CLUSTAL W(1.81) multiple sequence alignment ENSP00000412886/1-1241 MGTDSPSPRPLRPGVTLPPGALTMNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPE ENSMUSP00000043792/1-1208 -----------------------MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPE ENSRNOP00000053461/1-1202 -----------------------MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPE XP_004857374.1/1-1185 -----------------------MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPE ENSCPOP00000006597/1-1165 -----------------------MNTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPE ************************************* ENSP00000412886/1-1241 RLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDG ENSMUSP00000043792/1-1208 RLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDG ENSRNOP00000053461/1-1202 RLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDG XP_004857374.1/1-1185 RLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDG ENSCPOP00000006597/1-1165 RLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDG ************************************************************ ENSP00000412886/1-1241 KTTREDHMKLKVQGME-----CLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPAL ENSMUSP00000043792/1-1208 KTTREDHMKLKVQGMEPVSWQCLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPAL ENSRNOP00000053461/1-1202 KTTREDHMKLKVQGME-----CLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPAL XP_004857374.1/1-1185 KTTREDHMKLKVQGME-----------------------------NPDIVLVHYLNVPAL ENSCPOP00000006597/1-1165 KTTREDHMKLKVQGME-----CLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVPAL **************** *************** ENSP00000412886/1-1241 EDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEHLVQQI ENSMUSP00000043792/1-1208 EDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGAEEFSVEQLVQQI ENSRNOP00000053461/1-1202 EDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGLEEFSVEQLVQQI XP_004857374.1/1-1185 EDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEQLVQQI ENSCPOP00000006597/1-1165 EDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHGIKWSCGNGTEEFSVEQLVQQI *********************************************** ******:***** ENSP00000412886/1-1241 LDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPHAHPPEP ENSMUSP00000043792/1-1208 LDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALALASISHSKPPEP ENSRNOP00000053461/1-1202 LDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLASISHSKPPEP XP_004857374.1/1-1185 LDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTSIPH--PPEP ENSCPOP00000006597/1-1165 LDTHPTKPAPRTHACLCSGGLGSGSLTHKCSSTKHRIISPKVEPRALTLTS--------- ***********************************************:*:* ENSP00000412886/1-1241 PPLIAPLPPELPKAHTSP----------------SSSSSSSSSGFAEPLEIRPSPPTSRG ENSMUSP00000043792/1-1208 PPLIAPLPPELPKAHTSP---------------SSSSSSSSSSGFAEPLEIRPSPPTSRG ENSRNOP00000053461/1-1202 PPLIAPLPPELPKAHTSP----------------SSSSSSSSSGFAEPLEIRPSPPTSRG XP_004857374.1/1-1185 PPLIAPLPPELPKAHTSPSSSSSSSSSSSSSSSSSSSSSSSSSGFAEPLEVRPSPPISRG ENSCPOP00000006597/1-1165 ------------KAHTSP----------------SSSSSSSSSGFAEPLEVRPSPPTSRG ****** ****************:***** *** ENSP00000412886/1-1241 GSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADPRPSMSLAVVVGTEPSAPPAPPSPAFD ENSMUSP00000043792/1-1208 GSSRGGTAILLLTGLEQRAGGLTPTRHLAPQAEPRPPVSLAVVVGSEPSAPPAPPSPAFD ENSRNOP00000053461/1-1202 GSSRGGTAILLLTGLEQRAGGLTPTRHLASQAEPRPPVSLAVVVGSEPSAPPAPPSPAFD XP_004857374.1/1-1185 GSSRGGTAILLLTGLEQRAGGLTPTRHLASHADPRPSVSLAMVVGSEPSAPPAPPSPAFD ENSCPOP00000006597/1-1165 GSSRGGTAILLLTGLEQRAGGLTPTRHLAPQADPRPSVSLTVVVGSEPSAPPAPPSPAFD *****************************.:*:***.:**::***:************** ENSP00000412886/1-1241 PDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCSALEPAAALEPQAAARGPPPQSVAGG ENSMUSP00000043792/1-1208 PDRFLNSPQRGQTYGGGQGVNPDFPEAEGTHTPCPALEPAAALEPQAAARGLAPQLGANG ENSRNOP00000053461/1-1202 PDRFLNSPQRGQTYGGGQGVNPDFPEAEGTHTPCPALEPAAALEPQAAARGLPPQSGASG XP_004857374.1/1-1185 PDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCPALEPAAALEPQVSAQCTPPQSGTAG ENSCPOP00000006597/1-1165 PDRFLNSPQRGQTYGGGQGVSPDFPEAEAAHTPCPALEPAAALEPHVSARCPPPQTGAAG ********************.*******.:****.**********:.:*: .** : * ENSP00000412886/1-1241 RRGNCFFIQDDDSGEELKGHGAAPPIPSPPPSPPPSPAPLEPSSRVGRGEALFGGPVGA- ENSMUSP00000043792/1-1208 RRGNKFFIQDDDSGEELKGPGTVPPVPSSPPSSPSSPTALPPSGRATRGEALFGGSAGSS ENSRNOP00000053461/1-1202 RRGNKFFIQDDDSGEELKGPGTVPPVPSPPPSSPSSPAALQPSGRATRGETLFGGSAGST XP_004857374.1/1-1185 RRGNCFFIQDDDGGEELKGQGAAPPVPSPPPSTPSSPAPLEPSGRIARGENLFGGPGGA- ENSCPOP00000006597/1-1165 RKGNCFFIQDDDVGEELKGRG---------------PAPLEPSGRVARRENLFGGPGGA- *:** ******* ****** * *:.* **.* * * ****. *: ENSP00000412886/1-1241 SELEPFSLSSFPDLMGELISDEAPSIPAPTPQLSPALSTITDFSPEWSYPEGGVKVLITG ENSMUSP00000043792/1-1208 SELEPFSLSSFPDLMGELISDEAPGVPAPAPQLSPALNAITDFSPEWSYPEGGVKVLITG ENSRNOP00000053461/1-1202 SELEPFSLSSFPDLMGELITDEAPGVPAPSPQLSPVLNTITDFSPEWSYPEGGVKVLITG XP_004857374.1/1-1185 SELEPFSLSSFPDLMGELISDEAPSIPAPTPQLCPALSTITDFSPEWSYPEGGVKVLITG ENSCPOP00000006597/1-1165 SDLEPFSLSSFPDLMGELISDEAPSIPAPASQLSPALSTITDFSPEWSYPEGGVKVLITG *:*****************:****.:***:.**.*.*.:********************* ENSP00000412886/1-1241 PWTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYR ENSMUSP00000043792/1-1208 PWTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYR ENSRNOP00000053461/1-1202 PWTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYR XP_004857374.1/1-1185 PWTETTEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSTSVLFEYR ENSCPOP00000006597/1-1165 PWTETTEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYR ****::**********************************************:******* ENSP00000412886/1-1241 ARRFLSLPSTQLDWLSLDDNQFRMSILERLEQMEKRMAEIAAAGQVPCQGPDAPPVQDEG ENSMUSP00000043792/1-1208 ARRFLSLPSTQLDWLSLDDSQFRMSILERLEQMEKRMAEIAAAGQAPGQGPEAPPIQDEG ENSRNOP00000053461/1-1202 ARRFLSLPSTQLDWLSLDDSQFRMSILERLEQMEKRMAEIAAAGQAPGQGPEAPPIQDEG XP_004857374.1/1-1185 ARRFLSLPSTQLDWLSLDDNQFRMSILERLEQMEKRMAEIAAAGQTPCQGPKAHPIQDEG ENSCPOP00000006597/1-1165 ARRFLSLPSTQLDWLSLDDNQFRMSILERLEQMEKRMAEIAAAGQAPCQGPEVRPIQDEG *******************.*************************.* ***.. *:**** ENSP00000412886/1-1241 QGPGFEARVVVLVESMIPRSTWKGPERLAHGSPFRGMSLLHLAAAQGYARLIETLSQWRS ENSMUSP00000043792/1-1208 QGPGFEARVVVLVESMIPRSTWRGPERLIHGSPFRGMSLLHLAAAQGYARLIETLSQWRS ENSRNOP00000053461/1-1202 QGPGFEARVVVLVESMIPRSTWRGPERLMHGSPFRGMSLLHLAAAQGYARLIETLSQWRS XP_004857374.1/1-1185 QGPGFEARVVVLVESMIPRATWRGPERLTHGSPFRGMSLLHLAAAQGYARLIETLSQWRS ENSCPOP00000006597/1-1165 QGPGFEARVVVLVESMIPRSTWRGPERLTHGSPFRGMSLLHLAAAQGYARLIETLSQWRS *******************:**:***** ******************************* ENSP00000412886/1-1241 VETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFRWNRQALSIPDSLGRLPLS ENSMUSP00000043792/1-1208 VETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFCWNRQALSIPDSLGRLPLS ENSRNOP00000053461/1-1202 VETGSLDLEQEADPLNVDHFSCTPLMWACALGHLEAAVLLFCWNRQALSIPDSLGRLPLS XP_004857374.1/1-1185 VETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFRWNQQALSIPDSLGRLPLS ENSCPOP00000006597/1-1165 VETGSLDLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFRWNQQALSIPDSLGRLPLS ***********.***************************** **:*************** ENSP00000412886/1-1241 VAHSRGHVRLARCLEELQRQEPSVEPPFALSPPSSSPDTG-LSSVSSPSELSDGTFSVTS ENSMUSP00000043792/1-1208 VAHSRGHVRLARCLEELQRQELSVEHPLALSPPSSSPDTG-LSSASSPSELSDGTFSVTS ENSRNOP00000053461/1-1202 VAHSRGHVRLARCLEELQRQELSVEHPLALSPQSSSPDTG-LSSVSSPSELSDGTFSVTS XP_004857374.1/1-1185 VAHSRGHVRLARCLEELQRQEASVEPPLALSPPSSSPDTG-LSSVSSPSELSDATFSVTS ENSCPOP00000006597/1-1165 VAHSRGHVRLARCLEELQRQESSVEPPL-VCHPVSSPDTGCLSSVSSPSEMSDATFSVTS ********************* *** *: :. ****** ***.*****:**.****** ENSP00000412886/1-1241 AYSSAPDGSPPPAPLPASEMTMEDMAPGQLSSGVPEAPLLLMDYEATNSKGPLSSLPALP ENSMUSP00000043792/1-1208 AYSSAPDGSPPPAPPLASDISME-MIPGQLSCGAPETPLLLMDYEATNSKEPAPSPCGPP ENSRNOP00000053461/1-1202 AYSSAPDGSPPPAPMLASEISME-TIPGQLSFGAPETPLLLMDYEATNSKESAPSPSGLP XP_004857374.1/1-1185 AYSSAPDGSPPPGPLPASEITMEEMVPGQLSSGIPEAPLLLMDFEATNPKGSPPSPPALP ENSCPOP00000006597/1-1165 AYSSALDGSPPPGPLPASEITMEEMVPGQLSSGLPEAPLLLMDFEATNPKGSPPSPPALP ***** ******.* **:::** ***** * **:******:****.* . .* . * ENSP00000412886/1-1241 PASDDGAAPEDADSPQAVDVIPVDMISLAKQIIEATPERIKREDFVGLPEAGASMRERTG ENSMUSP00000043792/1-1208 LAQDNGAAPEDADSPPAVDVIPVDMISLAKQIIDATPERIKREDFSEFPDAGASPREHTG ENSRNOP00000053461/1-1202 LAQDDRAAPEDADSPPAVDVIPVDMISLAKQIIEATPERIKREDFSELPEAGASPREHTG XP_004857374.1/1-1185 PAPDDGAAPEDTDSPQTVDVIPVDMISLAKQIIEATPERIKQEDFMGLPEAGASMRERTG ENSCPOP00000006597/1-1165 PAPDDGTAPEDTDTPQTVDVIPVDMISLAKQIIEATPERIKQEDFVGLPEAGASMRERTG * *: :****:*:* :****************:*******:*** :*:**** **:** ENSP00000412886/1-1241 AVGLSETMSWLASYLENVDHFPSSTPPSELPFERGRLAVPSAPSWAEFLSASTSGKMESD ENSMUSP00000043792/1-1208 TVGLSETMSWLASYLENVDHFPSSAPPSELPFERGRLAIPPAPSWAEFLSASTSGKMESD ENSRNOP00000053461/1-1202 TVGLSETMSWLASYLENVDHFPSSAFPSELPFERGRPAIPPAPSWAEFLSASTSGKMESD XP_004857374.1/1-1185 PVGLSETMSWLASYLENVDHFPSSAPPSELPFERGRLAVPPTPSWAEFLSASTSGKMESD ENSCPOP00000006597/1-1165 AVGLSETMSWLASYLENVDHFPSSAPSSELPFERGHLAVPPTPSWAEFLSASTSGKMESD .***********************: .********: *:*.:****************** ENSP00000412886/1-1241 FALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALK ENSMUSP00000043792/1-1208 FALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALK ENSRNOP00000053461/1-1202 FALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALK XP_004857374.1/1-1185 FALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQ------- ENSCPOP00000006597/1-1165 FALLTLSDHEQRELYEAARVIQTAFRKYKGRRLKEQQEVAAAVIQRCYRKYKQLTWIALK ***************************************************** ENSP00000412886/1-1241 FALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRTSATLPA ENSMUSP00000043792/1-1208 FALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRPSGPLPA ENSRNOP00000053461/1-1202 FALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRPSGPLPS XP_004857374.1/1-1185 FALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQHYRSYRRRPGPPHRPSGPLPP ENSCPOP00000006597/1-1165 FALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQRYRSYRRRPGPPHRPSGPLPA ***************************************:*************.*..**. ENSP00000412886/1-1241 RNK--LLSHQEAGPGSP-------EDHEIPAALPTQDEGTEAEPGAGRASPAGTGHMTWP ENSMUSP00000043792/1-1208 RNKGTFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT------------ ENSRNOP00000053461/1-1202 RNKGTFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT------------ XP_004857374.1/1-1185 RNKSSFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGLPQPGLAT------------ ENSCPOP00000006597/1-1165 RNKAPFLTKKQDQAAR-IMRFLRRCRHRYPRAPPLLVPPGPPLPADSA------------ *** :*:::: .. *. . *. . ENSP00000412886/1-1241 PPFSPPWGRLVQS ENSMUSP00000043792/1-1208 ------------- ENSRNOP00000053461/1-1202 ------------- XP_004857374.1/1-1185 ------------- ENSCPOP00000006597/1-1165 -------------