CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000005788/1-1363 ----------------------MDALNRSRVGPGCKTQAVVQKGPLDLIDTGKGLKVQTD XP_004856780.1/1-1382 MRRPGRGLCWAPGTQEFWNPRTMDALNRSHVGPGCKTQAMVQKGPLDLIETGKGLKVQTD ENSP00000354498/1-1377 ----------------------MDALNRNQIGPGCQTQTMVQKGPLDLIETGKGLKVQTD ENSMUSP00000120208/1-1449 ----------------------MDPLNRSQLGPGCKTQAVVQKGPLDLIETGQGLKVQTD ENSRNOP00000046235/1-1381 ----------------------MATLNRNQLGPGCKTQAVVQKGPLDLIETGQGLKVQTD * .***.::****:**::*********:**:******* ENSCPOP00000005788/1-1363 KPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAKDISLQGPGLAPEHCYIENLRGTLTLYP XP_004856780.1/1-1382 KPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAKDISLQGPGLAPEHCYIENLRGTLTLYP ENSP00000354498/1-1377 KPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYP ENSMUSP00000120208/1-1449 KPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYP ENSRNOP00000046235/1-1381 KPHLVSLGSGRLSTAITLLPLEEGRTVIGSAARDISLQGPGLAPEHCYIENLRGTLTLYP ********************************:*************************** ENSCPOP00000005788/1-1363 CGNACTIDGLLVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGSRAAGPPYSP XP_004856780.1/1-1382 CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPGGGRAAGPPYGP ENSP00000354498/1-1377 CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGPPYSP ENSMUSP00000120208/1-1449 CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGVRAPGPTYNP ENSRNOP00000046235/1-1381 CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGRAPGSTYSP ********** *************************************.* **.*..*.* ENSCPOP00000005788/1-1363 GSAESESLVNGNHTPQPATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPVAAGKKPAA XP_004856780.1/1-1382 GSGESESLVNGNHAPQPATREPSACASHSSLVSSIEKDLQEIMDSLVLEESVAAGKKPAA ENSP00000354498/1-1377 VPAESESLVNGNHTPQTATRGPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAA ENSMUSP00000120208/1-1449 GSAESESLVNGNHTAQPATRAPSACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAA ENSRNOP00000046235/1-1381 GSAESESLVNGNHTAQPATRAPPACASHSSLVSSIEKDLQEIMDSLVLEEPGAAGKKPAA ..**********:.*.*** *.***************************. ******** ENSCPOP00000005788/1-1363 TSPLSPMTNGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPG XP_004856780.1/1-1382 TSPLSPMANGGRYLLSPATSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPG ENSP00000354498/1-1377 TSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPG ENSMUSP00000120208/1-1449 TSPLSPMANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPG ENSRNOP00000046235/1-1381 TSPLSPVANGGRYLLSPPTSPGAMSVGSSYENTSPAFSPLSSPASSGSCASHSPSGQEPG ******::*********.****************************************** ENSCPOP00000005788/1-1363 PSVPPLVPARSSSYHLALQPPQSRPSGGHSSDSPRLGRKGGHERPPSPGLRGLLTDSPAA XP_004856780.1/1-1382 PSVPPLVPARSSSYHLALQPPQPRPSGARSSDSPRLGRKGGHERPTSPGLRGLLTDSPAA ENSP00000354498/1-1377 PSVPPLVPARSSSYHLALQPPQSRPSGAR-SESPRLSRKGGHERPPSPGLRGLLTDSPAA ENSMUSP00000120208/1-1449 PSVPPLVPARSSSYHLALQPPQSRPSGSRSSDSPRLGRKGGHERPPSPGLRGLLTDSPAA ENSRNOP00000046235/1-1381 PSVPPLVPARSSSYHLALQPPQSRPSGSRSSESPRLGRKGGHERPPSPGLRGLLTDSPAA **********************.****.: *:****.********.************** ENSCPOP00000005788/1-1363 TVLAEARRATESPRLGGQLPVVAISLSEYPASGVRSQPTSIPGSPKFQPPVPAPRNKIGT XP_004856780.1/1-1382 TVLAEARRATESPRLGGQLPVVAISLSEYSASGARSQPTSIPGSPKFQPPVPAPRNKIGT ENSP00000354498/1-1377 TVLAEARRATESPRLGGQLPVVAISLSEYPASGALSQPTSIPGSPKFQPPVPAPRNKIGT ENSMUSP00000120208/1-1449 TVLAEARRTTESPRLGGQLPVVAISLSEYPSSGARSQPASIPGSPKFQSPVPAPRNKIGT ENSRNOP00000046235/1-1381 TVLAEARRTTESPRLGGQLPVVAISLSEYPSSGARSQPTSIPGSPKFQSPVPAPRNKIGT ********:********************.:**. ***:*********.*********** ENSCPOP00000005788/1-1363 LQDRPPSPFHEPPGTERVLTTSPMRQMVGRTFSDGS-STRTLQPPESPRLGRRGLDSMRE XP_004856780.1/1-1382 LQDRPPSPFCEPPGTERVLTTSPSRQLVGRTFSDGS-STRTLQPPESPRLGRRGLDSMRE ENSP00000354498/1-1377 LQDRPPSPFREPPGSERVLTTSPSRQLVGRTFSDGL-ATRTLQPPESPRLGRRGLDSMRE ENSMUSP00000120208/1-1449 LQDRPPSPFREPPGTERVLTSSPSRQLVGRTFSDGLAATRTLQPPESPRLGRRGLDSMRE ENSRNOP00000046235/1-1381 LQDRPPSPFREPPGTERVLTTSPSRQLVGRTFSDGS-ATRTLQPPESPRLGRRGLDSMRE ********* ****:*****:** **:******** :********************** ENSCPOP00000005788/1-1363 LPPLSPSLSRRALSPLPARTTPDPKLTREVAESPRPRRWAAHGTSPEDFSLTLGARGRRT XP_004856780.1/1-1382 LPPLSPSLSRRTLSPLPARTTPDPKLTREVAESPRPRRWAAHGTSPEDFSLTLGARGRRT ENSP00000354498/1-1377 LPPLSPSLSRRALSPLPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRT ENSMUSP00000120208/1-1449 LPPLSPSLSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGTSPEDFSLTLGARGRRT ENSRNOP00000046235/1-1381 LPPLSPSLSRRALSPLPARTAPDPKLSREVAESPRPRRWAAHGTSPEDFSLTLGARGRRT ***********:*****:**:*****.****************:**************** ENSCPOP00000005788/1-1363 RSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRAQRKLSSGDLRVPVVRDRK XP_004856780.1/1-1382 RSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRAQRKLSSGDLRVPVIRDRK ENSP00000354498/1-1377 RSPSPTLGESLAPHKGSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERK ENSMUSP00000120208/1-1449 RSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPRAQRKLSSGDLRVPIPRERK ENSRNOP00000046235/1-1381 RSPSPTLGESLAPRKGSFSGRLSPAYSLGSLTGASPRQSPHAQRKLSSGDLRVPIPRERK *************:********************** *** .************: *:** ENSCPOP00000005788/1-1363 NSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGEL XP_004856780.1/1-1382 NSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGEL ENSP00000354498/1-1377 NSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGEL ENSMUSP00000120208/1-1449 NSITEISDNEDELLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPETGEL ENSRNOP00000046235/1-1381 NSITEISDNEDDLLEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPETGEL ***********:********************************************:*** ENSCPOP00000005788/1-1363 PSIGEATAALALAGRRPSRGLAGPIVSSGRGGEELGGATQRLWESVERSDEENLKEECSS XP_004856780.1/1-1382 PSIGEATAALVLAGKRPSRGLAGAAVSSGRGSEEPGGATQRLWESVERSDEENLKEECSS ENSP00000354498/1-1377 PSIGEATAALALAGRRPSRGLAGA---SGRSSEEPGVATQRLWESMERSDEENLKEECSS ENSMUSP00000120208/1-1449 PSIGEATAALALAGRRPSRGLAGAIVVSGRCGEESGGASQRLWESMERSDEENLKEECSS ENSRNOP00000046235/1-1381 PSIGEATAALALAGRRPSRGLAGAIVVSGRSGEESGGASQRLWESMERSDEENLKEECSS **********.***:********. *** .** * *:******:************** ENSCPOP00000005788/1-1363 TESTQQEHEDAPSTKLQGEILALEEERAQVLGHVEQLKVHVKELEQQLQEAAREAEMERA XP_004856780.1/1-1382 TESTQQEHEDAPSTKLQGEILVLEEERAQVLGRVEQLKVHVKELEQQLQEAAREAEMERA ENSP00000354498/1-1377 TESTQQEHEDAPSTKLQGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERA ENSMUSP00000120208/1-1449 TESTQQEHEDAPGAKHQGEVLAVEEERAQVLGRVEQLKIRVKELEQQLQEAAREAEMERA ENSRNOP00000046235/1-1381 TESTQQEHEDAPSTKLQGEVLAVEEERAQVLGRVEQLKVRVKELEQQLQEAAREAEMERA ************.:* ***:*.:*********:*****::**********:********* ENSCPOP00000005788/1-1363 LLQGEREAERALLQKEQKAVEQLQEKLMALETGIQKERDK-------------------- XP_004856780.1/1-1382 LLQGEREAEWALLQKEQKAVDQLQEKLVALETGIQKERDKERAELAAGRRHLEARQALYA ENSP00000354498/1-1377 LLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKERDK-------------------- ENSMUSP00000120208/1-1449 LLQGEREAERASLQKEQRAVDQLQEKLVALETGIQKDRDK-------------------- ENSRNOP00000046235/1-1381 LLQGEREAERALLQKEQRAMDQLQEKLVALETGIQKERDK-------------------- ********* * *****:*::******:********:*** ENSCPOP00000005788/1-1363 -----------------------EAEALETETKLFEDLEFQQLERESRAEEERELAGQGL XP_004856780.1/1-1382 ELQTQLDNCPESVREQLQEQLRREAEALETETKLFEDLEFQQLERESRAEEERELAGQGL ENSP00000354498/1-1377 -----------------------EAEALETETKLFEDLEFQQLERESRVEEERELAGQGL ENSMUSP00000120208/1-1449 -----------------------EADALETETKLFEDLEFQQLERESRVEEERELAGQGL ENSRNOP00000046235/1-1381 -----------------------EADALETETKLFEDLEFQQLERESRVEEERELAGQGL **:**********************.*********** ENSCPOP00000005788/1-1363 LRSKAELLRSVAKRKERLAILDSQAGQIRAQAVQESERLAREKNASLQLLQKEKEKLAML XP_004856780.1/1-1382 LRNKAELLLSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTAL ENSP00000354498/1-1377 LRSKAELLRSIAKRKERLAILDSQAGQIRAQAVQESERLARDKNASLQLLQKEKEKLTVL ENSMUSP00000120208/1-1449 LRSKAELLRSVSKRKERLAVLDSQAGQIRAQAVQESERLAREKNAALQLLQKEKEKLNVL ENSRNOP00000046235/1-1381 LRSKAELLRSVSKRKERLAVLDSQAGQIRAQAVQESERLAREKNAVLQLLQKEKEKLTVL **.***** *::*******:*********************:*** *********** * ENSCPOP00000005788/1-1363 ERRYHALTGGRPFPKTTSTLKE-------------------------------------- XP_004856780.1/1-1382 ERRYHTLTGGRPFPKTNSTLKE-------------------------------------- ENSP00000354498/1-1377 ERRYHSLTGGRPFPKTTSTLKE-------------------------------------- ENSMUSP00000120208/1-1449 ERRYHSLTGGRPFPKTTSTLKEYVTLEQLRVVWGTPPMPPSPSPGLPSWASASQDLAPIT ENSRNOP00000046235/1-1381 ERRYHSLTGGRSFPKTTSTLKE-------------------------------------- *****:*****.****.***** ENSCPOP00000005788/1-1363 ------------------MEKLLLPAVDLEQWYQELMAGLGTVPAAASPRSSPPPLPAKA XP_004856780.1/1-1382 ------------------------------------------------------------ ENSP00000354498/1-1377 ------------------MEKLLLPAVDLEQWYQELMAGLGTGPAAASPHSSPPPLPAKA ENSMUSP00000120208/1-1449 CLPPMLPSSFASITRSSKMEKLLLPAVDLEQWYQELMSGLGTGLAAASPRSSPPPLPAKA ENSRNOP00000046235/1-1381 ------------------MEKLLLPAVDLEQWYQELMAGLGTGLAAASPRSSPPPLPAKA ENSCPOP00000005788/1-1363 SRQLQVYHSKVDGEAASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNG XP_004856780.1/1-1382 -----VYHSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNG ENSP00000354498/1-1377 SRQLQVYRSKMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLTQNG ENSMUSP00000120208/1-1449 SRQLQVYRSKMDSDAASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNG ENSRNOP00000046235/1-1381 SRQLQVYRSKMNGDMASPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLAQNG **:**::.: :****************************************:*** ENSCPOP00000005788/1-1363 TGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAA XP_004856780.1/1-1382 TGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGTA ENSP00000354498/1-1377 TGSLPRNLAATLQDIETKRQLALQQKGQQVIEEQRRRLAELKQKAAAEAQCQWDALHGAA ENSMUSP00000120208/1-1449 TSSLPRNLAATLQDIETKRQLALQQKGHQVIEEQRRRLAELKQKAAAEAQCQWDALHGAG ENSRNOP00000046235/1-1381 TSSLPRNLAATLQDIETKRQLALQQKGHQVIEEQRRRLAELKQKAAAEAQCQWDALHGAA *.*************************:******************************:. ENSCPOP00000005788/1-1363 PFPA-------LVHHSILHHLPAGRDRGEESEHAYDTLSLESSDSMETSISTGGNSACSP XP_004856780.1/1-1382 PFPA-------LVHHSILHHLPAGQERGEEGEHAYDTLSLESSDSMDTSISTGGNSACSP ENSP00000354498/1-1377 PFPAGPSGFPPLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP ENSMUSP00000120208/1-1449 PFSAGPSGFPALMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP ENSRNOP00000046235/1-1381 AFPAGPSGFPTLMHHSILHHLPAGRERGEEGEHAYDTLSLESSDSMETSISTGGNSACSP .*.* *:***********::****.***************:************* ENSCPOP00000005788/1-1363 DNMSSASGLDMGKIEEMEKMLREAHAEKSRLMESR-----------KLSMVTRIESLSHN XP_004856780.1/1-1382 DNMSSASGLDMGKIEEMEKMLREAHAEKSRLMESR-----------EREMELRRQALEEE ENSP00000354498/1-1377 DNMSSASGLDMGKIEEMEKMLKEAHAEKNRLMESR-----------EREMELRRQALEEE ENSMUSP00000120208/1-1449 DNMSSASGLDMGKIEEMEKMLKEAHAEKSRLMESRVRLTGARRQQVEREMELRRQALEEE ENSRNOP00000046235/1-1381 DNMSSASGLDMGKIEEMEKMLKEAHAEKSRLMESR-----------EREMELRRQALEEE *********************:******.****** : .* * ::*..: ENSCPOP00000005788/1-1363 LRNRHQVERRLQSEGARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSG XP_004856780.1/1-1382 RRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSG ENSP00000354498/1-1377 RRRREQVERRLQSESARRQQLVEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSG ENSMUSP00000120208/1-1449 RRRREQVERRLQSESARRQQLVEKEVKLREKQFSQARPLTRYLPNRKEDFDLKTHIESSG ENSRNOP00000046235/1-1381 RRRREQVERRLQSESARRQQLVEKEVKLREKQFSQARPLTRYLPNRKEDFDLKTHIESSG *.*.*********.************:**************** *************** ENSCPOP00000005788/1-1363 HGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY XP_004856780.1/1-1382 HGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY ENSP00000354498/1-1377 HGVDTCLHVVLSSKVCRGYLVKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY ENSMUSP00000120208/1-1449 HGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY ENSRNOP00000046235/1-1381 HGVDTCLHVVLSSKVCRGYLIKMGGKIKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIY ********************:*************************************** ENSCPOP00000005788/1-1363 FQAIEEVYYDHLRSAAK-----------SPNPALTFCVKTHDRLYYMVAPSAEAMRIWMD XP_004856780.1/1-1382 FQAIEEVYYDHLRSAAK----------QSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMD ENSP00000354498/1-1377 FQAIEEVYYDHLRSAAKKRFFRFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMD ENSMUSP00000120208/1-1449 FQAIEEVYYDHLRSAAKKRFFHFTMVTKSPNPALTFCVKTHDRLYYMVAPSAEAMRIWMD ENSRNOP00000046235/1-1381 FQAIEEVYYDHLRSAAKKRFFHFTMVTESPNPALTFCVKTHDRLYYMVAPSAEAMRIWMD ***************** ******************************** ENSCPOP00000005788/1-1363 VIVTGAEGYTQFMN XP_004856780.1/1-1382 VIVTGAEGYTQFMN ENSP00000354498/1-1377 VIVTGAEGYTQFMN ENSMUSP00000120208/1-1449 VIVTGAEGYTQFMN ENSRNOP00000046235/1-1381 VIVTGAEGYTQFMN **************