CLUSTAL W(1.81) multiple sequence alignment ENSP00000304408/1-1466 ---MMSFVQKGSWLLLALLHPTIILAQQ--EAVEGGCSHLGQSYADRDVWKPEPCQICVC ENSMUSP00000085192/1-1464 ---MMSFVQSGTWFLLTLLHPTLILAQQS-NVDELGCSHLGQSYESRDVWKPEPCQICVC ENSRNOP00000004956/1-1463 ---MMSFVQCGTWFLLTLLHPSLILAQQS-NVDELGCNYLGQSYESRDVWKPEPCQICVC ENSCPOP00000006162/1-1463 HLDMMSFVQKGTWLLLLLLHPTVILAQQTQEVDEGGCTYLGQSYAARDVWKPEPCQICVC XP_004872361.1/1-1465 ---MMSFVQKGTWLLLALLHPTVILAQQTPEVDEGGCTYLGQSYAARDVWKPEPCQICVC ****** *:*:** ****::***** :. * **.:***** ************** ENSP00000304408/1-1466 DSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPG ENSMUSP00000085192/1-1464 DSGSVLCDDIICDEEPLDCPNPEIPFGECCAICPQPSTPAPVLPDGHGPQGPKGDPGPPG ENSRNOP00000004956/1-1463 DSGSVLCDDIMCDDEPLDCPNPEIPFGECCAICPQPSTPAPVIPDGNRPQGPKGDPGPPG ENSCPOP00000006162/1-1463 DSGSVLCDDIICDEENLDCPNPEIPFGECCATCPQPSTPAPV-PNGRGPQGPKGDPGPPG XP_004872361.1/1-1465 DSGSVLCDDIICDEENLDCPNPEIPFGECCAACPQPSTPAPV-PSGRGPQGPKGDPGPPG **********:**:: *************** ****.*... *.*. ************ ENSP00000304408/1-1466 IPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGP ENSMUSP00000085192/1-1464 IPGRNGDPGLPGQPGLPGPPGSPGICESCPTGGQNYSPQFDSYDVKSG--VGGMGGYPGP ENSRNOP00000004956/1-1463 IPGRNGDPGLPGQPGLPGPPGSPGICESCPTGGQNYSPQFDSYDVKSG--VGGMGGYPGP ENSCPOP00000006162/1-1463 IPGRNGDPGIPGQPGPPGAPGAPGICQSCPTGSQNYSPQFDSYDVKSG-GPGGLAGYPGP XP_004872361.1/1-1465 IPGRNGDPGTPGQPGSPGPPGTPGICQSCPTGTQNYSPQFDSYDVKSG--VGGVSGYPGP ********* ***** **.**.****:***** ******:******** **:.***** ENSP00000304408/1-1466 AGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGR ENSMUSP00000085192/1-1464 AGPPGPPGPPGSSGHPGSPGSPGYQGPPGEPGQAGPAGPPGPPGALGPAGPAGKDGESGR ENSRNOP00000004956/1-1463 AGPPGPPGPPGSSGHPGSPGSPGYQGPPGEPGQAGPAGPPGPPGAIGPSGPAGKDGESGR ENSCPOP00000006162/1-1463 VGPPGPPGPPGSSGHPGAPGSPGYQGPPGEPGQAGPAGPPGPPGAIGPSGPAGKDGESGR XP_004872361.1/1-1465 AGPPGPPGPPGTSGHPGAPGSPGYQGPPGEPGQAGPAGPPGPAGAIGPVGPAGKDGESGR .**********:*****:******************:*****.**:** *********** ENSP00000304408/1-1466 PGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGA ENSMUSP00000085192/1-1464 PGRPGERGLPGPPGIKGPAGMPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGA ENSRNOP00000004956/1-1463 PGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGDNGA ENSCPOP00000006162/1-1463 PGRPGERGLPGPPGMKGPAGMPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGS XP_004872361.1/1-1465 PGRTGERGLPGPPGIKGPAGMPGFPGVKGHRGFDGRNGEKGETGAPGLKGENGLPGENGA ***.**********:*****:*****:*****************************:**: ENSP00000304408/1-1466 PGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGP ENSMUSP00000085192/1-1464 PGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGP ENSRNOP00000004956/1-1463 PGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGP ENSCPOP00000006162/1-1463 PGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPVPPGPPGTAGFPGSPGAKGEVGP XP_004872361.1/1-1465 PGPMGPRGAPGERGRPGLPGAAGTRGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGP ***********************:************* ********************** ENSP00000304408/1-1466 AGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGP ENSMUSP00000085192/1-1464 AGSPGSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPAGIPGAPGLIGARGP ENSRNOP00000004956/1-1463 AGSPGSNGSPGQRGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPAGIPGAPGLLGARGP ENSCPOP00000006162/1-1463 AGSPGSSGAPGARGEPGPQGHAGAQGPPGPPGSNGSPGGKGEMGPAGIPGAPGLMGARGP XP_004872361.1/1-1465 AGSPGSSGAPGARGEPGPQGHAGAQGPPGPPGNNGSPGGKGEMGPAGIPGAPGLMGARGP ******.*:** ******************** *********************:***** ENSP00000304408/1-1466 PGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGA ENSMUSP00000085192/1-1464 PGPAGTNGIPGTRGPSGEPGKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGA ENSRNOP00000004956/1-1463 PGPAGANGAPGQRGPSGEPGKNGAKGEPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGA ENSCPOP00000006162/1-1463 AGPPGTNGAPGQRGSPGEPGKNGAKGDPGARGERGEAGSPGIPGPKGEDGKDGSPGEPGA XP_004872361.1/1-1465 AGPPGTNGAPGQRGSPGEPGKNGAKGEPGARGERGEAGSPGIPGTKGEDGKDGSPGEPGA .**.*:** ** ** .**********:**.******** **:**.*************** ENSP00000304408/1-1466 NGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGM ENSMUSP00000085192/1-1464 NGLPGAAGERGPSGFRGPAGPNGIPGEKGPPGERGGPGPAGPRGVAGEPGRDGTPGGPGI ENSRNOP00000004956/1-1463 NGVPGNPGERGAPGFRGPAGPNGAPGEKGPAGERGGPGPAGPRGVAGEPGRDGTPGGPGI ENSCPOP00000006162/1-1463 NGLPGAAGERGAPGFRGPAGPPGLAGEKGPSGERGGPGPAGPRGAAGEPGRDGAPGTPGM XP_004872361.1/1-1465 NGVPGAAGERGAPGFRGPAGPPGLAGEKGPAGERGGPGPAGPRGGAGEPGRDGAPGTPGM **:** .****..******** * .*****.****.******** ********.** **: ENSP00000304408/1-1466 RGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE ENSMUSP00000085192/1-1464 RGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE ENSRNOP00000004956/1-1463 RGMPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE ENSCPOP00000006162/1-1463 RGAPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE XP_004872361.1/1-1465 RGAPGSPGGPGNDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE ** ********.************************************************ ENSP00000304408/1-1466 RGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGK ENSMUSP00000085192/1-1464 RGGPGGPGLPGPAGKNGETGPQGPPGPTGPAGDKGDSGPPGPQGLQGIPGTGGPPGENGK ENSRNOP00000004956/1-1463 RGGPGGPGLPGPAGKNGETGPQGPPGPTGAPGDKGDAGPPGPQGLQGIPGTSGPPGENGK ENSCPOP00000006162/1-1463 RGGPGGPGLPGPPGKNGETGPQGPPGPTGASGDKGDPGPPGPQGLQGLPGTAGPPGENGK XP_004872361.1/1-1465 RGGPGGPGLPGPSGKNGETGPQGPPGPTGPSGDKGDSGPPGPQGLQGLPGTAGPPGENGK ******** **.****************. *****.**********:***.******** ENSP00000304408/1-1466 PGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGP ENSMUSP00000085192/1-1464 PGEPGPKGEVGAPGAPGGKGDSGAPGERGPPGTAGIPGARGGAGPPGPEGGKGPAGPPGP ENSRNOP00000004956/1-1463 PGEPGPKGEAGAPGVPGGKGDSGAPGERGPPGTAGTPGLRGGAGPPGPEGGKGPAGPPGP ENSCPOP00000006162/1-1463 PGEAGPKGDVGAPGTPGGKGDAGAPGERGPPGLAGTPGLRGGAGPPGPEGGKGPAGPPGP XP_004872361.1/1-1465 PGEAGPKGDVGSPGTPGGKGDAGAPGERGPPGLAGTPGLRGGAGPPGPEGGKGPAGPPGP ***.****:.*:**.******:********** ** ** **************.****** ENSP00000304408/1-1466 PGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQ ENSMUSP00000085192/1-1464 PGASGSPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQ ENSRNOP00000004956/1-1463 PGTSGPPGLQGMPGERGGPGSPGPKGEKGEPGGAGADGVPGKDGPRGPAGPIGPPGPAGQ ENSCPOP00000006162/1-1463 PGASGTPGLQGMPGERGGPGSPGPKGEKGEPGGPGADGAPGKDGPRGPTGPIGPPGPAGQ XP_004872361.1/1-1465 PGASGSPGLQGMPGERGGPGGPGPKGEKGEPGGAGVDGAPGKDGPRGPTGPIGPPGPAGQ **::*.************ *.*****:******.*.**.*********:*********** ENSP00000304408/1-1466 PGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAP-GQNGEPGGKGERGAPGEKG ENSMUSP00000085192/1-1464 PGDKGEGGSPGLPGIAGPRGGPGERGEHGPPGPAGFPGAP-GQNGEPGAKGERGAPGEKG ENSRNOP00000004956/1-1463 PGDKGEGGAPGLPGIAGPRGGPGERGEHGPPGPAGFPGAP-GQNGEPGAKGERGAPGEKG ENSCPOP00000006162/1-1463 PGDKGESGAPGLPGIAGPRGGPGERGEHGPPGPAGFPGAPHGNTSEPRAQCTVRVSANRS XP_004872361.1/1-1465 PGDKGEGGAPGLPGIAGPRGGPGERGEHGPPGPAGFPGAP-GQNGEPGAKGERGAPGEKG ******.*:***********.****** ************ *:..** .: ...::. ENSP00000304408/1-1466 EGGPPG--VAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGP ENSMUSP00000085192/1-1464 EGGPPG--PAGPTGSSGPAGPPGPQGVKGERGSPGGPGTAGFPGGRGLPGPPGNNGNPGP ENSRNOP00000004956/1-1463 EGGPPG--AAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGGRGLPGPPGNNGNPGP ENSCPOP00000006162/1-1463 LYRPTGTECAGPPGGSGPAGPPGPQGVKGERGSPGGPGASGFPGARGPPGPPGSNGNPGP XP_004872361.1/1-1465 EGGAPG--IAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGP ..* ***.*.***********************::****.** *****.****** ENSP00000304408/1-1466 PGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGI ENSMUSP00000085192/1-1464 PGPSGAPGKDGPPGPAGNSGSPGNPGIAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGL ENSRNOP00000004956/1-1463 PGPSGAPGKDGPPGPAGNSGSPGNPGVAGPKGDAGQPGEKGPPGAQGPPGSPGPLGIAGL ENSCPOP00000006162/1-1463 PGVSGAPGKDGPPGPPGNNGAPGSPGISGPKGDAGQPGEKGPPGAQGPPGSAGPLGLVGV XP_004872361.1/1-1465 PGASGAPGKDGPPGPAGNSGSPGSPGVSGPKGDAGQPGEKGPPGAQGPPGAPGPLGLAGI ** **:*********.**.*:**.**::*************.********:.****:.*: ENSP00000304408/1-1466 TGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGR ENSMUSP00000085192/1-1464 TGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGR ENSRNOP00000004956/1-1463 TGARGLAGPPGMPGPRGSPGPQGIKGESGKPGASGHNGERGPPGPQGLPGQPGTAGEPGR ENSCPOP00000006162/1-1463 PGARGLAGPPGMPGPRGSPGPQGIKGENGKPGPSGHNGERGPPGPQGLPGLAGAAGEPGR XP_004872361.1/1-1465 TGARGLAGPPGMPGPRGSPGPQGIKGESGKPGTSGHNGERGPPGPQGLPGLAGTAGEPGR .**********************:***.****..* .************* .*:****** ENSP00000304408/1-1466 DGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGP ENSMUSP00000085192/1-1464 DGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPSGKSGDRGETGPAGP ENSRNOP00000004956/1-1463 DGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPSGKNGDRGETGPAGP ENSCPOP00000006162/1-1463 DGNPGSDGLPGRDGAPGGKGDRGES---------GHPGPAGPVGPAGKSGDRGETGEGKL XP_004872361.1/1-1465 DGNPGSDGQPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGETGPAGP ******** *****:*********. *****.*****:**.*****:* . ENSP00000304408/1-1466 AGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGS ENSMUSP00000085192/1-1464 SGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAIGS ENSRNOP00000004956/1-1463 SGAPGPAGARGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAVGS ENSCPOP00000006162/1-1463 SGLPSLAGSQGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGPAGHQGAVGS XP_004872361.1/1-1465 AGSPGPAGVRGAPGPQGPRGDKGETGERGSNGIKGHRGFPGNPGPPGSPGAAGHQGAVGS :* *. ** :*******************: *************.*****.**:***:** ENSP00000304408/1-1466 PGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQ---PGPPGP ENSMUSP00000085192/1-1464 PGPAGPRGPVGPHGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQ---PGPPGP ENSRNOP00000004956/1-1463 PGPAGPRGPVGPHGPPGKDGSSGHPGPIGPPGPRGNRGERGSEGSPGHPGQ---PGPPGP ENSCPOP00000006162/1-1463 PGPAGPRGPAGPNGPPGKDGTSGHPGPIGPPGPRGNRGERGSEKMNNDFTKHSCPQPPGP XP_004872361.1/1-1465 PGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNKGERGSEGSPGHPGQ---PGPPGP *********.** *******:***************:****** .. : * **** ENSP00000304408/1-1466 PGAPGPCCGGVGAAAIAGI--GGEKAG-GFAPYYGDEPMDFKINTDEIMTSLKSVNGQIE ENSMUSP00000085192/1-1464 PGAPGPCCGG-GAAAIAGV--GGEKSG-GFSPYYGDDPMDFKINTEEIMSSLKSVNGQIE ENSRNOP00000004956/1-1463 PGAPGPCCGG-G-AAIAGV--GGEKSG-GFSPYYGDDPMDFKINTEEIMSSLKSVNGQIE ENSCPOP00000006162/1-1463 PGAPGPCCGG-G-AAIAGFAAGGEKSA----PYYGDDPMDLKINTEEIMSSLKSVNGQIE XP_004872361.1/1-1465 PGAPGPCCGG-G-AAISGI-GGGEKSALGFVPYYGDEPMDFKINTEEIMSSLKSVNGQIE ********** * ***:*. ****:. *****:***:****:***:********** ENSP00000304408/1-1466 SLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISAN ENSMUSP00000085192/1-1464 SLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKMDAIKVFCNMETGETCINAS ENSRNOP00000004956/1-1463 SLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKMDAIKVFCNMETGETCINAS ENSCPOP00000006162/1-1463 SLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCRLDAIKVFCNMETGETCLSAS XP_004872361.1/1-1465 SLISPDGSHKNPARNCRDLKMCHPELKSGEYWVDPNQGCKMDAIKVFCNMETGETCLSAS ********:***********:******************::***************:.*. ENSP00000304408/1-1466 PLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQ ENSMUSP00000085192/1-1464 PMTVPRKHWWTDSGAEKKHVWFGESMNGGFQFSYGPPDLPEDVVDVQLAFLRLLSSRASQ ENSRNOP00000004956/1-1463 PMTVPRKHWWTDAGAEKKHVWFGESMNGGFQFSYGNPDLPEDVLDVQLAFLRLLSSRASQ ENSCPOP00000006162/1-1463 PPSVPLKNWWRDSGAEKKYVWFGESMDGGFQFSYGNPELPEDVLEVQLAYLRLLSSRASQ XP_004872361.1/1-1465 PSSIPLKNWWRDSGAEKKHVWFGESMDGGFQFSYGNPELPEDVLEVQLAHLRLLSSRASQ * .:* *:** *:.****:*******:******** *:*****::*:**.********** ENSP00000304408/1-1466 NITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSK ENSMUSP00000085192/1-1464 NITYHCKNSIAYMDQASGNVKKSLKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSK ENSRNOP00000004956/1-1463 NITYHCKNSIAYMDQANGNVKKSLKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSK ENSCPOP00000006162/1-1463 NITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGSSKFTYTVLEDGCTKHTGEWSK XP_004872361.1/1-1465 NITYHCKNSIAYMDQASGNVKKALKFMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSK ****************.*****:**:************.********************* ENSP00000304408/1-1466 TVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL ENSMUSP00000085192/1-1464 TVFEYQTRKAMRLPIIDIAPYDIGGPDQEFGVDIGPVCFL ENSRNOP00000004956/1-1463 TVFEYQTRKAMRLPIIDIAPYDIGGPDQEFGVDIGPVCFL ENSCPOP00000006162/1-1463 TVFEYRTRKAMRLPIIDIAPYDIGGPDQEFGVDVGPVCFL XP_004872361.1/1-1465 TVFEYRTRKAMRLPIIDISPYDIGGPDQEFGVDVGPVCFL *****:****:****:**:**************:******