CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000124394/1-1456 MIESENLNRGEIIKELCLCNGLTYEIVGQEGSDTSKLEMFFSGYPRIVGLSLFHNLSSLT ENSRNOP00000007339/1-1155 MIESEHFNRGEIIKELCLCNGLSYEMVGQEGSDTSKLEMFFSGYPRIVGLSLFHNLSSLT ENSP00000454748/1-1453 MIESENLNQEEIIKELCLCNGLSYEMVGQEGSDTSKLEMFFLGYPRIVGLSLFPNLTSLT ENSCPOP00000006727/1-1110 MTESENLSQEEIIKELCMCNGLSYEMVKQEGSDASKLEMFFSGYPCIVGLSLFPSLTSLT XP_004837510.1/1-1465 MTESEILNQEEIIKELCLCNGLSYEMVGQEGSDASKLEMFFSGYPHIVGLSLFPNLASLT * *** :.: *******:****:**:* *****:******* *** ******* .*:*** ENSMUSP00000124394/1-1456 IVAQDIREISGLETCLQLKELWIAECCIEKIEGLQGCRNLEKLYLYYNKISKIENLEKLI ENSRNOP00000007339/1-1155 IVAQDIKEISGLETCLRLKELWIAECCIEKIEGLHGCRNLEKLYLYYNKISKIENLEKLI ENSP00000454748/1-1453 IVAQDIKEISGLEPCLQLKELWIAECCIEKIEGLQECRNLEKLYLYFNKISKIENLEKLI ENSCPOP00000006727/1-1110 IVAQDIKEISGLETCLQLKELWIAECYIEKIRGLEECRNLKKLYLYYNKISKIENLEKLT XP_004837510.1/1-1465 IVAQDIKEISGFETCLQLKELWIAECFIEKIGGLQECRNLKKLYLYYNKISKIENLEKLT ******:****:*.**:********* **** **. ****:*****:************ ENSMUSP00000124394/1-1456 KLEVLWLNHNMIKNIEGLQTLKNLKDLNLAGNLVSSIGRCLDPNEQLEKLNLSGNQITSF ENSRNOP00000007339/1-1155 KLEVLWLNHNTIRNIEGLQTLKNLKDLNLAGNLISSIGRCLDPNEQLEKLNLSGNQITSF ENSP00000454748/1-1453 KLKVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLINSIGRCLDSNEQLERLNLSGNQICSF ENSCPOP00000006727/1-1110 RLEVLWLNHNTIKNIEGLQTLKNLKDLNLAGNLISSIGRCLDANEQLERLNLSGNQISSF XP_004837510.1/1-1465 QLEVLWLNHNTIKNIEGLQTLKNLNDLNLAGNLISSIGRCLDANEQLERLNLSGNQICSF :*:******* *:***********:********:.*******.*****:******** ** ENSMUSP00000124394/1-1456 KDLTNLTKLTRLKDLCLNDPQYKSNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKEL ENSRNOP00000007339/1-1155 KDLTNLTKLPRLKDLSLNDPQYKSNPVCQLCNYSTHVLYHLPSLQRLDTFDVSAKQIKEL ENSP00000454748/1-1453 KELTNLTRLPCLKDLCLNDPQYTTNPVCLLCNYSTHVLYHLPCLQRFDTLDVSAKQIKEL ENSCPOP00000006727/1-1110 KDLTNLTRLPSLKDLCLNDSQYKTNPVCQLCNYSTHVLYHLPCLERLDTFDVSAKQIKEL XP_004837510.1/1-1465 KDLTNLTGLPSLKDLCLNDPQYKANPVCQLCNYSTHVLYHLPCLQRLDTFDVSAKQIKEL *:***** *. ****.***.**.:**** *************.*:*:**:********** ENSMUSP00000124394/1-1456 ADSTAMKKIMYYNMRIKTVQRHLNEELEKLNDRKCKLQKLPEERIKLFNFAKKTLERELA ENSRNOP00000007339/1-1155 ADSTAMKKIMYYNMRIKTVQRHLNEELEKLNDRKCKLQKLPEERIKLFNFAKKTLERELA ENSP00000454748/1-1453 ADTTAMKKIMYYNMRIKTLQRHLKEDLEKLNDQKCKLQKLPEERVKLFSFVKKTLERELA ENSCPOP00000006727/1-1110 ADTTAMKKIMYYNMRIKTVQRHLNEDLEKLNDRKCKLQKLPEEQIKLLSFVKKNLERELT XP_004837510.1/1-1465 ADTTVMKKIMYYNMRIKTVQRHLNEDLEKLNVRKCKLQKLPEEQIKLLSFVKKNLERELA **:*.*************:****:*:***** :**********::**:.*.**.*****: ENSMUSP00000124394/1-1456 ELKISSKGQSD-----TTPEAEKPRNSEVVTQESVLQQKILTKLSALDDRVTFWNKKLHE ENSRNOP00000007339/1-1155 ELKISGKGQSD-----TAPEAEKARNSETLTQESVLQQKILTKLNALDDRVMFWNKKLHE ENSP00000454748/1-1453 ELKGSGKGHSDGSNNSKVTDPETLKSCETVTEEPSLQQKILAKLNALNERVTFWNKKLDE ENSCPOP00000006727/1-1110 ELKGSGKGHSDRSNNSKATEVEKSKSGETVTEELRLQQKIMIKLNALNERVTFWNKKLDE XP_004837510.1/1-1465 ELKGSGKGHSDRSNNNKVTEVEKSKSCETIIEEPNLQQKIMIKLNALNERVTFWNKKLDE *** *.**:** ...: *. :. *.: :* *****: **.**::** ******.* ENSMUSP00000124394/1-1456 IEAIYRTEVKQKKKTHGLLTPFLLTELETVGNIHFEEGTQADDWFNSCCELILSRFCTWD ENSRNOP00000007339/1-1155 IEAIYRTEVKQKKKSHGLLTPFLLTELETVGNIHFEEGTRADEWFNSCYELILSRFCTWD ENSP00000454748/1-1453 IEAIYHIEVKQKKKSHGLLIPLLLIELETVGNFHFEEGTRSDDWFNFCYELILSRFCAWD ENSCPOP00000006727/1-1110 IEEIYQIDVKQKKKSHGLLIPFLLIELETVGNIHFEQGTRSDDWYNSCYELILSRFCTWD XP_004837510.1/1-1465 IEAIYRIEVKQKKESHGLLIPFLLIELETVGNIYFEQGTRSDDWYNSCYELILSRFCTWD ** **: :*****::**** *:** *******::**:**::*:*:* * ********:** ENSMUSP00000124394/1-1456 FRAYGITGVKVKRVIKVNNRILRLKFEEKFQKCLDLEDTQDPD-YRKMLECLFYVFDPEV ENSRNOP00000007339/1-1155 FRAYGITGVKVKRVIKVNNRILRLRFEEKFQKCLDLEDIQDSESYRKMLECLFYVFDPEV ENSP00000454748/1-1453 FRTYGITGVKVKRIIKVNNRILRLKFEEKFQKFLENEDMHDSESYRRMLECLFYVFDPEV ENSCPOP00000006727/1-1110 FRAYGITGVKVKRVIKVNNRILRLKFEEKFQKFLCDEDMHDSESYRKMMDCLFYVFDPEV XP_004837510.1/1-1465 FRTYGITGVKVKRVIKVNNRILRLKFEKKFQKFLDVGDMHDSKSYRKMLECLFYVFDPEV **:**********:**********:**:**** * * :*.. **:*::********** ENSMUSP00000124394/1-1456 TVKKKHLLQILERGFKDSDTSKPSLKKEAVTLVNSLSMCECPRIEFLQQKYKEEKKGPSE ENSRNOP00000007339/1-1155 TVKKKHLLQILERGFKDSDTSKPPLRKEAVTLVNSLSMCECPRIEFLQQKYKEEKKSPSE ENSP00000454748/1-1453 SVKKKHLLQILEKGFKDSETSKLPLKKEAIIVSNSLSISECPRIEFLQQKHKDEKKISLK ENSCPOP00000006727/1-1110 TVKKKHLLQILERGFKESKTSKLPLRKEAVILTNSLSMCECPRIEFLQQKHKSEKKNSFD XP_004837510.1/1-1465 TVKEKHLLQIIEKGFKESERSKLPLRKEAVILANSLSMCECPRIEFLQQKYKDEKRSSFN :**:******:*:***:*. ** .*:***: : ****:.***********:*.**: . . ENSMUSP00000124394/1-1456 SELYRHGTILIAKVFLGQSIQARDQEPINKANYPMVNSVFVPQRHVLR----QRTCDCGY ENSRNOP00000007339/1-1155 SDLYRHGTILIAKVFLGQSIQARDQEPISKANYPMVNSVFVPQRHMLR----QRTCDCGY ENSP00000454748/1-1453 HELFRHGILLITKVFLGQSVQAHEKESISQSNYPMVNSVFIPRKYLLNSVMGQRNCDCSV ENSCPOP00000006727/1-1110 HELFRHGILLITKVFLGRSVQAHEQESINQANYPTVNSVFIPQKYLQSSIVGQTNCDCGF XP_004837510.1/1-1465 PDLFRHGILVITKVFLGQSVQAREQESISQANYPMVNSVFIPQKYLQNSIMGQRNCDCGF :*:*** ::*:*****:*:**:::*.*.::*** *****:*:::: * .***. ENSMUSP00000124394/1-1456 RQYKWFVFDHDLVLPEYIVEFEYTTVVKVHSLFSTSNNVILEEGKKYSEGLVFSQDLKFD ENSRNOP00000007339/1-1155 RQYKWFVFDHDLVLPEYIVEFEYTTVVKVHSLFSTLNNVILEEGKKYSEGLVFSQDLKFD ENSP00000454748/1-1453 RQCKWFVFDHDLVLPEYVVEFEYITMVKAPSLFSVFNNVILEESKKNPEVSVFSKDLKFD ENSCPOP00000006727/1-1110 RQCKWFVFDHDLVLPEYIVEFEYITVVKAHSLFSTFNNIIIEENKNYSEGSVLSQDLTFD XP_004837510.1/1-1465 RQCKWFVFDHDLVLPEYIVEFEYITVIKAHSLFSTFNNIIIEERKNYSEGSILSQDLKCD ** **************:***** *::*. ****. **:*:** *: .* ::*:**. * ENSMUSP00000124394/1-1456 DEVLKMEPRIKPRPKLISLDEKTIISLAKTNIYSHIVNLNLHGNSLSKLRDLAKLTGLRK ENSRNOP00000007339/1-1155 DEVLKMEPRIKPRPKLISLDEKTIISLARTNIYSHIVNLNLHGNSLSKLRDLSKLTGLRK ENSP00000454748/1-1453 DEVIKMEPRIKARPKLISLDDKTILSLAKTSVYSHIVSLNLHGNSLSKLRDLSKLTGLRK ENSCPOP00000006727/1-1110 DEVMKMEPRIKPRPRLLSLDDKTILSLAKTNAYTQIVSLNLHGNSLSKLRDLSKLTGLQR XP_004837510.1/1-1465 DEVMKMEPRIKPRPKLPSLDDKTILSLAKTNVYTHIVSLNLHGNSLSRLEDLSKLTGLRK ***:*******.**:* ***:***:***:*. *::**.*********:*.**:*****:: ENSMUSP00000124394/1-1456 LNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKTGEEIN ENSRNOP00000007339/1-1155 LNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKTGEEIN ENSP00000454748/1-1453 LNISFNEFTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSGNEIN ENSCPOP00000006727/1-1110 LSISFNELTCLDDVYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSGDEIN XP_004837510.1/1-1465 LNISFNELTCLDDLYHLYNLEYLDASHNHVITLEGFRGLMKLKHLDLSWNQLKKSGDEIN *.*****:*****:****************************************:*:*** ENSMUSP00000124394/1-1456 VLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLVISEEETRAALKFISGTK ENSRNOP00000007339/1-1155 VLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLDGLLISEEETRAALKFISGTK ENSP00000454748/1-1453 MLCKHTTSLLTLDIQHNPWQKPATLRLSVIGRLKTLTHLNGVFISEEEATAAMKFIAGTR ENSCPOP00000006727/1-1110 VLCKHTTSLHTLNIQHNPWQKPATLRLSVIGRLKTLTHLDGVLISEEEMTAALKFIAGTK XP_004837510.1/1-1465 VLCKHTTSLLTLNIQHNPWQKPATLRLSVIGRLKTLTHLDGLLISEEETTAALKFITGTK :******** **:**************************:*:.***** **:***:**: ENSMUSP00000124394/1-1456 ITQLTLLQHSSSKEERPRMLSTWPSAKILTQISKLGPHFHLTGNWYSKITALNLDGQHLF ENSRNOP00000007339/1-1155 ITQLTLLQHSSSKEERPRMLSIWPSAKILTQISKLGPHFHLTGNWYLKITALNLDGQHLF ENSP00000454748/1-1453 ITQLSLLRHSSTKEERPRILSIWPSAKILTQVSKLGPHLHLSGNCYLKITALNLDGQHLF ENSCPOP00000006727/1-1110 ITQSCILRHSSTKEERPRMLSIWPSAKILTQISKLGPYLHLSGNLYLKITALNLDGQHLF XP_004837510.1/1-1465 ITQSCVLWHCSTKEERPRTLSIWPSAKILTQISKLGPCLHLSGNWYLKITALNLDGQHLF *** :* *.*:****** ** *********:***** :**:** * ************* ENSMUSP00000124394/1-1456 EITNLEKLENLKWASFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSM ENSRNOP00000007339/1-1155 EITNLEKLENLKWASFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGITRLTKLSRLSM ENSP00000454748/1-1453 EITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGISKMTKLTRLSI ENSCPOP00000006727/1-1110 EIKNLEKLENLKWASFSNNNLTKMEGLESCTNLEELTLDGNCISKIEGISKLTKLTR-SI XP_004837510.1/1-1465 EIKNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCIAKIEGISKLTKLTRLSI **.******************:******** ************:*****:::***:* *: ENSMUSP00000124394/1-1456 NNNLLTGLEKHTFDNLLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNL ENSRNOP00000007339/1-1155 NNNLLTGLEKHTFDNMLHLHSLSLENNRITSLSALQKTFTLIELYISNNYIAVNQEIYNL ENSP00000454748/1-1453 NNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSFTLVELYISNNYIAVNQEMHNL ENSCPOP00000006727/1-1110 NNNLLTGLEKHTFDNMLHLHFLSLDNNRITSLSGLQKTFTLIELYISNNYIAINQEIYNL XP_004837510.1/1-1465 NNNLLTGLEKHTFDNMLHLHFLSLENNRITSLSGLQKTFTLIELYISNNYIAVNQEIYNL ******* *:*****:**** ***:********.***:***:**********:***::** ENSMUSP00000124394/1-1456 KGLCNLVILDMYGNIIIWNQENYRFFVIFHLPELKALDGVSIETSETETAKDLFGGRLTS ENSRNOP00000007339/1-1155 KGLCNLVILDMYGNIIIWNQENYRLFVIFHLSELKALDGMSIEPSETENAKDLFGGRLTS ENSP00000454748/1-1453 KGLCNLVILDMCGNIIIWNQENYRLFVIFHLPELKALDGIPIEPSETDSAKDLFGGRLTS ENSCPOP00000006727/1-1110 KGLCNLVILDIHGNVIVWNQENYRLFVIYHLPELKALDGISIETPETENAKDLFGGRLTS XP_004837510.1/1-1465 KGLCNLVILDMHGNIILWNQENYRLFVIYHLPELKALDGISIETPETETAKDLFGGRLTS **********: **:*:*******:***:**.*******:.**..**:.*********** ENSMUSP00000124394/1-1456 DMIAERQGHSNFIQMQELNWTSSAIRTVDLIPVDHFRNVSNVNLQNNNLTSFSGLIYLPN ENSRNOP00000007339/1-1155 DMIAERQGHSNFVQMQELNWTSSSIRTVDLIPVDHFRNVSNVNLQNNNLTSFSGLIYLPN ENSP00000454748/1-1453 DMIAERQGHSNFKQMQELNWTSSSIRTVDLIPVDQFRNVCNVNLQNNHLTSFSGLIYLPN ENSCPOP00000006727/1-1110 DMIVERQGHSNFTQMQELNWTSSSLR---------------------------------- XP_004837510.1/1-1465 DMIAERQGHSNFAQMQELNWTTSSLRTVDLIPVDQFRNLCNVNLQNNNLTSFSGLIYLPN ***.******** ********:*::* ENSMUSP00000124394/1-1456 VKVLCLNYNHIESIMPRLKPQTHLSSRQLLYQKVPSSGYGQQGTSKLNRDSVGSENLPPI ENSRNOP00000007339/1-1155 VKA--------------------------------------------------------- ENSP00000454748/1-1453 VKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSGYGQQGISKTNRDIMSSENLPPI ENSCPOP00000006727/1-1110 ------------------------------------------------------------ XP_004837510.1/1-1465 VKVLCLNYNHIESIIPKLKPHNHLTNKQMLYQKVPSSGYGQQGTPKTNRDTMNSENLPPI ENSMUSP00000124394/1-1456 MQSLEVLHLGYNGICNLVQLQLNRLRNLKFLFLQGNEISQVEGLDNLIVLQELVVDHNRI ENSRNOP00000007339/1-1155 ---------------------------------RG------------------------- ENSP00000454748/1-1453 MHSLEVLHLGYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEGLDNLVVLQELVVDHNRI ENSCPOP00000006727/1-1110 ------------------------------------------------------------ XP_004837510.1/1-1465 MHSLEVLHLGYNGICNLTQLQLNRLRNLKFLFLQGNKISQVEGLDNLVVLQELVVDHNRI ENSMUSP00000124394/1-1456 RAFNDTAFSKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGYNKIQDITELEKLDVIPS ENSRNOP00000007339/1-1155 ------------------------------------------------------------ ENSP00000454748/1-1453 RSFNDSAFAKPSSLLALHLEENRLRELGKLQSLVKLEKLFLGYNKIQDITELEKLDVIST ENSCPOP00000006727/1-1110 ------------------------------------------YNQFV------------- XP_004837510.1/1-1465 RAFNDSAFAKPSSLLALHLEENRLRELSKLQSLVKLEKLFLGYNKIQDMAELEKLDVISS ENSMUSP00000124394/1-1456 LRELTVYGNPICRKMVHRHVLIFRLPNLQMLDGIPINSDDRAKAEFHFSELQAKKSSIIQ ENSRNOP00000007339/1-1155 -----------CRA-------IFALKDFS------------------------------- ENSP00000454748/1-1453 LRELTVYGNPICRKMLHRHMLIFRLPNLQMLDGSPVNSDDRAKAEFHLAELQAKKNSLIP ENSCPOP00000006727/1-1110 ------------------------------------------------------------ XP_004837510.1/1-1465 LRELTVYGNPICRKILHRHVLIFRLPNLQMLDGIPVNSDDRVKAEFHFSELQAKKNLLIA ENSMUSP00000124394/1-1456 NNLPTSKSSLPSHLQTPLPCKFVPVTNSTDGGSFCHVKASPIKITNVLLPAGFSRFLGPD ENSRNOP00000007339/1-1155 -------TSFNLHLH--------------------------------------------- ENSP00000454748/1-1453 V------THSPM-----------------DGRSFGQVKTPPIEITNVLLPSGFSHYLGSD ENSCPOP00000006727/1-1110 ------------------------------------------------------------ XP_004837510.1/1-1465 G------TSSPM-----------------DGASFCQVKAPPIKITNLILPAGHSHYLGPD ENSMUSP00000124394/1-1456 FTLTPEVEGIFTKSFRENEKTNKQQQ---------------------- ENSRNOP00000007339/1-1155 ------------------------------------------------ ENSP00000454748/1-1453 VTLTPEVEEFLGATFQDQIECNCLKRNEHTPRNSPV------------ ENSCPOP00000006727/1-1110 ------------------------------------------------ XP_004837510.1/1-1465 FTLTPENEEFLEATFQDQIIYNCLKKNEHTPENLFLSVVVHKLAESSQ