CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000053232/1-1132 MFSQVPRTPAAGCYYLNPLTPESQEMYLRFDQTARRSPYRMSRILARHHLVTKIQQEIEA ENSRNOP00000001446/1-1112 MFSQVPRTPAAGCYCLNPLTPESQEMYLRFDQTARRSPYRMSRILARHHLVTKIQQEIEA ENSP00000338785/1-1113 MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEA XP_004854807.1/1-1112 MFRQMPRTPASSCYYLNSMTTEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEA ENSCPOP00000005394/1-1109 MFRQVPRTPASGCYYLNSMTTEGQEMYLRFDQTARRSPYRMSRILARHQLVTKIQQEIEA ** *:*****:.** **.:*.*.**********:**************:*********** ENSMUSP00000053232/1-1132 KEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMR ENSRNOP00000001446/1-1112 KEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMR ENSP00000338785/1-1113 KEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK XP_004854807.1/1-1112 KEACNWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK ENSCPOP00000005394/1-1109 KEACDWLRAAGFPQYAQLYEDSRFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMK ****:*****************:*****.***:******:*******************: ENSMUSP00000053232/1-1132 LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPVADRNGSPGGPRMRNT ENSRNOP00000001446/1-1112 LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHPLLPGADRNGSPGGPRMRNT ENSP00000338785/1-1113 LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMRNT XP_004854807.1/1-1112 LDVNLQKKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPGRDRNGSPGGPRMRNT ENSCPOP00000005394/1-1109 LDVNFQRKKGDDSDEEALCISNKWTFQRTSRRWSRVDDLHTLFPGGDRNGSPGGPRMRNT ****:*:********* **********************:.*:* ********. **** ENSMUSP00000053232/1-1132 ASSESVLTDLSEPEVCSIHSESSGGSDSRSQSGHHSADSTHALEATLVSSSLPQSTREGL ENSRNOP00000001446/1-1112 ASSESVLTDLSEPEVCSIHSESSGGSDGRGQSGHHFADGTPVLEGTLVGGSLPQSPRDSL ENSP00000338785/1-1113 TSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRDVL XP_004854807.1/1-1112 TSSESVLTDLSEPEVCSIHSESSGGSDSRSQSGQYCADSPGMLEGTLVSSSLPQNPRDIL ENSCPOP00000005394/1-1109 TSSESVLTDLSEPEVCSIHSESSGGSDGRSQSGQYCADSPVMLEPTLVGSSLPQNPRDLL :**************************.*.*.*: :*.. *: .**..**** .*: * ENSMUSP00000053232/1-1132 NQSFHPKNEKPTRTRAKSFLKRMDTLRVKGALGRHKGPGRTGGLVISRPVLQQEPESFKT ENSRNOP00000001446/1-1112 SQSFHPKNEKPTRTRAKSFLRRMDTLRVKGALGRHKGPGRTGGLVISRPMLQQEPESFKT ENSP00000338785/1-1113 NHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESFKA XP_004854807.1/1-1112 NYPFYPKNEKPTRTRAKSFLKRMETLRAKGAHGRHKGSGRTGGLVISGPVLQQEPESFKA ENSCPOP00000005394/1-1109 ----QPKHEKHTRTRAKSFLKRMETLRAKGAHGRHKGPGRTGGVVISGPVLQQEPESFKA **:** **:******:**:*** *** *****.*****:*** *:*********: ENSMUSP00000053232/1-1132 MQCVQIPNGDLQTSPPAACRKGLPCSSKSSGESSPLENSST-VSTPCMKERKCHHEANKR ENSRNOP00000001446/1-1112 MQHVQIPNGDLQTSPPAACKKGLPGSSKSSGENSPLESSR--VSTPCMKERKCQHEANKR ENSP00000338785/1-1113 MQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKC-HEANKR XP_004854807.1/1-1112 MQCIQIPNGDLRNSPPAVCRKGLPCSSKSSGESSPSENSSSGVSTPCLKERKCHHEANKR ENSCPOP00000005394/1-1109 MQCIQIPNGDLQNSSAAACRKGLP-SSKSSGESSPSENSSSGLSTPCLKEQKCHYEASKR ** :*******:.*....*:**** *.*****.** * * :****:**:** :**.** ENSMUSP00000053232/1-1132 GGMYLEDLDVLAGTALPDTSDQNHMHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTD ENSRNOP00000001446/1-1112 GGMYLEDLDVLAGTTLPDTGDQNHIHGFHSQENLVVHVPKDHKPGTFPKALSIESLSPTD ENSP00000338785/1-1113 GGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPTD XP_004854807.1/1-1112 SGMYLEDLDVLSGTALRDAGGQNHTHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTD ENSCPOP00000005394/1-1109 GGMYLEDLDVLAGPALRATGDQNHTHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTD .**********:*.:* :..*.: * **********:********************** ENSMUSP00000053232/1-1132 NSNGVNWRTGSISLGRQQGPGMREPRLMSSCHRASRVSIYDNVPSSHLYASTGDLLDLEK ENSRNOP00000001446/1-1112 SSNGVNWRTGSISLGRQQGPGIREPRLVSSCHRASRVSIYDNVPSSHLYASTGDLLDLEK ENSP00000338785/1-1113 SSNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEK XP_004854807.1/1-1112 NSNGVNWRTGNISLGSQQGPGTREPRLMASCHRASRVSVYDNVPGSHLCASTGDLLDLGK ENSCPOP00000005394/1-1109 NSNGVNWRTGSISLGRQQSPGTGNPGLMESCHRASRVSIYDNVPGSHLYASTGDLLDLEK .*********.**** :* ** :* *: *********:*****.*** ********* * ENSMUSP00000053232/1-1132 DGLLPQLDDILQHVNGIQEVVDDWSKNILPELQSHSTLAGDPGLSPFPSPNQVTLDFEGN ENSRNOP00000001446/1-1112 DGLLPQLDDIIQHVNGIQEVVDDWSRNILPELQSHDAVAGDPGQPPFQSPHQITLDFEGN ENSP00000338785/1-1113 DDLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEGN XP_004854807.1/1-1112 D--FPQLDDILQHVSGLQEVVDDWSKNVLPDLQSHDPLVGEPGLHPFPSSNQITLDFEGN ENSCPOP00000005394/1-1109 DDLFPHLDDILQHVNGLQEVVDDWSKNVLPELQSHDTLAGERGLPPFPSPNLITLDFEGH * :*:****:***.*:********:::**:**:*..:.*: * .* *.: :******: ENSMUSP00000053232/1-1132 SVSEGRTTPSDVERDRTSLNESEATGVRERRDSGVGASLTRPNRRLRWSSFQLSHQPQPS ENSRNOP00000001446/1-1112 SVSEGQTTPSDVERDRTSLNESDTTGVRERRDSGVGASLTRPNRRLRWSSFQLSHQPQLS ENSP00000338785/1-1113 SVSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPA XP_004854807.1/1-1112 SVSEGRTTPSDVERDGTSLNESEATGVRERRDSGVGASLTRPSRRLQWNSFQPSQQPQPS ENSCPOP00000005394/1-1109 SVSEGQTTPSDVERDGTSLNDSEALGVRERRDSGVGASLTRPNRRLRWNSFQLSHQPRPS *****:********* ****:*:. ***:*************.***:*.*** *:**: : ENSMUSP00000053232/1-1132 PATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWTCLSAQSAPGALHDLVSVNS ENSRNOP00000001446/1-1112 PATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWT------------------- ENSP00000338785/1-1113 PASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWT------------------- XP_004854807.1/1-1112 PASPHISSQTASQLNLLQRFSLLRLTAIMEKYSMSNKHGWT------------------- ENSCPOP00000005394/1-1109 PASPHISSQTASQLSLLQRFSLLRLTAIMEKYSMPNKHGWT------------------- **:********:**.****************:**.****** ENSMUSP00000053232/1-1132 RSVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRK ENSRNOP00000001446/1-1112 WSVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRK ENSP00000338785/1-1113 WSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRK XP_004854807.1/1-1112 WSVPKFMKRTKVPDYKDKAVFGVPLIVHVQRSRQPLPQSIQQALIYLRSNCLDQVGLFRK ENSCPOP00000005394/1-1109 WSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRSGQPLPQSIQQALIYLRSNCLDQVGLFRK ******** *.***:***************: *********** *************** ENSMUSP00000053232/1-1132 SGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQ ENSRNOP00000001446/1-1112 SGVKSRIHALRQMNENFPDNVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQ ENSP00000338785/1-1113 SGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQ XP_004854807.1/1-1112 SGVKSRIHALRQMNESFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLNETFLHIYQ ENSCPOP00000005394/1-1109 SGVKSRIHALRQMNESFPENVSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQ ***************.**:**.*****************************.******** ENSMUSP00000053232/1-1132 YVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH ENSRNOP00000001446/1-1112 YVPKEQRLQAVQAAILLLADENREALQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFH ENSP00000338785/1-1113 YVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFH XP_004854807.1/1-1112 FVPKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVDENQMTPMNLAVCLAPSLFH ENSCPOP00000005394/1-1109 FVPKEQRLQAVQAAILLLEDENRDVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFH :*.*************** ****:.********:******:******************* ENSMUSP00000053232/1-1132 LNLLKKESSPKVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRD ENSRNOP00000001446/1-1112 LNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRN ENSP00000338785/1-1113 LNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRN XP_004854807.1/1-1112 LNLSKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECNKLFEVPHEMVAQSRN ENSCPOP00000005394/1-1109 LNLLKKESSPKVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECNKLFEVPHEMVAQSRN *** ******:****************************** **::*******:*****: ENSMUSP00000053232/1-1132 SYLEAEIHVPSLEDLGAQLAESGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLA ENSRNOP00000001446/1-1112 SYLEAEIHAPSLEDLGTQLAENGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLA ENSP00000338785/1-1113 SYVEAEIHVPTLEELGTQLEESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLA XP_004854807.1/1-1112 SYVEAEIHVPTLEDLGTQLEESGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLA ENSCPOP00000005394/1-1109 SYVEAEIHVPTLEDLGAQLEESGATFHTYLEHLIQGLQKEIKEKFKGWVTCSSPDNTDLA **:*****.*:**:**:** *.********:**:****** ************.****** ENSMUSP00000053232/1-1132 FKKVGDGHPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVERLDKQTEIYQYV ENSRNOP00000001446/1-1112 FKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYV ENSP00000338785/1-1113 FKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYV XP_004854807.1/1-1112 FKKVGDGNPLKLWKAAVEVEAPPAVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYV ENSCPOP00000005394/1-1109 FKKVGDGNPLKLWKAAVEVEAPPAVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYV *******:*******:*******:************************ **:******** ENSMUSP00000053232/1-1132 LNSMVPHPSRDFLVLRTWKTDLPKGMCTLVSLSVEYEEAQLMGGVRAVVMDSQYLIEPCG ENSRNOP00000001446/1-1112 LNSMVPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGDVRAVVMDSQYLIEPCG ENSP00000338785/1-1113 LNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCG XP_004854807.1/1-1112 LNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGAVRAVVMDSQYLIEPCG ENSCPOP00000005394/1-1109 LNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLMGGVRAVVMDSQYLIEPCG ****.*******:**********************:*****:* **************** ENSMUSP00000053232/1-1132 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVTRIRNSFQPLVAEGPETKI ENSRNOP00000001446/1-1112 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLVAEGPETKI ENSP00000338785/1-1113 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI XP_004854807.1/1-1112 SGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI ENSCPOP00000005394/1-1109 SGKSRLTHICRMDLKGHSPEWYSKCFGHLCASEVARIRNSFQPLIAEGPETKI ***********:************ ******:**:*********:********