CLUSTAL W(1.81) multiple sequence alignment ENSMUSP00000138312/1-1266 MMCEVMPTISEAEGPPGGGGSHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET ENSRNOP00000032648/1-1190 MMCEVMPTISEAEGPPGGGGSHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET ENSCPOP00000004999/1-1202 MMCEVMPTISEAEVPSGGSGSRGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET ENSP00000253925/1-1202 MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET XP_004852217.1/1-1202 MMCEVMPTISEAEGPPGGSGSHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET ************* *.**.*.:************************************** ENSMUSP00000138312/1-1266 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN ENSRNOP00000032648/1-1190 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN ENSCPOP00000004999/1-1202 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNICREQLLEREEEIAELKAERNN ENSP00000253925/1-1202 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN XP_004852217.1/1-1202 LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN **************************************:********************* ENSMUSP00000138312/1-1266 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE ENSRNOP00000032648/1-1190 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE ENSCPOP00000004999/1-1202 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE ENSP00000253925/1-1202 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE XP_004852217.1/1-1202 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE ************************************************************ ENSMUSP00000138312/1-1266 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGLLDGNHEQESAPSTNGKRSSD ENSRNOP00000032648/1-1190 RLRVALERCSLLEEELGATHKELMILKEQNSQKKALTEGMLDGNHEQENAPSTNGKRSSD ENSCPOP00000004999/1-1202 RLRVALERCSLLEEELGTTHKELMILKEQNNQKKTLTDGVLDVNHEQEDTPSTNGKRSSA ENSP00000253925/1-1202 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD XP_004852217.1/1-1202 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGTLDVNHEQENTPSTNGKRSSD *****************:************.***:**:* ** *****.:***.***** ENSMUSP00000138312/1-1266 GSLSH-EDLAKVLELQEVIDRQAREQSQMKERLASLSSHAAELEEDLDTARKDLIKSEEM ENSRNOP00000032648/1-1190 GSLSH-EDLAKVLELQEVIDRQAREQSQMKERLASLSSHAAELEEDLDTARKDLIKSEEM ENSCPOP00000004999/1-1202 GSLSHEEDLAKVIELQEVIDKQSKEQSQMKERLAALSSHVSELEEDLDTARKDLIKSEEM ENSP00000253925/1-1202 GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM XP_004852217.1/1-1202 GSLSHEEDLAKVIELQEVIDKQSREQSQMKERLAALSSHVSELEEDLDTARKDLIKSEEM ***** ******:****:*.:*::**********:****.:******************* ENSMUSP00000138312/1-1266 NTKLQREVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT ENSRNOP00000032648/1-1190 NTKLQREVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT ENSCPOP00000004999/1-1202 NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSIHRQT ENSP00000253925/1-1202 NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT XP_004852217.1/1-1202 NTKLQREVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSIHRQT ******:************************************************:**** ENSMUSP00000138312/1-1266 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKSGPLSSGSSAAKEAKL ENSRNOP00000032648/1-1190 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS----------------- ENSCPOP00000004999/1-1202 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS----------------- ENSP00000253925/1-1202 EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS----------------- XP_004852217.1/1-1202 EDKNRQLQERLELAEQKLQQTLRKAESLPEVEAELAQRVAALS----------------- **************************:**************** ENSMUSP00000138312/1-1266 LELTSKLRKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL ENSRNOP00000032648/1-1190 --------KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL ENSCPOP00000004999/1-1202 --------KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL ENSP00000253925/1-1202 --------KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL XP_004852217.1/1-1202 --------KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL **************************************************** ENSMUSP00000138312/1-1266 SESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKDQLVVTIEALKAELEQMR ENSRNOP00000032648/1-1190 SESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKDQLVLNIEALKAELEQMR ENSCPOP00000004999/1-1202 SESNERLQLHLKERMAALEDKNSLLREVENAKKQLEEAQHDKEQLVLNIEALRAELDQMR ENSP00000253925/1-1202 SESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMR XP_004852217.1/1-1202 SESNERLQLHLKERMAALEDKNSLLREVENAKKQLEETQHDKEQLVLNIEALRAELDQMR *****************************.*******:****:***:.****:***::** ENSMUSP00000138312/1-1266 LRGPSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNE ENSRNOP00000032648/1-1190 LRGSSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNE ENSCPOP00000004999/1-1202 LRGPSLHLSRPHLGSVPDFRLPMADGHTDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNE ENSP00000253925/1-1202 LRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE XP_004852217.1/1-1202 LRGASLHLGRPHLGSVPDFRLPMADGHTDAYSTSAVLRRPQKGRLAALRDEPSKVQTLNE ***.*** .***********:.:****.*:****************************** ENSMUSP00000138312/1-1266 QDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQ ENSRNOP00000032648/1-1190 QDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQ ENSCPOP00000004999/1-1202 QDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAIMLQEQ ENSP00000253925/1-1202 QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQ XP_004852217.1/1-1202 QDWERAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQTLAMMLQEQ **********************.***************************:***:***** ENSMUSP00000138312/1-1266 LDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPP ENSRNOP00000032648/1-1190 LDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPP ENSCPOP00000004999/1-1202 LDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLAGSSPP ENSP00000253925/1-1202 LDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPP XP_004852217.1/1-1202 LDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPFPASSLAGSSPP ************************************************:******.**** ENSMUSP00000138312/1-1266 GSGRSTPRRVPHSPAREVDRLGVMTLPSDLRKHRRQLPASREEVRDDKTTIKCETSPPSS ENSRNOP00000032648/1-1190 GSGRSTPRRVPHSPAREVDRLGVMTL----------LPASREEVRDDKTTIKCETSPPSS ENSCPOP00000004999/1-1202 GSGRSTPRMVPHSPAREVDRLGVMTL----------LPPSREEVRDDKTTIKCETSPPSS ENSP00000253925/1-1202 GSGRSTPRRIPHSPAREVDRLGVMTL----------LPPSREEVRDDKTTIKCETSPPSS XP_004852217.1/1-1202 GSGRSTPRRVPHSPAREVDRLGVMTL----------SPASREEVRDDKTTIKCETSPPSS ******** :**************** *.********************* ENSMUSP00000138312/1-1266 PRPLRLDRMHKGAPHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKS ENSRNOP00000032648/1-1190 PRPLRLDRLHKGALHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKS ENSCPOP00000004999/1-1202 PKSLRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKS ENSP00000253925/1-1202 PRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKS XP_004852217.1/1-1202 PRSLRLDRLHKGALHTVSHEDIRDMRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKS *:.*****:**** **********:*********************************** ENSMUSP00000138312/1-1266 SIGRLFGKKEKGRPGPLGKESPGQVGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELL ENSRNOP00000032648/1-1190 SIGRLFGKKEKGRPGPLGKESPGQAGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELL ENSCPOP00000004999/1-1202 SIGRLFGKKEKGRPGQTGKESAGQAGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELL ENSP00000253925/1-1202 SIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELL XP_004852217.1/1-1202 SIGRLFGKKEKGRPGQTGKESPGQAGVSETENSSQDALGLSKLGGQAEKNRKLQKKHELL *************** ***: **.*****:***************************** ENSMUSP00000138312/1-1266 EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI ENSRNOP00000032648/1-1190 EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI ENSCPOP00000004999/1-1202 EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI ENSP00000253925/1-1202 EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI XP_004852217.1/1-1202 EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI ************************************************************ ENSMUSP00000138312/1-1266 SNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTTGNVWLTHEEMETLTATPQTEDEEGSWAQ ENSRNOP00000032648/1-1190 SNPLHRLKLRLAIQEIMSLTSPSAPPTSRT------------------------------ ENSCPOP00000004999/1-1202 SNPLHRLKLRLAIQEIMSLTSPSAPPTSRT------------------------------ ENSP00000253925/1-1202 SNPLHRLKLRLAIQEIMSLTSPSAPPTSRT------------------------------ XP_004852217.1/1-1202 SNPLHRLKLRLAIQEIMSLTSPSAPPTSRT------------------------------ ****************************** ENSMUSP00000138312/1-1266 TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRN ENSRNOP00000032648/1-1190 TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRN ENSCPOP00000004999/1-1202 TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRN ENSP00000253925/1-1202 TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRN XP_004852217.1/1-1202 TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRN ************************************************************ ENSMUSP00000138312/1-1266 SFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEYANNLIES ENSRNOP00000032648/1-1190 SFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEFANNLIES ENSCPOP00000004999/1-1202 SFQCGIMCLRRLNYDRKELERRREESQNEIKDVLVWTNDRVIRWVISIGLKEYANNLIES ENSP00000253925/1-1202 SFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIES XP_004852217.1/1-1202 SFQCGIMCLRRLNYDRKELERKREESQNEIKDVLVWSNDRVIRWILSIGLKEYANNLIES *********************:*****.* :*****:*******::******:******* ENSMUSP00000138312/1-1266 GVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLITGTDRRFDEDDDKSFR ENSRNOP00000032648/1-1190 GVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVTGTDRRFDEDDDKSFR ENSCPOP00000004999/1-1202 GVHGALLALDETFDYSTLALLLQIPTQNTQARTVLEKEFTDLLVLGTDRRFDDDDDKSFR ENSP00000253925/1-1202 GVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFR XP_004852217.1/1-1202 GVHGALLALDETFDFNALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFR **************:.:***************:***:**.:**: *******:******* ENSMUSP00000138312/1-1266 RAPSWRKKFRPKDIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMDGSVSGAQRLDSA ENSRNOP00000032648/1-1190 RAPSWRKKFRPKDIRGLASGSAETLPANFRVTSSMSSPSMQPKKVQMD-----------V ENSCPOP00000004999/1-1202 RAPSWRKKFRPKDIRGVAAGSSETLPANFRVSSSMSSPSMQPKKMQMDGSVSGTQRLDSA ENSP00000253925/1-1202 RAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSA XP_004852217.1/1-1202 RAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGSVSGTQRLDSA ****************:*:**:*********:************:*** . ENSMUSP00000138312/1-1266 TVRTYSC ENSRNOP00000032648/1-1190 YPHYFYR ENSCPOP00000004999/1-1202 TVRTYSC ENSP00000253925/1-1202 TVRTYSC XP_004852217.1/1-1202 TVRTYSC : :