CLUSTAL W(1.81) multiple sequence alignment ENSP00000287097/1-1445 MQGPPLLTAAHLLCVCTAALAVAP-GPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVK ENSCPOP00000006825/1-1437 MRGPQLLGELLLLCLGVAALAARPGGPSFLVTAPRTIRPGGNVTIGVELLEHSPSQITVK XP_004864011.1/1-1444 MRGPGRPGALLLLCLGAAALAARP-GPSFLVTAPGTIRPGGNVTVGVELLAHSPSQVTVK ENSMUSP00000091330/1-1442 MRSRRLLSAAHLLCLCAVALAAP--GSRFLVTAPGIIRPGANVTIGVDLLENSPPQVLVK ENSRNOP00000030391/1-1442 MRNPRLLSAAHLLSVCVVAVAAH--GSRFLVTVPGIIRPGANMTIGVELLQNSPPQVLVK *:. **.: ..*:*. *. ****.* ****.*:*:**:** :.*.*: ** ENSP00000287097/1-1445 AELLKTASNLTVSVLEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNS ENSCPOP00000006825/1-1437 AELLKKAANLTVSVLEAEGVFEKGSFKTLTLPSLPLNSKDESYELRVTGHAEDEILFYNS XP_004864011.1/1-1444 AELLKRASNLTVSVLEAEGVFEKGSFKTLTLPSLPLNSADERYELRVTGRVEDEILFYNS ENSMUSP00000091330/1-1442 AQVFKIASNKSRSILEAEGVFHRGHFKTLVLPALPLSSADKIYELHINGQSENEIVFSNR ENSRNOP00000030391/1-1442 ARVLKIASNRSTTVLEAEGVFNRGHFGILVLPALPLHKANKIYELHISGKSETEIVFSNR *.::* *:* : ::*******.:* * *.**:*** . :: ***::.*: : **:* * ENSP00000287097/1-1445 TRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQW ENSCPOP00000006825/1-1437 TPLSFEIKRVSVVIQTDKLLYKPGQEVKFRVIMFSSDFRPYKASLDVFIKVSGKDKVSCW XP_004864011.1/1-1444 TRLSFESKRMSVFIQTDKALYKPEQEVKFRIVTLLSDFRPFKASLDILIKDPKSNLIQQW ENSMUSP00000091330/1-1442 TRLTFESKSISVLIQTDKAFYKPKQEVKFRVLTLCSDLKPYRTSVDIFIKDPKSNVIQQW ENSRNOP00000030391/1-1442 TRLTFDSKRISVFIQTDKVIYKPKQEVKFRVLTLFSDLKPYKTPVDIYIKDPKSNLIQQW * *:*: * :**.***** :*** ******:: : **::*:::.::: ** . .: :. * ENSP00000287097/1-1445 LSQQSDLGVISKTFQLSSHPILGDWSIQVQVNDQTYYQSFQVSEYVLPKFEVTLQTPLYC ENSCPOP00000006825/1-1437 LLQRSDHGVISKTFQLSSHPILGDWSIQVQINDQTYYQSFQVSEYVLPNFSFTPST-FFC XP_004864011.1/1-1444 LSQQGDLGVISKTFQLSSHPVLGDWSIQVQVNGQTYYQSFQVSEYVLPKFEVVLQTPLYC ENSMUSP00000091330/1-1442 FSQKGDLGVVSKTFQLSSNPIFGDWSIQVQVNDQQYYQSFQVLEYVLPKFEVTVQTPLYC ENSRNOP00000030391/1-1442 LSQEGELGVVSKTFQLSSHPILGDWSIQVQVIDQLYYQSFQVLDYVLPKFEVTLQTPLYC : *..: **:********:*::********: .* ******* :****:*... .* ::* ENSP00000287097/1-1445 SMNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNITKTFKINGSANFSFNDEEM ENSCPOP00000006825/1-1437 TVNS--FHGPLSGKYTYGKPVKGDVTLTFLPLSFWGEKKNITKTFKINGSANFSFNDEEM XP_004864011.1/1-1444 SLNSKTLNGTITAKYTYGKPVKGDITLTFLPLSFWGEKKNITKTFKINGSANFSFNDEEM ENSMUSP00000091330/1-1442 SLKSKQLNGSVIAKYTYGKPVKGSLSLTFLPLSFWGKKKNITKSFEINGFANFSFDNYEM ENSRNOP00000030391/1-1442 SLKAKYLRGNVTAKYTYGKPVKGSLSLTFIPLSFWGKKKNITKNFEINGFTNFAFDADEM :::: :.* : .**********.::***:******:******.*:*** :**:*: ** ENSP00000287097/1-1445 KNVM------DSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEF ENSCPOP00000006825/1-1437 KKVM------DFADGHSKHVDLSTPGPVEILATVTESLTGISRNASSNVFFKQHDYIIEF XP_004864011.1/1-1444 KKVM------DFSHGLSEYMDLSTPGPVEILATVTESHTGISRNASSNVFFKQHDYIIEF ENSMUSP00000091330/1-1442 KKVMNLKPLTDVSEGSYENVDPSFPGPAEIIATVTESLTGISRMASTNVFFKQHDYIIEI ENSRNOP00000030391/1-1442 KKVMNLKKATEISDGNYDQVDPVFPGPVEIVATVTESLTGTSRKASTNVFFKQHDYVIEI *:** : :.* . :* ***.**::***** ** ** .*:*********:**: ENSP00000287097/1-1445 FDYTTVLKPSLNFTATVKVTRADGNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKME ENSCPOP00000006825/1-1437 FDYATVLKPSLNFTATVKVTRSDGSRLTQEERRNQVAIAVTQRNRTNLWSRWNHENEGME XP_004864011.1/1-1444 FDYVTVLKPSLNFTATVKVTRSDGSQLTQEERRNNVVIAVTQRNRIYLWSRWNSGNQEME ENSMUSP00000091330/1-1442 FDYTTVLKPSLNFTATVKVSRSDGNQLTPEEIENDLVTVVTQRKNNH---PESQRDQEMD ENSRNOP00000030391/1-1442 FDYTTVLKPTLNFTATVKISRSDGKQLTPEEMENDLVTVVTQKKNDN---PTREKAQGTD ***.*****:********::*:**.:** ** .*::. .***:: : : ENSP00000287097/1-1445 AVQKINYTVPQSGTFKIEFPILEDSSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTR ENSCPOP00000006825/1-1437 DAHITNYTVPPDGIFKIEFPVLDSSSQLQVKAYFLDSESNMEVHGTFTSPSKTYIQLKTR XP_004864011.1/1-1444 AAHITNYTVPPDGIFKIEFPILDSSSQLQVKAHFLNSESNMEVHGTFISPSKTYIQLKTR ENSMUSP00000091330/1-1442 YIQTVNYTIPQNGIIKIEFPVMSISGELQLKAYFLDGTSSVTVHSMFTSPSKTYIQLKTR ENSRNOP00000030391/1-1442 YIQMTEYSVPHNGVVKVEFPIMSDSSELQLKASFLDSASSVAVHSVFTSPSNTYIQLKTR : :*::* .* .*:***::. *.:**:** **.. *.: **. * ***:******** ENSP00000287097/1-1445 DENIKVGSPFELVVSGNKRLKE--LSYMVVSRGQLVAVGKQNSTMFSLTPENSWTPKACV ENSCPOP00000006825/1-1437 DENIKIGTLFEYLISFTQKLNSSAFSFQVVSRGQLVAVGKQSSTTFSLTPENSWAPKACI XP_004864011.1/1-1444 YENIKVGSPFELVVSGNKQLKE--FSYMVVSRGQLVAVGKQTSTTFSLTPENSWAPKACI ENSMUSP00000091330/1-1442 DEYIKVGSPFDLMVSGNRQFKD--LSYMVISKGQLVAAGKQSSRTFSLTPEASWAPKACI ENSRNOP00000030391/1-1442 DEHITVGSPFNLTVSGNQKFKE--ISYMVISKGQLVAVGKQSSRTFSLTPEASWAPKACI * *.:*: *: :* .::::. :*: *:*:*****.***.* ****** **:****: ENSP00000287097/1-1445 IVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVA ENSCPOP00000006825/1-1437 IVYYVENDGEIINDVLKIPVQLVFKNEVKLFWSKPNAEPSEKVSLRVAVTQPDSVVGIAA XP_004864011.1/1-1444 IVYYVENDGEIINDVLKIPVQLAFNNEIKLFWSKPNAEPSEKVSLRISVTQPESIVGIVA ENSMUSP00000091330/1-1442 IAYYIAEDGEIINDILKIPVQLVFENKVKLFWSKPTVKPSDKVSLRISATQSDSLVGIVA ENSRNOP00000030391/1-1442 IVYYIEQDGEVISDILKIPVQLDFKNKIKLSWSKPRVKPSDKVSLRISVTQSYSLVGIVA *.**: :***:*.*:******* *:*::** *** .:**:*****::.**. *:***.* ENSP00000287097/1-1445 VDKSVNLMNASNDITMENVVHELELYNTGYYLGMFMNSFAVFQECGLWVLTDANLTKDYI ENSCPOP00000006825/1-1437 VDKSVSLMNASNDITMGNVVHELELYNTGYYLGMFMNSFTVFQECGLWVLTDAHLMKDYI XP_004864011.1/1-1444 VDKSVNLMNTSNDITMENVVRELELYNTGYYIGMFMNSFTVFQECGLWVLTDAILVKDYI ENSMUSP00000091330/1-1442 VDKSVTLMENSNSITMETMVHELELYNTEYYLGMFMNSFAVFQECGLWVLTDATLIRDSI ENSRNOP00000030391/1-1442 VDKSVKLIGNSNDITMENVVHELELYNTEYYLGMFLNSFAVFQECGLWVLTDANLVRDNI *****.*: **.*** .:*:******* **:***:***:************* * :* * ENSP00000287097/1-1445 DGVYDNAEYAERFMEENEGHIVDIHDFSLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEV ENSCPOP00000006825/1-1437 DGVYDFVEYAERYMEENEG-YLDIHGFSSASNPHVRKHFPETWLWLDVHMGSKIYQEFEV XP_004864011.1/1-1444 DGVYDTADYAERFIEESLEEYEDMHDFSSVSSPRVRKHFPETWIWLDTHMGSKIYQEVEV ENSMUSP00000091330/1-1442 DEVYDTEEYSERFAEENEANLVDFEDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEV ENSRNOP00000030391/1-1442 DEVYDTQEYSERFAEENEANLVDFEDTSSASNSHVRKHFPESWIWLDFYMGSKNHEEYEV * *** :*:**: **. *:.. * .. :***:***:*:*** ** : ::* ** ENSP00000287097/1-1445 TVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSVIRGEEFALEITIF ENSCPOP00000006825/1-1437 TVPDSITSWVATAFVISEDLGLGLTTAPVELQAFQP-----NLPYSVIRGEEFALEVTIF XP_004864011.1/1-1444 TVPDSITSWVATAFVISEDLGLGLTTAPVELQAFQPFFIFLNLPYSVIRGEEFALEVTIF ENSMUSP00000091330/1-1442 TVPDSITSWVASAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIV ENSRNOP00000030391/1-1442 TVPDSITSWVASAFVISEDLGFGLTATPAELHAFQPFFISLNLPYSVIRGEEFALEVSIV ***********:.********:***:.*.**:**** ***************::*. ENSP00000287097/1-1445 NYLKDATEVKVIIEKSDKFDILMTSNEINATGHQQTLLVPSEDGATVLFPIRPTHLGEIP ENSCPOP00000006825/1-1437 NYLKDATEVKVIIEESDRFDILMTSKEINATGHQQDILVPSEDGTTVLFPIRPTHLGEIP XP_004864011.1/1-1444 NYLKDDTKVKVIVEESDRFDILMTSKEINTTGHQQDVLVPSEDGATVLFPVRPTHLGEIP ENSMUSP00000091330/1-1442 NYLKDTIKVVILIEESDSFDILMTSNDTNGTIYRKTVQVPRDNGVTLVFPIKPTHLGEIP ENSRNOP00000030391/1-1442 NYLKDTTKVVVLIEESDSFDILMFSNDINNTIYRKTALVPRENSVTLVFPIKPTHLGNVP ***** :* :::*:** ***** *:: * * ::: ** ::..*::**::*****::* ENSP00000287097/1-1445 ITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKTLSFSFPPNTVTG ENSCPOP00000006825/1-1437 ITVRAISPMASDAITQRILVKAEGIEKSYSQAVLLDSTNR--QPTVETLSFSFPPDTVSG XP_004864011.1/1-1444 ITVRALSPIASDAVTRRILVKAEGIEKSYSQAILLDSSDK--QTTLETLSFSFPPGTVSG ENSMUSP00000091330/1-1442 ITVTAASPTASDAVTQTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSFPPDTVIG ENSRNOP00000030391/1-1442 ITVTAASPTSSDVVTRTIVVKPEGVAKSYSQSVLLELIDKKQQTEPKSLSFSFPPDTISG *** * ** :**.:*: *:**.**: ****:::**: : :. ::: *****.*: * ENSP00000287097/1-1445 SERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKE ENSCPOP00000006825/1-1437 SERVQITAVGDVLGPSIHGLASLIRMPYGCGEQNMINFAPNIYILDYLTQKKQLTDNVKE XP_004864011.1/1-1444 SERVQITAVGDVLGPSINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLIDHLKE ENSMUSP00000091330/1-1442 SERVQITAIGDILGSSINGLSSLIRMPYGCGEQNMIYFAPNIYILDYLTKQKQLTVNLKE ENSRNOP00000030391/1-1442 SERIQITAIGDILGSSINGLSSLIRLPYGCGEQNMVYLAPNVYILDYLTKQKQLTVNLKE ***:****:**:**.**:**:****:*********: :***:*******::*** ::** ENSP00000287097/1-1445 KALSFMRQGYQRELLYQREDGSFSAFGNYDPSGSTWLSAFVLRCFLEADPYIDIDQNVLH ENSCPOP00000006825/1-1437 KALSFMRQGYQRELLYQRDDGSFSAFGNSDPSGSTWLSAFVLRCFLEADPYIDIDPNVLH XP_004864011.1/1-1444 KALSFMRQGYQRELLYQRDDGSFSAFGNNDPSGSTWLSAFVLRCFLEADPYIDIDQNVLH ENSMUSP00000091330/1-1442 KALSYMRQGYQRELLYQREDGSFSAFGDIDSSGSTWLSAFVLRCFLEADYYIDIDQDVLH ENSRNOP00000030391/1-1442 KALSFMRQGYQRELLYQREDGSFSAFGNSDSSGSTWLSAFVLRCFMEAAQYIDIDQDVLH ****:*************:********: *.**************:** ***** :*** ENSP00000287097/1-1445 RTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNIDVQES ENSCPOP00000006825/1-1437 RTYNWLKGHQKSSGEFWEPGRVIHSDLQGGNNSPVTLTAYIVTSLLGYRKYQPNIDVRDS XP_004864011.1/1-1444 RTFNWLKGHQKSSGEFWEPGTVIHSELQGGNKSPVTLTAYIVTALLGYRKYQPNIDVRDS ENSMUSP00000091330/1-1442 RTYTWLNAHKKFNGEFWEPGRVIHSELQGGTKSPVTLTAYIVTSVLGYKKYQPNIDVQDS ENSRNOP00000030391/1-1442 RTYSWLEAHKKTNGEFWEPGRVIHIELQGGNKSPITLTAYVVTSLLGYKKYQPNIEIQDS **:.**:.*:* .****:** *** :****.:**:*****:**::***:******::::* ENSP00000287097/1-1445 IHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKL ENSCPOP00000006825/1-1437 ISFLESKFSQGISDNYTLALVTHALSSVGSPKAAEALRVLSLRAEEEGGERFWVSPASTL XP_004864011.1/1-1444 INFLESEFSRGISDNYTLALVTYALSAVRSPVAKEALNVLTQRAEEEGGERFWASPTSTL ENSMUSP00000091330/1-1442 IKFLEFEFSRGISDNYTLAIISYALSTVGSPKAEEALNLLMQRSEKEGDTQFWLSSGPAL ENSRNOP00000030391/1-1442 IKFLENEFNRGISDNYTLALVTYALSAVGSPKAEEALTMLTQQAEKEGDTQFWLSSTSES * *** :*.:*********::::***:* ** * *** :* ::*:**. :** *. . ENSP00000287097/1-1445 SDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKAL ENSCPOP00000006825/1-1437 SEGWQPRSLDIEVAAYALLSHFLQRQAPQGLPVMRWLSRKRTSLGGFVSTQDTIVALKAL XP_004864011.1/1-1444 SQGWQPRSLDIEVAAYALLSHFLQLQASQGIPIMRWLSRQRNSLGGFASTQDTIVALKAL ENSMUSP00000091330/1-1442 SGSWQPRSVDIEIAAYALLAHTLH-HVSEGIPVMRWLIQQRNSLGGFVSTQDTVVALKAL ENSRNOP00000030391/1-1442 SESWQSLSAQIEIAAYALLAHTQH-HVPEGIPIMKWLIKQRNSLGGFVSTQDTVMALKAL * .**. * :**:******:* : :..:*:*:*:** ::*.*****.***** :***** ENSP00000287097/1-1445 SEFAALMNTERTNIQVTVTGPSSPSPVKFLIDTHNRLLLQTAELAVVQPTAVNISANGFG ENSCPOP00000006825/1-1437 SEFAVLMNTETKGIQVTVSGPSAPRPVKFLIDTHNRFLFQTAELAVTQLAAVDITANGFG XP_004864011.1/1-1444 SEFVVLMNTERANIQVTVMGPSSPHPVKFLINTHNRFLLQTAELAVGQPTAVNITANGFG ENSMUSP00000091330/1-1442 SEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQNLFLLHQEELHALDPITVNVSAHGSG ENSRNOP00000030391/1-1442 SEFSALVYKENRDMQVTIKGPNVPKPIRFWIDSQNLFKLHKEELAPLDPIAVNVSAHGSG *** .*: .* .:*:*: **. * .::* *:::* : :: ** : :*:::*:* * ENSP00000287097/1-1445 FAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNVCTSFSGPGRS ENSCPOP00000006825/1-1437 FAICQLNVVYNVKDSGSVRRRRSTQNQEAFDLDVNVKDDENDVNHVNLNVCTRFLGPDRS XP_004864011.1/1-1444 FAICQLNVIYNVKDSGSFRGQRSTQNQEAFDLDVNVKDDKNDINRVNLNVCTRFLGPDRS ENSMUSP00000091330/1-1442 FAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIV-NNEDDISHLNLNVCTSHLGSERT ENSRNOP00000030391/1-1442 FAICQLNVDYNVKASSSFKRRRSMENPIGFDLDVDV-NDEHDLRYMKLNVCTSHLGPGRT ******** **** *.* : :** :* ***** * :::.*: :.***** . *. *: ENSP00000287097/1-1445 GMALMEVNLLSGFMVPSEAISLSETVKKVEYDHGKLNLYLDSVNETQFCVNIPAVRNFKV ENSCPOP00000006825/1-1437 GMALMEVNLLSGFAVPSDTISLSETVKKVEYDHGKLNLYLDSVNETQFCVDIPAVRNFKV XP_004864011.1/1-1444 GMALMEVNLLSGFAVPSEAIPLSEMVKKVEHDHGKLNLYLDSVNGTQFCVDIPAVRNFKV ENSMUSP00000091330/1-1442 GMVLMEVNLLSGFSASSDSIPLSETLKKVEYDNGKLNLYLDSVNESQFCVNIPTVRDYKV ENSRNOP00000030391/1-1442 GMALLEVNLLSGFTATSDSIPLSEILKKVEYEPGKLNLYLDHVNETQFCVKIPTVRDFKV **.*:******** ..*::*.*** :****:: ******** ** :****.**:**::** ENSP00000287097/1-1445 SNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLCSDVQGCRPCEDGASGSHHHSSVIF ENSCPOP00000006825/1-1437 SNTQDASVSIVDYYEPRRQAVRSYNSRVKLSSCDLCQDVQGHCPCEDGASDPHHPSSVLF XP_004864011.1/1-1444 SNTQDASVSIVDYYEPRRQVVRSYNSQVKLSSCDLCGDVQGHCLCEDRAAGSLHRSSVLF ENSMUSP00000091330/1-1442 SNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSPD-TNCKSHTDGATDSLRRSSSLL ENSRNOP00000030391/1-1442 SNIRDGLVSIVDYYEPSRQAVRSYNTQMKLSSCYLSAD-PNCRSYMDRATDSLRHSSSLL ** :*. **::***** **.*****:.:***** *. * . * *:.. : ** :: ENSP00000287097/1-1445 IFCFKLLYFMELWL- ENSCPOP00000006825/1-1437 VFSLVLLCSLQHWL- XP_004864011.1/1-1444 IFSLVLLCLLQHWLR ENSMUSP00000091330/1-1442 VFCSVLLYFVQH--- ENSRNOP00000030391/1-1442 VLCSTLLYFVQH--- ::. ** ::