CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000039648/1-1169 ----------------MSADSSLLMGSTPPSYGTLTTGTSIDPLSSSASSVRLSGYCGSP ENSRNOP00000010884/1-1145 ----------------MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSP ENSP00000327214/1-1180 ----------------MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSP ENSCPOP00000006928/1-1177 ----------------LPTDSSPLMGSPPASYGTLMTGTSIGPHSSSASSVRLSGYCGSP XP_004851119.1/1-1184 MGGGRIGRSPKRCFSFLSTDSSPLVGSPAASYGTLMIGTSIGPLSSSASSVRLSGYCGSP :.:*** *:**....**** ****.* ***.************ ENSMUSP00000039648/1-1169 WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEIKDKEGSSRQLFT ENSRNOP00000010884/1-1145 WRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQLFT ENSP00000327214/1-1180 WRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFT ENSCPOP00000006928/1-1177 WRAIGYHAVVWVLAGIPLLLFRWKPLWGVRLRLRPCSLARAETLVIETRDKEDSSWQLFT XP_004851119.1/1-1184 WRAIGYHAVVWVLAGIPLLLFRWKPSWGVRLRSRPCSLAHAETLVIETRDKEDSSWQLFT **.****..**::**** ******* ****** :**.**:******* :***.** **** ENSMUSP00000039648/1-1169 VQVQTEAVVQG----SLELPPQAQAEDGRSQAAVGVTPEGTWQDTSELHRQEEA-----K ENSRNOP00000010884/1-1145 VQVQTEAVVDG----SLELPSQAKAEDGRSLAAVGVAPESMWQDTTQLHRQKEA-----K ENSP00000327214/1-1180 VQVQTEAIGEG----SLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQK ENSCPOP00000006928/1-1177 VQVQTEAIGEGSFLPSLELP--LQAEDGRSQVAVGAVPRSVWKDTAQLRRREEA-----K XP_004851119.1/1-1184 VQVQTEAVVEG----SLELP--LQAEDGRSKMALGAVPETPWKDTARLHRREEA-----K *******: :* *** . :****** *:*..*. *:**:.*:: :** * ENSMUSP00000039648/1-1169 QVLRYYVLQGQRYVWMETQQAFCQVSLLDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNV ENSRNOP00000010884/1-1145 QVLRYYILQGQRYVWMETQQAFCQVSLLDHGRACDDIHCSSSGLSLQDQAVRKTIYGPNV ENSP00000327214/1-1180 RVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNV ENSCPOP00000006928/1-1177 RVARYYLFQGRRYIWIETQQAFLQVSLLDHGHTCDDIHASRSGLSLPDQTVRKTIFGPNV XP_004851119.1/1-1184 QVVRYYLFQGRRYVWIETQQAFLQVSLLGHGHTCDDIHSSRSGLSLPDQTMRKTIFGPNV :* ***::**:**:*:****** *****.**::***:* * **** ** **:*:**** ENSMUSP00000039648/1-1169 ISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRK ENSRNOP00000010884/1-1145 IGIPVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRK ENSP00000327214/1-1180 ISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRK ENSCPOP00000006928/1-1177 ISIPVKSYPQLLVDEALNPYYGFQAFSIGLWLADHYYWYALCIFLISAVSICLAMYKTRK XP_004851119.1/1-1184 ISIPVKSYPQLLVDEVLNPYYGFQAFSIGLWLADHYYWYALCIFLISAISICLSMLKTRK *.****** ***.**.************.***********:******::****:: **** ENSMUSP00000039648/1-1169 QSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGVMPCDAALVAGECVV ENSRNOP00000010884/1-1145 QSMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVAGECVV ENSP00000327214/1-1180 QSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMV ENSCPOP00000006928/1-1177 QSKTLRDMVKLSMRVCVRRPGRGEEWVDSSELVPGDCLVLPPEGGPMPCDAALVAGECMV XP_004851119.1/1-1184 QSQTLKDMVKLSVRVRVCRPGEGEEWVDSSKLVPGDCLVLPPEGGLMPCDAALVAGECMV ** **:******:** * *** *******:********** *** ************:* ENSMUSP00000039648/1-1169 NESSLTGESTPVLKTALPEGPKPYCPETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGF ENSRNOP00000010884/1-1145 NESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRVLAVVTRTGF ENSP00000327214/1-1180 NESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGF ENSCPOP00000006928/1-1177 NESCLTGESVPVLKTALPEGPSPYCPETHRRHTLFCGTLVLQAKAYGGPHVLAVVTQTGF XP_004851119.1/1-1184 NESCLTGESVPVLKTALPEGPRPYCPESHRRHTLFCGTLVLQARAYGGPHVLAVVTQTGF ***.***** ********** ***.*:***********:***:** **:******:*** ENSMUSP00000039648/1-1169 CTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYRNRVPVREIVIR ENSRNOP00000010884/1-1145 CTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVKEIVIR ENSP00000327214/1-1180 CTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIR ENSCPOP00000006928/1-1177 CTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTVYSIFVLHRNRVPVNEIIIR XP_004851119.1/1-1184 CTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILHHNRVPVNEIVIR *****************.****:*****************:***::*::****:.**:** ENSMUSP00000039648/1-1169 ALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTE ENSRNOP00000010884/1-1145 ALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTE ENSP00000327214/1-1180 ALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTE ENSCPOP00000006928/1-1177 ALDLVTVVVPPALPAAMTVCTLYAQGRLRAQGIFCIHPLRINLGGKLRLVCFDKTGTLTE XP_004851119.1/1-1184 ALDLVTVVVPPALPAAMTVCTLYAQSRLQAQGIFCIHPLRINLGGKLRLVCFDKTGTLTE *************************.**: *****************:************ ENSMUSP00000039648/1-1169 DGLDVMGVVPLKGQVLLPLVPEPCHLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVES ENSRNOP00000010884/1-1145 DGLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGDPMDLKMVES ENSP00000327214/1-1180 DGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVES ENSCPOP00000006928/1-1177 DGLDVMGVVPVKGQVFLPLVPEPRCLPMGPLLRALATCHALSRLQDTAVGDPMDLKMVES XP_004851119.1/1-1184 NGLDVMGVVPLKGQAFLPLVPEPRCLPMGPLLRALATCHALSWLQDTPVGDPMDLKMVES :***:*****:*** :******* ** *******.****** *:** ************ ENSMUSP00000039648/1-1169 TGWVLEEGPAAGSAPGSQVLVVMRPPPGGPRQQE--EPPVPVSVLCRFPFSSALQRMDVV ENSRNOP00000010884/1-1145 TGWVLEEGSAAGSAPETQVLVVMRPPPRGPQQQE--ESPEPVSVLRRFPFSSALQRMDVV ENSP00000327214/1-1180 TGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVV ENSCPOP00000006928/1-1177 TGWVLEEESATDAALGTQVLAVMRPPPWESQTGAV-EPQVPLSVLGRFPFSSTLQRMSVV XP_004851119.1/1-1184 TGWVLEEEPAADAALGTPVLAVMRPPPWEPQTQG--TPHVPLGVLGRFPFSSSLQRMGVV ******* .*:.:* : **.***** .: . *:.** ******:****.** ENSMUSP00000039648/1-1169 VTWPGATQPEAYVKGSPELVASLCSPETVPSDFSQVLQSYTAAGYRVVALAGKPLPIAPS ENSRNOP00000010884/1-1145 VTWPGATQPEAYVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPS ENSP00000327214/1-1180 VAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPS ENSCPOP00000006928/1-1177 VAWPGAAQPETYVKGSPELVASLCSPDTVPSDFAQTLQSYTAAGYRVVALACKPLSIAPN XP_004851119.1/1-1184 VAWPGAAQPEAYIKGSPELVASLCSPDTVPADFSKTLQSYTAAGYRVVALACKPLSIAPS *:****:***:*:********.**.*:*** **.: *************** ***. .*. ENSMUSP00000039648/1-1169 LAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTV ENSRNOP00000010884/1-1145 LEAAQQLTRDTVEQELSLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTV ENSP00000327214/1-1180 LEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTV ENSCPOP00000006928/1-1177 LEATQQLSRDTVEQDLRFLGLLVLRNLLKPQTAPVIQALRRTSIRTVMVTGDNLQTAVTV XP_004851119.1/1-1184 MEAVQQLSRDTAEQDLSFLGLLVMRNLLKPQTTRVIQALRRTCIRTVMVTGDNLQTAVTV : *.***:***.* :* :*****:********: ***:**:* **:************** ENSMUSP00000039648/1-1169 ARACGMVGAQEHLAVIHATHPEQGQPAALEFLPTESSAVMNGAK----ATGYPTVPEPQS ENSRNOP00000010884/1-1145 AKACGMVGTQEHLAIIHATHPEQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEPESQS ENSP00000327214/1-1180 ARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRS ENSCPOP00000006928/1-1177 ARGCGMVGPQERLVIVHATHPEQGRPASLEFLPTEYPATVNGTKDPAQSESYTVEPDRRS XP_004851119.1/1-1184 ARGCGMVAPRERLVIIHATYPEQGRPASLEFLPTECPTAVNGAK----AASYTMEPDPQS *:.****..:*:* ::***:**:*:**:***** * .:.:**.* : .*. *: :* ENSMUSP00000039648/1-1169 CHLALSGSTFAVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGA ENSRNOP00000010884/1-1145 RHLALSGSTFAVLQKHFPKLLPKVLVQATVFARMAPEQKTQLVCELQRLQYCVGMCGDGA ENSP00000327214/1-1180 RHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGA ENSCPOP00000006928/1-1177 SHLALSGYTFGVLMKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVAMCGDGA XP_004851119.1/1-1184 SHLALSGSTFGVLMKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGA ****** **.:: *************.************:******:*****.****** ENSMUSP00000039648/1-1169 NDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALY ENSRNOP00000010884/1-1145 NDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALY ENSP00000327214/1-1180 NDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALY ENSCPOP00000006928/1-1177 NDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALY XP_004851119.1/1-1184 NDCGALKAADVGISLSQAEASVVSPFTSSMPSIECVPMVIREGRCSLDTSFSMFKYMALY ******************************.****** **************:******* ENSMUSP00000039648/1-1169 SLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVRARPPGALLSVP ENSRNOP00000010884/1-1145 SLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAVLMSRTGPALTLVRARPPGALLSVP ENSP00000327214/1-1180 SLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVP ENSCPOP00000006928/1-1177 SLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALALGRARPPGALLSVP XP_004851119.1/1-1184 SLTQFVSVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTQPALALGRARPPGALLSVP *****:**********************.************ ***.* *.********** ENSMUSP00000039648/1-1169 VLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVVFSLSGFQYLI ENSRNOP00000010884/1-1145 VLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVIFSLSGFQYLI ENSP00000327214/1-1180 VLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLI ENSCPOP00000006928/1-1177 VLSSLLLQVALVAGVQLGGYFLAVAQPWFVPLNKTIPAPDNLPNYENTVIFSLSGFQYLI XP_004851119.1/1-1184 VLSTLLLQMALVAGVQLGGYFLVVAQPWFVPLNKTVPAPDNLPNYENTVVFSLSSFQYLI **.:****:.**:*:*******.:*********:*:.************:****.***** ENSMUSP00000039648/1-1169 LAAAVSKGAPFRQPLYTNVPFLVALALLGSVLVGLILVPGLLQGPLGLRNIVDSSFKLLL ENSRNOP00000010884/1-1145 LAAAVSKGAPFRQPLYTN----------------------------GLRNIADSSFKLLL ENSP00000327214/1-1180 LAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFKLLL ENSCPOP00000006928/1-1177 LAAAVSKGAPFRRPLYTNVPFLVALVLLGSVLVGLILVPGLLQGPLGLRNITDTCFKLLL XP_004851119.1/1-1184 LAAAVSKGAPFRQPLYTNVPFLVALVLLGSVLVGLILVPGLLQGPLGLRNIADTCFKLLL ************:***** .****.*: ***** ENSMUSP00000039648/1-1169 LGLVAFNFVGAFMLESVLDQCLPACLRWLRPKRASKKQFKRLQQELAEHPWPTLP-VGSV ENSRNOP00000010884/1-1145 LGLVAFNFVGAFMLESVLDQCLPACLQWLRPKRASKKQFKQLQRELAERPWPTLP-VGSV ENSP00000327214/1-1180 LGLVTLNFVGAFMLESVLDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPPLP-AGPL ENSCPOP00000006928/1-1177 LGLVTCNFVGAFMLESMLDQCLPACLRQLRPKRASKKRFKQLEQELAEQPWPPLPAAGAV XP_004851119.1/1-1184 LGLAACNFVGAFMLESVLDQCLPACLQQLRPKRASKKRFKQLEQELAEQPWPPLPTAGAV ***.: **********:*********: *********:**:*::****:***.** .*.: ENSMUSP00000039648/1-1169 R ENSRNOP00000010884/1-1145 R ENSP00000327214/1-1180 R ENSCPOP00000006928/1-1177 R XP_004851119.1/1-1184 R *