CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000057956/1-1450 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE ENSRNOP00000066263/1-1452 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE ENSP00000426632/1-1419 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE ENSCPOP00000006661/1-1455 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE XP_004862914.1/1-1458 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE ************************************************************ ENSMUSP00000057956/1-1450 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV ENSRNOP00000066263/1-1452 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVV ENSP00000426632/1-1419 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV ENSCPOP00000006661/1-1455 LPKQLFNCQSLHKLSLPDNDLTALPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVV XP_004862914.1/1-1458 LPKQLFNCQSLHKLSLPDNDLTALPASIANLINLRELDVSKNGIQEFPENIKNCKVLTVV **********************:***********************************:* ENSMUSP00000057956/1-1450 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM ENSRNOP00000066263/1-1452 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPNMI ENSP00000426632/1-1419 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM ENSCPOP00000006661/1-1455 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM XP_004862914.1/1-1458 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM *********************************************************: : ENSMUSP00000057956/1-1450 N-RLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSK ENSRNOP00000066263/1-1452 TLTFTSLNHNYLGNSRARYLPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSK ENSP00000426632/1-1419 N-RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK ENSCPOP00000006661/1-1455 N-RLTQLERLDLGSNEFSEVPEVLEQLSGLKEFWMDGNRLTFIPGFIGSLKQLTYLDVSK XP_004862914.1/1-1458 N-RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDGNRLTFIPGFIGSLKQLTYLDVSK . :*.*:: **... :**********:*****.*************:********* ENSMUSP00000057956/1-1450 NNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLR ENSRNOP00000066263/1-1452 NNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLR ENSP00000426632/1-1419 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI ENSCPOP00000006661/1-1455 NNIEMIEEGISACENLQDLLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLM XP_004862914.1/1-1458 NNIEMVEEGISACENLQDLLLSSNSLQQLPETVGSLKNVTTLKIDENQLMYLPDSIGGLI *****:*****:******:*************:*****:******************** ENSMUSP00000057956/1-1450 SIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLET ENSRNOP00000066263/1-1452 SIEELDCSFNEIEALPSSIGQLTNIRTFAADHNYLQQLPPEIGNWKNVTVLFLHSNKLET ENSP00000426632/1-1419 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLET ENSCPOP00000006661/1-1455 SIEELDCSFNEIEALPSSIGQLNNIRTFAADHNYLQQLPPEIGNWKNVTVLFLHSNKLEL XP_004862914.1/1-1458 SVEELDCSFNEIEALPSSVGQLTNIRTFAADHNYLQQLPGEIGNWKNVTVLFLHSNKLET *:*********:******:***.*:************** ***.***:******.**** ENSMUSP00000057956/1-1450 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQK ENSRNOP00000066263/1-1452 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQK ENSP00000426632/1-1419 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQK ENSCPOP00000006661/1-1455 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKESDSETQK XP_004862914.1/1-1458 LPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKESDSETQK *****************************************************:*:**** ENSMUSP00000057956/1-1450 MVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGN ENSRNOP00000066263/1-1452 MVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGN ENSP00000426632/1-1419 MVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGN ENSCPOP00000006661/1-1455 MVLTNYMFPQQPRTEDVMFVSDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGN XP_004862914.1/1-1458 MVLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGN *******************:********:******************************* ENSMUSP00000057956/1-1450 LKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSEST ENSRNOP00000066263/1-1452 LKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKGVKPSESI ENSP00000426632/1-1419 LKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSEST ENSCPOP00000006661/1-1455 LKRYPTPYPDELKNMVKTVQTIVHRLKDEETSEDSLRDLKPHEDQQVTNKDLVVKGSEST XP_004862914.1/1-1458 LKRYPTPYPDELRNMVKTVQTIVHRLKDEETSDDSARDLKSHEDQQVANKDVGVKASGST ************:******************.::* **** ***** *** ** * * ENSMUSP00000057956/1-1450 TT-KSKLDEREKYM--NSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESE ENSRNOP00000066263/1-1452 TT-KSKLDEREKYM--NSVPKTSEPEAETNAGNSPVTTNRKSSGNMKHLVNHDDVFEESE ENSP00000426632/1-1419 TTVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESE ENSCPOP00000006661/1-1455 TPIKSKVDEREKHMIGNSIQKISEPEAEISSGNLPMTVNMKVSENLKHIVNHDDVFEEPE XP_004862914.1/1-1458 TPIKSKVDEREKHMIGNSIQSIQINEAEISPGNLPVTVNMKASENLKHVVNHDDVFEESE *. ***:*****:* **: . . *** . *. *:*.. * * *:**:*********.* ENSMUSP00000057956/1-1450 ELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCS ENSRNOP00000066263/1-1452 ELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDAKDTDSLSDEVTHNSNQNNSNCS ENSP00000426632/1-1419 ELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCS ENSCPOP00000006661/1-1455 ELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDETKDADSLSDEVTHNSNQNNSNCS XP_004862914.1/1-1458 ELSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDETKDTDSLSDEVTHNSNQNNSNCS *******************:****************::*::******************* ENSMUSP00000057956/1-1450 SPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEK ENSRNOP00000066263/1-1452 SPSRMSDSVSLNTDSSQDTALCSPAKQIPIDSNSKIRQEDENFNSLLQNGVNLNNSPEEK ENSP00000426632/1-1419 SPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEK ENSCPOP00000006661/1-1455 SPSRMSDSVSLNTDSSQDTSLCSPVKQTHIGINSQIRQEDENFNNLLQNGDILNNSPEEK XP_004862914.1/1-1458 SPSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGNILNNSPEEK *******************:****.** :. **::********.***** **.*.*** ENSMUSP00000057956/1-1450 FKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPE ENSRNOP00000066263/1-1452 FKINDKKDFKLPEYDLNIEEQLVLIEKDVDSKATSEDSHQLDHINMNLNKLVTNNIFQPE ENSP00000426632/1-1419 FKAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPE ENSCPOP00000006661/1-1455 FKVHDKKDFNFPEYDLNIEEQLVLIEKGIDSTATSDEPHKLDHINMNLNKLVNNDTFQPE XP_004862914.1/1-1458 FKVHDKKDFNFAGYDLNIEEQLVLIEKGVDSTATSDEPRRLDHINLNLNKLVTNDTFQPE ** :*****::. ****:**:******.:**.**:::.::*****:*:***:.*: **** ENSMUSP00000057956/1-1450 VMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQ ENSRNOP00000066263/1-1452 IMERSKMQDIVLGTGFLSIHSKSEAEHIENGNKFLNSESINKVNGLSEDTAQSPGRIEPQ ENSP00000426632/1-1419 IMERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPH ENSCPOP00000006661/1-1455 VMERLKTQDVVLGVGF--NNSKKEAEHLENGNKYHNLESINKVNGHSEEMPQSPTRTELQ XP_004862914.1/1-1458 IMERSKTQDIVLGTGFLNMNSKKETEHLENGNGYPNLESINKVNGHSEETPQSTSRTEPQ :*** * **:***..* :.*.*:**:*** : * **:***** .*: . *. * * : ENSMUSP00000057956/1-1450 KASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAV ENSRNOP00000066263/1-1452 NT-SPADVGISKSTEDLSPQRSGPAGSVVKSHSITNMETGGLKIYDILSDDGPQPPGATV ENSP00000426632/1-1419 DSDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTV ENSCPOP00000006661/1-1455 DTNSSIDVGISKSTEDISPQRSGPVGSVVKSHSITNMETGGLKIYDILSDNGPQQPSAAV XP_004862914.1/1-1458 DASSSVDVGISKSTEDLSPQRSVPVGSVVKSHSITNMETGGLKIYDILSDNGPQQPNAAV .: .. *:********:***:* *.*:*********** *********.*:*** *.::* ENSMUSP00000057956/1-1450 KIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIR ENSRNOP00000066263/1-1452 KVASTMDGKNIVRSKSATLLYDQPLQVFTASSSSSELLSGTKAVFKFDSNHNPEDPDIIR ENSP00000426632/1-1419 KITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIR ENSCPOP00000006661/1-1455 KITAAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLMSGTKAVLKFDSNHNPEEPDTLR XP_004862914.1/1-1458 KITSAIDGQNIVRSKSATLLFDQPLQIFTGSSSSSDLMSGTKAIFKFDSNHNPEEPDIVR *:::::**:***********:*****:**.:****:*:*****::*********:*: :* ENSMUSP00000057956/1-1450 AATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAEN ENSRNOP00000066263/1-1452 ASIVPGPQSIPQLYGPPQYNVQYSGSAAMKDTLWHPKQNPQIDPVSFPPQRLPRSESAEN ENSP00000426632/1-1419 GPT-SGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTEN ENSCPOP00000006661/1-1455 APTTSSPQSTSQMYGSPQYNIQYSSNAAVKDSLWYSKQSSQVDPVSFPPHRLPRSESTEN XP_004862914.1/1-1458 APTTSSPQSTPQIYGPPQYNVQYSSNAAVKDSLWHSKQSSQIDPVSF-PHRLPRSESTEN .. ..*** .::**.****:***..*::**:**:.**..*:* .** *: ******:** ENSMUSP00000057956/1-1450 HSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQS ENSRNOP00000066263/1-1452 HSYTKHSANMNFSNHNNVRANTAYHLHQRLAPTRHGEMWAVSPNDRLVPAVSRTTVQRQS ENSP00000426632/1-1419 QSYAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQS ENSCPOP00000006661/1-1455 HSYAKHSANMNFSNHNNVRANTAYHLHQRLGPTRHGEMWAVSPNDRLVPAVSRASVQRQG XP_004862914.1/1-1458 HSYAKHSANMNFSNHNNVRANTAYHLHQRLGP-RHGEMWAISPNDRLVPTVSRTTIQRQS :**:******************.***:***.* *******:******:*:*:*:::***. ENSMUSP00000057956/1-1450 SVSSTASVNLGDP--TRRTE---GDYLSYRELHSMGRT-PVMSGSQRPLSARAYSIDGPN ENSRNOP00000066263/1-1452 SVSSTASVNLGDPGPTRRTE---GDYLSYRELHSMGRT-PVTSGSQRPLSARAFSIDGPS ENSP00000426632/1-1419 SVSSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPN ENSCPOP00000006661/1-1455 SVSSAASVNLGDPGSTRHAQIPEGDYLSYRELHSVGRTPPLMSGSQRPLSARTYSMDGPN XP_004862914.1/1-1458 SVSSTASVNLGDPGSTRHAQISEGDYLSYRELHSVGRTPPVMSGSQRPLSARTYSIDGPN ****:******** **::: ********:** *** *: .*********::*:***. ENSMUSP00000057956/1-1450 TSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWRE ENSRNOP00000066263/1-1452 TSRPQSARPSISEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPHDWRE ENSP00000426632/1-1419 ASRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWRE ENSCPOP00000006661/1-1455 GSRPQSARPSVNEISERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPQGKSKVPHDWRE XP_004862914.1/1-1458 ASRPQSARPSINEISERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPHDWRE *********:.**.*********************:*********** ******:**** ENSMUSP00000057956/1-1450 QVLRHIEAKKLEKSMLSRSFNSNLTAVSSSHYGSSRDLHGSQGSLALSVADGRGSGGHIF ENSRNOP00000066263/1-1452 QVLRHIEAKKLEKSMLSRSFSSNLTAVSSSHYGSSRDLHGSQGSLALNVADGRGSGGHSF ENSP00000426632/1-1419 QVLRHIEAKKLEKSMLSRSFNSNFTTVSSFHCGSSRDLHGSQGSLALSVADRRGSGGHIF ENSCPOP00000006661/1-1455 QVLRHIEAKKLEKSMLSRSFNSNFTAVSSSQYGSSRDLHGSQGSLALSVADGRGSGAHIF XP_004862914.1/1-1458 QVLRHIEAKKLEKSMLSRSFNSNFTAVSSSQYGSSRDLHGSQGSLALSVADGRGSGGHIF ********************.**:*:*** : ***************.*** ****.* * ENSMUSP00000057956/1-1450 RHPQTSSPGECCQDDRFMSEEQNHPSGALSHRG-LPDSLMKMPLSNGQMGQPLRPQAHYS ENSRNOP00000066263/1-1452 RHPQTSSPGDCCQDDRFMSGEQNHPLGALSHRD-LRDSLMKMPLSNGQMGQPLRPQANYS ENSP00000426632/1-1419 R----------------------------------------MPLSNGQMGQPLRPQANYS ENSCPOP00000006661/1-1455 QHPWTSSPGDSCQDD---SELQNYSSAMLNHKDVLPDSLMKMPLSNGQMSQPLRPQANCS XP_004862914.1/1-1458 QHAWTSSPGDSCQDDTFISAQQSYSSATLSHKDVLPDSLMKMPLSNGQMGQPLRPQANYS : ********.*******: * ENSMUSP00000057956/1-1450 QTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPE ENSRNOP00000066263/1-1452 QTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPE ENSP00000426632/1-1419 QIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE ENSCPOP00000006661/1-1455 QIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSARPGHELAKQEIRVRIEKDPE XP_004862914.1/1-1458 QIHHPPQASVARHPSREQLIDYLMLKVAHQPPYTQPHCSPRQGHELAKQEIRVRVEKDPE * ********************************:****.* ************:***** ENSMUSP00000057956/1-1450 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQA ENSRNOP00000066263/1-1452 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQA ENSP00000426632/1-1419 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQA ENSCPOP00000006661/1-1455 LGFSISGGVGGRGNPFRPEDDGIFVTRVQPDGPASKLLQPGDKIIQANGYSFINIEHGQA XP_004862914.1/1-1458 LGFSISGGVGGRGNPFRPEDDGIFVTRVQPDGPASKLLQPGDKIIQANGYSFINIEHGQA ******************:***********:***************************** ENSMUSP00000057956/1-1450 VSLLKTFHNAVDLIIVREVSS ENSRNOP00000066263/1-1452 VSLLKTFHNAVELIIVREVSS ENSP00000426632/1-1419 VSLLKTFQNTVELIIVREVSS ENSCPOP00000006661/1-1455 VSLLKTFQNTVELIIVREISS XP_004862914.1/1-1458 VSLLKTFQNTVELIIVREVSS *******:*:*:******:**