CLUSTAL W(1.81) multiple sequence alignment ENSP00000278951/1-855 ------------------------------------------------------------ ENSMUSP00000110220/1-853 ------------------------------------------------------------ ENSRNOP00000024239/1-979 MTSAGGRSPAVYRGAAPGGPEFCAASAALKGPASGKPTGQGHRRLGSPGASGRRVSSRAG ENSCPOP00000006317/1-853 ------------------------------------------------------------ XP_004856712.1/1-852 ------------------------------------------------------------ ENSP00000278951/1-855 ------------------------------------------------------------ ENSMUSP00000110220/1-853 ------------------------------------------------------------ ENSRNOP00000024239/1-979 PGWGCGSRCRPREPGSARGPGAAPGRGRVLSQAGVKVLVPVRCWKLLRQPQRARSPSRRQ ENSCPOP00000006317/1-853 ------------------------------------------------------------ XP_004856712.1/1-852 ------------------------------------------------------------ ENSP00000278951/1-855 ------MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFN ENSMUSP00000110220/1-853 ------MIAWRLPLCVLLVASVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFN ENSRNOP00000024239/1-979 PPPPRAMIAWRLPLCVLLVAAVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFN ENSCPOP00000006317/1-853 ------MFAPGLPFLVLLAASVQSHMGVLGPKNVSQKDAEFERMYVDEVNSELVNIYTFN XP_004856712.1/1-852 ------MFAPGLPFLVLLAISVESHMGVLGPKNVSQKDAEFEHLYADEVNSELVNIYTFN *:* **: ***. :*:**:*.**************: *.*:************ ENSP00000278951/1-855 HTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVER ENSMUSP00000110220/1-853 HTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVER ENSRNOP00000024239/1-979 HTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVER ENSCPOP00000006317/1-853 HTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVER XP_004856712.1/1-852 HTVTRNRTEGVRVSVNVLNKEKGAPLLFVVRQKEAVVSFQVPLILRGLFQRKYLYQKVER ********************:**************************::*********** ENSP00000278951/1-855 TLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYF ENSMUSP00000110220/1-853 TLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYF ENSRNOP00000024239/1-979 TLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYF ENSCPOP00000006317/1-853 TLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVSRIDDFVLRTGEQFSFNTTAAQPQYF XP_004856712.1/1-852 TLCQPPTKNESEVQFFYVDVSTLSPVNTTYQLRVTRIDDFVLRTGEQFSFNTTAAQPQYF ************:*********************.*:*:******* *:*********** ENSP00000278951/1-855 KYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQ ENSMUSP00000110220/1-853 KYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQ ENSRNOP00000024239/1-979 KYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQ ENSCPOP00000006317/1-853 KYEFPEGVDSVIVKVTSYKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQ XP_004856712.1/1-852 KYEFPEGADSVIVKVTSDVAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQ *****:*.********* ***************************************** ENSP00000278951/1-855 RKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYV ENSMUSP00000110220/1-853 RKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYV ENSRNOP00000024239/1-979 RKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYV ENSCPOP00000006317/1-853 RKDFPSNSFYVVVVVKTEDQACGGSLPYYPFVEGEPVDQGHRQKTLSVLVSKAVTSEAYV XP_004856712.1/1-852 RKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSKAVTSEAYV ***************************:***.*.*****************:******** ENSP00000278951/1-855 SGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPY ENSMUSP00000110220/1-853 GGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLLAIDRACPESGHARVLADSFPGSAPY ENSRNOP00000024239/1-979 GGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLVAIDRACPESGHPRVLADSFPGSAPY ENSCPOP00000006317/1-853 GGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLLSIDRVCPESGHPRVLAGSFPGSSSY XP_004856712.1/1-852 GGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLLAIDRTCPESGHPRVLADSFPGSS-Y .***************************:*****::***.******.****.*****: * ENSP00000278951/1-855 EGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGHDQFKRRLPSGQMRQLCIAMGRSFEPV ENSMUSP00000110220/1-853 EGYNYGSFENGSGSTDGLVESAGSGDLSYSYQGHDQFKRRLPSGQMRQLCIAMDRSFDAV ENSRNOP00000024239/1-979 EGYNYGSFENGSGSTDGLVESTGSGDLSYSYQGHDQFKRRLPSGQMRQLCIAMDRSFDPV ENSCPOP00000006317/1-853 EGYNYGSLENGSGSTDALVDSTGTGDLSYTYQGHEQFKRRLPPGQMRQLCIAMDRAFEPV XP_004856712.1/1-852 EGYNYGSLENGSGSTDALVDSAGSGDLSYSYQGHDQFKRRLPFGQMRQLCIAMDHPFDPV *******:** *****.**:*:*:***** ****:******* **********.:.*:.* ENSP00000278951/1-855 GTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNI ENSMUSP00000110220/1-853 GPRPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNI ENSRNOP00000024239/1-979 GARPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNI ENSCPOP00000006317/1-853 GTRPRLDSMSSVEEDDYDTLTDIESDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNI XP_004856712.1/1-852 GPRPRLDSMSSVEEDDYDTLTDIESDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNI *.***:*****************:************ *********************** ENSP00000278951/1-855 ATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLG ENSMUSP00000110220/1-853 ATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLG ENSRNOP00000024239/1-979 ATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLG ENSCPOP00000006317/1-853 ATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLG XP_004856712.1/1-852 ATIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLG ***********:************************************************ ENSP00000278951/1-855 LLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNY ENSMUSP00000110220/1-853 LLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNY ENSRNOP00000024239/1-979 LLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNY ENSCPOP00000006317/1-853 LLFLLIILQREINHNRALLRNDLYAMECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNY XP_004856712.1/1-852 LLFLLIILQREINHNRALLRNDLYAMECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNY *********************** *:********************************** ENSP00000278951/1-855 TNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF ENSMUSP00000110220/1-853 TNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF ENSRNOP00000024239/1-979 TNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF ENSCPOP00000006317/1-853 TNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF XP_004856712.1/1-852 TNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF ************************************************************ ENSP00000278951/1-855 WIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLV ENSMUSP00000110220/1-853 WIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLV ENSRNOP00000024239/1-979 WIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLV ENSCPOP00000006317/1-853 WIVFSVIHIIATLLLSTQLYYMGRWKLDWGIFRRILHVVYTDCIRQCSGPLYVDRMVLLV XP_004856712.1/1-852 WIVFSVIHIIATLLLSTQLYYMGRWKLDWGIFRRILHVLYTDCIRQCSGPLYVDRMVLLV *****:****:***************** *********:*************.******* ENSP00000278951/1-855 MGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIV ENSMUSP00000110220/1-853 MGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIV ENSRNOP00000024239/1-979 MGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIV ENSCPOP00000006317/1-853 MGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCII XP_004856712.1/1-852 MGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGEQIKLIPLLCII ***:*********************************************:*********: ENSP00000278951/1-855 CTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLV ENSMUSP00000110220/1-853 CTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLV ENSRNOP00000024239/1-979 CTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLV ENSCPOP00000006317/1-853 CTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLV XP_004856712.1/1-852 CTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLNFFDDHDIWHFLSSIAMFGSFLV *************************************:********************** ENSP00000278951/1-855 SGPPGRAGWVREGSSCLLLCG ENSMUSP00000110220/1-853 LLTLDDDLDTVQRDKIYVF-- ENSRNOP00000024239/1-979 LLTLDDDLDTVQRDKIYVF-- ENSCPOP00000006317/1-853 LLTLDDDLDTVQRDKIYVF-- XP_004856712.1/1-852 LLTLDDDLDTVQRDKIYVF-- . . . : .. ::