CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000101480/1-1439 MTLPHSPGSAGEPQASQTVQVHRLEHRQEEEQKEERQHSLQMGSSVQRRTYR-SSEEEQQ ENSRNOP00000045729/1-1439 MTLPHSPGSAGEPQASQTVQVHRLEHKHEEEQKEEREHSLRMGSSVQRRTYR-SSEEEQQ ENSP00000332670/1-1440 MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGSSVRRRTFRSSSEEEHE ENSCPOP00000007217/1-1443 MTLPHNPGGGGEPQNPQAVQVHRLEHRREEEQKEQRQHSLHMGSSVRRRTFRSSSEEEHQ XP_004850644.1/1-1440 MTLPHSPGSVGESQPPQAIQVHRLEHRQEEEQKEERQHSLHMGSSVRRRTYH-SSEEEHQ *****. *. *:.: .*:::******::******:*:***:*****:***:: *****:: ENSMUSP00000101480/1-1439 FSSEDYALAAALALTASSELSWEAKLRRQTTTVELEERGQRRVGFGNDLERMELAFLRTQ ENSRNOP00000045729/1-1439 FSPEDYALAAALALTASSELSWEAKLRRQTTRVELEERGQKRIGFGNDLERMEMAFLRTQ ENSP00000332670/1-1440 FSAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRVGFGNDWERTEIAFLQTH ENSCPOP00000007217/1-1443 FSAADYALAAALALTASSELTWEARLRRQTSAVELEERGQKRVRFANAWERAEAGYLRTH XP_004850644.1/1-1440 FSAADYALAAALALTASSELSWEAQLRRQSSAVELEERGQKRVGFGNDCERTEVDYLHTQ **. ****************:***:****:: ********:*: *.* ** * :*:*: ENSMUSP00000101480/1-1439 RLLRQRRDWKALRQRTEEKVREAKELIELCSGRGPWFWIPLRSHAVWEHTTVLLTCTVQG ENSRNOP00000045729/1-1439 RLLRQRRDWKALRQRTEQKVLEAKELIELCSGRGPWFWIPLRSHAVWEYTTVLLTCTIQG ENSP00000332670/1-1440 RLLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWEHTTVLLTCTVQA ENSCPOP00000007217/1-1443 RLLRQRRDRRALRQRTEEKIREAKELRELCAGRGPWFWIPLRSHAVWEHTTVLLTCTVQG XP_004850644.1/1-1440 RLVRQHRDWKALGQWTEEKVQRAKELRELCSGRGPWFWIPLRSHAVWEHTTVRLTCTIQG **:**:** ::* : **:*: .**** *** *****************:*** ****:*. ENSMUSP00000101480/1-1439 SPPFQVTWYKNDIRIDPRLFPAGKYRITNNYGLLTLEIMRCTVEDSATYTVLVKNAYGQA ENSRNOP00000045729/1-1439 SFPFQVTWYKDDIQIDPRLFPAGKYRITNNYGLLTLEIRRCTVEDSATYTVLVKNAFGQA ENSP00000332670/1-1440 SPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIRRCAIEDSATYTVRVKNAHGQA ENSCPOP00000007217/1-1443 SPPPQVTWYKGDVPIDPRLFPAGKYHITNNYGLLALEIRRCTMEDSATYTVKVKNAYGQA XP_004850644.1/1-1440 SPPPQVTWYKNDMRIDPRLFSAGKYRITNNYGLLSLEIRRCTMEDSATYTVKVKNAYGQA * * ******.* ****** ****:********:*** **::******** ****.*** ENSMUSP00000101480/1-1439 SSFAKVLIRNYLGKDAGFDSEIFKRSMFGPSAEFTSVLKPIFAQEKEPFSLTCLFSDDVL ENSRNOP00000045729/1-1439 SSFAKVLIRTYLGKDAGFDSEIFKRSMFGPTVEFTSVLKPIFAQEKEPFSLTCLFSDDVL ENSP00000332670/1-1440 SSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVL ENSCPOP00000007217/1-1443 SSFAKVLVRTYLGKEAGFDSEIFKRAMFGPSVDFTSVLRPVFAREKEPFSLSCLFSDDVS XP_004850644.1/1-1440 SSFAKVLVRTYLGKEAGFDSEIFKRSMFGPSVEFTSVLKPVFAREKEPFSLSCIFSDDVL *******:*.****:**********: ***:.:*****:*:**:*******:*:**:** ENSMUSP00000101480/1-1439 EAEQRIQWYRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSA ENSRNOP00000045729/1-1439 EAEERIQWFRDGRLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTIRVSSPFGPQEQSA ENSP00000332670/1-1440 DAE-SIQWFRDGSLLRSSRRRKILYTDRQASLKVSCTYKEDEGLYMVRVPSPFGPREQST ENSCPOP00000007217/1-1443 DAEQNIQWFRDGRALRSSRRWQILYADRQASLKVTCAYKEDEGLYSIRVPSATGPREQSA XP_004850644.1/1-1440 HAEQNIQWFRDGRALRSSGHRQILYSDRQASLKVSCAHKEDEGLYSIRVSSPLGPREQST .** ***:*** **** : :***:*****:**:*::*****:* :**.*. **:***: ENSMUSP00000101480/1-1439 YVFIRDAAAEKPGAPGSPLNVRCLNVHRDCLTLTWVPPSDTRGSTITGYSIEMCQGDSEE ENSRNOP00000045729/1-1439 YVFIRDAAAEKPGAPGSPLNVRCLNVHRDCLTLTWVPPSDTRGSTITGYSIELCQGDSEE ENSP00000332670/1-1440 YVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQGESGE ENSCPOP00000007217/1-1443 YVFVRDAAAETPGAPGSPLNVRCLEVNRDCLILTWAPPSDTRGNPITGYAIELCQGDSEE XP_004850644.1/1-1440 YVFVRDAAAEKPGAPGSPLNVRCLNVSRDCLILTWAPPSDTRGNPITSYSIERCQGNSEE **::*** **.*************:* **** ***.*******..**.*:** ***:* * ENSMUSP00000101480/1-1439 WMPCLKAPGGTCRCPIQGLVEGQSYQFRVRAISKAGTSLPSKASEAVVTGDYDAVHKSTE ENSRNOP00000045729/1-1439 WVPCLKTPGGTCRCPIQGLIEGQSYRFRVRAISKAGTSLPSKASAAVVMGDYDTVQKKTE ENSP00000332670/1-1440 WIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVGSSVPSKASELVVMGDHDAARRKTE ENSCPOP00000007217/1-1443 WVPCHEAPGSTCRCPIQGLLEGQSYRFRVRAISKAGSSLPSKASEVVVMGPRDAVHRKTE XP_004850644.1/1-1440 WVPCHEAPGGTCRCPIQGLIEGQSYRFRVRAISKAGHSLPSKASEVVVMRDPDAAQRKTE *:.* ::**.*********:*****:*******:.* *:***** ** *:.::.** ENSMUSP00000101480/1-1439 IPYDLGSKITISKNDFEDAV-TIPSAPTNVHASEIREAYAVLSWEEPRPRGRAPLTYTLE ENSRNOP00000045729/1-1439 IPFDLGRKITISKNDFEDAV-TIPSAPTNVHASEIRDTYAVLSWEEPHPRGRAPLTYTLE ENSP00000332670/1-1440 IPFDLGNKITISTDAFEDTV-TIPSPPTNVHASEIREAYVVLAWEEPSPRDRAPLTYSLE ENSCPOP00000007217/1-1443 IPFDLGSKITISMDDFEAVL-VIPLPPTNVHASEIREAYVILSWEEPRPRGKAPLTYALE XP_004850644.1/1-1440 IPFDLGSKITVSMADFEDAMTTIPSPPTNVHASEILESYVVLSWEEPRPRGKAPLTYALE **:*** ***:* ** .: .** .********* ::*.:*:**** **.:*****:** ENSMUSP00000101480/1-1439 KSVIGSGTWEAISTETPIKSPRFALLDLEKGKSYVFRVRALNQYGMSDPSEPSEPVALKG ENSRNOP00000045729/1-1439 KSVIGSGTWEAISSETPIKSPRFALLDLEKGKSYVFRVRALNQYGMSDPSEPSEPITLKG ENSP00000332670/1-1440 KSVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRG ENSCPOP00000007217/1-1443 KSVIGSGTWETISSETPVKSPRFALLNLEKGKSYVFRVRAMNQYGISDPSEPSEPIALRG XP_004850644.1/1-1440 KSVIGSGTWEAISSENPVKSPRFALLNLEKGKSYVFRVRAMNQYGMSDPSEPSKPVALRG **********:**:*.*::*****:*:*** *********:****:*******:*::*:* ENSMUSP00000101480/1-1439 KPATLPPPAQVQAFRNTQTSVSLAWEPVDGGSELLGYYIYSREAGASEWQTVNNKPIQDT ENSRNOP00000045729/1-1439 KPATLPPPAQVQSFRNTQTSVSLTWEPVDGGSELLGYYIYSREAGASEWQTVNNKPIQDT ENSP00000332670/1-1440 PPATLPPPAQVQAFRDTQTSVSLTWDPVK-DPELLGYYIYSRKVGTSEWQTVNNKPIQGT ENSCPOP00000007217/1-1443 KKATLPPPAQVQAFRDTQTSVSLTWDPVDGGAELLGYYIYSREAGSSEWQTVNNKPIQGS XP_004850644.1/1-1440 KTATLPPPAQVQAFRDTQTSVFLTWDPVNGGAELLGYYIYSREAGSSEWQTVNNKPIQGS **********:**:***** *:*:**. ..**********:.*:************.: ENSMUSP00000101480/1-1439 KFTVPGLRTGKEYDFCIRSVSEAGVGESSAATQPVRVKQALATPSAPYDFALLNCGKNEM ENSRNOP00000045729/1-1439 KFTVPGLRTGKEYEFCIRSVSEAGVGESSAVTQPIRVKQALATPSAPYDFALLNCGKNEM ENSP00000332670/1-1440 RFTVPGLRTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEM ENSCPOP00000007217/1-1443 RFTVPGLRTGKEYEFCVRSVSEAGVGDSSAPTEPIRVKQALATPSAPYDFALLHCGKNEM XP_004850644.1/1-1440 RFTVPGLRTGKEYEFCIRSVSEAGVGESSAPTEPIRAKQALATPSAPYDFALLHCGKNEM :************:**:*********:*** *:*:*.***********.****:****** ENSMUSP00000101480/1-1439 VIGWKPPKRRGGGKILGYFMDQHDSVESDWHPVNRQPIPSRVCKVTNLHEGHFYEFRARA ENSRNOP00000045729/1-1439 VIGWKPPKRRGGGKILGYYVDQHDSEELDWHPVSHQPNPSRVCKVTNLHEGHFYEFRARA ENSP00000332670/1-1440 VIGWKPPKRRGGGKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARA ENSCPOP00000007217/1-1443 VIGWKPPKRRGGGKILGYFLDQHDSEEPDWHPVNQQPVPSRVCKVSDLHEGHFYEFRARA XP_004850644.1/1-1440 VIGWKSPKHRGGGKILGYYLDQHDSEEPDWHPVNQQPVPSRVCKVSNLHEGHFYEFRARA *****.**:*********::***** * ***.*.:** *:*****::************* ENSMUSP00000101480/1-1439 VNWAGIGELSAPSSLFECKEWTMPEPGPPYDVRVSEVQATSVMLQWEPPLYIGAGPVTGY ENSRNOP00000045729/1-1439 MNWAGIGELSAPSSLFECKEWTMPEPGPPYDVRASEIQATSVMLQWEPPLYIGAGPVTGY ENSP00000332670/1-1440 ANWAGVGELSAPSSLFECKEWTMPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGY ENSCPOP00000007217/1-1443 VNWAGVGELSAPSSLFECKEWTMPQPGPPYDVQASEVRATSLMLQWEPPIYTGAGPVTGY XP_004850644.1/1-1440 ANWAGVGELSAPSSLFECKEWTMPQPGPPYDVQVSEVRATSLMLQWEPPVYTGAGPVTGY ****:******************:*******:.**::***::******:* ******** ENSMUSP00000101480/1-1439 HVSFQEKGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNSAGLGQPSVPTDPVLL ENSRNOP00000045729/1-1439 RVSFQEIGSEEWKPVTPDATSDTHLRVSDLQPGKQYMFRVQAMNSAGLGQPSVPTDPVLL ENSP00000332670/1-1440 HVSFQEEGSEQWKPVTPGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLL ENSCPOP00000007217/1-1443 CISVQEEGSEEWKQITPHPVSATHFRVSDLQTGKKYVFQVQAMNSAGLGQPSMPTDPVLL XP_004850644.1/1-1440 RISFQEEGSEEWKQITPHSISDTHFRVSDLQTGKRYVFQVQAMNSAGLGQPSMPTDPVLL :*.** ***:** :** . * **:******.** *:*:*************:******* ENSMUSP00000101480/1-1439 EDKPDAQEIEVGVDDEGQIYLAFEAPEAPDFPEFQWSKDYQGPPDPQRVEVEDEISKSKV ENSRNOP00000045729/1-1439 EDKPDAHEIEVGVDEEGQIYLAFEAPEAPDFPEFQWSKDYKGPPDPQRVEVKDEINKSKV ENSP00000332670/1-1440 EDKPGAHEIEVGVDEEGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKV ENSCPOP00000007217/1-1443 EDKPDAHEIEVGVDEEGQIYMAFEAPEAPDDSEFQWSKDYKGPPDPQRVKVEDGVNKSKI XP_004850644.1/1-1440 EDKPDAHKIEVGVDEEGQIYLAFEAPEAPDDSEFQWSKDYQGPPDPQRVQVQDEANKSKV ****.*::******:** **:********* .********:** *****:::* .***: ENSMUSP00000101480/1-1439 ILKEPDLQDLGIYSVVVPDADEDTSASHTLTEEELNKLKKLSHEIRNPVIKLISGWNVEI ENSRNOP00000045729/1-1439 ILKEPDLQDLGVYSVVVTDADEDTSASHTLTEEELNKLKKLSHEIRNPVIKLISGWNVDI ENSP00000332670/1-1440 ILKEPGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDI ENSCPOP00000007217/1-1443 ILKEPDLQDLGTYSVTVTDADEDISASHTLTEEELDKLKKLSHEIRNPVIKLISGWNIDI XP_004850644.1/1-1440 ILKEPDLQDLGTYTVVVTDADEDISASHTLTEEELDKLKKLSHEIRNPVIKLISGWNIDI *****.*:*** *:* *.***** ***********:*********************::* ENSMUSP00000101480/1-1439 LEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFDREKGLVEVIIQQLSEDDKG ENSRNOP00000045729/1-1439 LEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFDREKGLVEVIIQQLSEDDKG ENSP00000332670/1-1440 LERGEVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKG ENSCPOP00000007217/1-1443 LERGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRTINFDREKGLVEVIIQQLTEDDKG XP_004850644.1/1-1440 LEQGEVRLWLEVEKLSPAAELHLIFNEKEIFSSPNRKINFDREKGLVEVIIQHLSEDDKG **:***********************:*********.***************:*:*:*** ENSMUSP00000101480/1-1439 SYTAQLQDGKAKNQITLALVDDEFDKLLRKADAKRRDWKRKQ---GPYFQEPLTWKVTDD ENSRNOP00000045729/1-1439 SYTAQLQDGKAKNQITLALVDDDFDKLLRKADAKRRDWKRKQ---GPYFQDPLTWKVTED ENSP00000332670/1-1440 SYTAQLQDGKAKNQITLTLVDDDFDKLLRKADAKRRDWKRKQGT-GPYFERPLQWKVTED ENSCPOP00000007217/1-1443 SYTAQLQDGKAKNQITLALVDDDFDQLLRKADAKRKDWKRKQGPTGPYFQEPLQWKVTED XP_004850644.1/1-1440 SYTAQLQDGKAKNQITLALVDDDFDQLQRKADAKRRDWKRKQ---GPYFQEPLQWKVTED *****************:****:**:* *******:****** ****: ** ****:* ENSMUSP00000101480/1-1439 CQVLLSCKVTNTKKESRFQWFFQKKEAPHGQYNPPTGDGSLSIEGFSKENQGVYRAVVSD ENSRNOP00000045729/1-1439 CQVLLTCKVTNTKKETRFQWLFQKKEAPRGQYSPQTGDGSLCIEEFSKEDQGLYRAVVSD ENSP00000332670/1-1440 CQVQLTCKVTNTKKETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSD ENSCPOP00000007217/1-1443 CQVLLTCKVTNTKKETRFQWFFRKREVPDGQYDPQTGEGLIRIEELSKEDKGIYRAEVSD XP_004850644.1/1-1440 CRVLLTCKVTNTKKETRFQWFFQKREAPDGQYDPQTGEGLICIEELSRENKGLYRAVVSD *:* *:*********:****:*:: * * ***.* ** * : ** :*::::*:*** *** ENSMUSP00000101480/1-1439 ERGEDDTVLDLTGEALDAVLTELGRIGALSATPLKIQGTEEGIRLFSKVKYYNVDYMKTA ENSRNOP00000045729/1-1439 ERGEDDTVLDLTGEALDAVLTELGRISALSATPLKIQGTEEGIRLFSKVKYYNVDYMKTA ENSP00000332670/1-1440 DRGEDDTILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTT ENSCPOP00000007217/1-1443 DRGEDDTILDLTGEDLDAIFTELGRISALSATPLKIQGTEEGIRIFSKVKYYNVDYMKTT XP_004850644.1/1-1440 DRGEDDTILDLTGEALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTT :******:*****: ***::******.*****************:*********:****: ENSMUSP00000101480/1-1439 WFHKDKRLESGDRVRAGTTLDEIWLHILDPKDSDKGKYTLEITAGKEVRQLSADLSGQAF ENSRNOP00000045729/1-1439 WFHKDKRLESGDRVRAGTTLDEIWLHILDPKDSDKGKYTLEITAGKEVCQLSADLSGQAF ENSP00000332670/1-1440 WFHKDKRLESGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAF ENSCPOP00000007217/1-1443 WFHKDKRLESGDRFRAGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEARQLSVDLSGQAF XP_004850644.1/1-1440 WFHKDKRLESSDRIRAGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSVDLSGQAF **********.**.*:**************************:****. ***.******* ENSMUSP00000101480/1-1439 DDALAEHQRLKALAVIEKNRAKVVRGLPDVATIMEDKTLCLTCVISGDPSPEISWLKNDQ ENSRNOP00000045729/1-1439 DDALAEHQRLKALAVIEKNRAKVVRGLPDVATIMEDKTLCLTCVISGDPSPEISWLKNDQ ENSP00000332670/1-1440 EDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQ ENSCPOP00000007217/1-1443 DDALAEHQRLKALAIIEKNRAKVVRGLPDVATIMEDKTLCLTCVISGDPAPEIFWLKNDQ XP_004850644.1/1-1440 DDALAEHQRLKDLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCVISGDPTPEISWLKNDQ :**:******* **:****************************::****:*** ****** ENSMUSP00000101480/1-1439 PISFFDRYHMEVKGTEVTVTIDKVTSEDSGRYGIFVKNKYGSETGQVTISVFKHGEEPKE ENSRNOP00000045729/1-1439 PVSFLDRYHMEVKGTEVTITIDKVTSEDSGRYGIFVKNKYGSETGQVTISVFKHGEEPKE ENSP00000332670/1-1440 PVTFLDRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKE ENSCPOP00000007217/1-1443 PVNFLDRYRMDVRGTEVTITIEKVTSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKE XP_004850644.1/1-1440 PVTFLDRYHMDVKGTEVTITIKKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKE *:.*:***:*:*:*****:**.**.********:*********************:**** ENSMUSP00000101480/1-1439 LKKK ENSRNOP00000045729/1-1439 LKKK ENSP00000332670/1-1440 LKSM ENSCPOP00000007217/1-1443 LKKM XP_004850644.1/1-1440 LKKM **.