CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000106846/1-1370 MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRCGTSPLACLNAML ENSRNOP00000015827/1-1414 MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEISSGTSPLACLNAML ENSP00000391447/1-1435 MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAML ENSCPOP00000006620/1-1323 -----------------------------------------------SGTSPLACLNAML XP_004839180.1/1-1386 MREKGRRKKGRTWAEAAKTVLEKYPNTPMSHKEILQVIQREGLKEIRSGTSPLACLNAML .************ ENSMUSP00000106846/1-1370 HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSEN-SSSSDG ENSRNOP00000015827/1-1414 HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSEN-SSSSDG ENSP00000391447/1-1435 HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDG ENSCPOP00000006620/1-1323 HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDG XP_004839180.1/1-1386 HTNSRGEEGIFYKVPGRMGVYTLKKDVPDGVKELSEGSEESSDGQSDSQSSENSSSSSDG ***************************************************** ****** ENSMUSP00000106846/1-1370 GSNKEGRKSRWKRKVSSRLSHPPSPPSGCPSPTIPASKVISPSQKHSKKALKQALKQQQQ ENSRNOP00000015827/1-1414 GSNKEGRKSRWKRKGTGRLSKAPGPPSSCPSPTIPASKVISPSQKHSKKALKQALKQQQQ ENSP00000391447/1-1435 GSNKEGKKSRWKRKVSS-----SSPQSGCPSPTIPAGKVISPSQKHSKKALKQALKQQQQ ENSCPOP00000006620/1-1323 GSNKEGKKSRWKRKVSSRLSQPSSPQSGCPSPTIPAGKVISPSQKHSKKALKQSHKVFKP XP_004839180.1/1-1386 GSNKEGKKSRWKRKVSSRLSQPSSPQSGCPSPTIPAGKVISPSQKHTKKALKQALKQQQQ ******:******* :. ..* *.********.*********:******: * : ENSMUSP00000106846/1-1370 K----KKQQQCRPSMSI-SNQHLSLKTVKAASDSVPAKPG-------------------- ENSRNOP00000015827/1-1414 KKQQQQQQQQCRPSMSI-SNQHLSLKTVKTASDSVPAKPALWEGKQSDGQSSSPQNSNSS ENSP00000391447/1-1435 K----KQQQQCRPSISISSNQHLSLKTVKAASDSVPAKPATWEGKQSDGQTGSPQNSNSS ENSCPOP00000006620/1-1323 K----RKEYQCGPGMSVSSSQHLSLKTVRAAGDSVPAKPG-------------------- XP_004839180.1/1-1386 R---QQQQQQCRPSVSVSSSQHPALKAVKAAGDSVPVKPG-------------------- : ::: ** *.:*: *.** :**:*::*.****.**. ENSMUSP00000106846/1-1370 ----------------------------QMKRTKCADIDVETPDSILVNTNLRALINKHT ENSRNOP00000015827/1-1414 FSSSVKVESSLLGLGKKSLQRSDRLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHT ENSP00000391447/1-1435 FSSSVKVENTLLGLGKKSFQRSERLHTRQMKRTKCADIDVETPDSILVNTNLRALINKHT ENSCPOP00000006620/1-1323 ----------------------------QMKRTKCADIDVETPDSILVNTNLRALINKHT XP_004839180.1/1-1386 ----------------------------QMKRTKCADIDVETPDSILVNTNLRALINKHT ******************************** ENSMUSP00000106846/1-1370 FSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPE ENSRNOP00000015827/1-1414 FSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPE ENSP00000391447/1-1435 FSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPE ENSCPOP00000006620/1-1323 FSVLPGDCQQRLLLLLPEVDRQVGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPE XP_004839180.1/1-1386 FSVLPGDCQQRLLLLLPEVDRQIGPDGLMKLNGSALNNEFFTSAAQGWKERLSEGEFTPE **********************:************************************* ENSMUSP00000106846/1-1370 MQVRIRQEIEKEKKVELWKEQFFENYYGQSSGLSLEDSQKLTASSSDPKAKKTPAEQPKS ENSRNOP00000015827/1-1414 MQVRIRQEIEKEKKVELWKEQFFESYYGQSSGLSLEDSQKLTASPSDPKANKSPAEQPKS ENSP00000391447/1-1435 MQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTASPSDPKVKKTPAEQPKS ENSCPOP00000006620/1-1323 MQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTSSPSDPKVKKTPTEQPKS XP_004839180.1/1-1386 MQVRIRQEIEKEKKVEPWKEQFFESYYGQSSGLSLEDSKKLTSSPGDPKAKKTPAEQPKP **************** *******.*************:***:*..***.:*:*:****. ENSMUSP00000106846/1-1370 ILPSEASPVRIVPVVPQSECKEEAVQIPSPSQKE--ENQDEARPDSK-SPEPVLASASNT ENSRNOP00000015827/1-1414 ILPSEASPVSTIPVFPQSECKEEAVQIPSPFKKE---SQDEARPISQ-SPETVLALASNT ENSP00000391447/1-1435 MPVSEASLIRIVPVVSQSECKEEALQMSSPGRKEECESQGEVQPNFSTSSEPLLSSALNT ENSCPOP00000006620/1-1323 MLPSEVSPTRTDPVVPLSECKEEVVQMPSRVRKEKHGSQEEAQPSFQ-SPEPPLASASNT XP_004839180.1/1-1386 MPPSEVSPVSEVPVVPQSECKEEAVQTPSPVRREKLESQEKAQPNFQ-STEPLPASAGST : **.* **.. ******.:* .* ::* .* :.:* . *.*. : * .* ENSMUSP00000106846/1-1370 NELITMKPIKSPKDEGLLEQKPVACAEQESEKENHVTTTSRNNKSENQEALAISPSKSKN ENSRNOP00000015827/1-1414 NELITVKPIKSPKDEGLLEQKPVASAEQESEKENHVTTSSS-NESENQEALAISASKPKN ENSP00000391447/1-1435 HELSSILPIKCPKDEDLLEQKPVTSAEQESEK-NHLTTASNYNKSESQESLVTSPSKPKS ENSCPOP00000006620/1-1323 KEL-SILPIKCPKPEDVLEQKPVASAEQQPEKENHVASASNYHRSESQEVLVTSPSKPKS XP_004839180.1/1-1386 DEL-TILS-KCPKAEGLVEQSPVACAEQESEKENHLATASNYNRSESQQVVVTSPSKPKS .** :: . *.** *.::**.**:.***:.** **::::* :.**.*: :. *.**.*. ENSMUSP00000106846/1-1370 AGLQKPIIKPVAEASPLNPDMKMPPATVTDQIQESLKRKSSLTDEEATSSWEKRPRITEN ENSRNOP00000015827/1-1414 AGFEKPTTTKPAGASPLGPDMQVPPAPVSDHIPESLKRKAALTQEEATSSWEKRPRITEN ENSP00000391447/1-1435 PGVEKPIVKPTAGAGPQETNMKEPLATLVDQSPESLKRKSSLTQEEAPVSWEKRPRVTEN ENSCPOP00000006620/1-1323 PGVEKAIMKPTIEAGPQETSVKEPLVTLAEQSPESLKRKSSLTQEEAPASWEKRPRVTED XP_004839180.1/1-1386 PGVEKAIMKPIVEAGPQEASVKEPPATLAEQSPESLKRKSALAQEDAPASWEKRPRVTED .*.:*. . *.* ..:: * ..: :: ******::*::*:*. *******:**: ENSMUSP00000106846/1-1370 RQHQQPFQVSPQPFLNRGDRVQVRKVPPLKIPVSRISPMLFSTSQVSPRARFPISITSPY ENSRNOP00000015827/1-1414 RQHQQPFQASPQPFLNRGDRAQVRKVPPLKIPVSRISPMLFSTSQVSPRARFPVSITSPY ENSP00000391447/1-1435 RQHQQPFQVSPQPFLNRGDRIQVRKVPPLKIPVSRISPMPFHPSQVSPRARFPVSITSPN ENSCPOP00000006620/1-1323 RQHQQPFQVSPQPFLNRGDRVQLRKVPPLKIPVSRISPMPFPASQVSPRARFPVSITSPN XP_004839180.1/1-1386 RQHQQPFQVSPQPFLNRGDRVQVRKVPPLKIPVSRISPMPFPTSQVSPRARFPVPITSPN ********.*********** *:**************** * .**********:.**** ENSMUSP00000106846/1-1370 RTGARTLADIKAKAQLVKAQKAAAAAAAAAAAAASVGGTIPGPGPGGGQSPREGGERKIA ENSRNOP00000015827/1-1414 RTGARTLADIKAKAQLVKAQKAAAAAAAAAAAAASVGGTIPGPGPGGGRSPREGGERKTA ENSP00000391447/1-1435 RTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGEGQTA ENSCPOP00000006620/1-1323 RTGARTLADIKAKAQLVKAQ---------------IGGTIPGPGPGGGQGPGEGGERKTT XP_004839180.1/1-1386 RTGARTLADIKAKAQLVKAQRAAAAAAAAAAAAASVGGTIPGPGPGGGQGPGEGGERKTA ******************** :************:.* **** : : ENSMUSP00000106846/1-1370 GGGSAGSDPVSTNGKGPTLELAGTGSRGGTRELLPCG----PQPETN-MPGQAQPPGISG ENSRNOP00000015827/1-1414 GGGSAGSDPVSTNGKGPALELAGTGSRGGTRELLPCD----PQPETN-TPGQAQPPGVSG ENSP00000391447/1-1435 RGGSPGSDRVSETGKGPTLELAGTGSRGGTRELLPCGPETQPQSETKTTPSQAQPHSVSG ENSCPOP00000006620/1-1323 GGGSPGSDRVSAPGKGPTLELAGTGSRGGPRELLPCGPDAQPQPETK-SPGQTQPHSVSG XP_004839180.1/1-1386 RGRSPASDRVSATGKGPTLELAGTGSRGGSRELLPRGPDTQPQPETK-TPGQTQPHSVSG * *..** ** ****:***********.***** . **.**: *.*:** .:** ENSMUSP00000106846/1-1370 AQLQQTSSVPTGLASSGACTSVPLPAHIEISNSEKPNLHKATATAASPCHLQDPRSCRLE ENSRNOP00000015827/1-1414 AQLQQTSSVPAGLAASGTCTSVPLPAHIEMSNREKPNPHRATATAASPCHSQEPRSCRLE ENSP00000391447/1-1435 AQLQQTPPVPPTPAVSGACTSVPSPAHIEKLDNEKLNPTRATATVASVSHPQGPSSCRQE ENSCPOP00000006620/1-1323 AQLQQTPSVPPAPAISGARTNAASPAHVEKLSHENLDPT-TTATVTSPSHSQRLSGCGQE XP_004839180.1/1-1386 AQLQQTPSVPPAPAISGACTNIASPAHVDKLSHESSDPPRAAATMTSPSHPQRFNACGQE ******..**. * **: *. . ***:: . *. : ::** :* .* * .* * ENSMUSP00000106846/1-1370 KALSPTGPPLISGASTVYFVADGTVEPKAGSNKNAPKPSALAKTTAPAPLDMTSSP---- ENSRNOP00000015827/1-1414 RALSPTGPPLISGASPVCFVADGTVEPKAGSNKNAPKPSALTKTTASAPLDMTSSP---- ENSP00000391447/1-1435 KAPSPTGPALISGASPVHCAADGTVELKAGPSKNIPNPSASSKTDASVPVAVTPSPLTSL ENSCPOP00000006620/1-1323 RAPSPKGPAVISGASPVHFVADGTVEPKACSSKNIPTPLASTKTTAVTPVDVAPSPLTSL XP_004839180.1/1-1386 RGPSPKGPALISGASPVCFVADGTVESKACSSKNTPNPSASTKTTANAPVDMTPSPLTSL :. **.**.:*****.* .****** ** ..** *.* * :** * .*: ::.** ENSMUSP00000106846/1-1370 VTTASLEKLPVPQISGTATSTGSAPSSSTLPAASSLKTPGTSANMNGPISRTSSSIPANN ENSRNOP00000015827/1-1414 VTTASLEKLPAPQISGAATSTGSAPSSSTLPVASSLKTPGTSANMNGPVSRPSSSIPANN ENSP00000391447/1-1435 LTTATLEKLPVPQVSATTAPAGSAPPSSTLPAASSLKTPGTSLNMNGPTLRPTSSIPANN ENSCPOP00000006620/1-1323 LTTTTIEKLPVPQASVTVASTGSAPSS----AASSLKTPGTTANMNGPISRSSSSIPANN XP_004839180.1/1-1386 LTTTTLEKLPVPQASVIVASTGSAPPS----ASSSLKTPGTSANMNGPISRSSSSIPANN :**:::****.** * .:.:****.* .:********: ***** *.:******* ENSMUSP00000106846/1-1370 PLVTQLLQGKDVPLEQILPKPLTKIEMKTVPLTTKEEK-GIGIFPGISVMESSSREEVNG ENSRNOP00000015827/1-1414 PLVTQLLQGKDVPLEQILPKPLTKIEMKTVPLHTKEERGGIGVFPGTSVVEGS-REDVSG ENSP00000391447/1-1435 PLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTAKEER-GMGALIATNTTENSTREEVNE ENSCPOP00000006620/1-1323 PLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTPKEEK-GVGPLTSTTGTETSTREEVSD XP_004839180.1/1-1386 PLVTQLLQGKDVPMEQILPKPLTKVEMKTVPLTTKEEK-GVGVLTGTTGTENSTREAVSD *************:**********:******* .***: *:* : . . * * ** *. ENSMUSP00000106846/1-1370 RQAH-LAIPQLGKPLQSKQLSQVPRP--VFTAKDRKDPCIDTHQYREGLSKTTQDQLFQT ENSRNOP00000015827/1-1414 RQAH-LAIQQLGKPLQSKQLSQAPRP--VCPAKDRKDPCIDTHQYQEGLSKTTQGQLFQT ENSP00000391447/1-1435 RQSHPATQQQLGKTLQSKQLPQVPRPLQLFSAKELRDSSIDTHQYHEGLSKATQDQILQT ENSCPOP00000006620/1-1323 RQPHPMVIQQLGKTLQSKQLPQVQRSPQLFSAKDLRDSSIDTHQYQEGLSKATQDQILQT XP_004839180.1/1-1386 RQPHPVVIQQLGKTLQSKQLPQVQRPLQLFSAKGLRDSSIDTHQYQEGLSKATQDQILQT **.* . ****.******.*. *. : .** :*..******:*****:**.*::** ENSMUSP00000106846/1-1370 LIQRAQRQSVLSFVPPSQFNFAHSGFHLEDISTSQKFMLGFAGRRTSKPAMAGHYLLNIS ENSRNOP00000015827/1-1414 LIQRAQRQSVLSFVPPTQFNFAHSGFHLEDISTSQKFMLGFAGRRTSKPAMAGHYLLNIS ENSP00000391447/1-1435 LIQRVRRQNLLSVVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNIS ENSCPOP00000006620/1-1323 LIQRVRRQNVVSFVPPSQFNFAHSGFQVEDISTSQRFMLGFAGRRTSKPAMSGHYLLNIS XP_004839180.1/1-1386 LIQRVRRQNVLSFVPPSQFNFAHSGFQLEDISTSQRFMLGFAGRRTSKPAMAGHYLLNIS ****.:**.::*.***:*********::*******:***************:******** ENSMUSP00000106846/1-1370 TYGRGTENIKRTHSVNPDDRFCLSSPTEALRMGHADYKNTTGEISS-KEDESDEDRVGDE ENSRNOP00000015827/1-1414 TYGRGTDSVKRTHSVNPEERFCLSSPTEALRVGHADCKNTTGESSSSKEEESDEDSVGDE ENSP00000391447/1-1435 TYGRGSESFRRTHSVNPEDRFCLSSPTEALKMGYTDCKNATGESSSSKEDDTDEESTGDE ENSCPOP00000006620/1-1323 TYGRGSESCRRSQSINPEDRVCLSSPPEGLRMEYTDCRNTAGDSSSGKDDETDEESSEEE XP_004839180.1/1-1386 TYGRSSESCRRSHSINPEDRFCLTSPTEALRMGYSDCKNTTGDSSSGKEDETDEESTGDE ****.::. :*::*:**::*.**:**.*.*:: ::* :*::*: ** *::::**: :* ENSMUSP00000106846/1-1370 QEPISVKEEPWASQSSGRH-----PHHGEASSTNDCLASKNGKTEAPVSEQTTLGQENYI ENSRNOP00000015827/1-1414 QESVSVKEEPWA------------PHSGEAPSTNDCLASKSGKTEVPVNEQTTLGKENYI ENSP00000391447/1-1435 QESVTVKEEPQVSQSAGKGDTSSGPHSRETLSTSDCLASKNVKAEIPLNEQTTLSKENYL ENSCPOP00000006620/1-1323 QDSVLVKEEPQACQNYGKHDASSGPQSREAPSTNDGLANKTVKAEAPMNEHTTLSKGSYL XP_004839180.1/1-1386 QDSVLVKEEPKAAQSPGKHDTSSGPHSRETPSSNDCLTNKTMKAETPVNEHATLSKENYL *:.: ***** . *: *: *:.* *:.*. *:* *:.*::**.: .*: ENSMUSP00000106846/1-1370 FSRGQASDEKSLPRDFIPAAHKQMTHAVRGKTVCSSPELFNSTALSLPADSPTHQPLLLP ENSRNOP00000015827/1-1414 LSRGQTFDEKTLARDFIQATHKQMAHAVRGKTVCSSPELFNSTALSLPADSPTHQPLLLP ENSP00000391447/1-1435 FTRGQTFDEKTLARDLIQAAQKQMAHAVRGKAIRSSPELFSSTVLPLPADSPTHQPLLLP ENSCPOP00000006620/1-1323 FPRGQTFDEKTLARDFIQVAQKQMAQAVRGKVMCSSPELFSSTALSLPADSPTHQPLLLP XP_004839180.1/1-1386 FPRGQTFDEKTLARDFLQAAQKQMAQAVRGKAMRSSPELFSSTGFSLPADSPTHQPLLLP :.***: ***:*.**:: .::***::*****.: ******.** :.************** ENSMUSP00000106846/1-1370 PLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAIPGSQVSSNVGDVMSFSVTVTTIPA ENSRNOP00000015827/1-1414 PLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAIPGSQVSSNVGDVMSFSVTVTTIPA ENSP00000391447/1-1435 PLQTPKLYGSPTQIGPSYRGMINVSTSSDMDHNSAVPGSQVSSNVGDVMSFSVTVTTIPA ENSCPOP00000006620/1-1323 PLQTPKLYGSPTQIGPSYRGMINVSTSSEVDHSSAVLGSQVSSSVGDVMSFSVTVTTIPA XP_004839180.1/1-1386 PLQTPKLYGSPTQIGPSYRGMINVSTSSEADHNSAVPGSQVSSNVGDVMSFSVTVTTIPA ****************************: **.**: ******.**************** ENSMUSP00000106846/1-1370 SQAMNPSSHGQTIPVQTFPDDNSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCV ENSRNOP00000015827/1-1414 SQAMNPSSHGQTIPVQTFPDENSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCV ENSP00000391447/1-1435 SQAMNPSSHGQTIPVQAFSEENSIEGTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCV ENSCPOP00000006620/1-1323 SQAMNPSSHGQTIPVQAFPEENSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCV XP_004839180.1/1-1386 SQAMNPSSHGQTIPVQTFPEENSIEDTPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCV ****************:*.::****.********************************** ENSMUSP00000106846/1-1370 SCLVVR ENSRNOP00000015827/1-1414 SCLVVR ENSP00000391447/1-1435 SCLVVR ENSCPOP00000006620/1-1323 SCLVVR XP_004839180.1/1-1386 SCLVVR ******