CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000081764/1-1437 MASSSTETQLQRIIRDLQDAATELSHEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEK ENSRNOP00000008630/1-1451 MASSSTETQLQRIIRDLQDAVTELSNEFKEGGEPITDDSTSLHKFSYKLEYLLQFDQKEK ENSP00000441178/1-1498 MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEK ENSCPOP00000007288/1-1432 MASSGAEGQLQRIIRDLQDAVMELSSEFKEVGEPITDDSASLHKFSYKLEYLLQFDLKEK XP_004835093.1/1-1444 MAASSAEGQLQRIIRDLQDAVTELSNEFKEAGEPITDDSPSLHKFSYKLEYLLQFDLKEK **::.:* ************. *** **:* ********.**************** *** ENSMUSP00000081764/1-1437 ASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADT ENSRNOP00000008630/1-1451 ASLLGSKKDYWDYFCACLAKVKGANDGIRFVRSISELRTSLGKGRAFIRYSLVHQRLADT ENSP00000441178/1-1498 ATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT ENSCPOP00000007288/1-1432 ASLLGTKKDYWDYFCACLAKVKGTNDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT XP_004835093.1/1-1444 ASLLGTRKDYWDYLCACLAKVKGASDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADT *:***.:******:*********:.******:**************************** ENSMUSP00000081764/1-1437 LQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLAPRGYDLDAAWPTFAR ENSRNOP00000008630/1-1451 LQQCFMNTKVTSDWYYARSPFLKPKLSSDIVGQLYELTEVQFDLASRGYDLDAAWPTFAR ENSP00000441178/1-1498 LQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFAR ENSCPOP00000007288/1-1432 LQQCFMNTKVTSDWYYARSPFLKLKLSADIVGQLYELTEVQFDLASRGYDLDAAWPTFAR XP_004835093.1/1-1444 LQQCFMNTKVTSDWYYARSPFLKLKLSSDIVGQLYELTEVQFDLASRGHDLDAAWPTFAR **********************: ***:*****************.**.*********** ENSMUSP00000081764/1-1437 RTLATSTSAYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNCSLNNEALESFDEMRLELD ENSRNOP00000008630/1-1451 RTLAT-SSSYMWKPPSRSSSMSSLVSNYLQTQEMASSLDLNSSLNNEALESFDEMRLELD ENSP00000441178/1-1498 RTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELD ENSCPOP00000007288/1-1432 RTLAPGSSAYLWKAPSRSSSMSSLVSSYLQTQEMASSFDLSSPLNNEALEGFDEMRLELD XP_004835093.1/1-1444 RTLAPGSPAYLWKAPSRSSSMSSLVSSYLQTQEMASNFDLSSPLNNEALEGFDEMRLELD ***:. :.:*:**.************.*******.*.:**...*******.********* ENSMUSP00000081764/1-1437 QLEVREKQLQERVQQLDRENQALRMLVSRQGGQLQVEKEMGYLAVEDSIGLVSLVAELQK ENSRNOP00000008630/1-1451 QLEVREKQLQEHVQQLNRENQALRMTISKQGGQLQVEKETGYLAVEDSIDLVSLVAELQK ENSP00000441178/1-1498 QLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQK ENSCPOP00000007288/1-1432 QLEVREKQLQERVHQLDRENQELRAAFSAQQEQLQVEKQWARVTAEDRSYLTGLVAQLQK XP_004835093.1/1-1444 QLEVREKQLQERVQQLEQEKQELQAALSTQQEQLQVEKQRGHAATEDHRHLVGLLAELQK *********:*:::**::*:* *: .* * ***.*:: . :.** *. *:*:*** ENSMUSP00000081764/1-1437 QGDVSQAT---VKKLQSCLQALEL-NVDKKEYSPSALQ-----LENMAKELDTVRGSLGR ENSRNOP00000008630/1-1451 QGEVTQAT---VKKLQTCLQALEL-AVDQKETSHSVLQ-----LENVAQALDAVRDSLGR ENSP00000441178/1-1498 QWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDK ENSCPOP00000007288/1-1432 QWVVTQATQDAIKELHVCLQALEQ-DIAKEGDS-SVLQRLEATLQPLAQELKAARDSLG- XP_004835093.1/1-1444 QWEVTQATQDTIKELQMCLQALER-DTAKEEDS-STLQHLGAMLQPLARELKAAWDSLGE * *:*** :*:*: ***.** :: :.*: *: :*: *.:. .**. ENSMUSP00000081764/1-1437 ENQLLASLSERLARAEKGEKTPPDTELHQEPVPADLVLKFQELKGKLQALEGENTEAQEL ENSRNOP00000008630/1-1451 KNQLLASLSECLTRAEKREHPSLDTKLHQEPVPTDLALKFQELKGKLQTLEGENTKAQEL ENSP00000441178/1-1498 KNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEV ENSCPOP00000007288/1-1432 KNQVLDSLSDWLARAEQGAALASNTKGQQEPIQADLGLKLQELEEKLQSLEEESTKVREL XP_004835093.1/1-1444 KNQLLSSLSDSLARAEQRADTALDTKGQQGPIPADSALKLQELGAKLQSLEAENSKVQEF :** * *:. *: *:: . :*: :* *: :* ::*** ***:** * ::..*. ENSMUSP00000081764/1-1437 NRQQSIKLEQLAKELQLKEEARASLAHLVKDVVPLQEELSGKKQESAQLRRQLQESLAHL ENSRNOP00000008630/1-1451 NRQQSLKLEQLAKELQLKEEARASLEHLVKDAVPLQEELSGKKQESAQLRRQLQESLAHL ENSP00000441178/1-1498 NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT ENSCPOP00000007288/1-1432 NRQQSAQLVQLATELQQKEEVRAGLEHQVQEM--------------AQLRQQLRESLART XP_004835093.1/1-1444 NRQQSA---QLATELQLKEEARAGLEHQVQEVAQLRKELSRKEQEAAQLQQQLQESLARS ***** **..*** **:.**.* : *:: ** ::*:* **: ENSMUSP00000081764/1-1437 SSVEEELAEARQQEKQHREEKQLLEQEATSLTWQLQLLETQLGQVSQLVSDLEEQKKQLM ENSRNOP00000008630/1-1451 SSVEEELAEARQQEKQHREEKQLLEQEAKSLTWQLQLLETQLGQVSQLVSDLEEQKKQLM ENSP00000441178/1-1498 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI ENSCPOP00000007288/1-1432 SSLEEELAGLRQAEQLQQEEKEMLAQEARSLSRQLQVLETQLAQVSQHVGDLEEQKRLLI XP_004835093.1/1-1444 SSLEEQLAGLRREEQLQQEEKEMLAQEARSLSRQLQVLETQLAQVSQHVGDLEEQKKQLI ** **:** *: :: ::***::* **. **: ***.*****.**** *.******: *: ENSMUSP00000081764/1-1437 QERDHLSQRVGTLEQLAEVHG-------------------PPQSAEMPEKRQQCLREEQV ENSRNOP00000008630/1-1451 QDKDHLSQKVGTLEQLAEAHG-----------ASKSKEAVPPQAGEMPEKGQHCLQEEQV ENSP00000441178/1-1498 QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQL ENSCPOP00000007288/1-1432 QDKDHLSQKVGTLERLTGQTAPEPPAASDQGEAPTSSVSTPQQASEKPEEQQG------- XP_004835093.1/1-1444 QDKDRLSQKVGALEQLAEQAAPEPSVASEWGEAPASPVSTLQQAGEKPAEGQR------- *::*:***:** **:*: . :: * : * ENSMUSP00000081764/1-1437 NNSTVSEAEQEE---------LQKELQNMVDRNQLLEGKLQALQTDYKALQQREAAIQGS ENSRNOP00000008630/1-1451 NNATVRGADQDE--LQKVNQELQKELQNMAVRNQLLEGKLQALQTDYKALQQREAAIQGS ENSP00000441178/1-1498 DDTKVQEGSQEEE-LRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGS ENSCPOP00000007288/1-1432 DGAKMPAGKQEDE-LLQAN---------MVGRNQLLEAKLQALQADYQALQQREASIQGS XP_004835093.1/1-1444 DSTEVQEPKQEEEDLRQANWELQRELQSMAGRNQLLEGKLQALQADYQALQQREAAIRGS :.: : .*:: :. ******.******:**:******::*:** ENSMUSP00000081764/1-1437 LASLEAEQASIRHLGNQMEASLLAVKKAKETMKAQVAEKEAALQSKESECQRLQEEADQC ENSRNOP00000008630/1-1451 LASLEAEQASIRQLGNQMEASLLAVRKAKETMKAQVAEKEAALQSKEGECRQLQEEAEQC ENSP00000441178/1-1498 LASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQC ENSCPOP00000007288/1-1432 LASLEAEQASIRHLGDQMEASLQAVQKAKRAMKVQVAEKEAALQSKEDECQQLREEAAQC XP_004835093.1/1-1444 LASLEAEQASIRHLGDQMEASLLAVQKAKQTMKAQVAKKEAALQSKEDECRQLREEVAQC ************:**:****** **:***.:**.*:*:*** *****.**::*:**. ** ENSMUSP00000081764/1-1437 RLQAEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVN-----TDQLALSQAQLE ENSRNOP00000008630/1-1451 RLRTEAQAQELRALENQCQQQIQLIEVLSAEKGQQGLSLPQVN-----TAQLALSQAQLE ENSP00000441178/1-1498 QQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLE ENSCPOP00000007288/1-1432 RRLAESRDADLKVLSNECHNQAQLIEALRAEKGQQDLSQPQDG-----TAQLALAQAQLE XP_004835093.1/1-1444 RQVAESRDKDLRVLSEECHHQAQLIDALKAEKGQQGLGPPQDG-----TTQLALAQAQLE : :*:: :*:.*..:*::* ***:.* ******.:. * . : ****:***** ENSMUSP00000081764/1-1437 IHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAETVLREHKTLVQQLKEQNEALNR ENSRNOP00000008630/1-1451 IHQGEAQRLQNEVVDLQAKLQVALGDRDKLQSQLGVAEAVLGEHKTLVQQLKEQNEALNR ENSP00000441178/1-1498 VHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNR ENSCPOP00000007288/1-1432 VHQGEAQRLRAELVDLQAKLQAALGDQDKAQSQLRVTVELLREQRMLVQQLQEQNEALNR XP_004835093.1/1-1444 VHQGEAERLRAELVDLQAKLWAALGDQDKVQSQLSVAEEMLREHRTLVQQLQEQNEALNR :****.:**: ::******: .**.*:** **** :: :* *:: *****:******** ENSMUSP00000081764/1-1437 AHVQELLQCS-EREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQL ENSRNOP00000008630/1-1451 AHIQELLQCS-EREGILQEESIYKAQKQEQELRALQAELSQVRCSSEGAHLEHAELQDQL ENSP00000441178/1-1498 AHVQELLQCS-EREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQL ENSCPOP00000007288/1-1432 AHVQELLQCSAAREGLLQEGRASAAQQHKQEMQALQEELARATHSSEEARLEHAELQEQL XP_004835093.1/1-1444 AHVQELL----------QEGRASAAQQRRQELRALQEELAQATRSSEEARLEHAELQEQL **:**** ** **::.:*::*** **::. *** *:*******:** ENSMUSP00000081764/1-1437 HRANTDTAELGIQVCALTAEKDRMEEALASLAQELQDSKEAALQERKGLELQVMQLQQEK ENSRNOP00000008630/1-1451 HRANTDTAELGIQVCALTAEKDRMEGALASLAQELQDSKEAALQERKGLELQVMQLQQEK ENSP00000441178/1-1498 HRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEK ENSCPOP00000007288/1-1432 HQANTDTAELGIQICNLTSEKERVEG-------ELRDCQEAASRERERLERQVAELLQET XP_004835093.1/1-1444 HRANTDTAELGIQVCTLTAEKERVEG-------ELRICREAASQEREGLERQVAGLLQEK *:***********:* ** **:*:* **: .:*** :**: ** ** * **. ENSMUSP00000081764/1-1437 EKLQEKVKAAEEAASSFSGLQAQLAQAEQLAQSLQETAHQEQDALKFQLSAEIMDHQNRL ENSRNOP00000008630/1-1451 ESLQEKLKATEEAASSFSVLQAQLAQAEQLAQSLQEAAHQEQDALKFQLSAEIMDHQNRL ENSP00000441178/1-1498 ESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRL ENSCPOP00000007288/1-1432 ASLQEKLTVAEDTASSLATLQAQLVQAEHQAQSLQEAARQEHDTLKFQLSAEIMDHQSRL XP_004835093.1/1-1444 ASLQEKLTAAENAAGSLASLQAQLAQAEQRAQSLEEAKHQEHDALKFQLSAEIMDHQSRL .****:..:: :*.*:. *****.***: ****:*: :** ::***********:*.** ENSMUSP00000081764/1-1437 KTANEECGHLRAQLEEQGQQLQMTKEAVQELEITKAAMEEKLNCTSSHLAECQATLLRKD ENSRNOP00000008630/1-1451 KTANEECGSLRAQLEEQGQELQMTKEAVQELKITKATMEEKLNCTGSHLAECQATLLRKD ENSP00000441178/1-1498 KNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKD ENSCPOP00000007288/1-1432 KAATEECRSLRAQLEQQSQQLQAADEAVAKLKATQADMAEKLSCTSSHLSKCQEAAAQKD XP_004835093.1/1-1444 KAATEECRSLRAQLEQQGQQLRATEEAVGKLKATQADMGEKLSCTSSRLSECQAAVVQKD * * *** **.***:*.::*: :.*** :*: *:* * ***.**..:*::** : :** ENSMUSP00000081764/1-1437 EESTMLQTSLERTQKELEKATSKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLE ENSRNOP00000008630/1-1451 EESAMLRINLERTQKELEKATSKFQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLE ENSP00000441178/1-1498 KEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLE ENSCPOP00000007288/1-1432 KEAVALREGLDRTQKELEVATTKVQEYCRRLRQEKSDREQSDQKMLAELDDLNRTKKYLE XP_004835093.1/1-1444 KEGSALRESLERTQKELEIATTRSQEYCNRLRQEVSERERSDQKMLADLDDLHRTKKYLE :*. *: .*:******* **:: *** .:* ** ::**:.******:****:******* ENSMUSP00000081764/1-1437 ERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEVNHCHDCKREFSWIVRRHHCRIC ENSRNOP00000008630/1-1451 ERLIELLRDKDALWQKSDALEFQQKLSAEEKCLGDMEANHCHDCKREFSWIVRRHHCRLC ENSP00000441178/1-1498 ERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRIC ENSCPOP00000007288/1-1432 ERLIELLRDKDALWQKSDALEFQQKLSAVERWLGDAEATHCLDCKREFSWMVRRHHCRVC XP_004835093.1/1-1444 ERLIELLRDKDALWQKSDALEFQQKLSSEERWLGDAEASHCLDCKREFSWMVRRHHCRVC ***************************: *: *** *..** ********:*******:* ENSMUSP00000081764/1-1437 GRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGEGSGSNDSSGSGTSQGEPSPMVSPAEA ENSRNOP00000008630/1-1451 GRIFCYYCCNNYVVTKPSGKKERCCRACFQKFGESSGSPDSSGSGTSQGEPSPMVSPAEA ENSP00000441178/1-1498 GRIFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASP ENSCPOP00000007288/1-1432 GHIFCYYCCNNYVLTRPGGRKERCCRACFRKFNESPGSPSSSESTTSPGDPSPRLSPAHA XP_004835093.1/1-1444 GHVFCYYCCNNYVLTKPSGRKERCCRACFRKFSEGPGSPNSSGSATSQGEPSPRLSPAHA *::**********::: .*:*********:*:.*..** .** * ** *:*** :*** . ENSMUSP00000081764/1-1437 SPQSIGSQGINSVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNTAEQ--- ENSRNOP00000008630/1-1451 APQSIGSQGINPVCRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSMDPNMAEQ--- ENSP00000441178/1-1498 GPQATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQASV ENSCPOP00000007288/1-1432 GTQAAGSQVAD--CRQPDDAVFDIITDEELCQIQESGSSLPATPTETDSLDPNVTEQ--- XP_004835093.1/1-1444 GPQAVGSQGAD--CRQPDDAVFDIITDEELCQIQESGSSLPATPTETDSLDPSMAEQ--- ..*: *.* : * ************************* *******:**. :** ENSMUSP00000081764/1-1437 -----------------DTTSNSLTPEDTEDVPMGQDAEICLLKSGELMIKLPLTVEEVA ENSRNOP00000008630/1-1451 -----------------DTTSNSLTPEDTEDMPLGQDAEICLLKSGELMIKLPLTVEEIA ENSP00000441178/1-1498 GASKGLGNLLCESSACRDTTSTSLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIA ENSCPOP00000007288/1-1432 -----------------DTTSNSLTSEDAEGMPMGQDTEICLLKSGELMIKLPLTVEEIA XP_004835093.1/1-1444 -----------------DTTSNSLTPEDTEDMPVGQDAEICLLKSGELMIKVPLTVDEIA ****.***.**:*.:*:***:*************:****:*:* ENSMUSP00000081764/1-1437 SFGEGSRELFVRSSTYSLITITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKV ENSRNOP00000008630/1-1451 SFGEGNRELFVRSSTYSLIPITVAEPGLTISWVFSSDPKSISFSVVFQETEDTPLDQCKV ENSP00000441178/1-1498 SFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKV ENSCPOP00000007288/1-1432 SFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFREAEDTPLDQCKV XP_004835093.1/1-1444 SFGEGSRELFVRSSTYSLIPITVAEPGLTISWVFSSDPKSISFSVVFREAEDAPLDQCKV *****.*************.*****.*********************:*:**:******* ENSMUSP00000081764/1-1437 LIPTTRCNSHKENIRGQLKVRIPGIYLLIFDNTFSRFISKKVLYHLTVDRPVIYDGSDFP ENSRNOP00000008630/1-1451 LIPTTRCNSHKESIRGQLKVRTPGIYLLIFDNTFSRFISKKVFYHLTVDRPVIYDGSDFP ENSP00000441178/1-1498 LIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL ENSCPOP00000007288/1-1432 LIPTTRCHSHKESIRGQLKVRSPGIYMLIFDNTFSRFISKKVFYHLTVDRPVIYDGSDFL XP_004835093.1/1-1444 LIPTTRCHSHKESIQGQLKVRTPGIYMLIFDNTFSRFISKKVFYHLTVDRPVIYDGSDFP *******:****.*:****** ****:**********:****:****************