CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000095675/1-1104 ---------------------------------------------MEELSGKPLSYAEKE ENSRNOP00000041446/1-1110 ---------------------------------------------MEELSGKPLSCAEKE ENSP00000261584/1-1186 ---------------------------------------------MDEPPGKPLSCEEKE ENSCPOP00000006213/1-1118 ---------------------------------------------MEEPPWKPLSCAEKE XP_004856007.1/1-1122 MSGRVLRRSRVPDSFPGASWTQVQLGLRVRGSWAGDGCSFRSPIPMDEPPWKPLSYAEKE *:* . **** *** ENSMUSP00000095675/1-1104 KLKEKLAFLKKEYSRTLARLQRAKRAEKAKNSKKAI---EDGVPQPEASSQLSHSESINK ENSRNOP00000041446/1-1110 KLKEKLAFLRKEYTKTLARLQRAKRAEKVKNSKKAI---EDCVPQQEISPQLSRSEPINK ENSP00000261584/1-1186 KLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQQDLSPQLKHSEPKNK ENSCPOP00000006213/1-1118 KLKEKLAFLKREYTKTLARLQRAQRAEKVKNSIKKT--EQDCSLQHKISPQLNNSEYKNE XP_004856007.1/1-1122 KLKKKLAFLKREYSKTLARLQRAQRAEKVKNSVTKTV-EQDCSPQREISLQLNHSEPKNE ***:*****::**::********:**** *:* . :* * . * **..** *: ENSMUSP00000095675/1-1104 GFPCDTLQ-SNHLDEETGENISQILDVEPQSFNCKQG-KEVLHTPRAGDIQGQLLHSTSS ENSRNOP00000041446/1-1110 GFPCDASLQSDHLDEETGENISQILDGDPQSFNCESG-QEVLHTPRAGDIQGQFLHSTSS ENSP00000261584/1-1186 ICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDG-PGGLPIQRTDDTQEHFPHRVSD ENSCPOP00000006213/1-1118 RSPCEKLQISTHVDEETGEKTSVTLDTETESLNYKDGLGEELCLQGTGDTQEHSPYKDSD XP_004856007.1/1-1122 GSPHGKLQISIHLDEETGEKTSVTLDDEAESFNSEDGLEEGLCLQRTDDTQEHLPYKVND . *:******: * ** .:*:* .* * :.* * : : .. ENSMUSP00000095675/1-1104 PDGKKEQNTLPGTTKTPWEKSSVSQEKEDYFDTNSLALLGKHRKGQESISRKNS-RTPVS ENSRNOP00000041446/1-1110 PDGKKGQSAFPGTTKKLRKRSSVLQEKDDFFDTSSLVLPGRHQKRQETVSSKNP-RAPEI ENSP00000261584/1-1186 PSGEQKQ-KLPSRRKKQQKRTFISQERDCVFGTDSLRLSGKRLKEQEEISSKNPARSPVT ENSCPOP00000006213/1-1118 PVGEKRQTELPGRKKQP-KRTLNSQERKDVFDISSLILSGKRVKKQEAINNENS-KLPVT XP_004856007.1/1-1122 PVAEKRQSELPGRKKQP-KRTLNSQER-GFFDISSLILSGKRLKKQEVINNKNP-TLSVT * .:: * :*. * ::: **: *. .** * *:: * ** :. :*. . ENSMUSP00000095675/1-1104 EK-THLLSLRSQIPDPPALVTGI-GEGILIPPSGKSERGIDTLVRGNTVSAEAAVPSCTA ENSRNOP00000041446/1-1110 EK-THLLCLKSQTPDPPALVTEIDGGGRLIVPSGKSERGIDTPVRGNNVSRETTVPSCTA ENSP00000261584/1-1186 EIRTHLLSLKSELPDSPEPVTEINEDSVLIPPTAQPEKGVDTFLRRPNFTRATTVPLQTL ENSCPOP00000006213/1-1118 EV-TYLLSPKSEIPDFSLPVTEDDEKNEFIPPTAKSERGVDTASRGNKFFKETTVPLHTL XP_004856007.1/1-1122 EV-THLSSPESEIPDFPAPVTENDGESELIPPTAKLERGVAISSRGNKFFKEAAVPLHTI * *:* . .*: ** . ** . :* *:.: *:*: * .. ::** * ENSMUSP00000095675/1-1104 SNSNHSQHLEHTPPKSGCKITTQGP-----ASSTNLVAQDQKMTIFTVNSVVYKAVRAHG ENSRNOP00000041446/1-1110 SDSNHSGHLELTPPNSGCKITTQGP-----ASSINLVAQDKKTTIFTDNPVVYKPVSAGS ENSP00000261584/1-1186 SDSGSSQHLEHIPPKGSSELTTHDLKNIRFTSPVSLEAQGKKMTVSTDNLLVNKAISKSG ENSCPOP00000006213/1-1118 SDSSNSGYLEHTPPKDYYELTSQGFKN---VSSISLEAQGIKMTVCTDNSVLNEGISTRR XP_004856007.1/1-1122 TDCSNSQHLEHVPPEGHYEFTSQGFKNINSVSSINLEAQGIKMTVCTDNEVINEAVSTSS ::.. * :** **:. ::*::. .*. .* **. * *: * * :: : : ENSMUSP00000095675/1-1104 QLPGSPNS-----CSVNDLTHSNLPANSTPN-------SKSLKSPSNTVDERNEPLQEDE ENSRNOP00000041446/1-1110 QLPGSPNS-----CSVNDLTHSNLPANTTPN-------SRSLKSPDNIVDGRNENLEEDE ENSP00000261584/1-1186 QLPTSSNLEANISCSLNELTYNNLPANENQNLKEQNQTEKSLKSPSDTLDGRNENLQESE ENSCPOP00000006213/1-1118 QLPKSSNLEADNSCSLNELTYNNSSADKSQQI------KKSLKSPSNTLSCRSINPQEDE XP_004856007.1/1-1122 QLPQSPNLQADDAYSVNKLIYNNSSANISQNVNEKNHAEKSLKSLSNILDSRSVNLQEDE *** *.* *:*.* :.* .*: . : .:**** .: :. *. :*.* ENSMUSP00000095675/1-1104 ILGPSKNFNLAAVSPPSTESQIHSCTMLEGLLFPAEYYVRTTRRMSDCQRKIALEAVIQS ENSRNOP00000041446/1-1110 IVGLSENLSPAAVSPPSTESQIHSCTMLEGLLFPAEYYVRTTRRMSDCQRKIALEAVIQS ENSP00000261584/1-1186 ILSQPKSLSLEATSPLSAEK--HSCTVPEGLLFPAEYYVRTTRSMSNCQRKVAVEAVIQS ENSCPOP00000006213/1-1118 VLSQPENLSLRAVSTVSTENQIHSYTMLEGLLFPAEYYVRTTRHMSNYKRKVALEAVIQS XP_004856007.1/1-1122 VLSQPKNLSLEVVSPVSTENQNHSCTMLEGLLFPAEYYVRTTRHMSNYQRKVALEAVIQS ::. .:.:. ..*. *:*. ** *: *************** **: :**:*:****** ENSMUSP00000095675/1-1104 HLGVKKKELKKKTK-ATKAVVLSSEDTDQSESGMLDTSTGQSSSGSLSQKLLSPAEVSSP ENSRNOP00000041446/1-1110 HLGVKKKERKKKNK-ATKNLVLSSEETDQSESGMLDTSIGHSSSESLSQKLISPVEVSSP ENSP00000261584/1-1186 HLDVKKKGFKNKNKDASKNLNLSNEETDQSEIRMSGTCTGQPSSRT-SQKLLSLTKVSSP ENSCPOP00000006213/1-1118 HLGTKKKEFKNKIKEATKDLKLSNEETDQNEVRMSDTCMVHPHSKI-PLEFLSLAEVSSP XP_004856007.1/1-1122 HLGARKKGFKNKIKEVTKDVKLSIEETDQSEGRISSTCPVHPNSKS-PLELLSLAEVISP **..:** *:* * .:* : ** *:***.* : .*. :. * . :::* .:* ** ENSMUSP00000095675/1-1104 PGPAG------KATTPPPGRGHRGKRKSARTSTLGHCQLLFPPCAALAVNRSKGKFTKHK ENSRNOP00000041446/1-1110 LGPANNR--SKKATARPPGRGHREKRTSACTSTLGHHQLLFPPCAALAVNRTRGKFTKHK ENSP00000261584/1-1186 AGPTEDNDLSRKAVAQAPGRRYTGKRKSACTPASDHCEPLLPTSSLSIVNRSKEEVTSHK ENSCPOP00000006213/1-1118 ARPAGDDDCSRKAVSQPCGRRNRRKRRSVSTPALD-CELLLPASSIVTVNKS-EEVTLYK XP_004856007.1/1-1122 AGATEDSGCSRKTISQPCGRRHRRKRKSVSTSALDHCELLLPASSISSVNSSEDKVTWYR .: *: : . ** ** *. *.: . : *:*..: ** : :.* :: ENSMUSP00000095675/1-1104 CQNRGVVIH--------------------------------------------------- ENSRNOP00000041446/1-1110 CQNRDVIIH--------------------------------------------------- ENSP00000261584/1-1186 YQHEKLFIQ---VKGKKSRHQKEDSLSWSNSAYLSLDDDAFTAPFHRDGMLSLKQLLSFL ENSCPOP00000006213/1-1118 HQDEKAVIY--------------------------------------------------- XP_004856007.1/1-1122 RQAKKAVVHDKRVKGKEVHCQKEESLYPSDSASLALDGDAFTSSFHKKEMLNLKQLLSSL * . .: ENSMUSP00000095675/1-1104 ---DFELPDEDFGLLKLEKLKSCSEKLIESPDSKNCGERLPREGNHAALEEL---QRDSE ENSRNOP00000041446/1-1110 ---DFELPDEDFGPLKLEKLKSYSEKLIESPDSKNCGESLPTEGKHAVLEEL---QIDSE ENSP00000261584/1-1186 SITDFQLPDEDFGPLKLEKVKSCSEKPVEPFESKMFGERHLKEGSCIFPEELSPKRMDTE ENSCPOP00000006213/1-1118 ---DFELPDEDFGHLKLEKLKSCSEKPIEPLDSKTYGERHLKEGNQIVQQEPVPKQRDAA XP_004856007.1/1-1122 SMTDFELPDEDFGPLKLEKLKSCSEKPSEPLESKICAERHLKEGNYIVLQEPIPNRLDAA **:******* *****:** *** *. :** .* **. :* : *: ENSMUSP00000095675/1-1104 TEGLEEELTVPPGEAYRPGPTLRRQPGSKDLSSSIVLFTPADTAAPNDSGRPPPSLCSPA ENSRNOP00000041446/1-1110 TEGLEVELTVLPGEACHPGPTLRWQPVSKGLSSSIVLFTPTDTAAPNNSDRSTASLCSPA ENSP00000261584/1-1186 MEDLEEDLIVLPGKSHPKRPNSQSQHTKTGLSSSILLYTPLNTVAPDDNDRPTTDMCSPA ENSCPOP00000006213/1-1118 TEDLEEDL-VLPEKAHLPVLNQKCQPTNPGLSSSILLFTPLNTAALNDNDPLTTDLCPPT XP_004856007.1/1-1122 TEDLGEDL-VLPEKAHLQVPNKKSQPTNKKLSSSMLLFTPSNTAAPNDSDPPAADLCSPA *.* :* * * :: . : * . ****::*:** :*.* ::.. ...:*.*: ENSMUSP00000095675/1-1104 FPILGMTPALGSQAAGETLSTE-AAQPCSTSQPPLLGDTNSLVNNSKQCNSSACSPKPDT ENSRNOP00000041446/1-1110 FPVLGRTPAFGSQATGENISAE-AGQPCSTSRPSHLGETNSLVNKNKQCDSSACSPKLDT ENSP00000261584/1-1186 FPILGTTPAFGPQGSYEKASTEVAGRTCCTPQLAHLKDSVCLASDTKQFDSSGSPAKPHT ENSCPOP00000006213/1-1118 FPFVGTTPAFGSQGHSEKMSVE-VGHICFTPQPSHLTDTVILARDSKQCDS---PPKLDT XP_004856007.1/1-1122 LPIVGTTPALGSQACSGKASAE-GGQTCSIPQLSHLEDTVLLASDSKQCDS---SSELDT :*.:* ***:*.*. . *.* .: * .: . * :: *. ..** :* ..: .* ENSMUSP00000095675/1-1104 NLQASGRQGQPACDSDSGPQATPLPVESFTFRENQLCGNACLELHEHSTEQTETADRPAC ENSRNOP00000041446/1-1110 SLQVSGRQGQATCDSDSGPQATPLPIESFTFREDQLCGSACLELHEHSTEQTEIADLPAC ENSP00000261584/1-1186 TLQVSGRQGQPTCDCDSVPPGTPPPIESFTFKENQLCRNTCQELHKHSVEQTETAELPAS ENSCPOP00000006213/1-1118 SLHGSGGRGQTACDHDSGTQATPLLTESLTFRENQLYGNTCPEWHKHSVEQAETADLPVS XP_004856007.1/1-1122 SLRVSGRRGQSACHHDAGPQAAPLLIESFAFRENQLCGNACLELHKHSTEQTEIADRPVC .*: ** :**.:*. *: . .:* **::*:*:** .:* * *:**.**:* *: *.. ENSMUSP00000095675/1-1104 DNLNPGNLQLVSELKNPSSSCSVDVSAMWWERAGAKEPCIVTACEDVVSLWKPLNSLQWE ENSRNOP00000041446/1-1110 DSLSPGNLQLVSELKNPSSSCSVDVSAMWWERAGTKEPCIITACEDVVSLWKPLDSMQWE ENSP00000261584/1-1186 DSINPGNLQLVSELKNPSGSCSVDVSAMFWERAGCKEPCIITACEDVVSLWKALDAWQWE ENSCPOP00000006213/1-1118 DSLNLCSLQLVSKLKNPSSSCSVDVSVMWWEEADFREPCIITACEYVVSLWKPVDPCQWE XP_004856007.1/1-1122 DSLNSGSLQLVSKLKNPSGSCSVDVSVMWWEEAGFKEPRIITACEYVVSLWKPMDPCQWE *.:. .*****:*****.*******.*:**.*. :** *:**** ******.::. *** ENSMUSP00000095675/1-1104 KVHTWHFTEVPVLQIVPVPDVYNLICVALGSLEIREIRALLCSSGDDSEKQVLLKSGDIK ENSRNOP00000041446/1-1110 KVHTWHFTEVPVLQIVPVPDIYSLICVALGSLEIREIRALLCSSGDECEKQVLLQSGDIK ENSP00000261584/1-1186 KLYTWHFAEVPVLQIVPVPDVYNLVCVALGNLEIREIRALFCSSDDESEKQVLLKSGNIK ENSCPOP00000006213/1-1118 KIHTWHFTEVPVLQIIPVPEVYNLVFVALGNLEIREIRALLCFSDDRNEKQTLLKSGNIK XP_004856007.1/1-1122 KIHTWHFTEVPVLQIVPVPDVCNLVFVALGNLEIREIRTLLCSSDDKNEKQKLLKSGNIK *::****:*******:***:: .*: ****.*******:*:* *.* *** **:**:** ENSMUSP00000095675/1-1104 AMLGLTKRRLVSSTGTFCNQQIQIMTFADDGSSKDEQLLMPPDETVLTFAEVQGTQEALL ENSRNOP00000041446/1-1110 AMLGLTKRRLVSSTGTFCNQQIQIMTFAEDGSSKDEQLLMPPDETILTFAEVHGMQEALL ENSP00000261584/1-1186 AVLGLTKRRLVSSSGTLSDQQVEVMTFAEDGGGKENQFLMPPEETILTFAEVQGMQEALL ENSCPOP00000006213/1-1118 AVLGLTRRRLVNSSGTLCDQQIEVMTFAEDGGCKEKQFLMSPEETILTFAEVQGMQEALL XP_004856007.1/1-1122 AVLGLTERRLVSSSGTLCDQQVEVVTFADDGGTKEKQFLMPPKETILTFAEVQGMQEALL *:****.****.*:**:.:**::::***:**. *::*:**.*.**:******:* ***** ENSMUSP00000095675/1-1104 GTTTVNSIVIWNLKTGQLLKKMHIDDSYQASVCHGAYSEKGLLFVVVSQPCAKESQALGS ENSRNOP00000041446/1-1110 GTTTVNSIVIWNLKTGQLLKKMHIDDSYQTCVCHRAYSEMGLLFIVLSHPCAKESQAFGS ENSP00000261584/1-1186 GTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPCAKESESLRS ENSCPOP00000006213/1-1118 GTTAMNNIVIWNLKSGQLLKKMYIDNSYQATVCHKAYSEMGLLFVVLSHPCAKETESLGS XP_004856007.1/1-1122 GTTAMNNVTIWNLKTGQLLKKIRIDDSYQATVCHKAYSEM----------VSDDVKPL-- *** :*.:.*****:******: **:***: *** **** :.: :.: ENSMUSP00000095675/1-1104 PVFQLLVINPKTAQSVGVLLCSLPQGQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHC ENSRNOP00000041446/1-1110 PVFQLLAINPMTAQSVGVLLCSLPQGQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHC ENSP00000261584/1-1186 PVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHCAAAILTSGTIAIWDLLLGQC ENSCPOP00000006213/1-1118 PVFQLIVINPKTTLNTGVMLYCLPQGQAGRFLEGDVKDHFAAAVLTSGTIAIWDLLLGHC XP_004856007.1/1-1122 ---------------------CV------------------------------------- .: ENSMUSP00000095675/1-1104 TALLPPVSDQSWSLVKWSGTDSHLLAGQKDGNIFIYRYF ENSRNOP00000041446/1-1110 TALLPPVSDQSWSLVKWSGTDSHLLAGQKDGNIFIYRYF ENSP00000261584/1-1186 TALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS ENSCPOP00000006213/1-1118 KVLLPPSSDQNWSFVKWSGTDSHLLAGQKDGNIFIYHYS XP_004856007.1/1-1122 ----------------------HLV-------------- **: