CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000005659/1-1350 MEDPSPPDVNENGRCQSGSVSVPSPAEGPSTQAASEPSKPLS-TRRHLSRKDGLSKLCQS XP_004868527.1/1-1376 MEDPGPPAVDKDGKCLSGSVSVPAPAKGLSAQAASDPSKPLS-AQRHLSRKDGLSRLCQS ENSP00000351475/1-1330 MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS ENSMUSP00000027493/1-1383 MEDRGPPVFAEDWKCLSESPPVQ---EGPAAQATFEPSKPLSIAHKHLSRKNGLSRLCQS ENSRNOP00000022748/1-1385 MEDRGPPVLAEDWK--SESLPAQ---EGPATQAFVEPSKPLSIAHRHLNRKNGLSRLCQS *** . . . :: : * * . :* ::*: :**:.:* :::**.*::***:**** ENSCPOP00000005659/1-1350 RIALSEDRWSSYCLSSLVAQNICTGRVRCPTAPEHVDP-AAPLGSASCCSLLRGLSSGCS XP_004868527.1/1-1376 RMTLSEDRWSSYCLSSLAAQNICTSRLRCPTEPEDGDL-AAPLGSASCCSLLRGLPLGCS ENSP00000351475/1-1330 RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDP-SEPRGSVSCCSLLRGLSSGWS ENSMUSP00000027493/1-1383 RMALSEDRWSSYCLSSLAAQNICTSKLHCAAAPEYADPTAGPLGSTSCCSLLRGLASGCS ENSRNOP00000022748/1-1385 RMALSEDRWSSYCLSSLAAQNICTSKLHCAATPDYADPIAGPLGSTSCCSLLRGLASGCS * :**************.******.:::*.: *: * : * **.*********. * * ENSCPOP00000005659/1-1350 MPLLPGPVYNPNKAIFTVDAKTTEILVANDKACGLLGYSSHDLIGQKLVQFFVQPDSEVA XP_004868527.1/1-1376 VHLLPAPVSNPNKAIFTVDAKTTEILVVNDKACGLLGYSSHDLIGQKLVQFFLQPDSEVA ENSP00000351475/1-1330 SPLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVV ENSMUSP00000027493/1-1383 GSLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLAQFFLKSDSEVV ENSRNOP00000022748/1-1385 GPLLSTPVCNPNKAVFTVDAKTTEILVANDKACSLLGYSSHDLIGQKLTQFFLKSDSEVV **. ** *****:************.*****.******:*******.***::.**:*. ENSCPOP00000005659/1-1350 EALSEEHVEADGHAAVVFGTVADIVSRSGDKIPVSVWMKRVRQERGLCCVVVLEPVERIS XP_004868527.1/1-1376 EALSEEHVEADGYATVVFGTVVDIVSRSGEKTPVSVWMKRVQQERGLCCVVVLEPVERIS ENSP00000351475/1-1330 EALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVS ENSMUSP00000027493/1-1383 EALSEEHVEADGHAAVVFGTVVDIVSRIGEKIPVSVWIKRLQQDRGLCCVVVLEPVERVS ENSRNOP00000022748/1-1385 EALSEEHVEADGHAAVVFGTVVDIVSRSGEKIPVSVWIKRLQQDRGLCCVVVLEPVERVS *******:****:*:******.**:** *:* *****:**::*:* ************:* ENSCPOP00000005659/1-1350 AWVAFQGEGTITSCDDLFAHLHGFSSGEDVVGQHITDLIPSLRLPSPGQPVPENLKIQRS XP_004868527.1/1-1376 AWVAFQSEGTITSCDDLFAHLHGFSSGEDVVGQHIIDLIPSLQVPPPGQPVPENLEIQRS ENSP00000351475/1-1330 TWVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRS ENSMUSP00000027493/1-1383 AWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSMQLPPPGQHIPKSLKIQRS ENSRNOP00000022748/1-1385 AWVAFQSDGTITSCDSLFAHLHGFTSPKDVVGQCVIDLIPSIQLPPPGQHVPKSLKIQRS :*****.:**:****.*******: * :**.** : *****:::*..** :*:.*:**** ENSCPOP00000005659/1-1350 VGRAKDGTTFPLSLKLKPKQDGE-AAEGEAVPEQGYWASVWVFCTISGLITLLPDGTIYG XP_004868527.1/1-1376 VGRARDGTTFPLSLKLKPKCGGE-VAEGEVAPRQGYWASVWVFCTISGLVTLLPDGTIYG ENSP00000351475/1-1330 VGRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHG ENSMUSP00000027493/1-1383 VGRARDGTTFPLSLKLKSKPSGRAVADSEAASEPGYQASVWVFCTISGLITLLPDGTIYG ENSRNOP00000022748/1-1385 VGRARDGTTFPLSLKLKSKTSGKAVAESEVASEPGYQASVWVFCTISGLITLLPDGTIYG ****:************.: ... .: .*... ** ************:********:* ENSCPOP00000005659/1-1350 INHNFALMLFGYGKTELLGKKITFLIPGFYHYMDITYDSSSQYPSS--CLDFSSENGHGE XP_004868527.1/1-1376 INHSFALMLFGYGRTELLGKNITFLIPAFYHYMDLACDSSLQQPDLTSCPDVGSENGCGE ENSP00000351475/1-1330 INHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGE ENSMUSP00000027493/1-1383 VNHSFALMLFGYGKTELLGKNITFLIPGFYHYMDLTYDSSVQLPDLVNCLDIGRKSGPGE ENSRNOP00000022748/1-1385 INHSFALMLFGYGKTELLGKNITCLIPGFYHCMDLAYDSSVQLPDLVNCLDIGSKSGPGE :**.*** *****:******:** ***.** **:: :** * *. * *.. :.* ** ENSCPOP00000005659/1-1350 MTLDTSQGWS-AGVYRNPKFDSVLAGHCVLPPDIMQKPVGSQGIAGGMQTQLETGCQLPA XP_004868527.1/1-1376 MSSDP---------CQYPKVGLVLASDHALPQDETLKLGGSQEVSGGMQMELETGRCLPA ENSP00000351475/1-1330 RTLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLS ENSMUSP00000027493/1-1383 MNSDAQHNWELASGAQGPRIDVVLARDHMPSQDETLKLVGGQ-VSSRTQTRLETGYKILP ENSRNOP00000022748/1-1385 MSSDAKQDWELASGAQDPRID-VLTRGHMPSQDETLKLRGGQ-VSPRTQTQLETGRHILP . *. : *:.. **: . * * .* : * .* :* : . ENSCPOP00000005659/1-1350 TCSPGSSPGEDSVLDGYPLAQDKRSLPTNQQSTPEEHVLAHE------------------ XP_004868527.1/1-1376 ARSLQPSPGADSVPEWHSLTQDERSLATDQQSIPEGHVPAQE------------------ ENSP00000351475/1-1330 CLSPQPAPGVDNVPE--------------------------------------------- ENSMUSP00000027493/1-1383 SSACQPSLGVDSNPE-----DGEQSLLTDQQSIPKRNLPAHG----GQNQLDTSEISLPV ENSRNOP00000022748/1-1385 SCASQPSLGVDSSPV-----DGERSLPTDQRNVPKRNLLAHAEQLLSQTQPDTLEISPPV : .: * *. ENSCPOP00000005659/1-1350 --KQSPSENQQDVSEESPPTHEEWLLRKDPQDSQDGSPPALSVRTLPRDQQDTALGSVGP XP_004868527.1/1-1376 --KQSLSENQQDVSEESPPPHGEWGLPEDLQDSEEGSPAAHSAWSLLTDQQVIASGRAEL ENSP00000351475/1-1330 -----------------------------------GSLPVHGEQALPKDQQITALGREEP ENSMUSP00000027493/1-1383 LKEHLLSEIQKNISEESPLTHRKW-LSKVQQNPTKGSLPIHEEQLLFAGQHIHVLGKEDP ENSRNOP00000022748/1-1385 LKE--LSEIQKNISEESPLTHRKWLLSKAQKDTTKGSLPIHDEKLLLASQHIHVLGKENP ** . * .*: . * ENSCPOP00000005659/1-1350 VVAQSSPQDLLGESGSEPADTKPFVSCEEPNPPVPPEDKCSNVGMGSLHQEAQWALTAAS XP_004868527.1/1-1376 VAAQTPMQGLLGESRSGSVDTKSFVSCEDAGPLVPAEDRSSGFRMWGLHQEAQRALTGAS ENSP00000351475/1-1330 VAIESPGQDLLGESRSEPVDVKPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVS ENSMUSP00000027493/1-1383 SAAESYRESLLEESKSKPVDAKLFASCEDSEPLVSVKDRGSSVDTCNLHQEAQLELMGVS ENSRNOP00000022748/1-1385 SAAESYREGLLAESRSKPVDAKPFASCEDSELLVPAKDRSNRADMSSLQQEAQLELMGIS . :: :.** ** * ..*.* *.***:. *. :* . .* *:** . * ENSCPOP00000005659/1-1350 ------------RPEPHAAGQPAGGDLLTYCPAYRSEWLPWPPGH------SGVACVSFG XP_004868527.1/1-1376 ---SASPQANATIPKPHGAGQPAGGGLLT-CPHYRSEWLLQQPNPDLAPSPPGVACVSFG ENSP00000351475/1-1330 GPSGSDLWAGAAVAKPQAKGQLAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFG ENSMUSP00000027493/1-1383 ---SPNPWADATMPEPHTTGQIAGGS-LTYCPQYRSEWASQQRGQDSAPSPSGMACVLLG ENSRNOP00000022748/1-1385 SPGSPNPWADATMPEPHTTGQIPGGS-LTYCPQHRSEWILQQRGQDSAPSPSAMGCVFVG .:*: ** .**. * ** : *** . ..:. : .* ENSCPOP00000005659/1-1350 TPTLDEPWPGRRASHEELQVCLVKEQLSRLSFEG---VSRLESVPTEHHPYTASLS-SSL XP_004868527.1/1-1376 TPTLDEPGPGGRADHEELQVCLVKEQLSRLSFEGAWGISCLEPVLTGDWPYSAPLS-CDL ENSP00000351475/1-1330 TPTLDEPWLGVENDREELQTCLIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDL ENSMUSP00000027493/1-1383 TPTLDEPWPGVRNDREELQTCLIKEQLSKSSCEGNLGISRVELVPEEHPPFTAPVSFCDL ENSRNOP00000022748/1-1385 TPTLDEPWPGVRNDREELQTCLIKEQLSKSSFGGALGISCVELVPAEHPPFTAPVSFCDW ******* * . .:****.**:*****: * * :. * * . :*.:* .. ENSCPOP00000005659/1-1350 EGRDLCGSHLGSSSACYALATDLPDALELVEAREAAMNSYSWNLRELLLSDDTDGTSSNC XP_004868527.1/1-1376 GGRDLHGSHLGGSPACYALATDLPSVPEAAEAWEAAMNSCSWSLRELLLRDEMDGTSSNC ENSP00000351475/1-1330 GGRDLCGGCTGSSSACYALATDLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNC ENSMUSP00000027493/1-1383 GGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVNSYSWNLKELFLKDQTDRTPSHC ENSRNOP00000022748/1-1385 GGRDLHASRSGSSSACYALATDLPGVLEAVEAQEADVSSYSWNLRELFLNDRTDRTPSHC **** .. *.*.**********. * .** *. :.* **.*:**:: * * *.*:* ENSCPOP00000005659/1-1350 SYTTSEPGGSPSPSAVSSDFNVHTLHKQRPGAFGDRERLLLTGTYFNLGEGQGSQESNLE XP_004868527.1/1-1376 SCATSELEGTPSPSAVHSDFDVDVLHRQRPDGLGDRERFLLTGTYFDLGEGGGPHESCPE ENSP00000351475/1-1330 SCATSELRETPSSLAVGSDPDVGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVG ENSMUSP00000027493/1-1383 SCTTSELSEAPSLSVVGSDLDVGILHRQTSDILVDREMLLLTGTYFDLSEGQRFQEMGAG ENSRNOP00000022748/1-1385 SCTTSELSETPSLSGVGSDLDVGILHRQTSDILAHREMLLLSGTYFDLREGHRFQEMGAG * :*** :** * ** :* *:.* . : .** :**:** .:* :* :* ENSCPOP00000005659/1-1350 HDSTELPVMDL-ASERYKMSNSQS--SELPAMDASQEDARASAEDPKLSAWVTSTPV--K XP_004868527.1/1-1376 HRPTEPPELYL-SPERCEASDTESPDRGLPTMDTSLEDAHPSAEDPRPDAWVTSTPV--T ENSP00000351475/1-1330 HDPTEPLEVCLVSSEHYAASDRESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVM ENSMUSP00000027493/1-1383 HDRAELSNISLVSSEHYETSDIESPGCDPPLPDPGPNDMCLSAEKPRPSAQITSTPV--A ENSRNOP00000022748/1-1385 HDGAELSNISLVSSEHYETSDIESLGCDPPIPDPGPNNMCLSAEKPRLSAQITSTPV--A * :* : * :.*: *: :* . *.. :: ***.*: .. :***** ENSCPOP00000005659/1-1350 PGAASLCREIQEGTYSGYCYHRDGLWLSICFEVKLVELQGPVSLFCCWLVKDLLHSHRSS XP_004868527.1/1-1376 PGAASLCLEIQEGTYSGSCYHRDGLRLSIHFEVKRVELQGPSSLFCCWLVKDLLHSHRDS ENSP00000351475/1-1330 RGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDS ENSMUSP00000027493/1-1383 RGATSLQQEIQEGIYSGSCYHRDGLQLSIQFEVKRVELQGSATLFCCWLVKDLFHSHRDS ENSRNOP00000022748/1-1385 PGPTSLQQEIQEGIFSGSCYHRDGLRLSVQFEVKRVQLQGSATLFCCWLVKDFLHSHRDS *.:.* ***** :** ******* **: ***: *:***. .*********::**:*.* ENSCPOP00000005659/1-1350 ATRTRLLLASLPSSTHSM-PDPSGRGLGEVLRTKPWAEEAPTPMELEGLAACEGEYSRKY XP_004868527.1/1-1376 ATRTRLLLASLASSTHSM-PEPPGPSLGEVLRAKTRPEEAPLPVELEGLAACEGEYSHKY ENSP00000351475/1-1330 AARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKY ENSMUSP00000027493/1-1383 ATRTRLFLASLPSSTHSM-PELSGSSFGEVLRAKPWFEESPTPAELEGLAACEGEYDYKY ENSRNOP00000022748/1-1385 ATRTRLFLASLPSSTHSM-PDLSGSSFGEMLRAKPWFEESPTPAELEGLAACEGEYSHKY *:****:****..**** .: .* .: *:**::. **.* . ************. ** ENSCPOP00000005659/1-1350 ITLRPLGSGAFGFVWIAMDKEQNKE-----------VVVKFIKKEKVLEDCWIEDTKLGK XP_004868527.1/1-1376 STLCPLGSGAFGFVWTAIHKDRNKEVLRLPEGATPAVVVKFIKKEKVLEECWIEDPKLGK ENSP00000351475/1-1330 STMSPLGSGAFGFVWTAVDKEKNKE-----------VVVKFIKKEKVLEDCWIEDPKLGK ENSMUSP00000027493/1-1383 NTISPLGSGAFGFVWTAVEKECNKE-----------VVVKFIKKEKVLEDCWIEDPKLGR ENSRNOP00000022748/1-1385 NTLRPLGSGAFGFVWTAVEKEGNKE-----------VVVKFIKKEKVLEDCWVEDPKLGR *: *********** *:.*: *** *************:**:**.***: ENSCPOP00000005659/1-1350 VTLEIAILSHVEHPNIIKVVDVFENQGFFQLVMEKHGSGLDLFAFIDQHPSLDEPLASHI XP_004868527.1/1-1376 VTLEIAILSSVEHSNIIKVVDVFENQGFFQLVMEKHGSGLDLFAFIDQHPSLDEPLASYI ENSP00000351475/1-1330 VTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYI ENSMUSP00000027493/1-1383 VTLEIAILSKVDHANIIKVLDIFENQEFFQLVMEKHGSGMDLFAFIDHHPCLDEPLASFI ENSRNOP00000022748/1-1385 VPLEISILSKVEHANIIKIVDVFENQGFFQLVMEKHGSGLDLFAFIDRHPCLDEPLASYI *.***:*** *:*.****::*:**** ************:*******:** *******.* ENSCPOP00000005659/1-1350 FRQ-------LLSAVGYLRSKGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT XP_004868527.1/1-1376 FRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFHT ENSP00000351475/1-1330 FRQVRAGQSRLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT ENSMUSP00000027493/1-1383 FRQ-------LVSAVGYLHSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT ENSRNOP00000022748/1-1385 FRQ-------LVSAVRYLRSQGIIHRDIKDENIVIAEDFTIKLIDFGSAAYLEKGKLFYT *** *:*** **: :.*******************************:****:* ENSCPOP00000005659/1-1350 FCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEATIHPPYLVS XP_004868527.1/1-1376 FCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLIFQENPFCEVEETVQATIHPPYLVS ENSP00000351475/1-1330 FCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVS ENSMUSP00000027493/1-1383 FCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHPPFLVS ENSRNOP00000022748/1-1385 FCGTIEYCAPEVLIGNPYRGPELEMWSLGVTLYTLIFEENPFCEVEETMEAVIHPPFLVS *************:*********************:*:******:***::*.****:*** ENSCPOP00000005659/1-1350 QELMSLLSGLLHPDPRQRTTLEKLVTDPWVTQPVNLAQYTWEEVCRISKPESGLLSTASL XP_004868527.1/1-1376 QELTSLVCGLLQPAPEQRTTLEKLMTDPWVTQPVNLAEYTWEEVYRTNKPEGSLLSTGSL ENSP00000351475/1-1330 KELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASL ENSMUSP00000027493/1-1383 QELMSLLSGLLQPCPEQRTTLEKLIRDPWVTQPVNLASYTWEEVCRTNQPESGLLSAASL ENSRNOP00000022748/1-1385 QELMSLLSGLLQPCPEQRTTLEKLIVDPWVTQPVNLDNYTWEEVCRTSQPESGLMSAASL :** **:.***:* *.:*******: ********** .****** * .:**..::*:.** ENSCPOP00000005659/1-1350 QHRTGSRSLSEAGSEFQAH--PAPEEAPSSQHCLGPEDPSPLAS XP_004868527.1/1-1376 ELRTGSRSLSEAAGDRRLHGPPGPAEAPSGQCCSGPEDPSPLVS ENSP00000351475/1-1330 EM--GNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRLLTS ENSMUSP00000027493/1-1383 EI--GSRSPSEMAQREGLCGPPAPRETRGDQHCLHLKDPSLPVS ENSRNOP00000022748/1-1385 EL--ASRSPSEVAQTEGLCRPPAPKEAP-GNHCLHLEDPSSPVS : ..** *: . * * *: .: * ** .*