CLUSTAL W(1.81) multiple sequence alignment ENSP00000375836/1-1268 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP ENSMUSP00000127903/1-1268 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEENDPPTYKDAFPPLPEKAACLESAQEP ENSRNOP00000048476/1-1268 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP ENSCPOP00000005675/1-1264 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKSACLESAQEP XP_004868537.1/1-1265 MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP **********************************.***************:********* ENSP00000375836/1-1268 SGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA ENSMUSP00000127903/1-1268 AGAWSNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA ENSRNOP00000048476/1-1268 AGAWSNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA ENSCPOP00000005675/1-1264 AGAWNNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA XP_004868537.1/1-1265 TGAWNNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA :***.******************************************************* ENSP00000375836/1-1268 KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT ENSMUSP00000127903/1-1268 KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGKNGEKLQDLELKT ENSRNOP00000048476/1-1268 KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGKNGEKLQDLELKT ENSCPOP00000005675/1-1264 KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGKNGEKLQDLELKT XP_004868537.1/1-1265 KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGKNGEKLQDLELKT ***********************************.************************ ENSP00000375836/1-1268 ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP ENSMUSP00000127903/1-1268 ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP ENSRNOP00000048476/1-1268 ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP ENSCPOP00000005675/1-1264 ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP XP_004868537.1/1-1265 ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP ************************************************************ ENSP00000375836/1-1268 YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV ENSMUSP00000127903/1-1268 YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV ENSRNOP00000048476/1-1268 YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV ENSCPOP00000005675/1-1264 YNRLVGEIMQETGTRINIPPPSVSRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV XP_004868537.1/1-1265 YNRLVGEIMQETGTRINIPPPSVSRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV ***********************.************************************ ENSP00000375836/1-1268 EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK ENSMUSP00000127903/1-1268 EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK ENSRNOP00000048476/1-1268 EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK ENSCPOP00000005675/1-1264 EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSTSETVILRGEPEKLGQALTEVYAK XP_004868537.1/1-1265 EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSTSETVILRGEPEKLGQALTEVYAK ************************************ *********************** ENSP00000375836/1-1268 ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA ENSMUSP00000127903/1-1268 ANSFTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA ENSRNOP00000048476/1-1268 ANSFTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA ENSCPOP00000005675/1-1264 ANSFTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVTVA XP_004868537.1/1-1265 ANSFTVSSVSAPSWLHRFIIGKKGQNLARITQQMPKVHIEFTEGEDKITLEGPTEDVNVA *********:******************:****************************.** ENSP00000375836/1-1268 QEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL ENSMUSP00000127903/1-1268 QEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL ENSRNOP00000048476/1-1268 QEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL ENSCPOP00000005675/1-1264 QEQIESMVKDLINRMDYVEINIDHRFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL XP_004868537.1/1-1265 QEQIESMVKDLINRMDYVEINIDHRFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSDL *****.******************:*********************************:* ENSP00000375836/1-1268 IRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV ENSMUSP00000127903/1-1268 IRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV ENSRNOP00000048476/1-1268 IRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV ENSCPOP00000005675/1-1264 IRIEGDPQGVQQAKRELLDLASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV XP_004868537.1/1-1265 IRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV ******************:***************************************** ENSP00000375836/1-1268 IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKG ENSMUSP00000127903/1-1268 IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKG ENSRNOP00000048476/1-1268 IINFPDPAQKSEIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKG ENSCPOP00000005675/1-1264 IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKG XP_004868537.1/1-1265 IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVAELVENSYSISVPIFKQFHKNIIGKG ***********:***********************:************************ ENSP00000375836/1-1268 GANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSI ENSMUSP00000127903/1-1268 GANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSI ENSRNOP00000048476/1-1268 GANIKKIREESNTKIDLPAENSNSETIVITGKRANCEAARSRILSIQKDLANIAEVEVSI ENSCPOP00000005675/1-1264 GANIKKIREESNTKIDLPAENSNSETIVITGKRANCEAARSRILSIQKDLANIAEVEVSI XP_004868537.1/1-1265 GANIKKIREESNTKIDLPAENSNSETIVITGKRANCEAARSRILSIQKDLANIAEVEVCI ***************************:******************************.* ENSP00000375836/1-1268 PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLA ENSMUSP00000127903/1-1268 PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLA ENSRNOP00000048476/1-1268 PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLA ENSCPOP00000005675/1-1264 PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLA XP_004868537.1/1-1265 PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSLDVEKAKKQLLHLA ********************************************** ************* ENSP00000375836/1-1268 EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKE ENSMUSP00000127903/1-1268 EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARIIFPAAEDKDQDLITIIGKE ENSRNOP00000048476/1-1268 EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARIIFPAAEDKDQDLITIIGKE ENSCPOP00000005675/1-1264 EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARIIFPAAEDKDQDLITIIGKE XP_004868537.1/1-1265 EEKQTKSFTVDIRAKPEYHRFLIGKGGGKIRKVRDSTGARIIFPAAEDKDQDLITIIGKE *******************:********************:******************* ENSP00000375836/1-1268 DAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS ENSMUSP00000127903/1-1268 DAVREAQKELEALIQNLENVVEDYMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS ENSRNOP00000048476/1-1268 DAVREAQKELEALIQNLDNVVEDYMLVDPRHHRHFVIRRGQVLREIAEEYGGVMVSFPRS ENSCPOP00000005675/1-1264 DAVREAQRELEALIQNLDNVVEDYMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS XP_004868537.1/1-1265 DAVREAQRELEALIQNLDNVVEDCMLVDSRHHRHFVIRRGQVLREIAEEYGGVMVSFPRS *******:*********:***** ****.:****************************** ENSP00000375836/1-1268 GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQIT ENSMUSP00000127903/1-1268 GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECAIPQKFHRSVMGPKGSRIQQIT ENSRNOP00000048476/1-1268 GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECAIPQKFHRSVMGPKGSRIQQIT ENSCPOP00000005675/1-1264 GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTMECAIPQKFHRSVMGPKGSRIQQIT XP_004868537.1/1-1265 GTQSDRVTLKGAKDCVEAAKKRIREIIEDLEAQVTVECAIPQKFHRSVMGPKGSRIQQIT *****:*****************:***********:************************ ENSP00000375836/1-1268 RDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKC ENSMUSP00000127903/1-1268 RDYNVQIKFPDREENPVHSVEPSIQENGDEAGEGREAKETDPGSPRRCDIIIISGRKEKC ENSRNOP00000048476/1-1268 RDYNVQIKFPDREENPVHSVEPSIQENGDEAGEGREAKETDPGSPRRCDIIVISGRKEKC ENSCPOP00000005675/1-1264 RDYNVQIKFPDREETPAHGMEPAIQENGDEASEGREA---DPGSPRRCDIITISGRKEKC XP_004868537.1/1-1265 RDYNVQIKFPDREEAPAHGMEPAIQENGDEAGEGREA---DPGSPRRCDIITISGRKEKC **:.********** ..*. ** :*******.***** *********** ******** ENSP00000375836/1-1268 EAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAI ENSMUSP00000127903/1-1268 EAAKEALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIHVPAPELQSDTIAI ENSRNOP00000048476/1-1268 EAAKEALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIHVPAPELQSHTIAI ENSCPOP00000005675/1-1264 EAAKEALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIHVPAPELQSDVIAI XP_004868537.1/1-1265 EAAREALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIHVPAPELQSDVIAI ***:**********************:****************************. *** ENSP00000375836/1-1268 TGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL ENSMUSP00000127903/1-1268 TGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL ENSRNOP00000048476/1-1268 TGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL ENSCPOP00000005675/1-1264 TGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLNVTVDPRYHPKIIGRKGAVITQIRL XP_004868537.1/1-1265 TGLATNLDRAKAGLLERVKELQAEQEDRALRSFKLNVTVDPKYHPKIIGRKGAVITQIRL ****:**********:*******************.*****:****************** ENSP00000375836/1-1268 EHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHA ENSMUSP00000127903/1-1268 EHEVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHRVHA ENSRNOP00000048476/1-1268 EHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHRVHA ENSCPOP00000005675/1-1264 EHDVNIQFPDKDDGSQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHRVHA XP_004868537.1/1-1265 EHDVNIQFPDKDDGSQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHRVHA **:***********.***********************:********************* ENSP00000375836/1-1268 RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD ENSMUSP00000127903/1-1268 RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD ENSRNOP00000048476/1-1268 RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD ENSCPOP00000005675/1-1264 RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD XP_004868537.1/1-1265 RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD ************************************************************ ENSP00000375836/1-1268 VVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK ENSMUSP00000127903/1-1268 VVDSEALQVYMKPPAHEESRAPSKGFVVRDAPWTSNSSEKAPDMSSSEEFPSFGAQVAPK ENSRNOP00000048476/1-1268 VVDSEALQVYMKPPAHEESKAPSKGFVVRDAPWTSNSSEKAPDMSSSEEFPSFGAQVAPK ENSCPOP00000005675/1-1264 VVDTEALQVYMKPPAHEEAKAPSKGFVVRDAPW-ASSSEKAPDMSSSEEFPSFGAQVAPK XP_004868537.1/1-1265 VVDSEALQGHMKPPAHGEVKAPSKGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK ***:**** :****** * :***:********* :.************************ ENSP00000375836/1-1268 TLPWGPKR ENSMUSP00000127903/1-1268 TLPWGPKR ENSRNOP00000048476/1-1268 TLPWGPKR ENSCPOP00000005675/1-1264 TLPWGPKR XP_004868537.1/1-1265 TLPWGPKR ********