CLUSTAL W(1.81) multiple sequence alignment ENSP00000308893/1-1413 MRHGVAWALLVAAALGLGARGVRGAVALADFYPFGAERGDAVTPKQDDGGSGLRPLSVPF ENSMUSP00000050832/1-1403 MRLGAAWALLLAAALGLGTRGVRAAVALADFYPFGTKRGDTVTPKQDDGGSGLQPLSVPF ENSRNOP00000022290/1-1404 MRRGAAWALLLAAALGLGARGVRAAVALADFYPFGTKRGDAVTPKQDDGGSGLQPLSVPF ENSCPOP00000005648/1-1404 MRRGAALALLLAAVLGLGARRARGAVALSDFYPFGTARGDAVTPKQDDGGSGLRPLSVPF XP_004868525.1/1-1411 MRRGAVWALLLAAALGLGARGAHGSVALANFYPFGAARGDAVTPKQDDGGSGLRPLSVPF ** *.. ***:**.****:* .:.:***::*****: ***:************:****** ENSP00000308893/1-1413 PFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYRE ENSMUSP00000050832/1-1403 PFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYRE ENSRNOP00000022290/1-1404 PFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYRE ENSCPOP00000005648/1-1404 PFFGTEHSGLYVNNNGIVSFLKEVSQFTPVAFPIAQDRCVVAAFWADVDNRRAGDVYYRE XP_004868525.1/1-1411 PFFGAEHSGLYVNNNGIISFLKEVSQFTPVAFPIAKDRCVVAAFWADVDNRRAGDVYYRE ****:************:*****************:************************ ENSP00000308893/1-1413 ATDPAMLRRATEDVRHYFPELLDFNATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGK ENSMUSP00000050832/1-1403 ATDPAMLNRATEDIRRYFPELPDFSATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGR ENSRNOP00000022290/1-1404 ATDAAMLNRATEDIRRYFPELPDFSATWVFVATWYRVTFFGGSSSSPVNTFQTVLITDGR ENSCPOP00000005648/1-1404 ATDAATLHRATADIRQYFPELANFSATWVFIATWYRVTFFGGSSSSPVNTFQIILITDGK XP_004868525.1/1-1411 ATDPATLHRATEDVRRYFPELLDFSATWVFIATWYRVTFFGGSTSSPVNTFQTILITNGK ***.* *.*** *:*:***** :*.*****:************:******** :***:*: ENSP00000308893/1-1413 LSFTIFNYESIVWTTGTHASSGGNATGLGGIAAQAGFNAGDGQRYFSIPGSRTADMAEVE ENSMUSP00000050832/1-1403 FSFTIFNYESILWTTGTHASSGGDTDGLGGIAAQAGFNAGDGHRYFNIPGSRTADMAEVE ENSRNOP00000022290/1-1404 FSFTIFNYESILWTTGTHASSGGDADGLGGIAAQAGFNAGDGHRYFNIPGSRTADMAEVE ENSCPOP00000005648/1-1404 VSFTIFNYESITWTTGTHASSGGDATGLGGIAAQAGFNAGDGRRYFNIPGSRTADMAEVE XP_004868525.1/1-1411 ASFTIFNYESITWTTGMHASSGGDSTGLGGIAAQAGFNAGDGRRYFNIPGSRTADMAELE ********** **** ******:: ****************:***.***********:* ENSP00000308893/1-1413 TTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCL ENSMUSP00000050832/1-1403 TTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLVLRPCLNGGKCIDDCVTGNPSYTCSCL ENSRNOP00000022290/1-1404 TTTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLVLRPCLNGGKCIDDCVTGNPSYTCSCL ENSCPOP00000005648/1-1404 ATTNVGVPGRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCL XP_004868525.1/1-1411 ATTNVGVPGRWAFRIDDAQVRVGGCGHTTSACLALRPCLNGGKCIDDCVTGNPSYTCSCL :*****************************.**.************************** ENSP00000308893/1-1413 SGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQH ENSMUSP00000050832/1-1403 AGFTGRRCHLDVNECASHPCQNGGTCTHGVNSFSCQCPAGFKGPTCESAQSPCDNKVCQN ENSRNOP00000022290/1-1404 AGFTGRRCHLDVNECASHPCQNGGTCTHGVNSFSCQCPAGFQGPTCESAQSPCDNKVCQN ENSCPOP00000005648/1-1404 AGFTGRRCQLDVNECASHPCQNGGTCTHSVNSFSCQCPAGFRGPTCESAQSLCDNTECQN XP_004868525.1/1-1411 AGFTGRRCQRDVNECASHPCQNGGTCTHGVNSFSCQCPTGFGGPTCGSAQSPCEDKQCQN :*******: *******:**********.:*** ****:** **** :*** *: . **: ENSP00000308893/1-1413 GGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGL ENSMUSP00000050832/1-1403 GGQCQAESSSAVCVCQAGYTGATCETDVDECSSDPCQNGGSCVDLVGNYSCICVEPFEGP ENSRNOP00000022290/1-1404 GGQCQAESSSAVCVCQAGYTGATCETDVDECSSDPCLNGGSCVDLVGNYSCICVEPFEGP ENSCPOP00000005648/1-1404 GGQCQDERGSAVCVCQAGYTGASCETNVDECSSDPCLNGGACVDLVGNYSCVCVEPFTGP XP_004868525.1/1-1411 GGQCQAESGSAVCVCPAGYTGTTCETDVDECGSGPCLNGGACVDLVGSYSCVCVEPFEGP ***** * .****** *****::** :**:*...** ***:******.*:*:*.*** * ENSP00000308893/1-1413 RCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRC ENSMUSP00000050832/1-1403 QCETGSYLVPSPCLSNPCQNGGTCVDADEGYVCECPEGFMGLDCRERILNDCDCRNGGRC ENSRNOP00000022290/1-1404 QCETGSYVVPSPCLSNPCLNGGTCVDADQGYVCECPEGFMGLDCRERILNDCDCRNGGRC ENSCPOP00000005648/1-1404 RCETGSHPVPDACFSAPCQNGGTCVDAGPGHVCECPEGFMGLDCRERTHNDCECRNGGRC XP_004868525.1/1-1411 RCDSGSPPVPDACLSAPCQNGGTCVDADQGFVCECPEGFMGLDCRERTH-DCECRNGGRC :*::*. **..*:* ** ********. *.**************** **:******* ENSP00000308893/1-1413 LGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHS ENSMUSP00000050832/1-1403 LGANTTLCQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHTDHNISHS ENSRNOP00000022290/1-1404 LGANTTICQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHTDHNISHS ENSCPOP00000005648/1-1404 LGSNTTLCQCPPGFFGLLCEFEVTATPCNMNTQCPDGGYCMEYGGSYLCVCHTDHNISHS XP_004868525.1/1-1411 LGANSTLCQCPPGFFGLLCEFGVTATPCNMNTQCPDGGYCMEYGGSYLCVCHTDHNISHS **:*:*:**** ********* :** ****************:************* *** ENSP00000308893/1-1413 LPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEK-ARPHLCSSGPCRNGGTCKEAG ENSMUSP00000050832/1-1403 LPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEK-ARPHLCSSGPCRNGGTCKEMG ENSRNOP00000022290/1-1404 LPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRHCEKTARPHLCSSGPCRNGGTCKETG ENSCPOP00000005648/1-1404 LPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGRHCEK-ARPHLCSSGPCRNGGTCKEAG XP_004868525.1/1-1411 LPSPCDSDPCFNGGSCDAHDDSYTCECPRGFQGRHCEK-ARPHLCSSGPCRNGGTCKEAG *******************:***********:*:**** ******************* * ENSP00000308893/1-1413 GEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPS ENSMUSP00000050832/1-1403 DEYRCTCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPS ENSRNOP00000022290/1-1404 DEYRCTCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPS ENSCPOP00000005648/1-1404 GEYHCSCPYRFTGKHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIVPS XP_004868525.1/1-1411 GEYHCSCPYRFTGRRCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCERVPS .**:*:*******::***************************************** .** ENSP00000308893/1-1413 PCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAV ENSMUSP00000050832/1-1403 PCFRSPCMNGGTCEDLGTDFSCYCQPGYTGHRCQAEVDCGHPEEVEHATMRFNGTHVGSV ENSRNOP00000022290/1-1404 PCFRSPCMNGGICEDLGTDFSCHCQPGYTGHRCQAEVDCGQPEEVKHATMRLNGTRMGSV ENSCPOP00000005648/1-1404 PCFRSPCLNGGTCEDLGTDFSCHCQVGYTGRWCQAEVDCGQPEEVEHASMRFNGTHVGSV XP_004868525.1/1-1411 PCFRSPCLNGGTCEDLGTDFSCRCQAGYTGRRCQAEVDCGWPEEVKHASMRFNGTRMGSV *******:*** *** .*** * ** ** *: ******** ****:**::*:***::*:* ENSP00000308893/1-1413 ALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLC ENSMUSP00000050832/1-1403 ALYTCEPGFSLSALSHIRVCQPQGVWSQPPQCIEVDECRSQPCLHGGSCQDLIADYQCLC ENSRNOP00000022290/1-1404 ALYTCDPGFSLSVLSHMRVCQPQGVWSQPPQCIEVDECQSQPCLHKGSCQDLIAGYQCLC ENSCPOP00000005648/1-1404 ALYMCDHGYSLNAPHHFRVCQPQGVWSQPPQCLEVDKCQSQPCLNGGSCQSHTTGYQCLC XP_004868525.1/1-1411 ALYTCDDGYSLNAPRHFRICQPQGVWSQPPQCLEADECQSQPCLNGGSCQSHTSGYHCLC *** *: *:**.. ::*:***:****:****:* *:*:*****: ****. :.* *** ENSP00000308893/1-1413 STGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQ ENSMUSP00000050832/1-1403 SPGYEGVHCELETDECQAQPCRNGGSCRDLPRAFICQCPEGFVGIHCETEVDACASSPCQ ENSRNOP00000022290/1-1404 SPGYEGVHCELETDECQAQPCRNGGSCRDLPGAFICQCPEGFVGTHCETEVDACASSPCQ ENSCPOP00000005648/1-1404 SAGYEGAHCELETDGCRAQPCKNRGSCMDLPGAFICQCPMGFVGVHCETELDACDSSPCL XP_004868525.1/1-1411 SAGYEGARCELETDECRAQPCRNGSSCRDLPGAFICQCSAGFVGVHCETEVDACDSSPCL *.****.:**** * *:*:**:* .** :** *::*:*. **** *****:*** **** ENSP00000308893/1-1413 HGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTG ENSMUSP00000050832/1-1403 HGGRCEDGGGAYLCVCPEGFFGYNCETVSDPCFSSPCGSRGYCLASNGSHSCTCKVGYTG ENSRNOP00000022290/1-1404 HGGRCEDGGGAYLCVCPEGFFGYNCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTG ENSCPOP00000005648/1-1404 HGGRCENGGGAYLCVCPEGFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTG XP_004868525.1/1-1411 HGGHCENGGGAYLCVCPEGFFGYHCETVSDPCFSSPCGGRGYCLASNGSHSCTCKVGYTG ***:**.***********.****:**************.********************* ENSP00000308893/1-1413 EDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYVSSDGSYRRTDFVD ENSMUSP00000050832/1-1403 KDCTKELLPPTALRVERVEESGVSISWSPPEGTTARQVLDGYAVTYASSDGSSRRTDFVD ENSRNOP00000022290/1-1404 KDCTKELLPPTALRVERVEESGVSISWSPPEGTTARQVLDGYAVTYASSDGSSRRTDFVD ENSCPOP00000005648/1-1404 KDCGTELLPPTALRVDRVEESGVSISWSPPNSPTARQVLDGYAVTYASSDGSYRRTDFVD XP_004868525.1/1-1411 KDCGTEILPPTALRVDRVEESGVSISWDPPDSPTARQVLDGYAVTYVSFDGSYRRTDFVD :** .*::*****:::***********.**:..:***:********.* *** ******* ENSP00000308893/1-1413 RTRSSHQLQALAAGRAYNISVFSVKRNSNNKNDISRPAVLLARTRPRPVEGFEVTNVTAS ENSMUSP00000050832/1-1403 RSRSSHQLRALAAGRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPIEDFEVTNISAN ENSRNOP00000022290/1-1404 RSRSSHQLRALAAGRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPIEDFEVTNISAN ENSCPOP00000005648/1-1404 RSHASHQLRALAPGRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPVEDFEVTNMTAS XP_004868525.1/1-1411 RSRTSHQLRALVPGRAYNISVFSVKRNTNNKNDISRPTALLTHTRPHPVEDFEVTNVTAN *:::****:**..**************:*********:.**::***:*:*.*****::*. ENSP00000308893/1-1413 TISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSVDRFTFRALLPGKRYTIQLTT ENSMUSP00000050832/1-1403 AISVQWALHRIQHATVSRVRVSILYPEASAVQSTEVDRSVDRLTFGDLLPGRRYTVRLTT ENSRNOP00000022290/1-1404 AISVQWALHRIQHATVSRVRVSVLYPEDTVVQSTEVDRSVDRLTFGDLLPGRRYSVRLTT ENSCPOP00000005648/1-1404 TVSVRWALHRIHHAAASRVRVSILHPGAPEAQATDVDRSVDQLTFGALLPGRKYTIWVAT XP_004868525.1/1-1411 AISVHWALHRIHHTTVSRVRLSILHPEAPEAQATDVDRSVDQLTFGALLPGRRYTMWVAA ::**:******:*::.* **:*: :* *:*:******::** ****::*:: ::: ENSP00000308893/1-1413 LSGLRGEEHPTESLATAPTHVWTRPLPPANLTAARVTATSAHVVWDAPTPGSLLEAYVIN ENSMUSP00000050832/1-1403 LSGPGGAEYPTESLASAPLNVWTRPLPPANLTASRVTATSAHMVWDTPAPGISLEAYVIN ENSRNOP00000022290/1-1404 LSGPGGAEYPTESLASAPLNVWTRPLPPANLTASRVTATSAHMVWDPPTPGISLEAYVIN ENSCPOP00000005648/1-1404 LSGPGGAEQPTESRASALLHVWTRPLPPANLTASRVTATSAHMVWDAPTPGVSLEAYVIN XP_004868525.1/1-1411 LSGPGEAERLTESRGSAPLHVWTRPLPPANLTAARVTASSAHVVWDAPTPGVLLEAYVIN *** * *** .:* :*************:****:***:***.*:** ******* ENSP00000308893/1-1413 VTTSQSTKSRYVPNGKLASYTVRDLLPGRRYQLSVIAVQSTELGPQHSEPAHLYIITSPR ENSMUSP00000050832/1-1403 VTTSQSTKSRYIPNGKLVSYTVRDLMPGRRYQLSVTAVQSTEQGQLHSEPAHLYIITSPR ENSRNOP00000022290/1-1404 VTTSQNTKSRYIPNGKLVSYTVRDLMPGRRYQLSVTAVQSTEQGQLHSEPAHLYIITSPR ENSCPOP00000005648/1-1404 VTTNQSTKSRYVPNGKLVSYTVRDLLPGRRYQLSVTAVQGTEQGQLHSEPAHLYIITSPR XP_004868525.1/1-1411 VTTSQSTKSRYVPNGKLVSYTVRDLLPGQRYQLSVTAVQGTEQGQLHSEPAHLYIITSPR ***.*.*****:*****.*******:**:****** ***.** * ************** ENSP00000308893/1-1413 DGADRRWHQGGHHPRVLKNRPPPARLPELRLLNDHSAPETPTQPPRFSELVDGRGRVSAR ENSMUSP00000050832/1-1403 DGTDRRWHHGGHHSRMLRNRPAPVRLPELRLLNDHSAPETPTQSSRFSELVDGRGRVSAR ENSRNOP00000022290/1-1404 DGTDRRWHQGGHHSRMLRNRPAPLRLPELRLLNDHGAPETPTQPPRFSELVDGRARVSAR ENSCPOP00000005648/1-1404 DSTDRRWHQGGHHTRVLRNRPPPVRLPELRLLNDRSFPEAPTQQPRFLELVDGRRRVSAR XP_004868525.1/1-1411 DGTDRRWHQGGRHPRVLRNRPPPVRLPELRLLSDRSSPETLTRPPRFLELVDGRGRVSAR *.:*****:**:*.*:*:***.* ********.*:. **: *: .** ****** ***** ENSP00000308893/1-1413 FGGSPSKAATVRSQPTASAQLENMEEAPKRVSLALQLPEHGSKDIGNVPGNCSENPCQNG ENSMUSP00000050832/1-1403 FGGLPSRAVTVRSQPTTPVPLKNTE-APEQVHLALQLPKNSSKDTESTPGSCSEDACQNG ENSRNOP00000022290/1-1404 FGGLPSRAVTVRSQPTTPVPLKNTE-APEQARLALQLPKNNSKDTESTPGSCSEDTCQNG ENSCPOP00000005648/1-1404 FSGPPNKLITSRPQPTSLVSPENTEEAPEQVHLALQLPELSDKDIERARGSCLEDTCHNG XP_004868525.1/1-1411 FDGSPSKPITSKPQPTSL-PLENTEAALEQVHLVLPLPERSDKDRESALGSCSEEACHNG *.* *.: * :.***: :* * * ::. *.* **: ..** . *.* *:.*:** ENSP00000308893/1-1413 GTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGVCHHVYKRVY ENSMUSP00000050832/1-1403 GTCVPGADAHSCDCRPGFKGRHCELACEKVPRPCTRLFSETKSFPVWEGDICHHVYKKVY ENSRNOP00000022290/1-1404 GTCVPGANAHSCDCRPGFKGRHCELACEKVPRPCTRLFSETKSFPVWEGDVCHHVYKKVY ENSCPOP00000005648/1-1404 GTCVPGTDTYSCNCGPGFKGRRCELACEKVPRPCTRLFSETKSFPVWEGGICHHMYKRVY XP_004868525.1/1-1411 GTCVPGTDTYSCDCRPGFKGRRCELACEKVPRPCTRLFSETKSFPVWEGGVCRRVYKRVY ******::::**:* ******:***** **.***********:******.:*:::**:** ENSP00000308893/1-1413 RVHQDICFKESCESTSLKKTPNRKQSKSQTLEKS ENSMUSP00000050832/1-1403 KVHQDVCFKERCQSTSLRK-PKQETK-------- ENSRNOP00000022290/1-1404 KVHQDVCFKERCQSTSLKK-LKQESN-------- ENSCPOP00000005648/1-1404 KVHQDVCFRELCESTSLKK-PQTGTS-------- XP_004868525.1/1-1411 KTHQDVCFKERCESISXRETPNRKKSNSQTLKKP :.***:**:* *:* * :: : .