CLUSTAL W(1.81) multiple sequence alignment ENSP00000331907/1-1143 ----------------------MPPPRTREGRDR--RDHHRAPSEEEALEKWDWNCPETR ENSMUSP00000113673/1-1145 ----------------------MPPPRTREGRGHRDRDHHRAPREEEAPEKWDWNCPETR ENSRNOP00000066304/1-1099 ----------------------MPPPRTREGRDHRDRDHHRAPRKEEAPEKWDWNCPETR ENSCPOP00000005862/1-1141 ----------------------MAPPRPREGRGH--RDHRWAPSEEEALEKWDWDCPETR XP_004867118.1/1-1166 MKKSGPGDQNQGPLRDNVVGHSMAPPRTREGRGH--RDHRWPPSEEEAWERWDWDCPETR *.***.****.: ***: .* :*** *:***:***** ENSP00000331907/1-1143 RLLEDAFFREEDYIRQGSEECQKFWTFFERLQRFQNLKTSRKEEKDPGQPKHSIPALADL ENSMUSP00000113673/1-1145 CLLEDVFFRDEDYIRRGSEECQKFWAFFERLQRFQHLKTSQKKEKDPGMPKHGIAALADL ENSRNOP00000066304/1-1099 CLLEDVFFRDEDYIRRGSEECQKFWAFFERLQKYQHLKTSQK-EKDPG-PKHGIAALADL ENSCPOP00000005862/1-1141 RRFEDAFFRDEDYIRQGSEDCHKFWAFFERLQRFQTLKTSKKEETDPGHPKHCVPALADL XP_004867118.1/1-1166 GLFEDAFFGDEDYIRQGSEECQKFWAFFERLQRFQNLKTSKKEEKDPRPPQHCIPALADL :**.** :*****:***:*:***:******::* ****:* *.** *:* :.***** ENSP00000331907/1-1143 PRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQ ENSMUSP00000113673/1-1145 PLTYDPRYRINLSILSPDTRGRHGPGRGLPPERVSEFRRALLHYLDFQQKQAFGRLVKLQ ENSRNOP00000066304/1-1099 PCTYDPRYRINLSILGPDTRGRHGPGKGLPPERVSEFRRALLHYLDFQQKQAFGRLAKLQ ENSCPOP00000005862/1-1141 PRPYDSRYRINLSVLGPDMRDIRGSGSQLPPKRVSEFRRALLHYLDFSQKQAFTRLAKLQ XP_004867118.1/1-1166 PRTYDPRYRINLSVLGPDAWSTRRLGSRLPPERVSEFRQALLHYLDFSQKQAFGRLAKLQ * .**.*******:*.* . : * **.:**:***:******** ***** **.*** ENSP00000331907/1-1143 RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIA ENSMUSP00000113673/1-1145 RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIA ENSRNOP00000066304/1-1099 RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIA ENSCPOP00000005862/1-1141 RDRAALPIAQYRKCILQTLKQHQVVVVAGDTGCGKSTQVPQYLLAAGFSHVACTQPRRIA XP_004867118.1/1-1166 RERAALPIAQYRNRILQMLKQHQVVVVAGDTGCGKSTQVPQYLLAGGFSHVACTQPRRIA *:********* : *** **:************************.************** ENSP00000331907/1-1143 CISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVL ENSMUSP00000113673/1-1145 CISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYQVL ENSRNOP00000066304/1-1099 CISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQCEPRLPQYQVL ENSCPOP00000005862/1-1141 CISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYKVL XP_004867118.1/1-1166 CVSLAKRVGFESLSQYGSQVGYQIRFESTRSVATKIVFLTVGLLLRQIQHEPSLPQYNVL *:*****************************.***************** ** ****:** ENSP00000331907/1-1143 IVDEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLF ENSMUSP00000113673/1-1145 IVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLF ENSRNOP00000066304/1-1099 IVDEVHERHLHNDFLLGVLQRLLPQRPDLKVILMSATINISLFSSYFSHAPVVQVPGRLF ENSCPOP00000005862/1-1141 IVDEVHERQLHNDFLLGVLQHLLPTRPDLKVVLMSATINIMLFSSYFGNAPVVQVPGRLF XP_004867118.1/1-1166 IVDEVHERQLHSDFLLGVLRRLLPTRPDLKVVLMSATINIELFSSYFGNAPVVQVPGRLF ********:**.*******::*** ******:******** ******.:*********** ENSP00000331907/1-1143 PITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEISAVLE ENSMUSP00000113673/1-1145 PITVVYQPQEADQTASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEITTVLD ENSRNOP00000066304/1-1099 PITVVYQPQEAEQSASKSEKLDPRPFLRVLEAIDNKYPPEERGDLLVFLSGMAEISTVLD ENSCPOP00000005862/1-1141 PITVIYQPQEAEQTASKSERLDPRPFLRVLEAIDNKYPAEERGDLLVFLSGMAEIGAVLE XP_004867118.1/1-1166 PITVIYQPQEAEQTASKTEKLDPRPFLRVLEAIDSKYPPEERGDLLVFLSGMAEISAVLE ****:******: ::**:*:***********:** ***.**************** :**: ENSP00000331907/1-1143 AAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVV ENSMUSP00000113673/1-1145 AAQAYASLTQRWVVLPLHSALSVSDQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVV ENSRNOP00000066304/1-1099 AAQAYATLTQRWVVLPLHSALSVADQDKVFDVAPAGVRKCILSTNIAETSVTIDGIRFVV ENSCPOP00000005862/1-1141 AAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVV XP_004867118.1/1-1166 AAQTYAIHTQRWVVLPLHSTLSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVL ***:** ***********:***:**********.************************: ENSP00000331907/1-1143 DSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYP ENSMUSP00000113673/1-1145 DSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYP ENSRNOP00000066304/1-1099 DSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYP ENSCPOP00000005862/1-1141 DSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFTPYP XP_004867118.1/1-1166 DSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCYRLYAESDYDAFAPYP ********************************************:***********:*** ENSP00000331907/1-1143 VPEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSEALTPI ENSMUSP00000113673/1-1145 VPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPPASVETAILYLQEQGALDSSEALTPI ENSRNOP00000066304/1-1099 VPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPAASVETAILYLQDQGALDSSEALTPI ENSCPOP00000005862/1-1141 VPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPPASLETAIQYLQEQGALDASEALTPI XP_004867118.1/1-1166 VPEIRRVALDALVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDASEALTPI **********:***********************.**:**** **::*****:******* ENSP00000331907/1-1143 GSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLE ENSMUSP00000113673/1-1145 GSLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLE ENSRNOP00000066304/1-1099 GSLLAQLPVDVVIGKMMILGSMFSLAEPVLTIAAALSVQSPFTRSAQSNLDCATARRPLE ENSCPOP00000005862/1-1141 GCLLAQLPVDVVIGKMLILGSMFSLAEPVLTIAAALSVQSPFPRSAQSSLECAAARQPLD XP_004867118.1/1-1166 GCLLAQLPVDVVIGKMLILGSTFSLVEPVLTIAAALSVQSPFTRSAQSSLECAAARRPLE *.**************:**** ***.****************.*****. :**:**:**: ENSP00000331907/1-1143 SDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLEDHGL ENSMUSP00000113673/1-1145 SDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGL ENSRNOP00000066304/1-1099 SDQGDPFTLFNVFNAWVQVKSERSGNSRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGL ENSCPOP00000005862/1-1141 SDQGDPFTLFNVFNAWVQVKAERSQNSRKWCRRRGVEEHRLYEMANLRRQFKDLLEDHGL XP_004867118.1/1-1166 SDQGDPFTLFNVFNAWVQVKAEHSRISRKWCRRRGVEEHRLYEMANLRRQFKELLEDHGL ********************:*:* *********:****************:******* ENSP00000331907/1-1143 LAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEQDGGSSD-EDRA ENSMUSP00000113673/1-1145 LSGAQVVAPGDSYSRLQQRRERRALHQLKRQHEEGGGRRRKVLRLQE--DGCSSDEEDRE ENSRNOP00000066304/1-1099 LRGAQVVAPRDSYSRLQQRRERQTLHQLKRQHEEGGGRRRKVLRLQE--DGCSSD-EDHE ENSCPOP00000005862/1-1141 LAGAEAATPGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRLQEEAEDGSSD-EDHA XP_004867118.1/1-1166 QAGAQVVRPRDSYSRLQQRRERRVLHQLKRQHEEGKGRRRKVLRLQEEADDGSSD-EDRA **:.. ************:.*********** *********** :. *** **: ENSP00000331907/1-1143 GPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGRGLYPQLAVP ENSMUSP00000113673/1-1145 GSTSQRA-DSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVP ENSRNOP00000066304/1-1099 GSASQRA-DSVDIQDVKFKLRHNLEQLQAAASSAQDLTRDQLALLKLVLGRGLYPQLAVP ENSCPOP00000005862/1-1141 GPAARHAEDSVDIQDVKFKLRHNLEQLQAAASSAQALSREQLVLLKLVLARGLYPQLAVP XP_004867118.1/1-1166 GPAAQGASDSVDIQDVKFKLRHNLEQLQAAASSAQELSREQLALLKLVLARGLYPQLAVP *.:. * *.************:* ********** *:*:**.******.********** ENSP00000331907/1-1143 DAFNSSRKDSDQIFHTQAKQGAVLHPTCVFAGSPEVLHAQELEASNCDGSRDDKDKMSSK ENSMUSP00000113673/1-1145 DAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGQEASGQEGSQDGRDQMSCK ENSRNOP00000066304/1-1099 DAFNSGRKDSDQIFHTQAKQGTVLHPTCVFANSPEVLHTQGPEASGREGSQDGKDQMSCK ENSCPOP00000005862/1-1141 DPFNSGRKDSDQIFHTQAKQGAVLHPTSVFASSPELLHVQEPQATCGGGSRDDKDKMSSK XP_004867118.1/1-1166 DPLNSGRKDSDQIFHTQAKQGAVLHPTCIFTGSPEVLHTWEPEATGGGGSRGDKDKMSSK *.:**.***************:*****.:*:.***:**. :*: **:..:*:**.* ENSP00000331907/1-1143 HQLLSFVSLLETNKPYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLADSES ENSMUSP00000113673/1-1145 HQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSES ENSRNOP00000066304/1-1099 HQLLAFVSLLETNKPYLVNCVRIPALQSLLLFSRSIDTNGDCSRLVADGWLELQLADSES ENSCPOP00000005862/1-1141 HQLLTFVSLLETNKLYLVNCVRVPALQSLLLFSRSLDTNGDCSRLVADSWLELQVVDSEG XP_004867118.1/1-1166 HQLLTFVSLLETNKLYLVNCVRIPALQSLLLFSRSLDTNGDCSRLVADGWLELQLVDSEG ****:********* *******:************:************.*****:.***. ENSP00000331907/1-1143 AIRLLAASLRLRARWESALDRQLAHQA--QQQLEEEEEDTP--VSPKEVATLSKELLQFT ENSMUSP00000113673/1-1145 AVRLLATSLRLRVHWESALDRQLARQA-QRRKLEQEEDMGSPAVSPQEVAALSRELLQFM ENSRNOP00000066304/1-1099 AVRLLATSLRLRAHWESALDRQLAQQA-QRRKLEQEEDPESPAVSPQEVAALSRELLQFM ENSCPOP00000005862/1-1141 AVQLLAAALRLRACWESALDRQLSHQG---EEDEDEEEAES--VSRAEVAALSRELLQFM XP_004867118.1/1-1166 AVRLLAAALRLRARWESALDQQLSHQAWQRQRLEEEDEAAL--ISHTEVAALSRELLQFV *::***::****. ******:**::*. .. *:*:: :* ***:**:***** ENSP00000331907/1-1143 ASKIPYSLRRLTGLEVQNMYVGPQTIPATPHLPGLFGSSTLSPHPTKGGYAVTDFLTYNC ENSMUSP00000113673/1-1145 VAKVPYRLRRLTGLEAQNLYVGPQTITTAPSLPGLFGNSTLSPHPTKGGYAVSDYLTYNC ENSRNOP00000066304/1-1099 AAKVPYRLRRLTGLEAQNLYVGPQTITTAPSLPGLFGNSILSPHPTKGGYAVSDYLTYNC ENSCPOP00000005862/1-1141 ATKVPYSLRRLTGLEAQNLYVGPQTVTATPKLPGLFGSSALSPHPTKGGYRVTNFLTYNC XP_004867118.1/1-1166 ATKVPYSLRRLTGLEAQNLYVGPQTILATPSLPGLFGSSTLSPHPTKGGYSVTSFLTYNC .:*:** ********.**:******: ::* ******.* ********** *:.:***** ENSP00000331907/1-1143 LTNDTDLYSDCLRTFWTCPHCGLHAPLTPLERIAHENTCPQAPQDGPPGAEEAALETLQK ENSMUSP00000113673/1-1145 LTSDTDLYSDCLRSFWTCPHCGLHMPFTPLERIAHENTCPEAPGDD-PGKSEAAPAPPQK ENSRNOP00000066304/1-1099 LTSDTDLYSDCLRSFWTCPHCGLHMPFTPLERIAHENTCPEAPSDG-PG----------- ENSCPOP00000005862/1-1141 LLSDTDLYSDCLRTFWTCPRCDLHLPLTPLERMAHESACATDLHGG-PGAEEATTEQSRK XP_004867118.1/1-1166 LSSDTDLYSDCLRTFWTCPHCGLHLPLTPLERMAHESVCTTGPDGA-PGAEEAAPEHPQK * .**********:*****:*.** *:*****:***..*. . ** ENSP00000331907/1-1143 TSVLQRPYHCEACGKDFLFTPTEVLRHRKQHV ENSMUSP00000113673/1-1145 TSALQRPYHCQVCGQDFLFTPTEVLRHRRQHV ENSRNOP00000066304/1-1099 -------------------------------- ENSCPOP00000005862/1-1141 PSALQRPYHCDSCQKDFLFTPTEALRHRRQHM XP_004867118.1/1-1166 PSALQRPYHCDTCQKDFLFTPTEALRHRRQHV