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD ENSP00000322915/1-1548 VFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD XP_004850978.1/1-1550 VFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSDVELSD ******************************************************.****