CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000041635/1-1349 MLAVEPTMDGDFPPHELPPPG----GGIQLQNRLLHCPWWGSFS------PSLYPTFSSE ENSRNOP00000062533/1-1284 ------------------------------------------------------------ ENSP00000354733/1-1366 MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFS------LPPYPAFSSD ENSCPOP00000006744/1-1327 MPAVGLAMDGEYPQHERPPAG-VLYSPPPLQNGLLHCPWWSSFSTPSYPAIPSYPGFSSD XP_004866032.1/1-1353 MLAVGPAMDRECPQHEPPPAG-ILYSPTPLQNGLLHCPWWSSFS------PPSYPGFSSD ENSMUSP00000041635/1-1349 NQQFVGSTPFLGGQSCPETSY-PTTATVPSFFSKSSDFPQDPSCLEDLSNASVFSSSVDS ENSRNOP00000062533/1-1284 -------MALLGDQN----SF-TVPCGIPTLGV------QDPSCLEDLSNASVFSSSVDS ENSP00000354733/1-1366 SRPFMSSASFLGSQPCPDTSY-APVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDS ENSCPOP00000006744/1-1327 SHVYASPTSFLDSQPCTNTSYGAAASSAPSFLSKGSDFPQD--YSEDLSNTSIFSSSVDS XP_004866032.1/1-1353 SHVFSSSASFLGGQPCPDASY-ATTATAPSYLSKSGTFPQD-SYFEDLSNASIFSSSVDS .:*..* *: . . .: ** **:** *:******* ENSMUSP00000041635/1-1349 LSDIPDTPDFLQADSLNEVPTIWDVSTTSTTHDKLFIPSGPFSAPEDPVTSLSSTPLLIS ENSRNOP00000062533/1-1284 LSDIPDTPDFLPADSLNEVPTIWDVSTTSTTRDKLFLPSVPFSALEDPVTAVSSTPLLVS ENSP00000354733/1-1366 LSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPS-HSTPLLVS ENSCPOP00000006744/1-1327 LSDIVDTPDFLSADSLTKVPTIWDVSTASSTHDKLASLSRPFPVLEDPVTSLPSTSLLVS XP_004866032.1/1-1353 LSDIVDTPDFLPADSLSQVPTIWDVSTASSTHDKLFLPGGPFPGLEDPVTSLPSTSLLVS **** ****** ****.:*.**** ..:.:*:*** . **. ** :.: **.**:* ENSMUSP00000041635/1-1349 YQ-------SHSQPEEE-EGEEEEETEELGHAETYADYVPSKSKIGKQHPDRVVETSTLS ENSRNOP00000062533/1-1284 YQ-------SHSQPEEE-EGEDEEEAEELGHAETYADYVPSKSKIGKQHPDRVVETSTLS ENSP00000354733/1-1366 YQEQ----SVQSQPEEE-DEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLS ENSCPOP00000006744/1-1327 YQVSLSWANVPCSPGGV-PEAEDLQHARLGHAETYADYVPSKSKIGKQHPDRVVETSTLS XP_004866032.1/1-1353 YQ-------SQSQPEDEVEDEEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLS ** ..* :: : .***:**************************** ENSMUSP00000041635/1-1349 SVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGR ENSRNOP00000062533/1-1284 SVPPPDITYTLALPTSDNGTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGR ENSP00000354733/1-1366 SVPPPDITYTLALP-SDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGR ENSCPOP00000006744/1-1327 SVPPPDITYTLALPTSDSMALSALQLEAITYACQQHEILLPSGQRAGFLIGDGAGVGKGR XP_004866032.1/1-1353 SVPPPDITYTLALPTSDSVALSALQLEAITYACQQHEILLPSGQRAGFLIGDGAGVGKGR ************** **. :*****************:********************** ENSMUSP00000041635/1-1349 TVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEG ENSRNOP00000062533/1-1284 TVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEG ENSP00000354733/1-1366 TVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEG ENSCPOP00000006744/1-1327 TVAGIIVENYVRGRKKALWFSVSNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEG XP_004866032.1/1-1353 TVAGIIVENYIRGRKKALWFSVSNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEG ****:*:**::**********.*****************.**************.***** ENSMUSP00000041635/1-1349 VLFATYSALIGESQAGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNASSTKMGKAVLD ENSRNOP00000062533/1-1284 VLFATYSALIGESQAGGQHRTRLRQILQWCGEAFDGVIVFDECHKAKNASSTKMGKAVLD ENSP00000354733/1-1366 VLFATYSALIGESQAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLD ENSCPOP00000006744/1-1327 VLFATYSALIGESQAGGQHRTRLRQILQWCGEAFDGVIVFDECHKAKNASSTKMGKAVLD XP_004866032.1/1-1353 VLFATYSALIGESQAGGQHRTRLRQILQWCGEAFDGVIVFDECHKAKNASSTKMGKAVLD ***************************:****.*:**************.********** ENSMUSP00000041635/1-1349 LQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIV ENSRNOP00000062533/1-1284 LQNKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIV ENSP00000354733/1-1366 LQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIV ENSCPOP00000006744/1-1327 LQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTSFRTFEEFLHAVEKRGVG----- XP_004866032.1/1-1353 LQTKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHNIEKRGVGAMEIV **.*** ******************************.**.****** :****** ENSMUSP00000041635/1-1349 AMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEALSVFQQAADWIGL ENSRNOP00000062533/1-1284 AMDMKVSGMYIARQLSFSGVTFRIEEIPLSPVFEQVYNRAARLWAEALSVFQQAADWIGL ENSP00000354733/1-1366 AMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGL ENSCPOP00000006744/1-1327 ----------VARQLSFSGVTFRIEEIPLPPDFERIYNRAALLWAEALGVFQQAADWIGL XP_004866032.1/1-1353 AMDMKVSGMYIARQLSFSGVTFRIEEIPLPPDFERVYNRAALLWAEALGVFQQAADWIGL :******************.* *: :***** ******.*********** ENSMUSP00000041635/1-1349 ESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVL ENSRNOP00000062533/1-1284 ESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVL ENSP00000354733/1-1366 ESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVL ENSCPOP00000006744/1-1327 ESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELARKELACNKCVVIGLQSTGEARTREVL XP_004866032.1/1-1353 ESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAREELACNKCVVIGLQSTGEARTREVL ***************************:******::**: :******************* ENSMUSP00000041635/1-1349 DENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGG-KRKRRPRGRGPKASRLSLEAA ENSRNOP00000062533/1-1284 DENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGG-KRKRRPRGRGPKASRLTLEAA ENSP00000354733/1-1366 GENDGHLNCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETA ENSCPOP00000006744/1-1327 DENEGRLDCFVSAAEGVFLSLIQKHFPSTRRKRDRGAGSKRRRRPCGRRTKALRLAPEGT XP_004866032.1/1-1353 DENEGRLDCFVSAAEGVFLSLIQKHFPSTKRKRDRGAGSKRRRRPRGRGTKVPRLALEGT .**:*:*:*********************:*:****.* **:*** ** .*. **: * : ENSMUSP00000041635/1-1349 GVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTHPTDDRGSLYPLQRDLQGPG ENSRNOP00000062533/1-1284 GVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTLPTDDRGPLYPLQRDLQGPG ENSP00000354733/1-1366 GVIRISDDSSTESDPGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPG ENSCPOP00000006744/1-1327 GVIRISDDSSTDSDAGLDSDFNSSPESLVDDDVVIVEAAGLPVDDRA-----QRDLHGPA XP_004866032.1/1-1353 GVIRISDDSSTESDAGLDSDFNSSPESLVDDDVVIVEASGHPVDDRGPLCLPQRDLHGPA *******.***:**.*********************:* * ***. *** :**. ENSMUSP00000041635/1-1349 VVERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGTVV ENSRNOP00000062533/1-1284 VLERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGSVV ENSP00000354733/1-1366 VLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVA ENSCPOP00000006744/1-1327 VLERVERLKQDLLAKVRALGRELPVNTLDQLIDQLGGPEHVAEMTGRKGRVVSRPDGTVT XP_004866032.1/1-1353 VLECVERLKQDLLAKVRALGRELPVNTLDQLIDQLGGPEHVAEMTGRKGRVVSRPDGTVT *:* ******.** *** ***********:**.*****: *****************:*. ENSMUSP00000041635/1-1349 FESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLE ENSRNOP00000062533/1-1284 FESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLE ENSP00000354733/1-1366 FESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLE ENSCPOP00000006744/1-1327 FESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVRNQRRRVHMTLE XP_004866032.1/1-1353 FESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLE ************************************************:*********** ENSMUSP00000041635/1-1349 LPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRA ENSRNOP00000062533/1-1284 LPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRA ENSP00000354733/1-1366 LPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRA ENSCPOP00000006744/1-1327 LPWSADRAIQQFGRTHRSNQVSAPEYIFLISELAGERRFASIVAKRLESLGALTHGDRRA XP_004866032.1/1-1353 LPWSADRAIQQFGRTHRSNQVSAPEYIFLISELAGERRFASIVAKRLESLGALTHGDRRA **************************:********************************* ENSMUSP00000041635/1-1349 TESRDLSKYNFENKYGARALSRVLATIMGQTDNRVPLPQGYPGGDTAFFRDMKQGLLSVG ENSRNOP00000062533/1-1284 TESRDLSKYNFENKYGARALSRVLATIMGQTNNRVPLPQGYPGGDAAFFRDMKQGLLSVG ENSP00000354733/1-1366 TESRDLSKYNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVG ENSCPOP00000006744/1-1327 TESRDLSKYNFENKYGTRALSCVLNTILSHTENQVPLPQGYPGGDAAFFRDMKQGLLSVG XP_004866032.1/1-1353 TESRDLSKYNFENKYGTRALSCVLSTILSQTENKVPLPQGYPGGDAAFFRDMKQGLLSVG ****************:*** ** **:.:*:*:**:******* .:************* ENSMUSP00000041635/1-1349 IGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDM ENSRNOP00000062533/1-1284 IGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDM ENSP00000354733/1-1366 IGGRESRNGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDM ENSCPOP00000006744/1-1327 IGGRESRSGGLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIAMDKKEGRYDM XP_004866032.1/1-1353 IGGRESRSGGLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKKEGRYDM **.****.* *************************************** :**:**:*** ENSMUSP00000041635/1-1349 GILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKQISVDRGMKWEEALTRSLELKGPYD ENSRNOP00000062533/1-1284 GILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYK-ISVDRGMKWEEAFTRSLELKGPYD ENSP00000354733/1-1366 GILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYK-ISVDRGLKWEDAFAKSLALTGPYD ENSCPOP00000006744/1-1327 GILDLAPGVDEIYEENQQVFLAPGHPRDGQVVFYK-VTVDRGLKWEQAFSKSLGFEGHYD XP_004866032.1/1-1353 GILDLAPGIDEIYEESQQVFLAPGHPQDGQVVFYT-ITVDRGLKWEEAFAKSLGLTGPYD ********::**:**.**********:*******. ::****:***:*:::** : * ** ENSMUSP00000041635/1-1349 GFYLSYKVRGSKMSCLLAEQNRGEYFTVYKPNIGRQSQLETLDSLCRKFHRVTVEEAREP ENSRNOP00000062533/1-1284 GFYLSYKVRGSKTSCLLAEQNRGDYFTVYKPNIGRQSQLETLDNLCRKFHRVTPEEAREP ENSP00000354733/1-1366 GFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEP ENSCPOP00000006744/1-1327 GFYLSYKVRGKKLSCLLAEQSSAKHFTVYKPNIGRQSQPETLDGLLRKFQKVSAEEAQEH XP_004866032.1/1-1353 GFYLSYKVRGNKLSCLLAEQGRGKHFTVYKPNIGRQSQPETLDSLCRKFQQVTAEEAQEH **********.* *******. ...************* *:**.* ***::*: ***:* ENSMUSP00000041635/1-1349 WESSYALSLEHCSHTTWNQRCRLTQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADV ENSRNOP00000062533/1-1284 WESSYALSLEHCSHTTWNQRCRLAQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADV ENSP00000354733/1-1366 WESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADV ENSCPOP00000006744/1-1327 WQSSYAYSLTHCSHMAWNQQCRAAQEGRDCVQGLRLRHHYVLCGALLRVWGRVANVMAEV XP_004866032.1/1-1353 WESSYAYSLTHCSHMAWNQHCRLTQEGKDCVQGLRLRHHYVLCGALLRVWGRVASVMADV *:*.** ** **** :**::** :***: * *********:***********:* ***:* ENSMUSP00000041635/1-1349 SSSSYLQIVRLKTKDKKKQVG-IKIPEGCVHRVLQELQLMDAEVKRRSTHGLAAR-PPTP ENSRNOP00000062533/1-1284 SSSSYLQIVRLKTKDKKKQVG-IKIPEGCVHRVLQELQLMDAEVKRRSAHGLAAR-PPTP ENSP00000354733/1-1366 SSSSYLQIVRLKTKDRKKQVG-IKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAP ENSCPOP00000006744/1-1327 SSSSYLQIVRLKTKDGKKQVGEHQDPRGCVHRVLQELRQMDAEVPLRL------------ XP_004866032.1/1-1353 SSSSYLQIVRLKTKDKKKQVG-IKIPEGCVRRVLQELRQMDTEVQRRSRPA---P-PPTP *************** ***** : *.***:******: **::* * ENSMUSP00000041635/1-1349 R-AITLPCGPGEVLDLTYSPPAEAFP------TPPRFAFPSLP---PPDPSSLMLGARDP ENSRNOP00000062533/1-1284 R-AITLPCGPGEVLDLTYSPPAEPFP------APPRFAFPSLP---PPDPSSLMLGTRDN ENSP00000354733/1-1366 R-PLALPCGPGEVLDLTYSPPAEAFP------PPPHFSFPA-PLSLDAGPGVVPLGTPDA ENSCPOP00000006744/1-1327 --PLALPFGPGEVLDLTYSPPAEAFPPSALPPPPPHFAFPQ-P---P------------- XP_004866032.1/1-1353 RLPLALPCGPGEVLDLTYSPPAEAFPPPLL--PPQCFAFPP-P---TPDPGALLLGARDA .::** ***************.** .* *:** * ENSMUSP00000041635/1-1349 ATNPVELAHQSCDINFREVLEDMLRSLRAGPTE--TPAPLVGV---GGGGTERQSVIHFS ENSRNOP00000062533/1-1284 ATNPVELAHQGCDINFREVLEDMLRSLRAGPTE--TPAPLVGVGGGGGGGTERQSVIHFS ENSP00000354733/1-1366 QADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFS ENSCPOP00000006744/1-1327 -PDPAALAHQGCDINFKEVLEDMLRSLHAAPAE--PPGPLMG----AGTGPERQSVIHFS XP_004866032.1/1-1353 VPDPAALAHQGCDINFKEVLEDMLRSLHAPPAE--PPGPLMAP---GAGGPERQSVIRFS .:*. ****.*****:**********:* *.. . . . .. *.******:** ENSMUSP00000041635/1-1349 PPFPNS---- ENSRNOP00000062533/1-1284 PPFPNS---- ENSP00000354733/1-1366 PPFPGAQAPL ENSCPOP00000006744/1-1327 PPFPNSQTPL XP_004866032.1/1-1353 PPFPNS---- ****.: