CLUSTAL W(1.81) multiple sequence alignment XP_004845859.1/1-1441 MAYSWQSDANPNETHEEQYEHRDFHSVNQSHSSSQVSLGFDQLVNEISNKIPLYQRNIPE ENSCPOP00000007134/1-1444 MAYSWQSALNPKEPPEKQYEHGEFHSVNQSFSPSQISLGFDQLVTEINNKISLYQRESED ENSP00000445381/1-1486 MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIVDEISGKIPHYESEIDE ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 MAYNWQTEPNRAEPQEGGHDHQQCHHADQHLSSRQVRLGFDQLVEELSNKTPLPEDE-KE XP_004845859.1/1-1441 NTLYVPHALHWDSKRHSLAGTHQMPLNEFPSKSPELSWNQSGKTVAVGFNPSVLQKPEVM ENSCPOP00000007134/1-1444 NTFFVPSELNWDSKRHSLPGTHHISLNNFLSKSSELSWNQSGKISPIGFNPSVLPKPEEM ENSP00000445381/1-1486 NTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNT ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 GTCFVPDTPNLDSKWQSIYGPHPRHFNEFTSQSPHFSQLPFGKASAIGFNPAVLPAHQFI XP_004845859.1/1-1441 NKQSSWGNSIRKYHGGDGS--SIVHPSCTDLDKINPQRELKNENHNYNIGFE-SISHVYS ENSCPOP00000007134/1-1444 NKQSSWETSIGKYHDSDRSRFSIGNPSCTNLGKMNPPRELKSQNHNYHIGFENSISHAYS ENSP00000445381/1-1486 NKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPPTNS ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 HEGASWRNPTRKYHGGEDPRFSALTPSSTGLDKCHQQGQSGTEHCNYYVELENNIPHHYS XP_004845859.1/1-1441 SFSTDFMPKDENKRSRNVNTVDPSPMLFKDSFLPRTRENTRPENIEPIGCSIQIIEVLQG ENSCPOP00000007134/1-1444 SFSTDFMPKDENKGGENVNTVNPSPEFFKDSFLPRSRESTWPENMEPIDCSMQIIEAPQG ENSP00000445381/1-1486 SFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQS ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 PYSMDSIPDSEEKGSGDADLVEPSLVFSKDSFLPRASENMSVESTEPIGCPLEIVEAPQG XP_004845859.1/1-1441 SNMTLASFCDKVKKIRETYHAADINSNSGKIWSPITAFPFQLFSNSKFNLSIFIDDSGQL ENSCPOP00000007134/1-1444 SNVSLASFCGKVKKIREMYHAAD-NLNSGKIWSPITAFPFQLFAKSKFNLSIFTDYSQQQ ENSP00000445381/1-1486 SNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQP ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 SNKSLASFCNNVTKIRGLYHASDTNSNSGKIWAITTAYPSRLFADTQFRVKISTDNSAQL XP_004845859.1/1-1441 LHLTPYGDYLVKDLIAEILHLCTSDQLCPKDHLLSVCGSEEFLQIDHCLGSHKMFQKNKS ENSCPOP00000007134/1-1444 LHLTPDAKYLVKDLITEILHLCTNEKLCSNDHLLNICGSEEFLQNDHCLGSHKMFQKNKS ENSP00000445381/1-1486 LHFMPCANYLVKDLIAEILHFCTNDQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKS ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 LLLKPPANYLVKDLIAEILLLCANEQLSPKEYLLSICGSEEFLQTDHCLGSHKIFQKSKS XP_004845859.1/1-1441 VIQLHLQKNRTAPGKLSRKPDDDYSELHLNQLLEFTHIWKVSRQCLSTAIKKYDFHLKNL ENSCPOP00000007134/1-1444 VIQLHLQKNTAALGKLSRKPDDDHSNLHLNQLLEFMHIWKVSRQCLSTVIKKYDFHLKYL ENSP00000445381/1-1486 VIQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHIWKVSRQCLLTLIRKYDFHLKYL ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 VIQLHLQRSRDTPGKLSRKRDDDRSRVHLNQLLEFTHIWKISRQCLSTVMKSYNLHVEHL XP_004845859.1/1-1441 LSTRQYV--------------------DNIIEEVKNLCSVLGCVETKQITDAVNELKLIP ENSCPOP00000007134/1-1444 LTNQQHM--------------------WIMYREVKNLCSILGCVETKQITDAVNELKLIL ENSP00000445381/1-1486 LKTQENV--------------------YNIIEEVKKICSVLGCVETKQITDAVNELSLIL ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 LKTQEDVEEKPLSSMFSCGRHPPQPHGNDIIEDVRNICSVLGCIETKQVSDAVKELTLIL XP_004845859.1/1-1441 QRTGENVHQSSETSTKGFIEKVTTKLSMSIYQLIGIYCSSFYADFQPVSAPGSISPVHPG ENSCPOP00000007134/1-1444 QKTEEVNIFISHTSSLGFIEKVTTELSTSIYGLIGIYCNSFYADFQPVGVPRSITSRHPG ENSP00000445381/1-1486 QRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPG ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 QRPSQNFHQNSETSKKGFIENVTSELSRSLHQLVDVYCSSFCTDFRPARAPGGVSRDHAG XP_004845859.1/1-1441 LDSHLSFTVSAMHNIPEPWVHR-------------------------------------- ENSCPOP00000007134/1-1444 LHAHLSFTVYAAHNIPETWVNR-------------------------------------- ENSP00000445381/1-1486 LPSHLSFTVYAAHNIPETWVHSYKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNW ENSMUSP00000107499/1-903 ------------------------------------------------------------ ENSRNOP00000043855/1-1505 LHSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTYAGKKLCQVKSCRSLPVTKSFSFSVNW XP_004845859.1/1-1441 ---INFPLETKSLPRESMLTIKVFGIGCTSNSAELLAWTCLPLFPKEKSILGSMLFSMTL ENSCPOP00000007134/1-1444 ---INFPLETKSLPRESMLTIKVFGIDY-TDNPNLLAWTCLPLFPKEKSILGSVLFSMTL ENSP00000445381/1-1486 NETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWTCLPLFPKEKSILGSMLFSMTL ENSMUSP00000107499/1-903 ---INFPLEIKSLPRESMLIIKLFGIDSATHSTNLLAWTCLPLFPRQESVLGSRLFSVTL ENSRNOP00000043855/1-1505 NEIINFPLEIKSLPRESMLVIKLFGIDSATHSANLLAWTCLPLFPKEKSPLGSRLLSMTL ****** ********* :*:*** :...:***********:::* *** *:*:** XP_004845859.1/1-1441 QNEPPIEMIAPGVWDGSQPGPVTLQIDFPATGWEYIKPDSEENRTHLEEPPRECLKHIAR ENSCPOP00000007134/1-1444 QNEPPIEMIAPGVWDGSQPTPVTLQIDFPATGWEYTKPDSEENRTHLQEPPKEYLKHIAR ENSP00000445381/1-1486 QSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENRSNLEEPLKECIKHIAR ENSMUSP00000107499/1-903 QSEPPIEMIAPGVWDGSQPSPLTLQIDFPDAGWEYLKPESEENRTDHEEPPRECLKHIAK ENSRNOP00000043855/1-1505 QSEPPIEMMAPGVWDGSQPTPLTLQIDFPAATWEYVKPETEENRTDHQEPPRECLKHIAR *.***:**::***** *** *:******* : *** **::****:. :** :* :****: XP_004845859.1/1-1441 LSQKQTSLLLSEEMRRYLWFYRFFCNNENCSLPLVLGSAPGWDERTISEMHTILRRWKFS ENSCPOP00000007134/1-1444 LSKKQTPLLLSEEKRRYLWFYRFFCNNQNCSLPLVLGSAPGWDERTISEMHTILRSWTFS ENSP00000445381/1-1486 LSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFS ENSMUSP00000107499/1-903 LSQKKSPLLLSEEKRRYLWFYRLYCNNENSSLPLVLGSAPGWDEETVSEMHAILRRWTFS ENSRNOP00000043855/1-1505 LSQKQSPLLLSVEKRRYLWFYRFYCNNENSSLPLVLGSAPGWDEGTVSEMHAVLRRWTFS **:*::.**** * :*******::***:*.************** *:****::** *.** XP_004845859.1/1-1441 HPSEALGLLSPSFPDQEIREAAIQQLDNLLNDELLEYLPQLVQAVKFERSLQSRLVELLL ENSCPOP00000007134/1-1444 HPLEALGLLTPSFPDQEIREVAVQQLDKLLNDELLEFLPQLVQAVKFEWSLQSPLVELLL ENSP00000445381/1-1486 QPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLL ENSMUSP00000107499/1-903 HPWEALGLLTSRFPDQDIREVAVQQLDTLLTDELLDCLPQLVQAVKFEWNLESPLVELLL ENSRNOP00000043855/1-1505 HPLEALGLLTSRFPDQDIREVAVQQLDNLLTDELLDCLPQLVQAVKFEWSLESPLVELLL :* ******:. ****:**:.*:****.**.****: *********** .*:* **:*** XP_004845859.1/1-1441 HRSLQSIQVAHRLYWLLMDAQNEAYFKSWYQKLLVALQFCVGKALNDEFSKEKKLIKILR ENSCPOP00000007134/1-1444 RRSLESVQVAHRLFWLLKDAQNEAYFKSWYQKLLAALQFCVGKALNDEFSKEKKLIKILR ENSP00000445381/1-1486 HRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILG ENSMUSP00000107499/1-903 RRSLQSIRVAHRLYWLLRDAQGEAYFKSWYQELLAALQFCAGEALNEELSKEQKLVKLLG ENSRNOP00000043855/1-1505 HRSLQSIRVAHRLFWLLRDAQGEDYFKSWYQELLAALQFCAGEALIEELSKEQKLVKLLG :***:*::*****:*** :*:.* *******:**.*****.*:** :*:***:**:*:* XP_004845859.1/1-1441 DIGEKVKSASDSQRQEVLKKEIGRLDKFFQDINTCHLPLNPALCIKGIDHDACSYFTSNA ENSCPOP00000007134/1-1444 DIGEKVKSASDPHRQEVLKKEIGRLNEFFQAINTCCLPLNPALCIKGIDHDACSYFTSNA ENSP00000445381/1-1486 DIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNA ENSMUSP00000107499/1-903 DIGEKVKSASDPQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCIKGIDRDACSYFTSNA ENSRNOP00000043855/1-1505 DIGEKVKSAGDAQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCVKGIDRDACSYFTSNA ****:****.* :*::******* *::**: ::** ********:****:********** XP_004845859.1/1-1441 LPLKITFINANPLGTNISIIFKAGDDLRQDMLVLQIIQVMDNIWLQEGLDMQMIIYKCLS ENSCPOP00000007134/1-1444 LPLKITFINANPMGTNISIIFKTGDDLRQDMLVLQIIQVIDNIWLQEGLDMQMIIYRCLS ENSP00000445381/1-1486 LPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLS ENSMUSP00000107499/1-903 SPLKITFINANPMGKNISVIFKAGDDLRQDMLALQIIQVMDNAWLQEGLDMQMITYGCLS ENSRNOP00000043855/1-1505 LPLKITFINANPMGKNISVIFKAGDDLRQDMLVLQIIQVMDNVWLQEGLDMQMIIYGCLA ***********:*.***:***:*********.**:***:** *********** * **: XP_004845859.1/1-1441 TGKSQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHIKEDYEKALSNFFCSC ENSCPOP00000007134/1-1444 TGKNQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHIKADYEKALRNFFYSC ENSP00000445381/1-1486 TGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSC ENSMUSP00000107499/1-903 TGRAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKEDYEKALRNFFYSC ENSRNOP00000043855/1-1505 TGKAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKEDYEKALRNFFYSC **: **:::************ **********************:* ****** *** ** XP_004845859.1/1-1441 AGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEME ENSCPOP00000007134/1-1444 AGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFKGIKRDRAPFIFTSEME ENSP00000445381/1-1486 AGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEME ENSMUSP00000107499/1-903 AGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEME ENSRNOP00000043855/1-1505 AGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEME ******************************************* **************** XP_004845859.1/1-1441 YFITEGGKKPQHFQDFVELCCRAYNIVRKHSRLLLNLLEMMLHAGLPELSGIQDLKYVYN ENSCPOP00000007134/1-1444 YFITEGGKNPQHFQDFVELCCRAYNIVRRHSWLLLNLLEMMLYAGLPELSGIQDLKYVYN ENSP00000445381/1-1486 YFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYN ENSMUSP00000107499/1-903 YFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLILSLLEMMLHAGLPELRGIEDLKYVHN ENSRNOP00000043855/1-1505 YFITEGGKNTQHFQDFVELCCRAYNIVRKHSQLLLSLLEMMLHAGLPELRGIEDLKYVHD ********:.****************:*:** *:*.******:****** **:*****:: XP_004845859.1/1-1441 NLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHILAQMSAVNPTKSPPMS-SRESCVL ENSCPOP00000007134/1-1444 NLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHILAQMSAVSPAKSPPQRSSQESCTP ENSP00000445381/1-1486 NLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLL ENSMUSP00000107499/1-903 NLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMPALSLAKPAPQTLLQESCIL ENSRNOP00000043855/1-1505 NLRPQDTDLEATSHFTTKIKQSLECFPVKLNNLIHTLAQMPAFSLARPAPQTPPQECCVL ****************.***:************** ****.*.. ::... :*.* XP_004845859.1/1-1441 STAGSIQRATILGLSKKPSDLYLIQVTHGNEETSLIEKSFDQFSKFHSQLQKQFTSLTIP ENSCPOP00000007134/1-1444 STVRSIRRATIIGFSKKPSDLYLIQVTHGNHEISLTEKSFDQFSKLHSQLQKQFASLTLP ENSP00000445381/1-1486 STTRSIERATILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLP ENSMUSP00000107499/1-903 NKTRTIQRVTILGFSKTHSNLYLMEVTCSDNRRSLTKKSFEQFYRLHSQMQKQFSSLALP ENSRNOP00000043855/1-1505 NKTRTIQRVTILGFSKTHSNLYLIEVTRSDNRKNLAKKSFEQFYRLHSQIQKQFPLLTLP ... :*.*.**:*:**. *:***::** .:.. .* :***:** ::***:****. *::* XP_004845859.1/1-1441 EFPHWWHLPFTNSDHKRCRDLNHYMEQILHRPYEVKNSDCVLTFFLSEPVQRTIEESSLV ENSCPOP00000007134/1-1444 EFPHWWHLPFTNSDHKRFRDLNHYMESILHGPYEVANSDCILTFFLSEPVQRTVEETSLV ENSP00000445381/1-1486 EFPHWWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVEESSPV ENSMUSP00000107499/1-903 EFPHWWHLPFTDSDHKRIRDLSHYVEQVLRGSYEVANSDCVLSFFLSEHIQPTLEDSPFV ENSRNOP00000043855/1-1505 EFPHWWHLPFTDSHHERIRDLSHYVEQVLHGSYEVANSDCVLSFFLSEHIQQTLEDSPFV ***********:*.*.* ***.**:*.:*. .:** ****:*:***** :* *:*::. * XP_004845859.1/1-1441 DLG-EKSSDKNPKVQLVISYEDAKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRR ENSCPOP00000007134/1-1444 DIGNEKSPDKTPKVQLVISYEDAKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVHR ENSP00000445381/1-1486 YLG-EKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVRR ENSMUSP00000107499/1-903 DPG-ENSLDKSPKVQLLMTYEDSRLTILVKHLKNIHLPDGSVPSAHVEIYLLPHPSEVRR ENSRNOP00000043855/1-1505 DPG-NTIPESSSREQQIISHEDNNSTVVLKRLKIMHLPDGSAPSAHVEIYLLPHPSEVRR * :. :...: * ::::** . *:::*::* :******.******:****:****:* XP_004845859.1/1-1441 RKTKSVPKCTDPTYNEIVVYDEVAELQGHVLMLIVKSKTVFVGAINIQLCSVLLNEEKWY ENSCPOP00000007134/1-1444 RKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIQLCSVPLNEEKWY ENSP00000445381/1-1486 RKTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKWY ENSMUSP00000107499/1-903 KKTKCVPKCTDPTYNEIVVYDEVLGLQGHVLMLIVKSKTVFVGAVNIQLCSVPLNEEKWY ENSRNOP00000043855/1-1505 KKTKCVPKCTDPTYNEIVVYDDVSGLQGHVLMLIVKSKTVFVGAVNIQLCSVPLNEEKWY :***.****************:* *******************:**:**** *::**** XP_004845859.1/1-1441 PLGNSII ENSCPOP00000007134/1-1444 PLGNSII ENSP00000445381/1-1486 PLGNSII ENSMUSP00000107499/1-903 PLGNSII ENSRNOP00000043855/1-1505 PLGNSII *******