CLUSTAL W(1.81) multiple sequence alignment ENSP00000386239/1-1378 MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERA ENSMUSP00000129597/1-1363 MTLEQELRQLSKAKTRAQRNGQLREEAAYCHQLGELLASHGRFKDALEEHQQELHLLESV ENSRNOP00000019754/1-1367 MTLEQELRQLSKAKARAQRNGQLCEEAVCCHQLGELLASHGRFQEALEEHQQELHLLESV ENSCPOP00000005196/1-1198 ------------------------------------------------------------ XP_004837767.1/1-1188 MILERELRQLNKAKARAKRSGQPREEAAFCHQLGELLAGHGRYAEALEEHREELRLLEGT ENSP00000386239/1-1378 DDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI ENSMUSP00000129597/1-1363 QDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDI ENSRNOP00000019754/1-1367 QDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDV ENSCPOP00000005196/1-1198 ------------------------------------------------------------ XP_004837767.1/1-1188 QDPLGCAVAHRKIGERLAEMEDYSAALRHQHCHLELAGSLSNHTEMQRAWATIGRTHLDI ENSP00000386239/1-1378 YDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTAL ENSMUSP00000129597/1-1363 YDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTAL ENSRNOP00000019754/1-1367 YDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTAQ ENSCPOP00000005196/1-1198 ---------------------------------------MRTRLYLNLGLTFESLQQMAL XP_004837767.1/1-1188 YDHCQSREALVQAQAAFEKSLAIVDEKLEGTLTQRELSEMRTRLYLNLGLTFESLQQTAL ************ ***** * ENSP00000386239/1-1378 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM ENSMUSP00000129597/1-1363 CNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARAMKMRFM ENSRNOP00000019754/1-1367 CNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARAMKMRFM ENSCPOP00000005196/1-1198 CNVEARKEQSICRHNHLYEDLYRARYNLGTIHWRAGQHSQAMRCLEGARECARAMKKRFM XP_004837767.1/1-1188 CNAYFKKSIFLSEHNHLYEDLYRARYNLGTIHWRAGQHSQAMRCLEGARECARAMKKRFM ** :*. :..:*******:*******:****.*****************::*: *** ENSP00000386239/1-1378 ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQH-VLAVVRLQQQL ENSMUSP00000129597/1-1363 ESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKPNQRVTVCQSLKY-VLAVIQLQQQL ENSRNOP00000019754/1-1367 ESECCMLVSQVLQDLGDFLAAKRALKKAYRLGSQKPNQRVAICQSLKY-VLAVVRLQQQL ENSCPOP00000005196/1-1198 ESECCVVVSQILQDLGDFLAAKRALKKAYRLGSQKPAQRAAVCQSLKYAVLAVVQLQQQL XP_004837767.1/1-1188 ESECCVVVSQVLQDLGDFLAAKRALKKAYKLGSQKPAQRAAVCQSLKY-VLAVVQLQQRL *****::::*:******************:****** **.::**.*:: ****::***:* ENSP00000386239/1-1378 EEAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLA ENSMUSP00000129597/1-1363 EEAEGNDLQGAMAICEQLGDLFSKAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLA ENSRNOP00000019754/1-1367 QEAEGNDLQGAMAICEQLGDLFSKADDFPKASEAYQKQLHFAELLNRPDLELAVIHESLA ENSCPOP00000005196/1-1198 EEAESSDRQDAMAICEQLGDLFSKAGDFPKAAEAYQKQLYFAEQLNRPDPELAIIHVSLA XP_004837767.1/1-1188 EEAEGSDLQGAMAFCEQLGDLFSKAGDFPKAAEAYQRQLHFAERLNRPDSELAIIHVSLA :***. * *.**.:***********.***:*:****:** :** *:**. * *:** *** ENSP00000386239/1-1378 TTLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALS ENSMUSP00000129597/1-1363 TTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFC ENSRNOP00000019754/1-1367 TTLGDMKDYHKAVHHYEEELRLRKGNALEEAKTWFNIGLAREEAGDAYELLAPCFQKAFG ENSCPOP00000005196/1-1198 TTLGDMKDHRQAVYHYEEELRLCKGNALEEAKTWLNIALSQEEAGDAYELLAPCFQKALS XP_004837767.1/1-1188 TTLGDMKDYRQAVHHYEEELRLCKGNSLEEAKTWLNIALSRDEAGDAYELLAPCFQTALN ********:: ** ******** .** *******:**.*:::**************.*: ENSP00000386239/1-1378 CAQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAE ENSMUSP00000129597/1-1363 CAQQAQRFQLQRQILQHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEA ENSRNOP00000019754/1-1367 CAQQAQRYQLQRQILQHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEA ENSCPOP00000005196/1-1198 CAQQAQQPQLQRQVLQHLHTVQLRLQPQDAPGTESKLQELSVA-----NEEEEEEVEEEA XP_004837767.1/1-1188 CAQQAQRPQLQRQVLQHLHTVQLRLQPQDAPGTETKLEELSVGK--EEEEEEEEEVEEEA ******: *****:****:****:****:* ** :*.***:. :** ** ENSP00000386239/1-1378 SEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIE ENSMUSP00000129597/1-1363 SEAPETSELELSESEDDADGLSQQLEEDEELQGCVGRRKVNKWNRRNDMGETLLHRACIE ENSRNOP00000019754/1-1367 SEALETSEMELSESEDDADGLSQQLEEEEELQGCVGRRKINKWNRRNDMGETLLHRACIE ENSCPOP00000005196/1-1198 TEAVEIIELELSESEDDSDDPSREPEEHEERQACLGRRKVNKWNRRNDMGETLLHRACIE XP_004837767.1/1-1188 IEALETIEPELSESEDDGDDPSREPEEDEERQGCLGRRKVNKWNRRNDMGETLLHRACIE ** * * ****.*** *. : : **.** *. :**** .******************* ENSP00000386239/1-1378 GQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGI ENSMUSP00000129597/1-1363 GQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGI ENSRNOP00000019754/1-1367 GQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGI ENSCPOP00000005196/1-1198 GRLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGASVDDPGGQGCEGI XP_004837767.1/1-1188 GRLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGASVDDPGGQGCEGI *:********:************************************:*********:** ENSP00000386239/1-1378 TPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARA ENSMUSP00000129597/1-1363 TPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAAT ENSRNOP00000019754/1-1367 TPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAAS ENSCPOP00000005196/1-1198 TPLHDALTCGHFEVAELLIERGASVTLQTKKGHSPLETLQNWVKLYCKDLDLETRQKAAA XP_004837767.1/1-1188 TPLHDALNCGHFEVAELLIDQGASVTLQTKKGHSPLETLQQWVKLYYKDLDLETQQKAAA *******.**********:::******:*:** *******:***** :******:*** : ENSP00000386239/1-1378 MEMLLQAAASGQDPHSSQAFHT-PSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRV ENSMUSP00000129597/1-1363 MEKRLQMASSGQASRSSPALQTIPSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPAKV ENSRNOP00000019754/1-1367 MERRLQMASSGQASHSSPALQTIPNNHLFDPETSPPSSPCPKPPSYTPRPPEASPAPAKV ENSCPOP00000005196/1-1198 MERRLQAASLGPASSSTPGPRTVLSNHLFDPEISPPLSPCFKPL--------ASPAHTRI XP_004837767.1/1-1188 MERRLKAASSGPAPHSTPAPRTVLSNHLFDPETSPPLNPCPEPL--------ASAAHARI ** *: *: * . *: . :* .. ***** *** .** :* ** * .:: ENSP00000386239/1-1378 SPGQAAPAMARPRRSRHGPASSSSSSE-GEDSAGPARPSQKRPRCSATAQRVAAWTPGPA ENSMUSP00000129597/1-1363 FLEETVSAVSRPRKTRHRPTSSSSSSE-DEDNPSPCRPSQKRLRHT--TQQGEVKIPDPP ENSRNOP00000019754/1-1367 FLEETVSAVCRPRKNRHRPASSSSSSEDDDDNTNPCRPSQKRLRHS--TQQGEAKTPDPS ENSCPOP00000005196/1-1198 SLKQTASAVARPRRSRHRL------SD-SENTVSPHGPSQKRLRRSAMAQQDEAWTSGSA XP_004837767.1/1-1188 SPKRTASAVARPRRSRHRLASSSSSSE-GEDSVSPHGPSQKRLKCSALAQQDEAWTSGPA .:..*:.***:.** *: .::. .* ***** : : :*: . .... ENSP00000386239/1-1378 SNREAATASTSRAAYQAAIRGVGSAQSR-LGPGPPRGHSKALAPQAALIPEEECLAGDWL ENSMUSP00000129597/1-1363 KSRETATSSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVPAPKTALIPEEEYLAGEWL ENSRNOP00000019754/1-1367 KSRETAISSACRAAYQAAIRGVGSAQSRRLVPSLPRGSNEVPAPKTALIPEEEFLAEEWL ENSCPOP00000005196/1-1198 SSKEAATASTSLAAYQAAIRSVGGVQSRCQGPGSFRDTSEGPVPQAALIPEEEYVARDWL XP_004837767.1/1-1188 STRE---ASTSRAAYQAAIRGVGSAQSRCRGPGLLWGTSEGPVPQAALIPEEEYLAGNWL ..:* :*:. ********.**..*** *. . .: .*::******* :* :** ENSP00000386239/1-1378 ELDMPLTRS---RRPRPRGTGDNRRPSSTSGSDSEE---SRPRARAKQVRLTCMQSCSAP ENSMUSP00000129597/1-1363 EVDTPLTRS---GRP------------STSVSDYER-CPARPRTRVKQSRLTSLDGWCAR ENSRNOP00000019754/1-1367 EVDTPLTRSSSSSRP------------STSISDYER-CPARPRTRAKQSRPASLDGWCTR ENSCPOP00000005196/1-1198 ELDEPLMYS----RPSHLACPQDSGDSGSSASGSDE-HPVRPGARARQSRLTCLKSWNPL XP_004837767.1/1-1188 EMDEPLMHS----RPSHIACPQGSGDSGSSPSESDKEHPIRPRAQAKQTRLTCLKSWSTL *:* ** * ** .:* * :. ** ::.:* * :.:.. . ENSP00000386239/1-1378 VNAGPSSLASEPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPH ENSMUSP00000129597/1-1363 TQAGDGSLNAEPAENPSVPRTSGPNKENYAAGQPLLLVQPPPIRVRVQIQDNLFLIPVPQ ENSRNOP00000019754/1-1367 TKAADASLTAEPTENSSMPRTTGPNKENCAAGQPLLLVQPPPIRVRVQIQDNLFLIPVPH ENSCPOP00000005196/1-1198 DKVG--GMAAEPSGNPIMPRALGPSGENSEAGQSMSLVPPPPIRVRVRVQDHLFLIPVPH XP_004837767.1/1-1188 DKVG--GMAAEPPGDPIMPKTSGASRESPDGGQSTSLVQAPPIRVRVRVQDHLFLIPVPH :.. .: :**. .. *:. .. :. .**. . .*******::**:*******: ENSP00000386239/1-1378 SSDTHSVAWLAEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSW ENSMUSP00000129597/1-1363 S-DIRPVAWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEVLAEVTSW ENSRNOP00000019754/1-1367 S-DVHSVAWLAEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEVMAEVTSW ENSCPOP00000005196/1-1198 SNEAHSVAWLVEQAAQRYYQTFGLLPRLTLQKEGALLAPQDPIPDVLQSNDEVLAEVTSW XP_004837767.1/1-1188 SSEAHSVAWLAEQAAQRYYQTCGLLPRLTLQKEGALLAPQDPILDVLQSNDEVLAEVTSW * : :.****.*******:** ********:*:******** * *********:****** ENSP00000386239/1-1378 DLPPLTDRYRRACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHT ENSMUSP00000129597/1-1363 DLPPLKDRYRRACLSLGQGEHQQVLHAMDHQSSSPSFSACSLALCQAQLTPLLRALKLHT ENSRNOP00000019754/1-1367 DLPPLKDRYRRACQSLGQGEHQQVLQAMEHQSSSPSFSACSLALCQAQLTPLLRALKLHT ENSCPOP00000005196/1-1198 DLPPLTDRYHRACQSLGQGEHVQVLRTIERQGSGPSFSICSLALCQTQLVPLLRALKMHT XP_004837767.1/1-1188 DLPPVTDRYRRACQSLGQGEHLQVLQAMEHQGSGPSFSTCSLALHQAHLTPLLRALKMHT ****:.***:*** ******* ***:::: *. . *** ***** *::*.*******:** ENSP00000386239/1-1378 ALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQS ENSMUSP00000129597/1-1363 ALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGQEGLRQLVEGSSGQAALQN ENSRNOP00000019754/1-1367 ALRELRLSGNRLGDPCATELLATLGTMPNLVLLDLSSNHLGPEGLRQLVEGSLGQTAFQN ENSCPOP00000005196/1-1198 GLRELRLAGNRLGDGCATELLSALATIPSLVLLDLSSNHLSQEGLRQLAGGPTGQGTLQN XP_004837767.1/1-1188 GLRELRLAGNRLGDGCATELLAALGTMPCLVLLDLSSNHLGQEGLRQLAGGPTGQATLQN .******:****** *.:**:::*.* * *.*********. ******. * ** ::*. ENSP00000386239/1-1378 LEELDLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEH ENSMUSP00000129597/1-1363 LEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSSSFFLSHQAALGGAFQDAVH ENSRNOP00000019754/1-1367 VEELDLSMNPLGDGCAQALASLLRTCPVLRTLRLQACGFSPSFFLSHQAALGSAFKDAEH ENSCPOP00000005196/1-1198 LEELDLSMNPLGDGSGQALASILRACPLLRILRLQACGFGPNFFLNHQAVLGSAFQDAEH XP_004837767.1/1-1188 LEELDLSMNPLGDSCGQALASILRACPFLSTLRLQACGFGPNFFLSHQATLGPAFQGP-- :************...*:***:*::**.* ********...***.**:.** **:.. ENSP00000386239/1-1378 LKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCAL ENSMUSP00000129597/1-1363 LKTLSLSYNLLGAPALARVLQTLPACTLKRLDLSSVAASKSNSGIIEPVIKYLTKEGCAL ENSRNOP00000019754/1-1367 LKTLSLSYNTLGAPALARVLQSLPTCTLLHLELSSVAASKSNSSLIEPVIKYLTKEGCAL ENSCPOP00000005196/1-1198 LKTLSLSYNPLGTPALARTLQNLPTCVL-HLELSSVAAGKSDLGLMEPIIRYLTKEGCAL XP_004837767.1/1-1188 ----------------CRACPPVPSCA--------------------------------- .*. :*: . ENSP00000386239/1-1378 AHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSF ENSMUSP00000129597/1-1363 AHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVSCASLEELLSALQERSQGLSF ENSRNOP00000019754/1-1367 AHLTLSANCLSDKAVRELSRCLPSCPSLTSLDLSANPEVSCAGLEELLSALQERPQGLSF ENSCPOP00000005196/1-1198 AHLTLSSNYLSDKAVGELSRCLPFCPSLISLDLSANPKISCTSLKELLSALQERCKGLSF XP_004837767.1/1-1188 ------------------------------------------------------------ ENSP00000386239/1-1378 LGLSGCAVQGPLGLGLWDKIAAQLRELQLCSRRLCAEDRDALRQLQPSRPGPGECTLDHG ENSMUSP00000129597/1-1363 LGLSGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKDRDSVCQRLPE----GACTMDQS ENSRNOP00000019754/1-1367 FDLSGCSIQGPLNSDLWDKILSQLQELQLCSKDLTTKDRDTLCQRLPA----GACTLNQG ENSCPOP00000005196/1-1198 LGLSGCAIQGPLGPGLWDKITAQLQELRLCSRSLCPEDRDALHQLLPA---LGVCSLDQG XP_004837767.1/1-1188 ------------------------------------------------------------ ENSP00000386239/1-1378 SKLFFRRL ENSMUSP00000129597/1-1363 SKLFFKCL ENSRNOP00000019754/1-1367 SKLFFKCL ENSCPOP00000005196/1-1198 SKLFFQRP XP_004837767.1/1-1188 --------