CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000099987/1-1128 MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSELETQSPPRED-DVEVQ ENSRNOP00000018846/1-1128 MAAVRTASLLCGLLALLALCPEGSPQTVLTDDEIQEFLEGFLSEFETQSPPRED-DVEAQ ENSP00000223357/1-1158 MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPE--PRED-DVEAP ENSCPOP00000005752/1-1023 MAGVRAAPLLGGLLLLLALCPGGRPQTVLTDDEIEEFLEGFLSELQPE--RREDYDVEAP XP_004839984.1/1-1152 MAGGRMAPLLGGLLVLLALCPGGRPQTVLTDDEIEEFLEGFLSELQPE--RRED-DVEAP ** * *.** ** **:*** * **********:*********::.: *** ***. ENSMUSP00000099987/1-1128 PLPEPTQRPRKSKAGGK----QRADVEVPPEKNKDKEKKGKKDKGPKATK--PLEGSTRP ENSRNOP00000018846/1-1128 PLPEPTQRARKSKAGGK----PRADAEAPPEKNKDKEKKGKKDKGPKAAK--HLEGSTRP ENSP00000223357/1-1158 PPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPK-ESLEGSPRP ENSCPOP00000005752/1-1023 APP---QGARPAQEGGQ----AGAAEGAPLEKAKDKGKKGKKDKGPKATK--------QP XP_004839984.1/1-1152 APP---QRARPAPEGGQ----AGAAEEALLEKAKDKGKKGKKDKGPKVSKQPPSEGTPRP . * * : **: : . ** *** **********..* :* ENSMUSP00000099987/1-1128 T-----------KKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPS ENSRNOP00000018846/1-1128 T-----------KKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPS ENSP00000223357/1-1158 P-----------KKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPP ENSCPOP00000005752/1-1023 P---------------------------------------------------------PA XP_004839984.1/1-1152 PKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPP . *. ENSMUSP00000099987/1-1128 AGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPE ENSRNOP00000018846/1-1128 AGKRFSTVAPLETPERSLTSPSNPGTRELPEERGRTSLNTWQGQGEETQVEARQHRPEPE ENSP00000223357/1-1158 SGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPE ENSCPOP00000005752/1-1023 AGRKFSTSAPLETEEWPLPSPPIPGPEMPVPEGGGAFPNAWQGP-EKVHVAPRKHQPELE XP_004839984.1/1-1152 AGKKFSTPAPLETKEWPLAPPPHPGPEEPVQEGGGTFPNGRQAPGQETHVAAQERQPEPE :*:: . ** ** : *..*. *... : . . * * ::.:* .:: :** * ENSMUSP00000099987/1-1128 EETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRR----RLWPERPEEKTEEPEE-- ENSRNOP00000018846/1-1128 EETEMPTLDYNDQIEREDYEDFEYIRRQKQPRPTPSRK----RIWPEPPEEKTQEPEE-- ENSP00000223357/1-1158 EETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAP-- ENSCPOP00000005752/1-1023 EETEMPTLDYNDQIEREDYEDFEYIRRQKQPKPPPSRR----RFWPERPGWTLAHTHL-- XP_004839984.1/1-1152 EETEMPTLDYNDQIEREDYEDFEYIRHQKQPKASPSRR----RFWPERPEEKAEQPEEKP **** **********:**********:****:..***: *.*** * . . ENSMUSP00000099987/1-1128 -----------RKEVEPPLKPLL---PPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEV ENSRNOP00000018846/1-1128 -----------RKEVDPPLKPLL---PPDYGDGYLIPNYDDLDYYFPHPPPQKPDVGQEV ENSP00000223357/1-1158 -----------EERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQT ENSCPOP00000005752/1-1023 -----------LISTEPPQKPLL----PDYDDGFVIPNYDDIDDYFPLPPPPKPDAWPET XP_004839984.1/1-1152 EERLEERPEERKEEIEPPLKPLL----PNYGDGFVIPNYDDMDYYFPLPPFPKPDAGQDT :** **** *:*.*.::******:* ** ** ***. :. ENSMUSP00000099987/1-1128 DEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHK-GPRKGEELEEEWAPVEKIKCPPIGM ENSRNOP00000018846/1-1128 DEEKEELKKPKKEGSSPKEDTEDKWAAEKNKDHKAGPRKGEELEEEWGPVEKIKCPPIGM ENSP00000223357/1-1158 DEEKEELKKPKKEDSSPKEET-DKWAVEKGKDHK-EPRKGEELEEEWTPTEKVKCPPIGM ENSCPOP00000005752/1-1023 DEEKEELKKPKKEGSSPKEETEDKGAVEKGKDHK-GPQKGEELEEEWAPMEKIKCPPIGM XP_004839984.1/1-1152 DEEKEELKKPKKEGNSPKEETEDKWAVEKGKDHK-GPQKGEDLEEEWAPVQKIKCPPIGM ******:******..****:* ** :.**.**** *:***:***** * :*:******* ENSMUSP00000099987/1-1128 ESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRR ENSRNOP00000018846/1-1128 ESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRR ENSP00000223357/1-1158 ESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR ENSCPOP00000005752/1-1023 ESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGPNEDDYYDGAWCAEDDPHTQWIEVDTRR XP_004839984.1/1-1152 ESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGTNEDDYYDGAWCAEDDPHTQWIEVDTRR ******************************:*..*************:.:********** ENSMUSP00000099987/1-1128 TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSE ENSRNOP00000018846/1-1128 TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSE ENSP00000223357/1-1158 TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSE ENSCPOP00000005752/1-1023 TTRFTGVITQGRDSTIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSE XP_004839984.1/1-1152 TTRFTGIITQGRDSSIHDDFVTTFFVGFSNDSQTWMMYTNGYEEMTFHGNVDKDTPVLSE ******:*******:********************:***********:************ ENSMUSP00000099987/1-1128 LPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDM ENSRNOP00000018846/1-1128 LPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDM ENSP00000223357/1-1158 LPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDM ENSCPOP00000005752/1-1023 FPESVVARFIRIYPLTWNGSLCMRLEVLGCPVSSIYSYYTQNEVVATDDLDFQHHSYKDM XP_004839984.1/1-1152 LPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVSPIYSYYAQNEVVATDDLDFRHHSYKDM :**.**************************.*:.:****:*****:**.***:******* ENSMUSP00000099987/1-1128 RQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVL ENSRNOP00000018846/1-1128 RQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGMHGNEVL ENSP00000223357/1-1158 RQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL ENSCPOP00000005752/1-1023 RQLMKQVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL XP_004839984.1/1-1152 RQLMKLVNEECPTVTRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVL ***** *******:*************************:*************:****** ENSMUSP00000099987/1-1128 GRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL ENSRNOP00000018846/1-1128 GRELLLLLMQYLCHEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL ENSP00000223357/1-1158 GRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL ENSCPOP00000005752/1-1023 GRELLLLLMQYLCREYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL XP_004839984.1/1-1152 GRELLLLLMQYLCHEYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGL *************:**********.*********************************** ENSMUSP00000099987/1-1128 WTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISW ENSRNOP00000018846/1-1128 WTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISW ENSP00000223357/1-1158 WTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAW ENSCPOP00000005752/1-1023 WTEEGFDIFEDFPDLTSVLWGAEERKWVPYHVPNNNLPIPERYLSPDATVSTEVRAIIAW XP_004839984.1/1-1152 WTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAW ***************.****.***:*****:***************************:* ENSMUSP00000099987/1-1128 MEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHA ENSRNOP00000018846/1-1128 MEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAAALAAARGEDEDEVSEAQETPDHA ENSP00000223357/1-1158 MEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHA ENSCPOP00000005752/1-1023 MEKNPFVLGANLNGGERLVSYPYDMAHTPSQEQLLAAAMAAARGEDDDEVSEAQETPDHA XP_004839984.1/1-1152 MEKNPFVLGANLNGGERLVSYPYDMAHTPSQEQLLAAAMAAARGEDEDEVSEAQETPDHA **************************:**:****** *:*******:* *********** ENSMUSP00000099987/1-1128 IFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLE ENSRNOP00000018846/1-1128 IFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLE ENSP00000223357/1-1158 IFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLE ENSCPOP00000005752/1-1023 IFRWLAISFASAHLTMTEPYRGGCQAQDYTNGMGIINGAKWNPRSGTINDFSYLHTNCLE XP_004839984.1/1-1152 IFRWLAISFASAHLTMTEPYRGGCQAQDYTNGMGIVNGAKWKPRSGTINDFSYLHTNCLE ***************:**************.****:*****:**:**:************ ENSMUSP00000099987/1-1128 LSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGI ENSRNOP00000018846/1-1128 LSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGI ENSP00000223357/1-1158 LSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGI ENSCPOP00000005752/1-1023 LSIYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGI XP_004839984.1/1-1152 LSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGI **.********************************************************* ENSMUSP00000099987/1-1128 NHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRI ENSRNOP00000018846/1-1128 NHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRI ENSP00000223357/1-1158 NHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRI ENSCPOP00000005752/1-1023 NHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCTVDYDIGATQCNFILARSNWKRI XP_004839984.1/1-1152 NHGVKTASGGDYWRILNPGEYRVTAHADGYTPSAKTCNVDYDIGATQCNFILARSNWKRI ***************************:***.*** *.********************** ENSMUSP00000099987/1-1128 REILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLN--STAGPATSP ENSRNOP00000018846/1-1128 REILAMNGNRPILRVDPSRPMTPQQRRLQQRRLRYRLRMREQMRLRRLN--STTGPATSP ENSP00000223357/1-1158 REIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVP ENSCPOP00000005752/1-1023 REIMAMNGNRPILRVDPSRPMT--------------LRLREQMRLRRLN-S--------- XP_004839984.1/1-1152 REIMAMNGNRPILRVDPSRPMTPQQRRLQQWRLQQRLRLREQMRLRRLN-TTTVGPTTAP ***:******** ::******* **:* ******** ENSMUSP00000099987/1-1128 TPALMP------PPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFET----EYGT ENSRNOP00000018846/1-1128 TPALTL------PPSPTPGSTSRLWEILPTTAAGWEESETETYTEVVTEFET----EYGP ENSP00000223357/1-1158 PTLPP-------APATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGT ENSCPOP00000005752/1-1023 ------------VPVLTPGPTRGPQDYLPHITEGWEELETETYTEVVTELET----DYGT XP_004839984.1/1-1152 TPTPVPTSAPTATPVLTLGLTQGPQDLLPHTTEGWEESETETYTEVVTELGT----EFGI * * . * :* : **** ***********: * ::* ENSMUSP00000099987/1-1128 DLEV----------------EEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF ENSRNOP00000018846/1-1128 DLEV-----------------EELEEEEEEEEEMDTGLTFPVTTVETYTVNFGDF ENSP00000223357/1-1158 KVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF ENSCPOP00000005752/1-1023 -----------------------------------TGLDFPFTTEETYTVNFGDF XP_004839984.1/1-1152 ELEP-------------------KEEVEEEEEEEITGLEFPFTTVETYTVNFGDF ** **.** **********