CLUSTAL W(1.81) multiple sequence alignment ENSP00000430945/1-1584 MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAV ENSRNOP00000015578/1-1578 MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAV ENSMUSP00000046097/1-1582 MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAV ENSCPOP00000007402/1-1544 MRGQAAAPGPFWILTSLLLLLLCLGHWARAAIGADTGPGAETCATLVQGKFFGYFSAAAV XP_004838161.1/1-1557 MRGQAAAPGPFWILAPLLFLLLLLGRRARAAVGADTGPGAETCTTLVQGKFFGYFSAAAV **********.***:.**:*** **: **** *** ***.* *:**************** ENSP00000430945/1-1584 FPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESF ENSRNOP00000015578/1-1578 FPANASRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESF ENSMUSP00000046097/1-1582 FPANASRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESF ENSCPOP00000007402/1-1544 FPDNASRCSWTLRNPDPRRYTLYMKVAKAPTPCSGPGRVRTYQFDSFLESTRTYLGVESF XP_004838161.1/1-1557 FPANASRCSWTLRNPDPRRYTLYMKVAKAPTPCSGPGRVRTYQFDSFLESTRTYLGVESF ** ***************************.***************************** ENSP00000430945/1-1584 DEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRN ENSRNOP00000015578/1-1578 DEVLRLCDPSAPLAFLQASKQFLQMQRQQPPQDGDLGPQG----SGDDFSVEYLVVGNRN ENSMUSP00000046097/1-1582 DEVLRLCDSSAPLAFLQASKQFLQMQRQQPPQDGDLGPQGEFPSSSDDFSVEYLVVGNRN ENSCPOP00000007402/1-1544 DEVLRLCDPTAPLAFLQASKQFLQMQRQQPPQDGDLGVPGEALGPSDDFSVEYLVVGNRN XP_004838161.1/1-1557 DEVLRLCDPSAPLAFLQASKQFLQMQRQQPPQDGDLGLPGEALGPSDDFSVEYLVVGNRN ********.:***************:******...* . . ************** ENSP00000430945/1-1584 PSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAV ENSRNOP00000015578/1-1578 PSHAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGDTASSPLVPRGDVCLRDGV ENSMUSP00000046097/1-1582 PSHAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGDVGDPASSPLVPRGDVCLRDGV ENSCPOP00000007402/1-1544 PSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGDPASSPLVPRGDVCLRDGV XP_004838161.1/1-1557 PSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGDPASSHLVPHGDVCLRDSV **:***********************************:.*..*:. *.*:*******.* ENSP00000430945/1-1584 AGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCE ENSRNOP00000015578/1-1578 AGGPENCLTSLTQDRGGHGSAGGWKLWSLWGECTRDCGGGLQTRTRTCSPTLGVEGRGCE ENSMUSP00000046097/1-1582 AGGPENCLTSLTQDRGGHGSAGGWKLWSLWGECTRDCGGGLQTRTRTCLPTLGVEGGGCE ENSCPOP00000007402/1-1544 AGSPENCLTSLTQDRGGHSAAGGWKLWSLWGECTRDCGGGLQTRTRTCLPTPGLEGSGCE XP_004838161.1/1-1557 AGSPENCLTSLTQDRGGHGSAGGWKLWSLWGECTRDCGGGLQTRTRTCLPTRGVEGGGCE **.***************.::*************************** *: *:** *** ENSP00000430945/1-1584 GVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEW ENSRNOP00000015578/1-1578 GVLEEGRLCNRKACGPTGRTSSRSQSLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEW ENSMUSP00000046097/1-1582 GVLEEGRLCNRKACGPTGRSSSRSQSLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEW ENSCPOP00000007402/1-1544 GVLEEGRLCNRKACGPAGRTSSRSQSLRSTDARRREELGDDLQHFGFPSPQTGDPAAEEW XP_004838161.1/1-1557 GVLEEGRLCNRKACGPAGRASSRSQSLRSTDARRREELGDDLQQFGFPSPQTGDPAAEEW ******* ***:****:**:*****************:**:**:****:*********** ENSP00000430945/1-1584 SPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSL ENSRNOP00000015578/1-1578 SPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSL ENSMUSP00000046097/1-1582 SPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSL ENSCPOP00000007402/1-1544 SPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSL XP_004838161.1/1-1557 SPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSL ************************************************************ ENSP00000430945/1-1584 CSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACS ENSRNOP00000015578/1-1578 CSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSTCS ENSMUSP00000046097/1-1582 CSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSTCS ENSCPOP00000007402/1-1544 CSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSTCS XP_004838161.1/1-1557 CSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACS *********************************************************:** ENSP00000430945/1-1584 ASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGA ENSRNOP00000015578/1-1578 ASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGG ENSMUSP00000046097/1-1582 ASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGG ENSCPOP00000007402/1-1544 ASCAQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGG XP_004838161.1/1-1557 ASCAQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGG ***:*******************************************************. ENSP00000430945/1-1584 GSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVA ENSRNOP00000015578/1-1578 GSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAGEVA ENSMUSP00000046097/1-1582 GSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAGEVA ENSCPOP00000007402/1-1544 GSQRRERVCSGPFFGGAACQGPQDEYRQCSTQRCPEPHEICDEDNFGAVVWKETPAGEVA XP_004838161.1/1-1557 GSQRRERGCSGPFFGGAACQGPQDEYRKCGTQRCPEPHEICDEDNFGAMVWKETPAGEVA ******* *******************:*.:*****************::********** ENSP00000430945/1-1584 AVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGE ENSRNOP00000015578/1-1578 AVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGE ENSMUSP00000046097/1-1582 AVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGE ENSCPOP00000007402/1-1544 AVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGE XP_004838161.1/1-1557 AVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGE ************************:*********************************** ENSP00000430945/1-1584 GVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLL ENSRNOP00000015578/1-1578 GVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLL ENSMUSP00000046097/1-1582 GVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLL ENSCPOP00000007402/1-1544 GVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLL XP_004838161.1/1-1557 GVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLL *********:*********************************************:**** ENSP00000430945/1-1584 AEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG ENSRNOP00000015578/1-1578 AEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG ENSMUSP00000046097/1-1582 AEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG ENSCPOP00000007402/1-1544 AEENREKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASS XP_004838161.1/1-1557 AEENREKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASS *****:******* *********************************************. ENSP00000430945/1-1584 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLA ENSRNOP00000015578/1-1578 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLA ENSMUSP00000046097/1-1582 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLA ENSCPOP00000007402/1-1544 ATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLA XP_004838161.1/1-1557 ATDISFPMKGWRATGDWAKVPEDRVTVSKTVFSTGVAEADDSSVFVVGTVLYRNLGSFLA *****************************:*****::***::****************** ENSP00000430945/1-1584 LQRNTTVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSS-APP ENSRNOP00000015578/1-1578 LQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPGHT-LNP ENSMUSP00000046097/1-1582 LQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPSSS-APP ENSCPOP00000007402/1-1544 LQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDVPGSM-APP XP_004838161.1/1-1557 LQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAAPP ************************ ************************** *. * ENSP00000430945/1-1584 QLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSS ENSRNOP00000015578/1-1578 DLGPRTWRGSPKAELDVLRVRRLKERWNWFGPCSQTAGESTLDQVALPVVVLVVVVVVVV ENSMUSP00000046097/1-1582 QLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTVPSVTLIVGCGVSS ENSCPOP00000007402/1-1544 KLWAWLFRRCHTVPLDGLRTRCLCDRLSTFAILAQLSADATMEKATVPSVTLIVGCGVSS XP_004838161.1/1-1557 QLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADATMEKATVPSVTLIVGCGVSS .* . :* . .. ** **.* * :* . *. :* :.::.:::.::* *.*:* * ENSP00000430945/1-1584 LTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTR-NKVVCTLVAAFL ENSRNOP00000015578/1-1578 VVVVVVVLLMVSVWRQVGMEATVFLENRCLTALLLSEKLLVSVAQTRWQKVVCTLVAAFL ENSMUSP00000046097/1-1582 LTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTR-NKVVCTLVAAFL ENSCPOP00000007402/1-1544 LTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTR-NKVVCTLVAAFL XP_004838161.1/1-1557 LTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTR-NKVVCTLVAAFL :.::::*:: ***** : * :*:* * **: : . :*:. :*** :*********** ENSP00000430945/1-1584 HFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYS ENSRNOP00000015578/1-1578 HFFFLSSFCWVLTEAWQSYMAVTGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYS ENSMUSP00000046097/1-1582 HFFFLSSFCWVLTEAWQSYMAVTGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYS ENSCPOP00000007402/1-1544 HFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFVCLGWGLPALVVAISVGFTKAKGYS XP_004838161.1/1-1557 HFFFLSSFCWVLTEAWQSYMAVTGRLRNRLIRKRFVCLGWGLPALVVAISVGFTKAKGYS ************************:**.**:****:************************ ENSP00000430945/1-1584 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWS ENSRNOP00000015578/1-1578 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWS ENSMUSP00000046097/1-1582 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWS ENSCPOP00000007402/1-1544 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWS XP_004838161.1/1-1557 TMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWS ************************************************************ ENSP00000430945/1-1584 SCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCR ENSRNOP00000015578/1-1578 SCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCR ENSMUSP00000046097/1-1582 SCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCR ENSCPOP00000007402/1-1544 SCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCR XP_004838161.1/1-1557 SCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCR ************************************************************ ENSP00000430945/1-1584 VVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSL ENSRNOP00000015578/1-1578 VVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTFKRPSL ENSMUSP00000046097/1-1582 VVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTFKRPSL ENSCPOP00000007402/1-1544 VVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSL XP_004838161.1/1-1557 VVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSL ******************************************************:***** ENSP00000430945/1-1584 PEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSS ENSRNOP00000015578/1-1578 PEEEKMKLA--KGPPPTFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKKDKAPKSS ENSMUSP00000046097/1-1582 PEEEKMKLA--KGPPPTFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKKDKAPKSS ENSCPOP00000007402/1-1544 PEEEKLKLAHAKGPPSTFNSLPANVSKLRLQGSPHCPGGPLPAFPNHSLTLKKDKAPKAS XP_004838161.1/1-1557 PEEEKLKLAHTKGPPSTFNSLPANVSKLRLQGSPHCPGGPLPAFPNHSLTLKKDKAPKAS *****:*** ****..***********:*:***: ****** *********:*****:* ENSP00000430945/1-1584 FVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLI ENSRNOP00000015578/1-1578 FIGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLI ENSMUSP00000046097/1-1582 FIGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLI ENSCPOP00000007402/1-1544 FIGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLI XP_004838161.1/1-1557 FVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLI *:***********************************************:********** ENSP00000430945/1-1584 HLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPS ENSRNOP00000015578/1-1578 HLSMAPDASFPTRSPPAREPPGGAPPEVPPVQ-PPPPPPPPPPPQQPIPPPPSLEPAPPS ENSMUSP00000046097/1-1582 HLSMAPDASFPTRSPPAREPPGGAPPEVPPVQPPPPPPPPPPPPQQPIPPPPTLEPAPPS ENSCPOP00000007402/1-1544 HLSMAPDTSFPSR----------------------------------------MEPAPPS XP_004838161.1/1-1557 HLSMAPDASFPTRSPPTR----------------------------ALPPLPSLEPAPPS *** **::*:*:* :****** ENSP00000430945/1-1584 LGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQD ENSRNOP00000015578/1-1578 LGDTGEPSAHPGPSSGAGTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQD ENSMUSP00000046097/1-1582 LGDTGEPAAHPGPSSGAGAKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQD ENSCPOP00000007402/1-1544 LGDTAEPAAHAGPSTVTGPKTENVATLSMSSLERRKSRYAELDFEKIMHTRKRHQDMFQD XP_004838161.1/1-1557 LGDTAEPAPHAGPSTVAGPKTENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQD ***..**:.*.***: ...*.*******:******************************* ENSP00000430945/1-1584 LNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQPSPLEL ENSRNOP00000015578/1-1578 LNRKLQHAAEKEKEVPGVDNKPEKQQTPNKRAWESLRKPHGTPAWVKKELEPLPPSPLEL ENSMUSP00000046097/1-1582 LNRKLQHAAEKEKEVPGADSKPEKQQTPNKRAWESLRKPHGTPAWVKKELEPLPPSPLEL ENSCPOP00000007402/1-1544 LNRKLQHAAEKDKEAMAPDGKPEKQQTPSKRPWESLRKAHGTPAWVKKELEPLPPSPLEL XP_004838161.1/1-1557 LNRKLQHAAEKDKEAMGPDCKPEKQQTPSKRPWESLRKAHGTPAWVKKELEPLPPSPLEL ***********:**. . * ********.**.******.****:********* ****** ENSP00000430945/1-1584 RSVEWERSGATIPLVGQDIIDLQTEV ENSRNOP00000015578/1-1578 RSVEWEKAGATIPLVGQDIIDLQTEV ENSMUSP00000046097/1-1582 RSVEWEKAGATIPLVGQDIIDLQTEV ENSCPOP00000007402/1-1544 RSVEWEKAGATIPLVGQDIIDLQTEV XP_004838161.1/1-1557 RSVEWEKAGATIPLVGQDIIDLQTEV ******::******************