CLUSTAL W(1.81) multiple sequence alignment ENSP00000370369/1-996 MPALA-RDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSES ENSCPOP00000006563/1-974 ---------------VVFSVMICETITNQDVPVIKCVLINHKTNDSAVGKPSSYPTVPES XP_004854861.1/1-993 MPVLA-RHGGRLPLLVVFSVMILETIANQDLPVIKCVLINHKNNDSAVGKSSSYPKVPES ENSMUSP00000039041/1-1000 MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGS ENSRNOP00000057874/1-997 -RALR-XWASALPLRVVLSVMILETVTNQDLPVIKCVLIIHKNNGSAAGKSSSHVMVPES **:*.** *::***:******** *:.*.*:.**.**: * * ENSP00000370369/1-996 PEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFD ENSCPOP00000006563/1-974 QEDLGCMLRPESAGAVYGTATVEVDMSASITLQVLVATPGNISCLWVFKHSSLDCQPHFD XP_004854861.1/1-993 PEDLGCTLRPERAGAVYEAATVEVDMSASITLQVLVTNPGNISCLWVFKHSSLDCQPHFD ENSMUSP00000039041/1-1000 PEDLQCAPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFD ENSRNOP00000057874/1-997 PEDLRCAPKHRSEGVVYEAVTVEVAQSASFTLQVQLTTPGDVSCLWVFKHSSLGCQPHFD *** * : . *.** :.:*** *.*:**** : **::***********.****** ENSP00000370369/1-996 LQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQ ENSCPOP00000006563/1-974 FLNRGVVSMVILKMTETQAGEYLLFIQSEVTNYTILFTVSIRNTLLYTLRRPYFRKLENE XP_004854861.1/1-993 LLNRGVVSMVILKMTETQAGEYLLFIQSEVTNYTILFTVSIRNTLLYTLRRPYFRKLEDQ ENSMUSP00000039041/1-1000 LQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQ ENSRNOP00000057874/1-997 LQNRRIVSMTILNVTETQAGEYLLHIQSEATNHTVLFTVNVRDTQLYVLRRPSFRKMENQ : ** :***.**::**********.****.:*:*:****.:*:* **.**** ***:*:: ENSP00000370369/1-996 DALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGR ENSCPOP00000006563/1-974 DALVCVSEGVPEPTVEWVLCDLQGESCKEENPAVVKKEEKVLHELFGTDIRCCARNELGR XP_004854861.1/1-993 DALVCISESVPEPTVEWVFCNSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGR ENSMUSP00000039041/1-1000 DALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGR ENSRNOP00000057874/1-997 DALLCVSEGVPEPTVEWVVCSSHRDSCREEGSAVVKKEEKVLHELFETDIRCCARNALGR ***:*:**.**** ****.*. : :**:**..***:********** ********* *** ENSP00000370369/1-996 ECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFE ENSCPOP00000006563/1-974 ECTKLFTIDLNQTPRTTLPQLFLKVGEPLWIRCKAVHVNHGFGLSWELENKALEEGSYFE XP_004854861.1/1-993 ECTKLFTIDLNQTPQTRLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELENKALEEGNFFE ENSMUSP00000039041/1-1000 ECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFE ENSRNOP00000057874/1-997 ECTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELGNKVLEEGSYFE ***:********:*:: ******************:********:*** :*.****.:** ENSP00000370369/1-996 MSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDY ENSCPOP00000006563/1-974 MSTYSTNRTMIRILFAFVSSVGRNNTGYYTCSSSKHASQSALVTILEKGFINATNSSEDY XP_004854861.1/1-993 MSTYSTNRTMIRILFAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATNSSENY ENSMUSP00000039041/1-1000 MSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEY ENSRNOP00000057874/1-997 MSSYSTNRSMIRILLAFVSSVGRNNTGYYTCSSSKHPSQTALVTILEKGFINATSSQEEY **:*****:*****:******.**:***********.**:*****:********.*.*:* ENSP00000370369/1-996 EIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFH ENSCPOP00000006563/1-974 AIDQYEEFCFSVKFKAYPQIRCTWTFSRKSFPCEQSSLEDGYSISKFCNHKHQPGEYIFH XP_004854861.1/1-993 EIDQYEEFCFSVKFKAYPQIRCTWTFSRKSFPCEQSGLEDGYSISKFCNHKHQPGEYIFH ENSMUSP00000039041/1-1000 EIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFY ENSRNOP00000057874/1-997 EIDPYEKFCFSVRFKAYPQIRCKWTFSQTSFPCEQSGLEDGYSISKFCDHKNNPGEYIFH ** **:*****:*****:***.* **: ****** .*::********:**::******: ENSP00000370369/1-996 AENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEIT ENSCPOP00000006563/1-974 AENDDAQFTKMFTLNIRRKPQVLAEASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIT XP_004854861.1/1-993 AENDDAQFTKMFTLNIRRKPQVLAEASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIT ENSMUSP00000039041/1-1000 AENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIP ENSRNOP00000057874/1-997 GENDDAQFTKMFILNIRRKPQVLANASASQASCFSDGYPLPNWTWKKCSDKSPNCTEEIP .*********** ****:******:******** *******.*****************. ENSP00000370369/1-996 EGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQ ENSCPOP00000006563/1-974 EGVWNKKANRKVFGQWVSSSILNMSEAVKGFLVKCCAYNSVGTSCETILLNSPGPFPFIQ XP_004854861.1/1-993 EGVWNKKANRKVFGQWVSSSTLNMSEAVKGFLVKCCAYNSVGTSCETILLNAPGPFPFIQ ENSMUSP00000039041/1-1000 EGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQ ENSRNOP00000057874/1-997 EGVWNKKANRKVFGQWVSSSTLNMSEAGRGFLVKCCAYNSMGTSCETILLNSPGPFLFIQ *****:************** ****** :*:*********:*******:**:**** *** ENSP00000370369/1-996 DNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEY ENSCPOP00000006563/1-974 DNISFYATIGLCLPFIVVLIMLICHKYKKQFRYESQLQMVQVTGSLDNEYFYIDFREYEY XP_004854861.1/1-993 DNISFYATVGLCLPFIIVLIMLICHKYKKQFRYESQLQMVQVTGSLDNEYYYIDFREYEY ENSMUSP00000039041/1-1000 DNISFYATIGLCLPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEY ENSRNOP00000057874/1-997 DNISFYATIGLCPPFIVVLTVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYIDFRDYEY ********:*:* **:** :******************:****. ****:*:***:*** ENSP00000370369/1-996 DLKWEFPRENLEFGKVLGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREAL ENSCPOP00000006563/1-974 DLKWEFPRENLEFGKVLGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREAL XP_004854861.1/1-993 DLKWEFPRENLEFGKILGSGAFGKVMNATAY-GISKTGVSIQVAVKMLKEKADSSEREAL ENSMUSP00000039041/1-1000 DLKWEFPRENLEFGKVLGSGAFGRVMNATAY-GISKTGVSIQVAVKMLKEKADSCEKEAL ENSRNOP00000057874/1-997 DLKWEFLFLNVFFGSFFFFGAGDRTQGLTAYHSLPEVNT---VSAPPLTEKADRCEREAL ****** *: **..: ** .:. . *** .:.:... *:. *.**** .*:*** ENSP00000370369/1-996 MSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIF ENSCPOP00000006563/1-974 MSELKMLTQLGHHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIF XP_004854861.1/1-993 MSELKMLTHLGHHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRNKREKFHRTWTEIF ENSMUSP00000039041/1-1000 MSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIF ENSRNOP00000057874/1-997 MAELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCHGDLLNYLRSKREKFHRTWTEIF *:****:*:** *:**************:********:********.************* ENSP00000370369/1-996 KEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRL--EE ENSCPOP00000006563/1-974 KEHNFSFYPTFQSHPNSSMPASREVQIHQDSDQMSGFNGNSTHSEDEVEYENQKRL--EE XP_004854861.1/1-993 KEHNFSFYPTFQSHPNSSMPGSREVQIHQDSDQISGFNGNSTHSEDEVEYENQKRL--EE ENSMUSP00000039041/1-1000 KEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEE ENSRNOP00000057874/1-997 KEHNFSFYPTFQSHSNSSMPGSREVQIYPPVDQVSGFNGNSIHSEDEIEYENQKRLEEEE ************:*.*****.*****:: **:**::** *****:******** ** ENSP00000370369/1-996 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI ENSCPOP00000006563/1-974 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI XP_004854861.1/1-993 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI ENSMUSP00000039041/1-1000 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI ENSRNOP00000057874/1-997 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI ************************************************************ ENSP00000370369/1-996 MSDSNYVVRGNVRLARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP ENSCPOP00000006563/1-974 LSDSNYVVRGN---ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP XP_004854861.1/1-993 LSDSNYVVRGN---ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP ENSMUSP00000039041/1-1000 LSDSSYVVRGN---ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP ENSRNOP00000057874/1-997 LSDSSYVVRGN---ARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP :***.****** ********************************************** ENSP00000370369/1-996 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA ENSCPOP00000006563/1-974 VDANFYKLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEA XP_004854861.1/1-993 VDANFYKLIQSGFKMDQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSSLGCQLADAEEA ENSMUSP00000039041/1-1000 VDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEA ENSRNOP00000057874/1-997 VDANFYKLIQSGFKMEQPFYATEEIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEAA **********.****:******* **::******************** ******:** * ENSP00000370369/1-996 MYQNVDGRVS-ECPHTYQNRRPFSREMDLGLLSPQAQVEDS---- ENSCPOP00000006563/1-974 MYQNVDGSIP-ERPSIYQNRRAFGREMAPEPPSPQS--------- XP_004854861.1/1-993 MYQNVDCSIS-ERPSIYQNRRPFGREMGSELLSSQAQVEDS---- ENSMUSP00000039041/1-1000 MYQNMGGNVP-EHPSIYQNRRPLSREAGSEPPSPQAQVKIHGERS ENSRNOP00000057874/1-997 MYQNMGGDVPLEHPAIYQNRRPASREAGSEPPSPQVQEKTHRERS ****:. :. * * *****. .** *.*