CLUSTAL W(1.81) multiple sequence alignment ENSP00000428714/1-1278 MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPF ENSMUSP00000046774/1-1274 MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSL-VPEVLSVFVPPF ENSRNOP00000014542/1-1278 MAEPSARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVNGASSL-VPEVLSVFVPPF ENSCPOP00000005898/1-1284 MAETAPRHLSLPSGLVELCALLGASRDSRRSLEQVVQRRGVRSLSSL-DPEVLSVFVPPF XP_004837945.1/1-1281 MAEATQQHLSLPSGLLELCALLGAPRDSLRSLEQFTQKRGVRSLSFL-DPEVLSVFVPPF ***.: ********:********.:** *.***.. ::**. * * *****:***** ENSP00000428714/1-1278 ISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLL ENSMUSP00000046774/1-1274 TTKEDGQVPGASC-ALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLL ENSRNOP00000014542/1-1278 TTKEDGQVVGASC-TLSKGRRRSFRKKREKPRMESWKSHPGDSKGPDSEDVTIPGGVDLL ENSCPOP00000005898/1-1284 ITKEDSQGAGGNCATLGKGRRRSFRKKREKPKIEAWKGSPGDSKGPDSEDISVPGGVDLH XP_004837945.1/1-1281 ISKEDSQGAGGNCATLGKGRRRSFRKKREKPKTEPWKGPPGDSKGPDTEDISIPGGVDLL :***.* *..* :*.* * **:*******: * **. ** .:.*:.**:::****** ENSP00000428714/1-1278 TLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE ENSMUSP00000046774/1-1274 ALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWE ENSRNOP00000014542/1-1278 ALPQLCFPGGVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWE ENSCPOP00000005898/1-1284 ALPQLCFPGGMDVASEPKEDHVHFLVLTDVCGNRTYGVVAQYYRPLHDDCCFYNGTAHWE XP_004837945.1/1-1281 ALPQLCFPGGMHVASEPKEDHVHFLVLTDVCGNRTYGVVAQYYRPLHDDRCFYNGTAHWE :******** : **:***** :**************************: *****.:* * ENSP00000428714/1-1278 --------CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKL ENSMUSP00000046774/1-1274 PS----VISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARL ENSRNOP00000014542/1-1278 PS----MSSARRFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARL ENSCPOP00000005898/1-1284 PSWPSTVGAAGCFVPFAVCVVSRFPYYNSFKDCLSCLLTHLKLCKDFEVDNHIKDFAARL XP_004837945.1/1-1281 PSWPSIVGAAGCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDSHIKDFAARL .. *****************:********: ** *******.*******:* ENSP00000428714/1-1278 SLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT ENSMUSP00000046774/1-1274 SLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILT ENSRNOP00000014542/1-1278 SLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIIDLDLHLPLLCFRPEKVLQILTCILT ENSCPOP00000005898/1-1284 SLIPSPPPGPLHLMFNMKPLQVVFPSRADPESPVIDLDLHLPLLCFQPEKVLQILSCLLT XP_004837945.1/1-1281 SLIPSPPPGPLHLMFNMKPLHIVFPSRADPESPVIDLDLHLPLLCFRPEKVLQILSCLLT *************:****.*::*:*:*******::***********:********:*:** ENSP00000428714/1-1278 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDH ENSMUSP00000046774/1-1274 EQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDH ENSRNOP00000014542/1-1278 EQRMVFFSSDWALLTLMAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDH ENSCPOP00000005898/1-1284 EQRIVFFSSDWALLTLVAECFMVYLHPLQWQHTFVPILSGQMLDFIMAPTSFLMGCHLDH XP_004837945.1/1-1281 EQRIVFFSSDWALLTLIAECFRVYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDH ***:************::*** .*::******.******.*****:************** ENSP00000428714/1-1278 FEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAA ENSMUSP00000046774/1-1274 FEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLA ENSRNOP00000014542/1-1278 FEEVRKEADGLVLIDIDLGSVTCSKSSDEDVDIPDVPLLLAQAFIQRVQSLQLHPDLHLA ENSCPOP00000005898/1-1284 FEEVSKEADGLILIDIDHGSITCSKSSDNNMDIPDIPFLVAELFIQRVQSLQLHPELHLI XP_004837945.1/1-1281 FEEVSKEADGLILIDIDHGSITCSRSSDNDMDIPDIPLLVAQMFIQRVQSLQLHPELHLA **** ******:**:** **:* *:*:*:::****:*:* *: *********** :** ENSP00000428714/1-1278 HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKT ENSMUSP00000046774/1-1274 HLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKT ENSRNOP00000014542/1-1278 HLSASTDLNEGRARRRAWQQALNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKT ENSCPOP00000005898/1-1284 HLSSSTDLNEGRARQRAWQQTLNSRIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKT XP_004837945.1/1-1281 HLSSSTDLNEGRARQRAWQQTLNSRIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKT ** :****:****::*:*** **.:**: ******.***:******************** ENSP00000428714/1-1278 RAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVE ENSMUSP00000046774/1-1274 RAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVE ENSRNOP00000014542/1-1278 RAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVE ENSCPOP00000005898/1-1284 RAPGEQQFYKQVLDTYMFHSFLKARLSRRMDAYAQMDLDTQSEEDRISGMLRSPRRPTVE XP_004837945.1/1-1281 RATGEQQFYKQVLDTYMFHSFLKARLSRRMDAYAHMDLDTQSEEDRIRGMLISPRRPTVE **.*::********************. ****:*:************ ** ******** ENSP00000428714/1-1278 KRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKS ENSMUSP00000046774/1-1274 KMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKS ENSRNOP00000014542/1-1278 KMASRKASPLNIAHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSSCKSSSPVLKVTPKS ENSCPOP00000005898/1-1284 KMASRKSSPLNITHRRMVVSMPSLQDITLPELPARNSSLRIMDITGCKRNSPVLNVAPKS XP_004837945.1/1-1281 KMASRN---LNATHRRMVVSMPSLQDITLPELPPRNASLRIMDTTACRTSSPVLNVAPKS * ***: *: :*********.****::***..**:***: * : *: .*.**:*:*** ENSP00000428714/1-1278 PYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQ ENSMUSP00000046774/1-1274 TYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQ ENSRNOP00000014542/1-1278 TYTFKIPEIHFPLVSQCVQAYFTDLVTLLSKAMALLGPGDSLLLARYFYLRGLIHLMQGQ ENSCPOP00000005898/1-1284 TYTFKIPEIHFPLMSQCIQMYHANFITMLSKAMSLLGPDNSLLLARYFYLRGLVHLMQGQ XP_004837945.1/1-1281 TYMFKIPEIHFPLVSQCIQAYHSNFVTLLSKAMSLLGPDNSLLLARYFYLRGLVHLTQGQ .* ****:***** *:*:* *.:.::::**:**.:*.*.:*******:*****::* *** ENSP00000428714/1-1278 LLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEAS ENSMUSP00000046774/1-1274 LLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAP ENSRNOP00000014542/1-1278 LLNALLDFQSLYKTDIRIFPADLVKGMVDSMSASERAQAERTPELRRLITEVFDKQGEAP ENSCPOP00000005898/1-1284 LLSALSDFQYLYKTDIQIFPADLVKGTVESMSAPERSQAEQTPELRRLITEVLDKPGETT XP_004837945.1/1-1281 LLSALSDFQNLYKTDIQIFPADLVKGTVESMSASERAQAERTPELRRLITEVLDKPGEAA **.** *** ****** ***:**** *:****.* **::*** ***:*::** *:. ENSP00000428714/1-1278 KLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDF ENSMUSP00000046774/1-1274 KADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDF ENSRNOP00000014542/1-1278 KVDDAVKNFELPKKHMQLNDFVKRVQESGIVKDTTIIHRLFDALTVGHEKQIDPETFRDF ENSCPOP00000005898/1-1284 KADDAVKHFELPKKHMQLEDFVKRVQESGIVKDTHIIHRLFDALTVGQQKVIDPETFRDF XP_004837945.1/1-1281 KADDAVKHFELPKKHMQLEDFVKRVQESGIVKDTNIIHRLFDALTVGQQKLIDPETFRNF * ** **:*:******** **:***********: ******:***.*::* ******::* ENSP00000428714/1-1278 YNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGR ENSMUSP00000046774/1-1274 YTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGR ENSRNOP00000014542/1-1278 YTCWKETEAEAQEVSLPALLVDHLDRNECVYKLSSSVKTNRGVGKIAMTQKRLFLLPEGR ENSCPOP00000005898/1-1284 YNCWKETEAQAQEVSLPSLVEEHLDKNECVYKLSNSVKTNRGVGKIAMTQKRLFLLTEGR XP_004837945.1/1-1281 YNCWKETEAEAQEVSLPSLVMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGR *.*******:******* *: :***:**** ***.***** ***************.*** ENSP00000428714/1-1278 PGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMW ENSMUSP00000046774/1-1274 PGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMW ENSRNOP00000014542/1-1278 PSYVEIATFRNIEEVKSTTVAFLLLKIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMW ENSCPOP00000005898/1-1284 PGYVEISTFRNIEEVKSTTVAFLLLRIPTLKIKMMSKKDVFEANLKSECDLWYLMVKEMW XP_004837945.1/1-1281 PGYVEISTFRNIEEVRSTTVAFLLLRIPTLKIKMTSKKEVFEANLKSECDLWHLMVKEMW *.*:**:********: :*.:*** :******: :**:*******:*****:******* ENSP00000428714/1-1278 AGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPE ENSMUSP00000046774/1-1274 AGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPK ENSRNOP00000014542/1-1278 AGKKLADDHKDPQYVQQALTNVLLMDAVVGTLQSSGAIYAASKLAYFDKMKNELPMAVPK ENSCPOP00000005898/1-1284 AGKKLADDHKDPQYVQQALTNVLLMDAVVGTLQSPGAISAASKLSYFDKMKNEMPMAVPK XP_004837945.1/1-1281 AGKKLADDHKDPQYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMKNEMPMAVPK ***:********:*********************..** *****:***:*.:: **::*: ENSP00000428714/1-1278 TTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNAS ENSMUSP00000046774/1-1274 TTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDAS ENSRNOP00000014542/1-1278 TTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDAS ENSCPOP00000005898/1-1284 TTSETLKHKINPSAGETDPQAIDVLLYTPGHLDPAEKVEDAHPKLWCALSEGRVVVFDAS XP_004837945.1/1-1281 TTSETLKHKINPSAGETGPQAIDVLLYTPGHLDPAEKVEDAHPKLWCALSEGRVIVFDAS ** *************: ***::*******:******************.**:* **:** ENSP00000428714/1-1278 SWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDL ENSMUSP00000046774/1-1274 SWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGL ENSRNOP00000014542/1-1278 SWTIHQHCFKVGSSKVNCMVMAEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGL ENSCPOP00000005898/1-1284 SWTIHQPCFKVGTSKVNCMVMAEQSQVWVGSDDSIIYIINVHSMSCNKQLTDHRTAVTGL XP_004837945.1/1-1281 SWTIHQHCFKVGTSKVNCMVMAEQSQVWVGSEDSIIYIINVHSMSCNKQLTDHRAAITGL ***:** .****::********::.******:**:**************** * :.:*.* ENSP00000428714/1-1278 IVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSI ENSMUSP00000046774/1-1274 AVHNGKK-PSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKI ENSRNOP00000014542/1-1278 AVPSGKK-PSAVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDRVFCCTARSI ENSCPOP00000005898/1-1284 IVQNGKK-PSEVYSCSLDGTVLAWNVSTLEVNSRFQLPCCGLTSISLHSSSLWCCTGSSI XP_004837945.1/1-1281 IVHDGKK-PSEVYSCSLDGTVLAWNVSTLRVTCHFQLPCCGLTSISLHSSSLWCCAGSSI * .*:: ** :****:** *:.******.* .:*** .* ** **.. ::**: .* ENSP00000428714/1-1278 MVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPP ENSMUSP00000046774/1-1274 LVVTPQGFVRQELKHPKD-----ASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPP ENSRNOP00000014542/1-1278 LVVTLQGFVRQELRIQPS-EEPSASFLAIQLLPEEQQLWVACTGVSELYIWSLKDLGQPP ENSCPOP00000005898/1-1284 LVVTMHDFLCQELRREKDPREAQTSFLGLQILPEQGQLWTACAGRSEVCIWSLQDLTQAP XP_004837945.1/1-1281 VVVTTHGFLCQELRIDEDLREAKTSFLGLQLLPEQGQLWTTCAGSGEVYIWSLQDLAQAP :*:. :. : ***: . :***.:*:***: ***.:.:* .*: :***:** *.* ENSP00000428714/1-1278 QRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRT ENSMUSP00000046774/1-1274 QKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRT ENSRNOP00000014542/1-1278 QKTHLQDCTEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRT ENSCPOP00000005898/1-1284 QRIHLQDCSEVSCMIRVKRKIWVGGRGLSQGRLKGMIYVIDVEQKTVEKELVAHADCVRT XP_004837945.1/1-1281 QRIHLQDCSEVSCMIRVKRQVWVGGKGLSQGRPQGKIYVIDVERKTVEKELVAHADTVRT *: *:**:*:.******:::***.:**.** :* ***:*.*: *:******* * *** ENSP00000428714/1-1278 LCSAEDRYVLSGSGREEGKVAIWKGE ENSMUSP00000046774/1-1274 LCSAEDRYVLSGAGQEEGKIAIWKVE ENSRNOP00000014542/1-1278 LCSAEDRYVLSGAGGEEGKIAIWKVE ENSCPOP00000005898/1-1284 LCSAEDRYVLSGSGREEGKIAIWKVE XP_004837945.1/1-1281 LCSAEDRYVLSGSGREEGKIAIWKVE ************:* ****:**** *