CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000025681/1-1551 MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWASPFVTK ENSRNOP00000029466/1-1551 MEQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWAGPFVTK ENSP00000345133/1-1551 MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSK ENSCPOP00000007323/1-1540 MEQRLRALEQL----------IDGLLDLLLGLHHELSSAPLRRERNVAQFLSWATPFVTK XP_004852510.1/1-1552 MEQRLRALEQLGRGEAGGGLGLDGLLDLLLGLHHELSSAPLRRERNVVQFLSWATPFVTK **:******** :********.:*:****.******.*.****** ***:* ENSMUSP00000025681/1-1551 VKELRLQRDDFEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREER ENSRNOP00000029466/1-1551 VKELRLQRDDFEILKVIGRGAFGEVAVVRQRDSGQIFAMKMLHKWEMLKRAETACFREER ENSP00000345133/1-1551 VKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER ENSCPOP00000007323/1-1540 VKELRLQRDDFEILKVIGRGAFGEVAVVRQRDSGQIFAMKMLHKWEMLKRAETACFREER XP_004852510.1/1-1552 VKELRLQRDDFEILKVIGRGAFGEVAVVRQRDSGQIFAMKMLHKWEMLKRAETACFREER *************************:*****.:*************************** ENSMUSP00000025681/1-1551 DVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV ENSRNOP00000029466/1-1551 DVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV ENSP00000345133/1-1551 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV ENSCPOP00000007323/1-1540 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV XP_004852510.1/1-1552 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV ************:*********************************************** ENSMUSP00000025681/1-1551 LAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISP ENSRNOP00000029466/1-1551 LAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISP ENSP00000345133/1-1551 LAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISP ENSCPOP00000007323/1-1540 LAIDSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNSGMVDSSVAVGTPDYISP XP_004852510.1/1-1552 LAIDSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNSGMVDSSVAVGTPDYISP ***.****************:***:****************..***************** ENSMUSP00000025681/1-1551 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPAD ENSRNOP00000029466/1-1551 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPSD ENSP00000345133/1-1551 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPD ENSCPOP00000007323/1-1540 EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPSD XP_004852510.1/1-1552 EILQAMEEGQGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPSD *********:************************************************.* ENSMUSP00000025681/1-1551 VTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFFEGVDWERLATSTAPYIPELRGPM ENSRNOP00000029466/1-1551 VDDVPASAQALIRQLLCRQEERLGRGGLDDFRSHPFFEGVDWERLATSTAPYIPELRGPV ENSP00000345133/1-1551 VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPM ENSCPOP00000007323/1-1540 VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGIDWEQLASTTAPYIPELQGPV XP_004852510.1/1-1552 VPDVPSSAQDLIRQLLCRQEERLGRGGLDDFRSHPFFEGVDWEQLAASTAPYIPELQGPV * ***:*** **********************.******:***:**::********:**: ENSMUSP00000025681/1-1551 DTSNFDVDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGSPFDVQSSELMAAPEGTPH ENSRNOP00000029466/1-1551 DTSNFDVDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGSLTDDKSSELMATPEWKPH ENSP00000345133/1-1551 DTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQ ENSCPOP00000007323/1-1540 DTSNFDVDDDTLNHPDTLPPPSHGSFSGHHLPFIGFTYTSGCPSAESSSELAASWERKSH XP_004852510.1/1-1552 DTSNFDVDDDTLNHPDTLPPPSHGSFSGHHLPFVGFTYTSGSLSPESSSELAAAQEWKLR *************:* ****.***:********:*******. .*** *: * . : ENSMUSP00000025681/1-1551 CVEQVKVELSHKCQEPL---HGPLQPQELVRLQKEVQVLQEKLAETLRDSKASLSQTDGL ENSRNOP00000029466/1-1551 GVEQMKVELSQKCQEAL---HSSLQPQELVRLQKEVQVLQEKLTETLRDSKASLSQADGL ENSP00000345133/1-1551 CLEQEKVELSRKHQEAL---HAPTDHRELEQLRKEVQTLRDRLPEMLRD-KASLSQTDGP ENSCPOP00000007323/1-1540 CLEEEKVELSWEHQVLT---HGPSDHQELARLQKEVETLRGKLAEMLRDSKASLSQMGES XP_004852510.1/1-1552 CLEEEKVELSWKCQGLAAHSRGPSDHQELAQLQKEVETLRERLAETLRDSKASLSQRDGS :*: ***** : * :.. : :** :*:***:.*: :*.* *** ****** . ENSMUSP00000025681/1-1551 HARSPAPNIQLQQEKDRLQQELTEAQAALRVQDAELCQAQNRQEEFLQRLWEAQEREAAA ENSRNOP00000029466/1-1551 HVRSPAPDIQLQQEKDRLQQELAEAQAALQVRDAELCQAQNRQEEFLQRLWEAQEREAAA ENSP00000345133/1-1551 PAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAAT ENSCPOP00000007323/1-1540 SVDSPGQVSDLQQEKDQLQQELAEARAGLQAQAQELCRAQSLQEELLLRLQEAQEKEAAT XP_004852510.1/1-1552 PGDSPGQVSDLQSEKDQLQQELAEAQAGLQAQARELCRAQSLQEELLLRLREAQKKEVAT **. :*:.* *:*::**:*.:*.*:.: ***:**. ***:* ** ***::*.*: ENSMUSP00000025681/1-1551 ASQIQALNSQLEEAWVVRRELEGQVTTLSQEVTRLQGQCKQ----ESSQAKTVHAAPETN ENSRNOP00000029466/1-1551 ASQIQALNSQLEEAWVVRRELEGQVNTLSQEVTQLQGQCKQD---SSSQAKTVHAAPETN ENSP00000345133/1-1551 ASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLE-ESSQAKTIHTASETN ENSCPOP00000007323/1-1540 ASQTQTLSSQLEEVWDARRELETQVAALSQEVARLRGQHKQSLEKESSQAKTIHMATETN XP_004852510.1/1-1552 TSQIQALSSQLEEVCDIRKELENQVASLSQEVMRLRGPQDRSLKKESSQTKTVHAASETN :** ::*.*****. ::*** ** :**::* :*:* .: .***:**:* *.*** ENSMUSP00000025681/1-1551 GIGSPEGQSQEAQLRKEVAALREQLEHACSQGISVGKEEVLCRLQEENQRLSREQERLAG ENSRNOP00000029466/1-1551 GIGSPEGQSQEAQLRKEVAALREQLECACSQGVNVGKEEVLCRLQEENQRLSREQERLAE ENSP00000345133/1-1551 GMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPS-GKEEALCQLQEENRRLSREQERLEA ENSCPOP00000007323/1-1540 GTGPSEGGPHEVQLLKEVAALREQLKQAGSCGSS-GKEEALCQLREENQRLSREQERLAE XP_004852510.1/1-1552 GTGSSEEGTHEAQLLKEVAILREQLEQACRYGPN-GKEEALCQLREENQRLSREQEQLAE * *..* .:*.** **** *****: * . ****.**:*:***:*******:* ENSMUSP00000025681/1-1551 ELELELQSKQRLEGERRETESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRN ENSRNOP00000029466/1-1551 ELDLELQSRQRLEGERRESESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRN ENSP00000345133/1-1551 ELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRN ENSCPOP00000007323/1-1540 ELEQELQTKKRLEGERRETESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRN XP_004852510.1/1-1552 ELEQELQTKQRLEGERRETESNWEAQIADILSWVNDEKVSRGYLQALATKMAEELESLRN ** * ::::********:*******:********************************* ENSMUSP00000025681/1-1551 VGTQTLPTRPLDHQWKARRLQKMEASARLELQSALEAEIRAKQSLQEQLTQVQEAQRQAE ENSRNOP00000029466/1-1551 VGTQTLPTRPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQEQLTQVQEAQRQAE ENSP00000345133/1-1551 VGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAE ENSCPOP00000007323/1-1540 VGTQMITTRPLDHQWKVRRLQKMEASARLELQSALDAEIRAKQGLQERLTQVQEAQLQAE XP_004852510.1/1-1552 VGTQTITTRPLDHQWKARRLQKMEASARLELQSALDAEIRAKQGLQERLTQVQEAQLQAE **** :.:********.******************:*******.***:******** *** ENSMUSP00000025681/1-1551 RRLQEAEKQSQALQQEVAELREELQARGPGDARPSTSLIPLLSFWNTEKDSAKDPGNSGE ENSRNOP00000029466/1-1551 RRLQEAEKQNQALQQEVAELREELQARGPGDAKPCTSLIPLLSFWNTEKDSAKDPGNSGE ENSP00000345133/1-1551 RRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGE ENSCPOP00000007323/1-1540 RRLEEAEKQNQTLQQELAMLREELRARGPGDTKPSNSLIPFLSFRSTEKDSAKDSGILGE XP_004852510.1/1-1552 RRLEEAEKQNQALQQELAALRDELRARGPGDTKASHSLIPFLSFRSTEKDSAKDSGISGE ***:*****.*:****:* **:**:**** *::.. ****:*** .:*******.* ** ENSMUSP00000025681/1-1551 GPRSGAEAELRPEGRRSLRMGSVFPRVPAATTTPAEGPPAKPGSHTLRPRSFPSPTKCLR ENSRNOP00000029466/1-1551 SPRSGAEAELRPEGRRSLRMGSVFPRVPAANPTPAEGPPAKPGSHTLRPRSFPSPTKCLH ENSP00000345133/1-1551 ATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLR ENSCPOP00000007323/1-1540 TPKPGIEPELRPEGRRSLRRGATFPWVPAVTATPAEGPPAKPSSHTLRPRSFPSPTKCLR XP_004852510.1/1-1552 TPRPGVEPELRPEGRRSLRMGAVFPWVPAVTATSAEDPPAKPGSHTLRPRSFPSPTKCLC .: * *.:********** *:.** .*:...:.:*. ****.**************** ENSMUSP00000025681/1-1551 CTSLMLGLGRQGLGCDTCGYFCHSACASQAPPCPVPPELLRTALGVHPETGTGTAYEGFL ENSRNOP00000029466/1-1551 CTSLMLGLGRQGLGCDTCGYFCHSACATQAPPCPVPPELLRTALGVHPETGTGTAYEGFL ENSP00000345133/1-1551 CTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFL ENSCPOP00000007323/1-1540 CTSLMLGLGRQGLGCDACGFFCHSTCAPQAPPCPVPPDLLHTALGVHPETGTGTAYEGFL XP_004852510.1/1-1552 CTSLMLGLGRQGLGCDACGFFCHSTCAPQAPLCPVPPDLLHTALGVHPETGTGTAYEGFL ****************:**:***::**.*** *****:**:******************* ENSMUSP00000025681/1-1551 SVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAP ENSRNOP00000029466/1-1551 SVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSMASGVLLQALDLRDPQFSATPVLAP ENSP00000345133/1-1551 SVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLAS ENSCPOP00000007323/1-1540 SVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRASPASAALLQALDLRDPQFSAIPVLAS XP_004852510.1/1-1552 SVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRASPASTALLQALDLRDPQFSATPVLAS ***************:*************** * * .* .***.********** ****. ENSMUSP00000025681/1-1551 DVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLLAENEGERERWLQVLGELQRLLLDARPR ENSRNOP00000029466/1-1551 DVIHAQSKDLPRIFRVTASQLTVPPSTCTVLLLAENEGERERWLQVLSELQRLLLDARPR ENSP00000345133/1-1551 DVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPR ENSCPOP00000007323/1-1540 DVIHAQSRDLPRIFRVTASQLTVPPTTCTVLLLADSEGERERWLQVLGELQRLLLEARPR XP_004852510.1/1-1552 DVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLLSGSEGERERWLQVLGELQQLLLEARPR *******:*********:***:***:*******: .***********.***:***:**** ENSMUSP00000025681/1-1551 PRPVYTLKEAYDNGLPLLPHALCAAVIDQERLALGTEEGLFVIHLHSNDIFQVGDCRRVQ ENSRNOP00000029466/1-1551 PRPVYTLKEAYDNGLPLLPHTLCAAIIDRERLALGTEEGLFVIHLHSNDIFQVGDCRRVQ ENSP00000345133/1-1551 PRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQ ENSCPOP00000007323/1-1540 PRPVYTLKEAYDNGLPLLSHTLCAAVIDQERLALGTEEGLFVIHLHNNDIFQVGECRRVQ XP_004852510.1/1-1552 PRPVYTLKEAYDNGLPLLPHTLCAAVIDRGRLALGTEEGLFVIHLHNNDIFQVGECRRVQ ******************.*:****::*: ***************:.*******:***** ENSMUSP00000025681/1-1551 RLAVSSAAGLLAVLCGRGPSVRLFALDELESAEVAGAKIPESRGCQALVAGRILQARTPV ENSRNOP00000029466/1-1551 RLTVSSAAGLLVVLCGRGPSVRLFTLSELENAEVAGAKIPESRGCQALVAGSILQARTPV ENSP00000345133/1-1551 QLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPV ENSCPOP00000007323/1-1540 QLTLSPSAGLLVVLCGRGPSVRLFALAELESTEAAGAKIPESRGCQVLAAGRILQARTPV XP_004852510.1/1-1552 QLTLSPSAGLLVVLCGRGPSVRLFALAELESTEAAGAKIPESRGCHVLAAGRILQARTPV :*::*.:****.************:* ***. *.***********:.*.** ******** ENSMUSP00000025681/1-1551 LCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNE ENSRNOP00000029466/1-1551 LCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGTFALYPLLNE ENSP00000345133/1-1551 LCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNE ENSCPOP00000007323/1-1540 LCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGAFALYPLLNE XP_004852510.1/1-1552 LCVAVKRQVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGDRLCVGAAGAFALYPLLNE ********************************.***************** ********* ENSMUSP00000025681/1-1551 AAPLALGTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDSAGRKSRSHELL ENSRNOP00000029466/1-1551 AAPLALGTGLVAEELPASRGGLGEALGAVELSLSELLLLFATAGVYVDGAGRKSRSHELL ENSP00000345133/1-1551 AAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELL ENSCPOP00000007323/1-1540 AAPLSLGAGLAPEELPPSRGGLGEALGVVELSLNELLLLFTTAGVYVDGAGRKSRNHELL XP_004852510.1/1-1552 AAPLALGAGLVPEELPPSRGGLGEALGAVELSLNELLLLFTTVGVYVDGTGRKSRSHELL ****:**:**..****.**********.*****.*:****:*.*:***.:*****.**** ENSMUSP00000025681/1-1551 WPAAPTGWGYTAPYLTVFSENALDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVR ENSRNOP00000029466/1-1551 WPVAPTGWGYTAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLLLYGTEKVR ENSP00000345133/1-1551 WPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVR ENSCPOP00000007323/1-1540 WPVAPIGWGYTAPYLTVFSENSIDVFDVRRTEWVQTVPLKKVRPLNPEGSLFLYGTEKVR XP_004852510.1/1-1552 WPVAPIGWGYTAPYLTVFSENSIDMFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVR **.** ****:**********::*:*****:********************:******** ENSMUSP00000025681/1-1551 LTYLRNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRS ENSRNOP00000029466/1-1551 LTYLRNPLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSDELRQQQRREMLKDPFVRS ENSP00000345133/1-1551 LTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRS ENSCPOP00000007323/1-1540 LTYLRNRLAEKDEFDIPDLTDNSRRQLFRTKSKRRWFFRVSDEQRLQQRREMLKDPFVRS XP_004852510.1/1-1552 LTYLRNRLAEKDEFDIPDLTDNSRRQLFRTRSKRRFFFRVSDEQRTQQRWEMLKDPFVRS ****** ***********************:****:*****:* : *** ********** ENSMUSP00000025681/1-1551 KFISPPTNFNHLVHVGPTEGRPNTRDGTRAQEQKSRGARSSGPQRPHSFSEAFRRPVSTG ENSRNOP00000029466/1-1551 KFISPPTNFNHLVHVGPTEGRPGPRDGTRAQEQKSRGTRSSGPQRPHSFSEALRRPVSMG ENSP00000345133/1-1551 KLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMG ENSCPOP00000007323/1-1540 KLISPPTNFNHLVHMGPTDGRPSAR----APEEKAKGARGSGPQRPHSFSETSRLPTSVG XP_004852510.1/1-1552 KLISPPTNFNHLVHVGPNDGRPSAR----APEEKGRGARGSGPQRPHSFSEASRLSAFMG *:************:** :***..* * *:*.: :*.***********: * .. * ENSMUSP00000025681/1-1551 SDGLPGETDPLVKRKPWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESESSP ENSRNOP00000029466/1-1551 NDGLPGETDP-LKRKVWTSLSSESVSCPQGSLSPAASLIQVSERPRSLPPDPESEGSP ENSP00000345133/1-1551 SEGLGGDADP-MKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP ENSCPOP00000007323/1-1540 RDSLLRDADSTVKRKPWTSLSSESVSCSQGPLSPAASLTKVSERPRSLPAAPESESSL XP_004852510.1/1-1552 SDNLPRDADS-MNRKPWTSLSSESVSCPQGSLSPAASLIKVSERPRSLPPAPESESSP :.* ::*. ::** ***********.**.****:** :********* ** *.*