CLUSTAL W(1.81) multiple sequence alignment ENSP00000355060/1-1279 -----MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSL ENSCPOP00000007285/1-1283 AGPCLMASSNPPAQPAIGDPLVPAAPGPYPEVEEDPGEVFEFDDSDDEEDTSTGLGDPLL XP_004850452.1/1-1276 -----MASSNPPAQPAVGDLLVPAAPGPSPEVE-DPGEAFEFDDSDDEEDTSTGLGVPCL ENSMUSP00000101425/1-1280 -----MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGL ENSRNOP00000066971/1-1207 -----MASSNPPPQPAIGDPLAPRAPGPSPEVEEDSGEAFEFDDSDDEEDTNTGLVVPGL *******.***:* *.* .*** .*.* *.**.*******:****.:.* * * ENSP00000355060/1-1279 APERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSR ENSCPOP00000007285/1-1283 APERHDDPPLIHFDSAPGSDPDSATAPPQTEVPAVVSNGHAVDVAFSEVQRSSWKRKSSR XP_004850452.1/1-1276 APERN-EPLLIHFDSTLGSDLDPATAPPQTEVPAVVSNGDAVDVVFSGVQRSSWKRKSSR ENSMUSP00000101425/1-1280 APERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSR ENSRNOP00000066971/1-1207 APERDTEPSLICFDTVPSSDLDPAAAPPQTEAPTVVSNGDAVGAALSGVRHSSWKRKSSR ****. :* ** :*: :* *.*:*** * .*: ****.*....:* .::********* ENSP00000355060/1-1279 RIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFE ENSCPOP00000007285/1-1283 RIDRFTFPALEEDVIYDDVPCESPDAHQPGVERNLLDEEARR--APREAEDLGWSSSEFE XP_004850452.1/1-1276 RIDRFSFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDVQR--AAREPEDLGWSSSEFE ENSMUSP00000101425/1-1280 RIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFE ENSRNOP00000066971/1-1207 RIDRFTFPALEEDVIYDDVPCESPDAHQPGLSLGRRGRAMLRGGAAPST---------F- *****:************************ . . . * *. .. * ENSP00000355060/1-1279 SYSEDSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQEL ENSCPOP00000007285/1-1283 SYSEDSAEEAKP--EVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQEL XP_004850452.1/1-1276 SYSEDSGEEAKP--EAEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQEL ENSMUSP00000101425/1-1280 SYSEDSGEETKP--EAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQEL ENSRNOP00000066971/1-1207 ------------------------------------------------------------ ENSP00000355060/1-1279 KHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSD ENSCPOP00000007285/1-1283 KHKYDYKMTQLMKAAKSGTKDGLEKTRMAVMRRVSFLHRKDVLGDSEEEDMGLLEVSVTD XP_004850452.1/1-1276 KHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVTD ENSMUSP00000101425/1-1280 KLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTD ENSRNOP00000066971/1-1207 -----TQMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDTLGDSEEEDMGLLEVGVTD :************:************:********.**************.*:* ENSP00000355060/1-1279 IKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALS ENSCPOP00000007285/1-1283 IKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKVLS XP_004850452.1/1-1276 IKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALS ENSMUSP00000101425/1-1280 IKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALS ENSRNOP00000066971/1-1207 IKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALS ************:********************************************.** ENSP00000355060/1-1279 ARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVN ENSCPOP00000007285/1-1283 VRKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKCMVLDVYSDYVN XP_004850452.1/1-1276 VRKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVN ENSMUSP00000101425/1-1280 ARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVN ENSRNOP00000066971/1-1207 ARKCQMVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASLSKSMMSEPFSHCIL .****:***************************************:**.*: : :*. : ENSP00000355060/1-1279 NFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN ENSCPOP00000007285/1-1283 NFTNAMSIIKKACLTKPSFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN XP_004850452.1/1-1276 NFTNAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN ENSMUSP00000101425/1-1280 NFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKN ENSRNOP00000066971/1-1207 PFSRAVAWVRVAFLSRPRDCESRGRGCVCACPCVCMHVCMCVYVVQCTCSLWPWQDMLKN *: *:: :: * *::* * * **: * :: * : : . : ****** ENSP00000355060/1-1279 TPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQR ENSCPOP00000007285/1-1283 TPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQR XP_004850452.1/1-1276 TPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQR ENSMUSP00000101425/1-1280 TPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQR ENSRNOP00000066971/1-1207 TPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQR ************************************************************ ENSP00000355060/1-1279 QLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGP ENSCPOP00000007285/1-1283 QLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGP XP_004850452.1/1-1276 QLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGP ENSMUSP00000101425/1-1280 QLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGP ENSRNOP00000066971/1-1207 QLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFNPKSRRGQLEISSLVPLGP *****************************************:* .:************** ENSP00000355060/1-1279 KYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQE ENSCPOP00000007285/1-1283 KYVVKWNTALPQVQVVEVGQDGGAYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQE XP_004850452.1/1-1276 KYVVKWNTELPQVQVVEVGQDGGAYDKDNVLIQHSGAKKASATGQAQNKVCLGPPRLFQE ENSMUSP00000101425/1-1280 KYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQE ENSRNOP00000066971/1-1207 KYVVKWNTALPQVQVVEVGQDGGAYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQE ******** **************:*****:****:*****:*:******* ********* ENSP00000355060/1-1279 LQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLR ENSCPOP00000007285/1-1283 LQDLQKDLAVVEQITLLVSTLHGTYQNLNMTVAQDWCLALQRLLRVKEEEIHSANKCRLR XP_004850452.1/1-1276 LQDLQKDLAVVEQITLLVSTLHGTYQNLNMAVAQDWCLALQRLLRVKEEEIHSANKCRLR ENSMUSP00000101425/1-1280 LQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLR ENSRNOP00000066971/1-1207 LQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLR *****************:************:************:**************** ENSP00000355060/1-1279 LLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSK ENSCPOP00000007285/1-1283 LLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDRKSK XP_004850452.1/1-1276 LLLPGKPDKSGRPISFMVIFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDRKSK ENSMUSP00000101425/1-1280 LLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSK ENSRNOP00000066971/1-1207 LLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSK ******************:*************************************:*** ENSP00000355060/1-1279 APFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGA ENSCPOP00000007285/1-1283 APFWCPILACCVPAFSSRALNLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGA XP_004850452.1/1-1276 APFWCPILACCVPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGA ENSMUSP00000101425/1-1280 APFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGA ENSRNOP00000066971/1-1207 APFWCPILACCVPAFSSRALSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGA ***********:******:*.****.*******.************************** ENSP00000355060/1-1279 GGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSA-TVHPTI ENSCPOP00000007285/1-1283 GGQVEIFSLNRPSPRTVKSFPLAAAVLCMEYIPEPEEDPEGGDESQVAADPTAGTVHPTI XP_004850452.1/1-1276 GGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPEPEEDPEGRQESRVSADPSAGTVHPTI ENSMUSP00000101425/1-1280 GGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSV-TVHPTV ENSRNOP00000066971/1-1207 GGQVEIFSLNRPSPRTVKSFPLSAPVLCIEYIPDPEEEAEGAEESRATTDPSV-TVHPTV *********************::*.***:****: **:.*. :** . :**:. *****: ENSP00000355060/1-1279 CLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSG ENSCPOP00000007285/1-1283 CLGLQDGSILLYGSVDTGTQCLATCRSPGLQPVLCLRHSPSHLLAGLQDGTLAAYPRTSG XP_004850452.1/1-1276 CLGLQDGSILLYGSVDTGTQCLASCRTPGLQPVLCLRHSASYLLAGLQDGTLAAYPHSSG ENSMUSP00000101425/1-1280 CLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSG ENSRNOP00000066971/1-1207 CLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHGPFYLLAGLQDGTLAAYPRTSG ************.*********.:*::** ********.. :**************::** ENSP00000355060/1-1279 GVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPWVTVLEATTLQPQQSFEAHQDEAV ENSCPOP00000007285/1-1283 AVPWDLESPPVCLTVGPGPIRTLLSLEDAVWASCGSRVTVLDATSLRTQQSFEAHQDEAV XP_004850452.1/1-1276 GVPWDLESLPMCLTVGPGPVRTLLSLEDAVWASCGPRVTVLDGTTLQTQQSFDAHQDEEV ENSMUSP00000101425/1-1280 DIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAV ENSRNOP00000066971/1-1207 EIPWDLESPPVCLTVGPGPIRTLLSLEDAAWASCGARVTVLDAATLQTQQSFEAHQDEAV : ***** *:*:******:*********.*****. ****:.::*:.****:***** * ENSP00000355060/1-1279 SVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLIC ENSCPOP00000007285/1-1283 SVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLIC XP_004850452.1/1-1276 SVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKRLCVTSLLIC ENSMUSP00000101425/1-1280 SVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLIC ENSRNOP00000066971/1-1207 SVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLIC *******************:******************************:********* ENSP00000355060/1-1279 QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSD ENSCPOP00000007285/1-1283 QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSD XP_004850452.1/1-1276 QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLTVATSILAPDILRSD ENSMUSP00000101425/1-1280 QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSD ENSRNOP00000066971/1-1207 QGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSD *********************************************:** *********** ENSP00000355060/1-1279 QEEAEGPRAEEDKPDGQAHE--PMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMRE ENSCPOP00000007285/1-1283 HEEAEGPRAEEDKLDGQAQEPAPVPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMRE XP_004850452.1/1-1276 QEEAEGPRAEEDKLDGQGQELAPAPNSHMGRELTRKKGILLQYRLRSTAHLPGPLLSMRE ENSMUSP00000101425/1-1280 QEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVRE ENSRNOP00000066971/1-1207 QEEAEGPQAEEDKPDGQAHETVPAPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVRE :******:***** ***.:* * *:** .***************************:** ENSP00000355060/1-1279 PAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGS ENSCPOP00000007285/1-1283 PSPADSSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRNFSS XP_004850452.1/1-1276 PEPGDSSALEHSEEDGSIYEMADDPDVWVRSRPCTRDAHRKEICSVAIISGGQGYRNFGS ENSMUSP00000101425/1-1280 PAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGG ENSRNOP00000066971/1-1207 PAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGS * *.*.:*******************:*******:*********************:*.. ENSP00000355060/1-1279 AL-GSSGRQAPCGETDSTLLIWQVPLML ENSCPOP00000007285/1-1283 GP-GVSGRPAPCGETDSTLLIWQVPLML XP_004850452.1/1-1276 AL-GSSGKPALCGDSDSTLLIWQVPLML ENSMUSP00000101425/1-1280 APGGLSGRAAPCSETDSTLLIWQVPLAL ENSRNOP00000066971/1-1207 APGGLSGRPAPCSETDSTLLIWQVPLAL . * **: * *.::*********** *