CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000007200/1-1070 ------------------------------------------------------------ XP_004847647.1/1-1061 ------------------------------------------------------------ ENSP00000259698/1-1068 ------------------------------------------------------------ ENSMUSP00000106013/1-1078 ------------------------------------------------------------ ENSRNOP00000048390/1-1310 MQHCLEQSDITQYQQYYSSWCDARALGPRLSPVALSLLVGRNEHRLSAEPEVHRSQGRCV ENSCPOP00000007200/1-1070 ---------------------------------GLPTRLPETMLVGSQSFSPGGPNGIIR XP_004847647.1/1-1061 ------------------------------------------MLVGSQSFSPGGPNGIIR ENSP00000259698/1-1068 ------------------------------------------MLVGSQSFSPGGPNGIIR ENSMUSP00000106013/1-1078 ---------------MPPG--TKRLRALGAFSAGLPTRLPEIMLVGSQSFSPGGPNGIIR ENSRNOP00000048390/1-1310 GVEVPREDINYLSTTCKPEIKSRNLKEDSEDQGRLPTRLPEIMLVGSQSFSPGGPNGIIR ****************** ENSCPOP00000007200/1-1070 SQSFAGFSGLQERRSR---------------------------------------CNSFI XP_004847647.1/1-1061 SQSFAGFSGLQERRSR---------------------------------------CNSFI ENSP00000259698/1-1068 SQSFAGFSGLQERRSR---------------------------------------CNSFI ENSMUSP00000106013/1-1078 SQSFAGFSGLQERRSR---------------------------------------CNSFI ENSRNOP00000048390/1-1310 SQSFAGFSGLQERRSRQVLGVSPGITRAPSKDVYCKPGYACRVEFLLCKAFSKQTCNSFI **************** ***** ENSCPOP00000007200/1-1070 ENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKL XP_004847647.1/1-1061 ENSSALKKPQAKLKKMHNLGHKNNNHPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKL ENSP00000259698/1-1068 ENSSALKKPQAKLKKMHNLGHKNNNPPKEPQPKRVEEVYRALKNGLDEYLEVHQTELDKL ENSMUSP00000106013/1-1078 ENASALKKPQAKLKKMHNLGHKNNNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKL ENSRNOP00000048390/1-1310 ENASALKKPQAKLKKMHNLGHKNTNTPKEPQPKRVEEVYRALKNGLDEYLEFHQTELDKL **:********************.* *************************.******** ENSCPOP00000007200/1-1070 TAQLKDMKRNSRLGVLYDLDKQMKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKM XP_004847647.1/1-1061 TAQLKDMKRNSRLGVLYDLDKQMKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKM ENSP00000259698/1-1068 TAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKM ENSMUSP00000106013/1-1078 TAQLKDMKRNSRLGVLYDLDKQIKTIERYMRRLEFHISKVDELYEAYCIQRRLQDGASKM ENSRNOP00000048390/1-1310 TAQLKDMKRNSRLGVLYDLDKGVL----------YDLDKVDELYEAYCIQRRLQDGASKM ********************* : :.:.********************** ENSCPOP00000007200/1-1070 KQAFAMSPASKAARESLSEINRSYKEYTENMCTIEAELENLLGEFSIKMKGLAGFARLCP XP_004847647.1/1-1061 KQAFAMSPASKAARESLSEINRSYKEYTENMCTIEAELENLLGEFSIKMKGLAGFARLCP ENSP00000259698/1-1068 KQAFATSPASKAARESLTEINRSFKEYTENMCTIEVELENLLGEFSIKMKGLAGFARLCP ENSMUSP00000106013/1-1078 KQAFATSPASKAARESLSEINRSYKEYTENMCAIEAELESLLGEFSIKMKGLAGFARLCP ENSRNOP00000048390/1-1310 KQAFATSPASKAARESLSEINRSYKEYTENMCTIEAELESLLGEFSIKMKGLAGFARLCP ***** ***********:*****:********:**.***.******************** ENSCPOP00000007200/1-1070 GDQYE------------------------------------IFMKYGRQRWKLKGKIEVN XP_004847647.1/1-1061 GDQYE------------------------------------IFMKYGRQRWKLKGRIEVN ENSP00000259698/1-1068 GDQYE------------------------------------IFMKYGRQRWKLKGKIEVN ENSMUSP00000106013/1-1078 GDQYE------------------------------------IFMKYGRQRWKLKGKIEVN ENSRNOP00000048390/1-1310 GDQYESMDGPNPYQRQQGEVYFSLLATRRIGDGSCLSKGARIFMKYGRQRWKLKGKIEVN ***** **************:**** ENSCPOP00000007200/1-1070 GKQSWDGEEMVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAAHPQVVAVDIND XP_004847647.1/1-1061 GKQSWDGEETVFLPLIVGLISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDIND ENSP00000259698/1-1068 GKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDIND ENSMUSP00000106013/1-1078 GKQSWDGAETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDIND ENSRNOP00000048390/1-1310 GKQSWDGEETVFLPLIVGFISIKVTELKGLATHILVGSVTCETKELFAARPQVVAVDIND ******* * ********:******************************:********** ENSCPOP00000007200/1-1070 LGTIKLNLEFVWNPFDVEDMTPSSGAGNKAAALQRRMSMYSQGTPETPTFKDHAFFRWLL XP_004847647.1/1-1061 LGTIKLNLEITWYPFDVEDTTPSSGAGNKAVALQRRMSMYSQGTPDTPSFKDHAFFRWLL ENSP00000259698/1-1068 LGTIKLNLEITWYPFDVEDMTASSGAGNKAAALQRRMSMYSQGTPETPTFKDHSFFRWLH ENSMUSP00000106013/1-1078 LGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFFRWL- ENSRNOP00000048390/1-1310 LGTIKLNLEITWYPFDVEDTTPSSGPGNKTAALQRRMSMYSQGTPETPTFKDQSFF---- *********:.* ****** *.***.***:.**************:**:***::** ENSCPOP00000007200/1-1070 PSPDKPRRLSVLSALRDTVFAKPHGGRSVGDLPSLGLSPRAVLEFYSNLPDDIFENGKVA XP_004847647.1/1-1061 PSPDKPRRLSVFSALRDTVFAKPHGGCSVGDLPSLGLSPRAVLEFYSNLPDDIFEDGKAA ENSP00000259698/1-1068 PSPDKPRRLSVLSALQDTFFAKLHRSRSFSDLPSLRPSPKAVLELYSNLPDDIFENGKAA ENSMUSP00000106013/1-1078 -------RLSVLSALRDTFFATLHHNHSVGDLPSLSLNPKALLEFYSNLPDDIFESGKAA ENSRNOP00000048390/1-1310 ----------------------------------------------SNLPDDIFESGNAA *********.*:.* ENSCPOP00000007200/1-1070 EEKMPLSLSFSDLPDGDCTLTSSSAASPSSSCSANPEITITPAECSHGSLCSQSEGTGDS XP_004847647.1/1-1061 EEKMPLSLSLSDLPDGDCTLTSSSAVSPSSSSLANPEITITAAEHSHGSLCSQSEGTEDS ENSP00000259698/1-1068 EEKMPLSLSFSDLPNGDCALTSHSTGSPSNSTN--PEITITPAEFNLSSLASQNEGMDDT ENSMUSP00000106013/1-1078 EEKRPLSLSFSDLQDGDCVFTSSSATSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDS ENSRNOP00000048390/1-1310 EEKRPLSLSFSDLQDGDCVFTSSSTTSPSSSHSAHPEITITPAELTHSSLSSQNEGTEDS *** *****:*** :***.:** *: ***.* ******.** . .**.**.** *: ENSCPOP00000007200/1-1070 SSASSRSSLGQGQEPGCPTQ-GDAAEPGKTAVAT---------GASAKHLFLEDGVAEAL XP_004847647.1/1-1061 GSASSSSSLGQGQEPGCPLQ-GDTAEPEKAALAP---------VAGSKPLFLEDGVAEAL ENSP00000259698/1-1068 SSASSRNSLGEGQEPKSHLKEEDPEEPRKPASAPSEACRRQSSGAGAEHLFLENDVAEAL ENSMUSP00000106013/1-1078 SSASSRNSLGEDHEPKSHPK-SDTVEPGKPGVAT---------RSGTESLFLESSVAEAL ENSRNOP00000048390/1-1310 SSASSRNSLGEDHEPKSHSK-SDTVEPKKPSVDA---------RSGTESLFLENSVAEAL .**** .***:.:** . : *. ** *.. . :.:: ****..***** ENSCPOP00000007200/1-1070 LQESDEASELKPVELDTFEGNLTKQLVKRLTSAEGPAATERQLYEGSVSGESEGCRSFLD XP_004847647.1/1-1061 LQESDEASELKPVELDTFEGNLTKQLVKRLTSAEGPAAAERQLYEGSVSGESEGCRSFLD ENSP00000259698/1-1068 LQESEEASELKPVELDTSEGNITKQLVKRLTSAEVPMATDRLLSEGSVGGESEGCRSFLD ENSMUSP00000106013/1-1078 LQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPVTTDKLFFEGSVGSESEAGRSFLD ENSRNOP00000048390/1-1310 LQESDEASELKPVELDTFEGNITKQLVKRLTSAEGPITTNKLFFEGSVGSESEAGRSFLD ****:************ ***:************ * :::: : ****..***. ***** ENSCPOP00000007200/1-1070 GSLEDAFSGLFLALEPHKEQYKEFQALSQEVMHLDDILKCKPAGSRSRSSSLSLAVESAL XP_004847647.1/1-1061 GSLEDAFSGLFLALEPHKEQYKEFQDLSQEVLHLDDILKCKPTGSHSRSSSLSLAVESAL ENSP00000259698/1-1068 GSLEDAFNGLLLALEPHKEQYKEFQDLNQEVMNLDDILKCKPAVSRSRSSSLSLTVESAL ENSMUSP00000106013/1-1078 GSLEDAFNGLFLALDPHKKQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESAL ENSRNOP00000048390/1-1310 GSLEDAFNGLFLALDPHKEQYKEFQDLNQEVTHLDDVLKCKPAGSRSRSSSLSLTVESAL *******.**:***:***:****** *.*** :***:*****: *:********:***** ENSCPOP00000007200/1-1070 ESFDFLNTSDFDEEEEDGNEVCHV-GGGADSVFSDTETEKNSYRSVHPEARGHLSEALTE XP_004847647.1/1-1061 ESFDFLNTSDFD-EEEDGEEVCHVRGGGADSVFSDTETEKNSYRSVHPEARGHLSEALTE ENSP00000259698/1-1068 ESFDFLNTSDFD-EEEDGDEVCNV-GGGADSVFSDTETEKHSYRSVHPEARGHLSEALTE ENSMUSP00000106013/1-1078 ESFDFLNTSDFDEEEEDGDDVCHV-GGGADSVFSDTETEKSGYRSVHPEARGHLSEALTE ENSRNOP00000048390/1-1310 ESFDFLNTSDFDEEEEDGDEVCHV-GGGADSVFSDTETEKSG--SVHPEARGHLSEALTE ************ *****::**:* *************** . **************** ENSCPOP00000007200/1-1070 DTGVGTSVAGSPLPLTSGNESLDITIVHHLQYCTQLIQQIVFSSKTPFVARNLLEKLSRQ XP_004847647.1/1-1061 DTGVGTSVAGSPLPLTTGNESLDITIVRHLQYCTQLIQQIVFSSKTPFVARNLLEKLSRQ ENSP00000259698/1-1068 DTGVGTSVAGSPLPLTTGNESLDITIVRHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQ ENSMUSP00000106013/1-1078 DTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLIQQIVFSSKTPFVARSLLEKLSRQ ENSRNOP00000048390/1-1310 DTGVGTSVAGSPLPLTTGNESLDITIVKHLQYCTQLVQQIVFSSKTPFVARSLLEKLSRQ ****************:**********:********:**************.******** ENSCPOP00000007200/1-1070 TQVMEKLAAVSDENIGNISSVVEAIPEFHKKLSLLSFWTKCCSPSGVYHSSADRVIRQLE XP_004847647.1/1-1061 TRVVEKLAAVSDENIGNISSVMEAIPEFHKKLSLLSFWTKCCSPAGVYHSSADRVIRQLE ENSP00000259698/1-1068 IQVMEKLAAVSDENIGNISSVVEAIPEFHKKLSLLSFWTKCCSPVGVYHSPADRVMKQLE ENSMUSP00000106013/1-1078 VLVMQKLAAVSDENLGNITSVVEAIPEFHKKLSLLAFWTKCCSPSGVYHSSAARLIKQLE ENSRNOP00000048390/1-1310 VLVLQKLAAVSDENLGNITSVVEAIPEFHKKPSLLSFWTKCCSPSGVYHSSAAHLIKQLE *::*********:***:**:********* ***:******** *****.* ::::*** ENSCPOP00000007200/1-1070 ASFARVLNKEYPGLAEPVFRTLVSQILDQTEPLLSSNLSSEVVTVFQYHSYFTSHGVSDL XP_004847647.1/1-1061 TSFARALNKEYPGLAEPVFRTLVSQILDRAEPLLSSNLSSEVVTVFQYHSYFTSHGMSDV ENSP00000259698/1-1068 ASFARTVNKEYPGLADPVFRTLVSQILDRAEPLLSSSLSSEVVTVFQYYSYFTSHGVSDL ENSMUSP00000106013/1-1078 ASFARSINKDYPGLAEPVFRTLVSQILDRAEPLLSSSLSSEVITVFQYYSFFTSHGVSDL ENSRNOP00000048390/1-1310 ASFARNINKDYPGLAEPVFRTLVSQILDRAEPLLCSGLSSEVITVFQYYSFLTSHGVSDL :**** :**:*****:************::****.*.*****:*****:*::****:**: ENSCPOP00000007200/1-1070 ESYLSQLARQVSVVQTLQTLKDEKLLQTLSDLSPSNLPAQQEVLRTLALLLARDSSEVSE XP_004847647.1/1-1061 ESCLSQLARQVSMVQTLQSLREEKLLQTLNDLSPSNLPAQQEVFRTLALLLTRDSSEVSE ENSP00000259698/1-1068 ESYLSQLARQVSMVQTLQSLRDEKLLQTMSDLAPSNLLAQQEVLRTLALLLTREDNEVSE ENSMUSP00000106013/1-1078 ETYLGQLTRQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTRDDNEVSE ENSRNOP00000048390/1-1310 ETHLGQLARQVAMVQTLQSLRDEKLLQTMSDLAPSNLPAQQEVLRTLALLLTKDDNEVSE *: *.**:***::*****:*::******:.**:**** *****:*******:::..**** ENSCPOP00000007200/1-1070 AVGLFLTAASKNEHFREKALLYYCKALTETNLELQKGACLALRSLQATESIKMLVTLCQS XP_004847647.1/1-1061 AVRLFLTAASKNEHFREKALLYYCKTLTETNLELQKAACLALKTLQATESIKMLVNLCQS ENSP00000259698/1-1068 AVTLYLAAASKNQHFREKALLYYCEALTKTNLQLQKAACLALKILEATESIKMLVTLCQS ENSMUSP00000106013/1-1078 AVTLYLAAASKNEHFREKALLYYCEALTKANLQLQKAACLALKSLEATESIKMLVTLCQS ENSRNOP00000048390/1-1310 AVTLYLAAASKNEHFREKALLYYCEALTKTNLQLQKAACLALKSLEATESIKMLVTLCQS ** *:*:*****:***********::**::**:***.*****: *:*********.**** ENSCPOP00000007200/1-1070 DTEEMRTVASETLLSLG------------------------------------------- XP_004847647.1/1-1061 NTEEMRTVASETLLSLG------------------------------------------- ENSP00000259698/1-1068 DTEEIRNVASETLLSLG------------------------------------------- ENSMUSP00000106013/1-1078 DTEEIRTVASETLLSLG------------------------------------------- ENSRNOP00000048390/1-1310 DTEEIRTVASETLLSLAPYSGSAMTSQIRQNYSTEVEAAVNRLVNLHLRASYTYLSLGFF :***:*.*********. ENSCPOP00000007200/1-1070 ------------EDGRLAYEQLDKFPRD-------------------------------- XP_004847647.1/1-1061 ------------EDGRLAYEQLDKFPRD-------------------------------- ENSP00000259698/1-1068 ------------EDGRLAYEQLDKFPRD-------------------------------- ENSMUSP00000106013/1-1078 ------------EDGRLAYEQLDKFPRD-------------------------------- ENSRNOP00000048390/1-1310 FDPDDVALEGNERGGRALFQDVQKPSQDEWGKTLEAMEAALALEKNLNQALLDLHALGSA ..** :::::* .:* ENSCPOP00000007200/1-1070 ------Y-------------------------VKVGGRHGTEVATAF------------- XP_004847647.1/1-1061 ------Y-------------------------IKVGGRHGTEVATAF------------- ENSP00000259698/1-1068 ------C-------------------------VKVGGRHGTEVATAF------------- ENSMUSP00000106013/1-1078 ------C-------------------------VKVGGRHGTEVATAF------------- ENSRNOP00000048390/1-1310 RTDPHLCDFLESHFLDKEVKLIKKMGNHLTNLRRVAGPQPAQTGVAQASLGEYLFERLTL :*.* : ::...* ENSCPOP00000007200/1-1070 --- XP_004847647.1/1-1061 --- ENSP00000259698/1-1068 --- ENSMUSP00000106013/1-1078 --- ENSRNOP00000048390/1-1310 KHD