CLUSTAL W(1.81) multiple sequence alignment ENSP00000314444/1-1181 MFFYLSKKISIPNNVKLQCVSWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN ENSMUSP00000082895/1-1181 MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSN ENSRNOP00000042019/1-1170 MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLETQTDDSKLRGLAAPSN ENSCPOP00000006363/1-1183 MFFYLTKKIAIPNSVKLKCISWNKEQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN XP_004839096.1/1-1181 MFFYLSKKITIPNSVKLKCISWNKDQGFIACGGEDGLLKVLKLETQTDDAKLRGLAAPSN *****:***::**.***:*:****:****************:*******:********** ENSP00000314444/1-1181 LSMNQTLEGHSGSVQVVTWNEQYQKLTTSDENGLIIVWMLYK--GSWIEEMINNRNKSVV ENSMUSP00000082895/1-1181 LSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYK--GSWYEEMINNRNKSVV ENSRNOP00000042019/1-1170 LSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYK--GSWYEEMINNRNKSVV ENSCPOP00000006363/1-1183 LSMNQILEGHSGSVQVVAWNEQYQKLTTSDQNGLIIVWMLYKETGSWYEEMINSRNKSVV XP_004839096.1/1-1181 LSMNQTLEGHSGSVQVVAWNEQYQKLTTSDQNGLIIVWMLYK--GSWYEEMINSRNKSVV ***** ******:****:************:*********** *** *****.****** ENSP00000314444/1-1181 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLSHVTWSADSKVLLFGMANG ENSMUSP00000082895/1-1181 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANG ENSRNOP00000042019/1-1170 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLCHVTWSADSKILLFGMANG ENSCPOP00000006363/1-1183 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKELKGIQLCHVAWSADSKILLFGMANG XP_004839096.1/1-1181 RSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKELKGIQLCHVAWSTDSKILLFGMANG **********************************:******.**:**:***:******** ENSP00000314444/1-1181 EIHIYDNQGNFMIKMKLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAVCFDNGRCQI ENSMUSP00000082895/1-1181 EIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQI ENSRNOP00000042019/1-1170 EIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQI ENSCPOP00000006363/1-1183 ETHIYDNQGNFIMKMRLSCLVNVTGAVSIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQI XP_004839096.1/1-1181 EIHVYDNQGNFIIKMRLSCLVNVTGAISIAGIHWYHGTEGYVEPDCPCLAICFDNGRCQI * *:*******::**:*.********:***********************:********* ENSP00000314444/1-1181 MRHENDQNPVLIDTGMYVVGIQWNHMGSVLAVAGFQKAAMQDKDVNIVQFYTPFGEHLGT ENSMUSP00000082895/1-1181 MRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDINIVQFYTPFGEHLGT ENSRNOP00000042019/1-1170 MRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEHLGT ENSCPOP00000006363/1-1183 MRHESDPNPVLIDTGMYVVSIQWNHVGSVLAVAGSQKVVTQDKDVNIVQFYTPFGEYLGT XP_004839096.1/1-1181 MRHENDRNPVLIDTGMHVVSIQWNHTGSVLAVAGSQKVVTQDKDVNTVQFYTPFGEHLGT ****.* *********:**.***** ******** **.. ****:* *********:*** ENSP00000314444/1-1181 LKVPGKEISALSWEGGGLKIALAVDSFIYFANIRPNYKWGYCSNTVVYAYTRPDRPEYCV ENSMUSP00000082895/1-1181 LKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCV ENSRNOP00000042019/1-1170 LKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTRPDRPEYCV ENSCPOP00000006363/1-1183 LKVPGKQMSALSWEGGGLKIALAVDSLIYFANIRPDYKWGYCLNTVVYAYTKPDRPEYCV XP_004839096.1/1-1181 LKVPGKRMSALSWEGGGLKIALAVDSFIYFANIRPDYKWGYCSNTVVYAYTTPDRPEYCV ******.:.:****************:********:****** ******** ******** ENSP00000314444/1-1181 VFWDTKNNEKYVKYVKGLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSI ENSMUSP00000082895/1-1181 VFWDTKNSEKYVKYVKSLISITTCGDFCILATKADENHPQEENEMETFGATFVLVLCNSI ENSRNOP00000042019/1-1170 VFWDTKNNEKYVKYVKSLISITTCGDFCILATKADENHPQ-----------FVLVLCNSI ENSCPOP00000006363/1-1183 VFWDTKNNEKYVKYVKSLISITTWGDFCILATKADESHPQEEDEMETFGATFVLILCNSI XP_004839096.1/1-1181 VFWDTKNNEKYVKYVKSLISVTTCGDFCILATKADESHPQEEDETETLGAMFVLVLCNSI *******.********.***:** ************.*** ***:***** ENSP00000314444/1-1181 GTPLDPKYIDIVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRER ENSMUSP00000082895/1-1181 GTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLTALEINQITRSRKEGRER ENSRNOP00000042019/1-1170 GTPLDPKYIDLVPLFVAMTKTHVIAASKEALYTWQYRVAKKLTALEINQITRSRKEGRER ENSCPOP00000006363/1-1183 GTPLDPKYIDVVPLFVTMTKTHVIAASKEAFYVWQYRVAKKLTALEINQITRSRKEGRER XP_004839096.1/1-1181 GTPLDPKYIDIVPLFVTMTKTHVIAASKEAFYIWQYRVAKKLMALEINQITRPRREGRER **********:*****:*************:* ********* *********.*:***** ENSP00000314444/1-1181 IYHVDDTPSGSMDGVLDYSKTIQGTRDPICAITASDKILIVGRESGTIQRYSLPNVGLIQ ENSMUSP00000082895/1-1181 IYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQ ENSRNOP00000042019/1-1170 IYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIVGRESGVIQRYSFPNVALIQ ENSCPOP00000006363/1-1183 FLEIEEAGSGSGGGIQLYQKRIRGTRDPICAITASDKTLIVGRESGTMQRYSLPNVGLIQ XP_004839096.1/1-1181 VYHVDDTPSASVDGVPDYSKAIQGTRDPICAITASDKTLIVGRESGTIQRYSLPNVGLIQ . .:::. *.* .*: *.* *:************** ********.:****:***.*** ENSP00000314444/1-1181 KYSLNCRAYQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSTGQQVVGELLKLERRDVWD ENSMUSP00000082895/1-1181 KYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWD ENSRNOP00000042019/1-1170 KYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVTDSTGQQVVGELLKLERKDVWD ENSCPOP00000006363/1-1183 IYSLHCRALQLSLNCNSSRLAIIDISGVLTFFDLDARVTDSAGQQVVGELLKLERKDVWD XP_004839096.1/1-1181 KYFLNCRAYRLSLNCNSSRLAIIDISGVLTFFDLDSRAMDSTGQQVIGELLKLERKDVWD * *.*** :***************:*********:*. **:****:********:**** ENSP00000314444/1-1181 MKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHP ENSMUSP00000082895/1-1181 MKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHP ENSRNOP00000042019/1-1170 MKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKNPEHP ENSCPOP00000006363/1-1183 MQWARDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHP XP_004839096.1/1-1181 MKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHP *:**:**************************************************:**** ENSP00000314444/1-1181 NKDYLINFEIRSLRDSRALIEKVGIKDASQFIEDNPHPRLWRLLAEAALQKLDLYTAEQA ENSMUSP00000082895/1-1181 SKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQA ENSRNOP00000042019/1-1170 SKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQA ENSCPOP00000006363/1-1183 NKDYILNFEIRSLRDSRALIEKVGIEDALQFIEDNPHPRLWRLLAEAALQKLDLSTAEQA XP_004839096.1/1-1181 NKDYMLNFEIRSLRDSRALLEKVGIEDASQFIEDNPHPRLWRLLAEAALQKLDLCTAEQA .***::*************:*****:** ************************* **:** ENSP00000314444/1-1181 FVRCKDYQGIKFVKRLGKLLSESMKQAEVVGYFGRFEEAERTYLEMDRRDLAIGLRLKLG ENSMUSP00000082895/1-1181 FVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLG ENSRNOP00000042019/1-1170 FVRCKDYQGIKFVKRLGNLQSESMKQAEVIAYFGRFEEAERMYLDMDRRDLAIGLRLKLG ENSCPOP00000006363/1-1183 YVRCKDYQDIKFVKRLGKLQSEAMRRAEVVAYFGRFEEAERMYLDMDRRDLAIGLRLKLV XP_004839096.1/1-1181 FVRCEDYQGIKFVKRLGNLQSEAMKQAEVVAYFGRFEEAERMYLDMDRRDLAIGLRLKLV :***:***.***** **:* **:*::***:.******:*** * :***********:** ENSP00000314444/1-1181 DWFRVLQLLKTGSGDADDSLLEQANNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYM ENSMUSP00000082895/1-1181 DWFRVLQLLKTGSGDADDSLLEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYM ENSRNOP00000042019/1-1170 DWFRVLQLLKTGSGDADDSLLEQAHNAIGDYFADRQKWMNAVQYYVKGRNQERLAECYYM ENSCPOP00000006363/1-1183 DWFRVLHLLKTGSGDADDSLLEQAHNAIGDYFADRQKWLNAVQYYVQGRNQERLAECYYM XP_004839096.1/1-1181 DWFRVLHLLKTGSGVADDSLLEQAHNAIGDYFADRQKWLNAVEYYVQGRNQERLAECYYM ******:******* *********:****:******** ***:***:************* ENSP00000314444/1-1181 LEDYEGLENLAISLPENHKLLPEIAQMFVRVGMCEQAVTAFLKCSQPKAAVDTCVHLNQW ENSMUSP00000082895/1-1181 LEDYEGLETLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQW ENSRNOP00000042019/1-1170 LEDYEGLENLANSLPENHKLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQW ENSCPOP00000006363/1-1183 LEDFEGLENLANSLPENHKLLPEIAQMFVRVGMCEPAVAAYLKCNQPKAAVDTCVHLHQW XP_004839096.1/1-1181 LEDYEGLESLASSLPENHKLLPDIAQMFVRVGMCGQAVTAFLRCNQPKAAVDTCVHLHQW ***:****.** **********:*********** **:*:*:*.************:** ENSP00000314444/1-1181 NKAVELAKNHSMKEIGSLLARYASHLLEKNKTLDAIELYRKANYFFDAAKLMFKIADEEA ENSMUSP00000082895/1-1181 NKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEA ENSRNOP00000042019/1-1170 NKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEA ENSCPOP00000006363/1-1183 NKAVELAKSHSMKEIGSLLARYASHLLEKNKTLDAVELYRKASYFFDAAKLMFKIADEEA XP_004839096.1/1-1181 NKAVELAKSHNMKEIGSLLARYASHLLEKNKTLEAIELYRKASYFFDAAKLMFKIADEEA ********.*.**********************:*:******.*********:******* ENSP00000314444/1-1181 KKGSKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKSSEATSALAGLLEEEVLSTTDR ENSMUSP00000082895/1-1181 KKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSR ENSRNOP00000042019/1-1170 KKRTKPLRVKKLYVLSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSR ENSCPOP00000006363/1-1183 KKRTKPLRVKKLYVLAALLVERHHQQVKSAQRGKAPGKSSEATSALAGLLEEEALSTASR XP_004839096.1/1-1181 KKRAKPLRVKKLYVLAALLVQQHQEQVKSAQRGKAGGESSEAASALAGFLEEEVLPTAGR ** :***********:***::::::*:*.*****. *:.***:*****:****.*.*:.* ENSP00000314444/1-1181 FTDNAWRGAEAYHFFILAQRQLYEGCVDTALKTALHLKDYEDIIPPVEIYSLLALCACAS ENSMUSP00000082895/1-1181 FTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACAS ENSRNOP00000042019/1-1170 FTDNAWRGAEAYHFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACAS ENSCPOP00000006363/1-1183 FTDNAWRGAEAYHFFLLAQRQLYEGYVDTALKTALHLRDYEDVIPAVEIYSLLALCACAS XP_004839096.1/1-1181 FTDSAWRGAEAYHFFVLAQRQLYEGYVDTALQTAFHLRDYEDIIPAVEIYSLLALCACAS ***.***********:********* *****:**:**:****:**.************** ENSP00000314444/1-1181 RAFGTCSKAFIKLKSLETLSSEQKQQYEDLALEIFTKHTSKDNRKPELDSLMEGGEGKLP ENSMUSP00000082895/1-1181 RAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLP ENSRNOP00000042019/1-1170 RAFGTCSKAFIKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLP ENSCPOP00000006363/1-1183 RAFGTCSKAFIKLESLESLSAEQRQQYEDLALEIFTNHTPKDTRKSDLDSLLEGGEGKLP XP_004839096.1/1-1181 RAFGTCSKAFIKLESLETLSSEQKQQYEDLALEIFTKHTPKDNRKSELDSLLEGGEGKLP *************:***:**:**:************:**.**.**.:*:**:******** ENSP00000314444/1-1181 TCVATGSPITEYQFWMCSVCKHGVLAQEISHYSFCPLCHSPVG ENSMUSP00000082895/1-1181 TCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE ENSRNOP00000042019/1-1170 TCIATGSPIIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE ENSCPOP00000006363/1-1183 TCVATGSHITEYQFWMCSVCKHCAHTQEMSSYAFCPLCHSAVG XP_004839096.1/1-1181 TCVATGRPITEYQFWMCSVCRHCVHAQEISSCAFCPLCHSAVG **:*** * *****:*.**:* . :**:* *******.*