CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000025036/1-1086 ------------------------------------------------------------ ENSRNOP00000066803/1-1099 ------------------------------------------------------------ ENSP00000440495/1-1130 ------------------------------------------------------------ ENSCPOP00000005395/1-1066 ------------------------------------------------------------ XP_004865766.1/1-1161 MPLPRALAEGSAASDRAGYPARAGPWGCDAEGGGARAAAPGPGRARRFRSCQRCKRSLTE ENSMUSP00000025036/1-1086 --------------------------------MGSEDHSAQNPSCKIMTFRPTMDEFRDF ENSRNOP00000066803/1-1099 --------------------------------MGSEDHSAQNPSCKIMTFRPTMDEFRDF ENSP00000440495/1-1130 --------------------------------MGSEDHGAQNPSCKIMTFRPTMEEFKDF ENSCPOP00000005395/1-1066 --------------------------------MGSEDHGAQNPSCKIMTFRPTMEEFKDF XP_004865766.1/1-1161 ILADYWSTCPSAASATRTHLGAARCGAHAAAAMGSEDHGAQNPSCKIMTFRPTMEEFKDF ******.***************:**:** ENSMUSP00000025036/1-1086 NRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNI ENSRNOP00000066803/1-1099 NRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNI ENSP00000440495/1-1130 NKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNI ENSCPOP00000005395/1-1066 NKYVAYIESQGAHRAGLAKVSPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNI XP_004865766.1/1-1161 NKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNI *:*****************: *************************************** ENSMUSP00000025036/1-1086 QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQ ENSRNOP00000066803/1-1099 QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQ ENSP00000440495/1-1130 QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQ ENSCPOP00000005395/1-1066 QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVSQ XP_004865766.1/1-1161 QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQ **********************************************************:* ENSMUSP00000025036/1-1086 WNIGNLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS ENSRNOP00000066803/1-1099 WNIGNLRSILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS ENSP00000440495/1-1130 WNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS ENSCPOP00000005395/1-1066 WNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS XP_004865766.1/1-1161 WNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS ****.**:**************************************************** ENSMUSP00000025036/1-1086 WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEF ENSRNOP00000066803/1-1099 WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEF ENSP00000440495/1-1130 WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEF ENSCPOP00000005395/1-1066 WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEF XP_004865766.1/1-1161 WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEF ************************************************************ ENSMUSP00000025036/1-1086 MITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPE ENSRNOP00000066803/1-1099 MITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPE ENSP00000440495/1-1130 MITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPE ENSCPOP00000005395/1-1066 MITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPE XP_004865766.1/1-1161 MITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPE ************************************************************ ENSMUSP00000025036/1-1086 RYEQWKQGRDLTVLDHTRPTALSSPELSSWSASRTSIKAKLLRRQISVKESRPWRKAEE- ENSRNOP00000066803/1-1099 RYEQWKQGRDLTVLDHTRPTALSSPELSSWSASRTSLKAKLLRRQISVKESRPWRKAEEE ENSP00000440495/1-1130 RYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRQISLKENRHWRKTEEE ENSCPOP00000005395/1-1066 RYELWKQGKDLPVLDHTRPTALSSPELSSWSASRASLKAKLLRR---------------- XP_004865766.1/1-1161 RYELWKQGKDLPVLDHTRPTALSSPELSSWSASRASLKAKLLRR---------------- *** ****:**.**********:***********:*:******* ENSMUSP00000025036/1-1086 -----ERRREPTRRPGPASHRRRSQPKKSKPEESRSPGEATAGVSTLDEARGCSRGEAMP ENSRNOP00000066803/1-1099 RRPSLERRREPTRRPGPASHRRRSQPKKSKPEDSRSPGEATAGVAGLDEARGCSRRETMP ENSP00000440495/1-1130 RKPSLERKKEQTKRPGLSSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGP ENSCPOP00000005395/1-1066 ------------------SHRKRCQPKRPKPEDLRCPGEGAAGVALLEEAAGCAKEDTAP XP_004865766.1/1-1161 ------------------SHRKRSQPKKPKPEDPRCPGEGAAGVALLEEVAGCTKEEAAP ***:*.***:.***: : ***.:**.: *:*. *. : :: * ENSMUSP00000025036/1-1086 E-DEEEEELLP---SQGHEAEGVEEDGRGKPRPTKARN--KKKTPSPSSPPLLS----AP ENSRNOP00000066803/1-1099 E-EEEEEELSP---SQGHEAEGVEEDGRGKPRPTKARS--KKKTPSLLSPPLLS----AP ENSP00000440495/1-1130 EVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLP-----PP ENSCPOP00000005395/1-1066 DADPDEEDEEP---AQGQDGEGAEEDSRGKPRPAKPKGERKKRSPGPFCPQLPPQ---PP XP_004865766.1/1-1161 DADPDEEDEEP---AQGQDGEGAEEDSRGKPRPAKPKGDRKKKSYGPLSPQLPPQALPPP : : :**: * .:*::.**.***.*** **:*.:. **:: . * * .* ENSMUSP00000025036/1-1086 PALFPTEEVLRPPPQPKSPGPAMGPMAAEGGPPPTPLNVVPPGAPVEEAEVRPRPIIPML ENSRNOP00000066803/1-1099 PALFPAEEVLRLPPQPKSPGPAMGPMAAEGGPPPTALNVVPPGVPGEETEVRPRPIIPML ENSP00000440495/1-1130 PAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPML ENSCPOP00000005395/1-1066 PAPFPTEEPPRLLPPLELP-------AAEEGPPPAPLNVVPPEVPGEEQEAKPRPIIPML XP_004865766.1/1-1161 PVLVPAEEATRLPPPLEPP-------TAEEGPPPPPLNVVPPEVPSEEQEAKPRPIIPML *. .*:** . : * : * .* *..****** .* ** *.:******** ENSMUSP00000025036/1-1086 YVLPRTSSTD---------------GDREHSAHAQLAPMEL-GPEE----------ENQA ENSRNOP00000066803/1-1099 YVLPRANSSD---------------GDREHAAHPQLAPMEL-GPEE----------EDQA ENSP00000440495/1-1130 YVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKA ENSCPOP00000005395/1-1066 YVLPRASERD-----------------HGL---PQATPMELAGPED----------EAKA XP_004865766.1/1-1161 YVVPRASERD-----------------RGP---PQAAPMELAGPED----------EANA **:**... : :**** ***: * :* ENSMUSP00000025036/1-1086 QAGDSQGTTPFSKLKVEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEAFLF-SGEDDVTD ENSRNOP00000066803/1-1099 QAGDSQGTTSFSKLKVEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEAFPF-SGEDDGSD ENSP00000440495/1-1130 RAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPF-SGEEDVSD ENSCPOP00000005395/1-1066 RGGEVQVPSTFSKLKMEIKRSRRHPLGRPPARSPLSVVKQEASSDEEALPFPGTGEDTRD XP_004865766.1/1-1161 RGGEVQVPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEALPFPSGEEDVGD :.*: * .:.*****:***:**********:***************** * . :* * ENSMUSP00000025036/1-1086 PEALRSLLSLQWKNKAASFQAERKFNAAAALSEPYCAICTLFYPYSQSVQTERD------ ENSRNOP00000066803/1-1099 PEALRSLLSLQWKSKAASFQAERKLNAAAALSEPYCAVCTLFYPYSQSVQTERE--VLAT ENSP00000440495/1-1130 PDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASL ENSCPOP00000005395/1-1066 PEALRSLLSLQRKNKTAGFQAERKFNAAAALAEPHCAICSLFYPYSQSLQVEKERPLASV XP_004865766.1/1-1161 PEALRPLLSLQWKNKAAGFQAERRANSAAALTEPYCAICSLFCPYSQSLQTEKEAPLASV *:***.***** *.::*.*****: *:*** :**:**:*:** **.*::*.*:: ENSMUSP00000025036/1-1086 ---SAVQPPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGEDGTSPLISCAHCCLQVH ENSRNOP00000066803/1-1099 PGDSAVQPPSKSGQRTRPLIPEMCFTSSGENTEPLPANSYVGEDGTSPLISCAHCCLQVH ENSP00000440495/1-1130 GKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVH ENSCPOP00000005395/1-1066 LEGPSAPPPSKCGQRTRPLIPEMCFTSSGENTEPLPANSCVGDDGTSPLIACAKCCLQVH XP_004865766.1/1-1161 TEGPPAPPPSRCGLKTRPLIPEMCFTSSGENTEPLPANSCVGDDGTSPLIACAKCCLQVH .. **:. :************.*********** :*:*******:*.:****** ENSMUSP00000025036/1-1086 ASCYGVRPELAKEGWTCSRCAAHAWTAECCLCNLRGGALQRTTEHRWIHVICAIAVPEVR ENSRNOP00000066803/1-1099 ASCYGVRPELAKEGWTCSRCAAHAWTAECCLCNLRGGALQRTTEHRWIHVICAIAVPEVR ENSP00000440495/1-1130 ASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEAR ENSCPOP00000005395/1-1066 ASCYGVRPELVKEGWTCSRCAAHAWTAECCLCNLRGGALQTTTDRRWIHIICAIAVPEVR XP_004865766.1/1-1161 ASCYGVRPELVKDGWTCSRCTAHAWTAECCLCNLRGGALQTTTDRRWIHVICAIAVPEVR *****:****.::*******:******************* **::****:********.* ENSMUSP00000025036/1-1086 FLNVIERNPVDVSAIPEQRWKLKCIYCRKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGV ENSRNOP00000066803/1-1099 FLNVIERNPVDVSAIPEQRWKLKCVYCRKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGV ENSP00000440495/1-1130 FLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGV ENSCPOP00000005395/1-1066 FLNVIERHPVDISGIPEQRWKLKCVYCRKRMKRVSGACVQCSSERCSTSFHVTCARAAGV XP_004865766.1/1-1161 FLNVIERHPVDISGIPEQRWKLKCVYCRKRMKRVSGACIQCSFERCSTSFHVTCARAAGA *******:***:*.**********:*******:*****:*** *:**********:***. ENSMUSP00000025036/1-1086 LMEPDDWPYVVSITCLKHRASGAGGQLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFY ENSRNOP00000066803/1-1099 LMEPDDWPYVVSITCLKHRASGAGGQLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFY ENSP00000440495/1-1130 LMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCY ENSCPOP00000005395/1-1066 LLEPDDWPYAVAITCLKHRAGGHAAQALRAVALGQVVITKNRNGLYYRCRVIGTTTQVFY XP_004865766.1/1-1161 LLEPDDWPYAVSITCLKHRAGGHAAQALRAVSLGQVVITKNRNGLYYRCRVIGTTTQIFY *:*******.*:******::.* . * **:*:***:*****************:::* * ENSMUSP00000025036/1-1086 EVNFDDGSYSDNLYPESITSRDCLRLGPPPEGELVELRWTDGNLYRARFISMATSLIYQV ENSRNOP00000066803/1-1099 EVNFDDGSYSDNLYPESITSRDCLRLGPPPEGELVELRWTDGNLYRARFISMATSLIYQV ENSP00000440495/1-1130 EVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQV ENSCPOP00000005395/1-1066 EVNFDDGSYSDNLYPESIQSRDCVRLGAPAEGELVELRWTDGNIYKARFISSVTSHIYQV XP_004865766.1/1-1161 EVNFDDGSYSDNLYPESITSRDCVQLGPPPEGELVELRWTDGNIYKAKFISSVTSHIYQV ****************** ****::**.*.*************:*:*:*** .** **** ENSMUSP00000025036/1-1086 EFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGTPQEPSFSGDDVKAAKRPRVASVLA ENSRNOP00000066803/1-1099 EFEDGSQLTVKRADIFTLEEELPKRVRSRLSLSTGTPQEPSFSGDGVKAAKRPRVATVLA ENSP00000440495/1-1130 EFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLA ENSCPOP00000005395/1-1066 EFEDGSQLTVKRSDIFTLEEELPKRVRSRLSLSTGAPQEAAFAGEEVKAAKRPRVGAPLA XP_004865766.1/1-1161 EFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEASFEGEEVKAAKRPRVGAPLP ************.**********************:***.:* *: .********.: *. ENSMUSP00000025036/1-1086 TT---TEDTGRSPEYLSFMESLL--QAQGRPGAPF ENSRNOP00000066803/1-1099 TT---TEDTGRSPEYLAFMESLL--QAQGQPGAPF ENSP00000440495/1-1130 T-----EDSGRSQDYVAFVESLL--QVQGRPGAPF ENSCPOP00000005395/1-1066 TAAPATQDSGHSPDCPAFAESLLPAQVQARPGAPF XP_004865766.1/1-1161 TTSPAAEDSGRGPDYLAFGESLLQGQAQARPGVPF * :*:*:. : :* **** *.*.:**.**