CLUSTAL W(1.81) multiple sequence alignment ENSP00000356064/1-1543 ------------------------MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVC ENSMUSP00000049248/1-1547 ------------------------MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVC ENSRNOP00000024412/1-1546 ------------------------MYAAVEHGPLLCSDSNILCLSWKGRVPKSEKEKPVC ENSCPOP00000006303/1-1547 ------------------------MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVC XP_004874615.1/1-1588 MKEIGLKFSALSIIFQVKQFIEKSMYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVC *********:************************** ENSP00000356064/1-1543 RRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQK ENSMUSP00000049248/1-1547 RRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQK ENSRNOP00000024412/1-1546 RRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQK ENSCPOP00000006303/1-1547 RRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQK XP_004874615.1/1-1588 RRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQK ************************************************************ ENSP00000356064/1-1543 LATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSG ENSMUSP00000049248/1-1547 LATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSG ENSRNOP00000024412/1-1546 LATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSG ENSCPOP00000006303/1-1547 LATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRNGFVLVGSVSG XP_004874615.1/1-1588 LATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRNGFVLVGSVSG *************************************************:********** ENSP00000356064/1-1543 QRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMS ENSMUSP00000049248/1-1547 QRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMS ENSRNOP00000024412/1-1546 QRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGILSMS ENSCPOP00000006303/1-1547 QRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHQFDGILNMS XP_004874615.1/1-1588 QRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHQFDGILSMS ***************************************************: **:*.** ENSP00000356064/1-1543 WNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDL ENSMUSP00000049248/1-1547 WNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNTKPLLTVSFTSGDISLMNNYDDL ENSRNOP00000024412/1-1546 WNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDL ENSCPOP00000006303/1-1547 WNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDL XP_004874615.1/1-1588 WNYPIFLVEDSSESDTDSDDYSPPQDGPAAYPIPIQNIKPLLTVSFTSGDISLMNNYDDL *********************:************:** ********************** ENSP00000356064/1-1543 SPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFT ENSMUSP00000049248/1-1547 SPTVIRSGLKEVVAQWCTQGDLLAVAGMEQQAQLSELPNGPLLKSAMVKFYNVRGEHIFT ENSRNOP00000024412/1-1546 SPTVIRSGLKEVVAQWCTQGDLLAVAGMEQQAQLSELPNGPLLKSAMVKFYNVRGEHIFT ENSCPOP00000006303/1-1547 SPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLSELPNGPLLKSAMVKFYNVRGEHIFT XP_004874615.1/1-1588 SPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLTELPNGPLLKSAMVKFYNVRGEHIFT *****************************:*:** ************************* ENSP00000356064/1-1543 LDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVS ENSMUSP00000049248/1-1547 LDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVN ENSRNOP00000024412/1-1546 LDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVN ENSCPOP00000006303/1-1547 LDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVS XP_004874615.1/1-1588 LDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIANTLREDKDVS **************************************************.********. ENSP00000356064/1-1543 KLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGP ENSMUSP00000049248/1-1547 KLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGP ENSRNOP00000024412/1-1546 KLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGP ENSCPOP00000006303/1-1547 KLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGP XP_004874615.1/1-1588 KLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGP ************************************************************ ENSP00000356064/1-1543 CYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDS ENSMUSP00000049248/1-1547 CYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKSDEIYGNSLISTVIDSCNCSDS ENSRNOP00000024412/1-1546 CYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKSDEIYGNNLISTVIDSCNCSDS ENSCPOP00000006303/1-1547 CYTLYLEYLGGLVPILKGRRVSKLRPEFVIMDPRSDSKSDEIYGNSLISTVIDSCNCSDS XP_004874615.1/1-1588 CYTLYLEYLGGLVPILKGRRVSKLRPEFVIMDPRTDSKSDEIYGNSLISTVIDSCNCSDS ********************:*************:***.******.************** ENSP00000356064/1-1543 SDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVG ENSMUSP00000049248/1-1547 SDIELSDDWAAKKSPKISRSSKSPKLPRISIEARKSPKLPRAAQEISRSPRLPMRKPSMG ENSRNOP00000024412/1-1546 SDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQEISRSPRLPMRKPSMG ENSCPOP00000006303/1-1547 SDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQEISRSPRLPIRKPSIG XP_004874615.1/1-1588 SDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQEISRSPRLPIRKPSIG *******************:*************************:*******:****:* ENSP00000356064/1-1543 SPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPR ENSMUSP00000049248/1-1547 SPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPR ENSRNOP00000024412/1-1546 SPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPR ENSCPOP00000006303/1-1547 SPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPR XP_004874615.1/1-1588 SPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPANLGAVIYKTSLLHLQPR ******************************************:***************** ENSP00000356064/1-1543 QMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENSPPCTVNIPIAPIHS ENSMUSP00000049248/1-1547 QMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHS ENSRNOP00000024412/1-1546 QMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHS ENSCPOP00000006303/1-1547 QMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPESNPPCTVNIPIAPIHS XP_004874615.1/1-1588 QMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENNPPCTVNIPIAPIHS ********************************************..************** ENSP00000356064/1-1543 SAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGTAEHAGDSATQYPVSNRYSNPGQV ENSMUSP00000049248/1-1547 SAQALSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGSAEHAGDAATQYPVSSRYSNPGQV ENSRNOP00000024412/1-1546 SAQALSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGSVEHAGDAATQYPVSSRYSNPGQV ENSCPOP00000006303/1-1547 SAQAISPTQNMGLVQSLLANQNVQLDVLTNQTTAVGASEHIGDSMTQYPVPSRYSNPGQV XP_004874615.1/1-1588 SAQAISPTQNIGLVQSLLASQNVQLDVLTNQTTAVGAAEHIGDNSTQYPIPNRYSNPGQV ****:****.:********.****************: ** ** ****:..******** ENSP00000356064/1-1543 IFGSVEMGRIIQNPPPLSLPPPPQ--------------------GPMQLSTVGHGDRDHE ENSMUSP00000049248/1-1547 IFGGVEMGRIIQNPPQLPLPPPPPPPPQ----------------APMQLSAVDHGDRDHE ENSRNOP00000024412/1-1546 IFGGVEMGRIIQNPPQLPLPPPPPPPPQ----------------GPIQLSAVDHGARDHE ENSCPOP00000006303/1-1547 IFGGMEMGRIIQNPPQLPLPPPPPPPPP----------------GVMQLAVMDHVDRDHE XP_004874615.1/1-1588 IFGGVEMARIIQNPPQLPLPPPPPPPPPPPPPPPLPPPLPPPPQGVMQLTMVDHGDRDHE ***.:**.******* *.***** . :**: :.* **** ENSP00000356064/1-1543 HLQKSAKALRPTPQLAAEGDAVVFSAPQEVQVTKINPPPPYPGTIPAAPTTAAPPPPLPP ENSMUSP00000049248/1-1547 HLQKSAKALRPVPQLAAEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPP ENSRNOP00000024412/1-1546 HLQKSAKALRPVPQL-AEGDAVVFSAPQEVQVAKMNPPPPYPGTIPAAPTTAAPPPPLPP ENSCPOP00000006303/1-1547 HLQKSAKALRPVPQLAAEGDAVVFGAPQEIQVTKMNPPPPYPGTIPAAPTTAAPPPPLPP XP_004874615.1/1-1588 HLQKSAKALRPVPQLAAEGDAVVFSAPQEVQVTKMNPPPPYPGTIPAAPTTAAPPPPLPP ***********.*** ********.****:**:*:************************* ENSP00000356064/1-1543 PQPPVDVCLKKGDFSLYPTSVHYQTPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTL ENSMUSP00000049248/1-1547 PQPPVDVCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTL ENSRNOP00000024412/1-1546 PQPPVDVCLKKGDFSLYPTAAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTL ENSCPOP00000006303/1-1547 PQPPVDVCLKKGDFSLYPTSAHYQPPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTL XP_004874615.1/1-1588 PQPPVDVCLKKGDFSLYPTSAHYQHPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTL *******************:.*** *********************************** ENSP00000356064/1-1543 PGPGSSATLRLTATEKKVPQPCSSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGRGAAQ ENSMUSP00000049248/1-1547 PGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGRSAAQ ENSRNOP00000024412/1-1546 PGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGRNATQ ENSCPOP00000006303/1-1547 PGPGSSATLRLTATEKKVSQPCTSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGRGTVQ XP_004874615.1/1-1588 PGPGSSATLRLTATEKKVPQPCTSATLNRLTVPRYSIPTGDPPPYPEIANQLAQGRGTVQ ******************.***:**************************.******.:.* ENSP00000356064/1-1543 RSDNSLIHATLRRNNREATLKMAQLADSPRAPLQPLAKSKGGPGGVVTQLPARPPPALYT ENSMUSP00000049248/1-1547 RLDNSLIHATLRRNNREVALKMAQLADSSRAPLQPLAKPKGGAAGAVAQLPARPPPALYT ENSRNOP00000024412/1-1546 RLDNSLIHATLRRNNREVALKMAQLADSSRAPLQPPAKPKGGTGGAVAQLPARPPPALYT ENSCPOP00000006303/1-1547 RLDSSLIHATLRRNNREVALKMTQLADSSRVPLQPLAKPKGGPSGAVAQLPARPPPALYT XP_004874615.1/1-1588 RLDSSLIHATLRRNNREVALKMAQLADSSRPPLQPLAKPKGGPAGAVAQLTTRPPPALYT * *.*************.:***:*****.* **** **.***..*.*:**.:******** ENSP00000356064/1-1543 CSQCSGTGPSSQPGASLAHTASASPLASQSSYSLLSPPDSARDRTDYVNSAFTEDEALSQ ENSMUSP00000049248/1-1547 CSQCSGAGPSSQSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTDYVNSAFTEDEALSQ ENSRNOP00000024412/1-1546 CSQCSGAGPSSQSGAALAHAISTSPLASQSSYNLLSPPDTSRDRTDYVNSAFTEDEALSQ ENSCPOP00000006303/1-1547 CSQCSGAGPSSQSGAILAHAVSTSPLASQSSYSLLSPPDSARDRTDYVNSAFTEDEALSQ XP_004874615.1/1-1588 CSQCSGAGPSSQSGAILAHAVSTSPLASQSSYSLLSPPDSTRDRTDYVNSAFTEDEALSQ ******:*****.** ***: *:*********.******::******************* ENSP00000356064/1-1543 HCQLEKPLRHPPLPEAAVTLKRPPPYQWDPMLGEDVWVPQERTAQTSGPNPLKLSSLMLS ENSMUSP00000049248/1-1547 HCQLEKPLRHPPLPEAAVTMKRPPPYQWDPMLGEDVWVPQERTAQPTVPNPLKLSPLMLG ENSRNOP00000024412/1-1546 HCQLEKPLRHPPLPEATVTMKRPPPYQWDPVLGEDVWVPQERTAQPTVPNPLKLSPLMIG ENSCPOP00000006303/1-1547 HCQLEKPLRHPMLPEAAVTMKRPPPYQWDPVLGEDVWVPQERTAQPAVPNPLKLPPLILG XP_004874615.1/1-1588 HCQLEKPLRHPTLPEAAVTLKRPPPYQWDPVLGEDIWVPQERTAQPAVPNPLKLPPLILG *********** ****:**:**********:****:*********.: ******..*::. ENSP00000356064/1-1543 QGQHLDVSRLPFISPKSPASPTATFQTGYGMGVPYPGSYNNPPLPGVQAPC-SPKDALSP ENSMUSP00000049248/1-1547 QGQHLDVARVPFVPPKSPSSPTATFPTGYGMGMPYPGSYNNPSLPGVQAPC-SPKDALSQ ENSRNOP00000024412/1-1546 QGQHLDVARVPFVSPKSPSSPTATFQTGYGMGVPYPGSYNTPSLPGVQAPC-SPKDALSP ENSCPOP00000006303/1-1547 QGQHLDVARVPFVSPKSPTSPTATFQTGYGMGVPYPGSYNNPSLPGVQASC-SPKDALSP XP_004874615.1/1-1588 QGQHLDVARVPFVSPKSPTSPTATFQTGYGMGVPFPGSYNNPPLPGVQAPCSSPKDALAP *******:*:**:.****:****** ******:*:*****.*.******.* ******: ENSP00000356064/1-1543 TQFAQQEPAVVLQPLYPPSLSYCTLPPMYPGSSTCSSLQLPPVALHPWSSYSACPPMQNP ENSMUSP00000049248/1-1547 AQFAQQESAVVLQPAYPPSLSYCTLPPTYPGSSTCSSVQLPPIALHPWNSYSTCPPMQNT ENSRNOP00000024412/1-1546 AQFAQQESAVVLQPAYPPSLSYCTLPPTYPGSSTCSSLQLPPIALHPWNSYSTCPPMQNT ENSCPOP00000006303/1-1547 TQFAQQESAVVLQPTYPPSLSYCTLPPMYPGSSTCSSLQLPPIALHPWSSYGTCPPMQNP XP_004874615.1/1-1588 TQFAQQESAVILQPAYPPSLSYCTLPPMYPGSSTCSSLQLPPVALHPWSSYSTCPPVQNP :******.**:*** ************ *********:****:*****.**.:***:**. ENSP00000356064/1-1543 QGTLPPKPHLVVEKPLVSPPPADLQSHLGTEVMVETADNFQEVLSLTESPVPQRTEKFGK ENSMUSP00000049248/1-1547 QGTLPPKPHLVVEKPLVSPPPAELQSHMGTEVMVETADNFQEVLSLTESPVPQRTEKFGK ENSRNOP00000024412/1-1546 QGTLPSKPHLVVEKPLVSPPPAELQSHMGTEVMVETADNFQEVLSLTESPVPQRTEKFGK ENSCPOP00000006303/1-1547 QGTLPPKPHLVVEKPLVSPPPADLQSHMGTEVMVETTDNFQEVLSLTESPVPQRSEKFGK XP_004874615.1/1-1588 QGTLPPKPHLVVEKPLVSPPPADLQSHMGTEVMVETTDNFQEVLSLTESPVPQRTEKFGK *****.****************:****:********:*****************:***** ENSP00000356064/1-1543 KNRKRLDSRAEEGSVQAITEGKVKKEARTLSDFNSLISSPHLGREKKKVKSQKDQLKSKK ENSMUSP00000049248/1-1547 KNRKRLDSRAEEGSVQAITEGKVKKDARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKK ENSRNOP00000024412/1-1546 KNRKRLDSRAEEGSVQAITEGKVRKDARTLSDFNSLIASPRLGREKKKVKSQKDQLKSKK ENSCPOP00000006303/1-1547 KNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKK XP_004874615.1/1-1588 KNRKRLDSRAEEGNVQAITEGKVKKEARTLSDFNSLISSPRLGREKKKVKSQKDQLKSKK *************.*********:*:***********:**:******************* ENSP00000356064/1-1543 LNKTNEFQDSSESEPELFISGDELMNQSQGSRKGWKSKRSPRAAGELEEAKCRRASEKED ENSMUSP00000049248/1-1547 LNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRTASELEEFKCRKASEKED ENSRNOP00000024412/1-1546 LNKTNEFQDSSESEPELFISGDELMNQSQGSKKGWKSKRSLRTASELEEFKGRKASEKED ENSCPOP00000006303/1-1547 LNKTNEFQDSSESEPELFISGDELMNQNQGSKKGWKSKRSLRTASELEEFKCRKASEKED XP_004874615.1/1-1588 LNKTNEFQDSSESEPELFISGDELMNQNQGSKKGWKSKRSLRTASELEEFKCRKASEKED ***************************.***:******** *:*.**** * *:****** ENSP00000356064/1-1543 GRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGS ENSMUSP00000049248/1-1547 GRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGN ENSRNOP00000024412/1-1546 GRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGN ENSCPOP00000006303/1-1547 GRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESTKNFQIELEGRQVMQFGRIDDN XP_004874615.1/1-1588 GRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESTKNFQIELEGRQVMQFGRIDDN **************************************:*******************.. ENSP00000356064/1-1543 AYILDFQYPFSAVQAFAVALANVTQRLK ENSMUSP00000049248/1-1547 AYILDFQYPFSAVQAFAVALANVTQRLK ENSRNOP00000024412/1-1546 AYILDFQYPFSAVQAFAVALANVTQRLK ENSCPOP00000006303/1-1547 AYILDFQYPFSAVQAFAVALANVTQRLK XP_004874615.1/1-1588 AYILDFQYPFSAVQAFAVALANVTQRLK ****************************