CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000045667/1-1450 ---MISKRRRLDSEDKENLTEDASKTM--PLSKLAKKSHNSHEVEENGSVFVKLLKASGL ENSRNOP00000033638/1-1454 MVKMVSKRSRLDFEDKETLAEDASKIMKQPLSKLAKKSCGSHEVEENGSVFVRLLKASGL ENSP00000287647/1-1471 ---MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGI ENSCPOP00000005156/1-1428 ---MVSKRRLSKSEDKETSTGEASKTKKQQLSKKIKKSHASNEVEEN--VFVKLLKTSGL XP_004835381.1/1-1450 ---MVSKRRLSKSEDKEASTEEASRAKKQQLSKKIKKS-ASNEGEENDNVFVKLLKTSGL *:*** . **** : :**: *** *** ::* *** :**:*** **: ENSMUSP00000045667/1-1450 TLKTGENQNQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNCLLSC ENSRNOP00000033638/1-1454 TLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCLLSC ENSP00000287647/1-1471 ILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSC ENSCPOP00000005156/1-1428 ILKTGENQNQLVVDQIVFQKKLFQSLKKHPSYPKVIEEFVSGLESHIEDHDTFRNCLLPC XP_004835381.1/1-1450 ILKTGENQNQLAVDQIVFQKKLFQSLRKHPSYPKVIEEFVSGLESHIEDHDTFRNCLLSC ****:.**** ***: **:****:*::**:***:*****.****: ** :::*****.* ENSMUSP00000045667/1-1450 ERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLII ENSRNOP00000033638/1-1454 ERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLII ENSP00000287647/1-1471 ERLQDEEASMGASYSKSLIKLLLGIDILQPAIIKTLFEKLPEYFFENKNSDEINIPRLIV ENSCPOP00000005156/1-1428 ERLQDEELSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLFVKVNSDGISMPRLII XP_004835381.1/1-1450 ERLQDEESSMGTSYSKSLIKLLLGIDILQPAIVKTLFEKLPEFLFVNVNSDGINMPRLII ******* * *: *******************:* ****:*:::* . . * *.:.***: ENSMUSP00000045667/1-1450 NQLKWLDRIVDGKDLTAQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQ ENSRNOP00000033638/1-1454 SQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQ ENSP00000287647/1-1471 SQLKWLDRVVDGKDLTTKIMQLISIAPENLQHDIITSLPEILGDSQHADVGKELSDLLIE ENSCPOP00000005156/1-1428 SQLKWLDRVVDSKDLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVE XP_004835381.1/1-1450 SQLKWLDRVVDCKDLTTKIMQLIHVSPECLQHDFITSLPEILGDSQHAAVGKDLSNLLVE .*******:** ****:::**** ::* ****:************** **::*. **:: ENSMUSP00000045667/1-1450 NTSLTVPILDVFSSLRLDPNFLSKIRQLVMGKLSSVRLEDFPVIVKFLLHSVTDTTSLEV ENSRNOP00000033638/1-1454 NTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEV ENSP00000287647/1-1471 NTSLTVPILDVLSSLRLDPNFLLKVRQLVMDKLSSIRLEDLPVIIKFILHSVTAMDTLEV ENSCPOP00000005156/1-1428 STQLTVPILDVLSSLQLDPDFLSKVRQLAMGKLVSIKLDDFPVIIKFILHSITATNAFEV XP_004835381.1/1-1450 STGLTVPILDVLSSLQLDPDFLSEVRQLAMGKLESIRLDDLPVIIKFILHSITSTNAFEV .* ********:***:***:** ::***.*.** *::*:*:***:**:***:* ::** ENSMUSP00000045667/1-1450 IAELRENLNVQQFILPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLVFDVIKSAIRYE ENSRNOP00000033638/1-1454 IAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSAIRYE ENSP00000287647/1-1471 ISELREKLDLQHCVLPSRLQASQVKLKSKGRASSSGNQESSGQSCIILLFDVIKSAIRYE ENSCPOP00000005156/1-1428 ISELRRKLDLQHFIFPSLLQASQFTLKRKGGASSSGSQNSSHPDYVTLIFDVIKSAVRYE XP_004835381.1/1-1450 ISELRGKLDLQHFILPSVLHASQVKLKRKGGTSSSGNQESSHPDYVTLIFDVIKSAVRYE *:*** :*::*: :** ::*** .** ** :****.*:.* . : *:*******:*** ENSMUSP00000045667/1-1450 KTISEAWFKAIERIESAAEHKALDVVMLLIIYSTSTQTKKGVEKLLRNKIQSDCIQEQLL ENSRNOP00000033638/1-1454 KTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLL ENSP00000287647/1-1471 KTISEAWIKAIENTASVSEHKVFDLVMLFIIYSTNTQTKKYIDRVLRNKIRSGCIQEQLL ENSCPOP00000005156/1-1428 KAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLRSKIRSGCFHQQLL XP_004835381.1/1-1450 KNISEAWIKAIESTVSGSDHTTFDVVMLFIIYSTNTHTKKYIEKVLRSKIRSGCFDQQLL * *****.**** ::*..:*:.**:***.*..:*** ::::**.**:*.*:.:*** ENSMUSP00000045667/1-1450 DSAFSTHYLVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGAL ENSRNOP00000033638/1-1454 DSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGAL ENSP00000287647/1-1471 QSTFSVHYLVLKDMCSSILSLAQSLLHSLDQSIISFGSLLYKYAFKFFDTYCQQEVVGAL ENSCPOP00000005156/1-1428 ESTFCVHFMVLEDVCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGAL XP_004835381.1/1-1450 EGTFCVHFMVLEDICPSILLLAQSLFHSQDESITSFGSLLYKYSFRIFDTYCQQEVVGAL :.:*..* :**:*:*.*** :**.*:** :: * *.*** **:*: ************* ENSMUSP00000045667/1-1450 VTHVCSGTEAEVDTALDVLLELIVLNASAMRLNAAFVKGILDYLENMSPQQIRKIFCILS ENSRNOP00000033638/1-1454 VTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILS ENSP00000287647/1-1471 VTHICSGNEAEVDTALDVLLELVVLNPSAMMMNAVFVKGILDYLDNISPQQIRKLFYVLS ENSCPOP00000005156/1-1428 VTHVCSGNEAEVDAALYVLLELSVLDPSAMRLNAAFVKGLLDYLDNMSPQQIRKLFHILS XP_004835381.1/1-1450 VTHVCSGNEAEVDAALDVFLELTILDPPAMRLNAVFVKGLLDYLDNMSPQQIRKLFHILS ***:***.*****:** *:*** :*:..** :**.*:**:****:*:*******:* :** ENSMUSP00000045667/1-1450 TLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSSQ ENSRNOP00000033638/1-1454 TLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTMPSNSTQ ENSP00000287647/1-1471 TLAFSKQNEASSHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAADRSESPSLTQ ENSCPOP00000005156/1-1428 TLAFSEQHEASSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGIMAADRSGYSNFSQ XP_004835381.1/1-1450 TLAFSEQHEASSHIKDDMHLVIRKQLSSTVVKYQLIGIIGAVAMAGHMAADRSESSNLTR *****:* :*.**:*************::.**:********:*** ** **: .. :: ENSMUSP00000045667/1-1450 RSANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIF ENSRNOP00000033638/1-1454 RSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIF ENSP00000287647/1-1471 ERANLSDEQCTQVTSLLQLVHSCSEQSPQASALYYDEFANLIQHEKLDPKALEWVGHTIC ENSCPOP00000005156/1-1428 ERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLIQEGNIAPKTLEWVGQTIC XP_004835381.1/1-1450 GRANPRNEQGTQVTSLLQLVHSSSQQSPQASALYYDEFANLIQEGKMAPKTLEWVGKTIC .. .** *** ******:*.:::** **:***********. :: **:****.:** ENSMUSP00000045667/1-1450 NDFQDAFVVDFCAAPEGDFPFPVKALYGLEEYSTQDGIVINLLPLFY-QECAKDASRATS ENSRNOP00000033638/1-1454 NDFQDAFVVDFCAVPEGDFPFPVKALYGLEECNTQDGIVINLLPLFF-QEFAKDVSQVTS ENSP00000287647/1-1471 NDFQDAFVVDSCVVPEGDFPFPVKALYGLEEYDTQDGIAINLLPLLFSQDFAKDGGPVTS ENSCPOP00000005156/1-1428 SDFQDAFVVDLCDVSEGALPFPGKALYGLEEYNTCDGIAINLLPLLYSEEFAKDGGHMTA XP_004835381.1/1-1450 NDFQDAFVVDLCDVSKGEFPFPVKALYGLEEYNTHDGIAINLLPLFFSEESVKDGYQMTS .********* * ..:* :*** ******** .* ***.******:: :: .** *: ENSMUSP00000045667/1-1450 QESSQRSMSSLCLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAK ENSRNOP00000033638/1-1454 QESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAK ENSP00000287647/1-1471 QESGQKLVSPLCLAPYFRLLRLCVERQHNGNLEEIDGLLDCPIFLTDLEPGEKLESMSAK ENSCPOP00000005156/1-1428 QESGQKLVSTLCLAPYFRLLRFCVAKQHNGNLEEIDGLLDCPLFLTDLEPGERLESMPAK XP_004835381.1/1-1450 QESGKKLVSPLCLAPSFRLLRFCMTRQHNGNLEEIDGLLDCPLFLTDLEPGERLESMPAK ***.:: :*.****. *****:*: :**:***:***.*****:**.******:****.** ENSMUSP00000045667/1-1450 DRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIPDYV ENSRNOP00000033638/1-1454 DRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYV ENSP00000287647/1-1471 ERSFMCSLIFLTLNWFREIVNAFCQETSPEMKGKVLTRLKHIVELQIILEKYLAVTPDYV ENSCPOP00000005156/1-1428 ERSFLCSLTFLTLNWFREVVNAFCQQPSPEMKGKVLMRLKVIVELQDILEKHLAVTPDYV XP_004835381.1/1-1450 ERSFMCSLIFLTLNWFREVMNAFCQQPSPEMKGKVLTRLKNIVELQDILEKYLAVTPDYV :**::*** ***:*****::*****:.********* *** :**** ****:*** **** ENSMUSP00000045667/1-1450 PPFASVDLDTLDMMPRSSSAVAAKNRNKGKT-GGKKQKADSNKASCSDTLLTEDTSECDM ENSRNOP00000033638/1-1454 PPFTSVDLDTLDVIPRSNSAVAAKSRHKGKT-GGKKQKADSSTASCTDTLLTEDTSECDV ENSP00000287647/1-1471 PPLGNFDVETLDITPHTVTAISAKIRKKGKI--ERKQKTDGSKTSSSDTLSEEKNSECDP ENSCPOP00000005156/1-1428 PPFAHFDLETLDVIPHSSSA-SAKSRSKGKIKGGRKQKADDGKASPADKLSKEDNSECEP XP_004835381.1/1-1450 PPLANFDLETLDVIPHSSSA-STKSRNKGKI-RGRKRKADDSKASSPDKLSKEDNSECEP **: .*::***: *:: :* ::* * *** :*:*:*...:* .*.* *..***: ENSMUSP00000045667/1-1450 APSGRSHVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEAT ENSRNOP00000033638/1-1454 APSGKSQVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEAT ENSP00000287647/1-1471 TPSHRGQLNKEFTGKEEKTSLLLHNSHAFFRELDIEVFSILHCGLVTKFILDTEMHTEAT ENSCPOP00000005156/1-1428 VASGRSQLDKEFTGKEARASVSLQNYRAFFRELDIEVFSILRCGLVTKVILDTEMHTEAT XP_004835381.1/1-1450 VPSGRSQLDKEFTGKEGRASVSLQNYHAFFRELDIEVFSILRCGLVTKVILDTEMHTEAT ..* :.:::** **** :: : *:* :**************:.*****.*********** ENSMUSP00000045667/1-1450 EVVQLGPAELLFLLEDLSQKLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHC ENSRNOP00000033638/1-1454 EVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFKNKGSRNIGFSHLHQRSVQDIVHC ENSP00000287647/1-1471 EVVQLGPPELLFLLEDLSQKLESMLTPPIARRVPFLKNKGSRNIGFSHLQQRSAQEIVHC ENSCPOP00000005156/1-1428 EVLQLGPPELLFLLEDLSQKLENMLLPSCTKRMSFLKSKGSRNIGFSHLHQSSASEVVNC XP_004835381.1/1-1450 EVLQLGPSELLFLLEDLSQKLENMLLPSCTKRMPFLKNKGSRNVGFSHLQQSCASEVVYC **:****.**************. * .. ::*: :*.** :*:*****:* ...::* * ENSMUSP00000045667/1-1450 VVQLLTPMCNHLENIHNFFQCLGAEHLSA--DDKARATAQEQHTMACCYQKLLQVLHALF ENSRNOP00000033638/1-1454 VVQLLTPMCNHLENIHNFFQCLGAENLSV--NDKARVTAQEHYTMSSCYQKLLQVFHALL ENSP00000287647/1-1471 VFQLLTPMCNHLENIHNYFQCLAAENHGV--VDGPGVKVQEYHIMSSCYQRLLQIFHGLF ENSCPOP00000005156/1-1428 VVQLVTPMCNHLENIHNYFQCLVPENHGVPTVGGPGGNAQEYQIMSSCYLRLLQIFHWLF XP_004835381.1/1-1450 VVKLMTPLCNHLENIHNYFQSLVPEDRGM--VDAPGENAQEYQIMSSCYLRLLQIFHWLF *.:*:**:*********:**.* .*. . . . ..** *:.** :***::* *: ENSMUSP00000045667/1-1450 AWKGFTHQSKHRLLHSALEVLSNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLY ENSRNOP00000033638/1-1454 AWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLY ENSP00000287647/1-1471 AWSGFSQPENQNLLYSALHVLSSRLKQGEHSQPLEELLSQSVHYLQNFHQSIPSFQCALY ENSCPOP00000005156/1-1428 AWSGFSNIENHSYLYSALEVLTGRVKQLQPDEALEELLSQSFNYLQNFHNSIPSFQCGLC XP_004835381.1/1-1450 AWSGFLHIVNHRLLYSALQALSRRMKQLQRDEALEELISQSFNYLQNFHHSIPSFQCGLY **.** : :: * ***..*: *:** : .:.****:***. ****:::*:*****.* ENSMUSP00000045667/1-1450 LLRLLMALLEKSAVPNQKKEKLASLAKQLLCRAWPHGEKEKNPTFNDHLHDVLYIYLEHT ENSRNOP00000033638/1-1454 LLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPHGDKEKNPTFNDHLHDLLCIYLEHT ENSP00000287647/1-1471 LIRLLMVILEKSTASAQNKEKIASLARQFLCRVWPSGDKEKSNISNDQLHALLCIYLEHT ENSCPOP00000005156/1-1428 LIRILMALFKRSVDPAPKKEKIAFLARQFLCRVWPHGEKEKTSVFKDQLQDLLCIYLEHT XP_004835381.1/1-1450 LLRILMALLKRSVAPTQKREKIASLARQFLCREWPQGEKEKSTLFKDQLQDLLCIYLEHT *:*:**.::::*. . ::**:* **:*:*** ** *:***. :*:*: :* ****** ENSMUSP00000045667/1-1450 DNVLKAIEEITGVGVPELVSAPKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGT ENSRNOP00000033638/1-1454 DNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGT ENSP00000287647/1-1471 ESILKAIEEIAGVGVPELINSPKDASSSTFPTLTRHTFVVFFRVMMAELEKTVKKIEPGT ENSCPOP00000005156/1-1428 DSVLKAIEEIAGVGVPELIHSPKDACSPTFPTLTRQTFVIFFRVMMAKLEKTVKSLQAGS XP_004835381.1/1-1450 DSVLKAIEEIAGVGVPELIHSPRQASSCTFPTLTRHTFVIFFRVMMAKLEKTVKGLQAGT :.:*******:*******: :*::*.* *******:***:*******:****** ::.*: ENSMUSP00000045667/1-1450 AADSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLL ENSRNOP00000033638/1-1454 ATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLL ENSP00000287647/1-1471 AADSQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHVCLKYGRLFVEAFLKQCMPLL ENSCPOP00000005156/1-1428 AVQPPKVHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHACLKYGRLFVEAFLKQCMPLL XP_004835381.1/1-1450 AAQPQQIHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHACLKYGRLFVEVFLKQCMPLL *.:. ::******************:**:*****:****.****** ***.********* ENSMUSP00000045667/1-1450 DFSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSLELLVCRVKA ENSRNOP00000033638/1-1454 DFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKA ENSP00000287647/1-1471 DFSFRKHREDVLSLLETFQLDTRLLHHLCGHSKIHQDTRLTQHVPLLKKTLELLVCRVKA ENSCPOP00000005156/1-1428 DFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLEQLVCRVKA XP_004835381.1/1-1450 DFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLELLVCRVKA ********:******:*:**:*************:******:*******:** ******* ENSMUSP00000045667/1-1450 MLVLNNCREAFWLGTLKNRDLQGEEIISQDPSSSESNAEDSEDGVTSHVSRNRATEDG-E ENSRNOP00000033638/1-1454 MLVLNNCREAFWLGTLKNRDLQGEEIISQHPSSPENTSEDSEDGMTSYVSRNRAIEDG-E ENSP00000287647/1-1471 MLTLNNCREAFWLGNLKNRDLQGEEIKSQN--SQESTADESEDDMSSQASKSKATE---- ENSCPOP00000005156/1-1428 MLVLNNCREAFWLGNLKNRDLQGEEIVSQD--SQGSTAEESEDSTTSQVSQNNAAK---- XP_004835381.1/1-1450 MLVLNNCREAFWLGNLKNRDLQGEEIVSQD--SQGSTAEESEDGMTSHVSQSNATKDDEE **.***********.*********** **. * ..:::***. :* .*:..* : ENSMUSP00000045667/1-1450 DEASDEQKDQDSDESDDSSS---------------------------- ENSRNOP00000033638/1-1454 DEANDG-QDRDSDESDDSSS---------------------------- ENSP00000287647/1-1471 ----VSLQNPPESGTDGCILLIVLSWWSRTLPTYVYCQMLLCPFPFPP ENSCPOP00000005156/1-1428 ------------------------------------------------ XP_004835381.1/1-1450 DEASDTEQDQQSDESDDSLD----------------------------