CLUSTAL W(1.81) multiple sequence alignment ENSP00000323926/1-1104 ------------------------------------------------------------ ENSMUSP00000108739/1-1104 ------------------------------------------------------------ ENSRNOP00000025879/1-1104 ------------------------------------------------------------ ENSCPOP00000004963/1-1104 ------------------------------------------------------------ XP_004868422.1/1-1175 MRTDCNVCRTCSSTGWSWAAAVTVLWITSYESTCVCTERTAKPMLILKVTMAAAFTSHDG ENSP00000323926/1-1104 -----------MSFRAARLSMRNRRNDTLDSTRTLYSSASRSTDLSYSESDLVNFIQANF ENSMUSP00000108739/1-1104 -----------MSFEGARLSMRSRRNGTMGSTRTLYSSVSRSTDVSYSDSDLVNFIQANF ENSRNOP00000025879/1-1104 -----------MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANF ENSCPOP00000004963/1-1104 -----------MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSDSDLVNFIQANF XP_004868422.1/1-1175 PAGVSWKCAGKMSFEGARLSMRNRRNGTLGSTRTLYSSVSRSTDVSYSDSDLMNFIQANF ***..******.***.*:.********.*****:***:***:******* ENSP00000323926/1-1104 KKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFE ENSMUSP00000108739/1-1104 KKRECVFFTRDSKAMENICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFE ENSRNOP00000025879/1-1104 KKRECVFFTRDSKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFE ENSCPOP00000004963/1-1104 KKRECVFFTKDSKATENLCKCGYARSQHIEGTQVNDSDKWNYKKHTKELPTDAFGDIQFE XP_004868422.1/1-1175 KKRECVFFTKDSKAMENVCKCGYTQSQHMEGTQVNETEKWNYKKHTKEVPTDAFGDIQFE *********:**** *.:*****::***:****:*:.:**********.*********** ENSP00000323926/1-1104 TLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLI ENSMUSP00000108739/1-1104 TLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLI ENSRNOP00000025879/1-1104 TLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLI ENSCPOP00000004963/1-1104 TLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLI XP_004868422.1/1-1175 SLGRKGKYIRLSCDTDSEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLI :**:****:*******:* ***************************************** ENSP00000323926/1-1104 YIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRN ENSMUSP00000108739/1-1104 YIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRS ENSRNOP00000025879/1-1104 YIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRN ENSCPOP00000004963/1-1104 YIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLVRT XP_004868422.1/1-1175 YIAQSKGAWILTGGTHYGLMKFIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRS *********************:************.**********************:*. ENSP00000323926/1-1104 CDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERT ENSMUSP00000108739/1-1104 CDDEGHFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERT ENSRNOP00000025879/1-1104 CDDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERT ENSCPOP00000004963/1-1104 CEAEEHFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTIEAKLRNQLEKYISERT XP_004868422.1/1-1175 CEAEGYFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTIEAKLRSQLEKYISERT *: * :* ***:**** **************************:*****.********** ENSP00000323926/1-1104 IQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEVEDAL ENSMUSP00000108739/1-1104 SQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVL ENSRNOP00000025879/1-1104 SQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVL ENSCPOP00000004963/1-1104 SPDSNYGGKIPIVCFAQGGGRETLKAINTAVKSKIPCVVVEGSGQIADVIASLVELEDAL XP_004868422.1/1-1175 SQDSNYGGKIPIVCFAQGGGRETLKAINTAIKSKIPCVVVEGSGQIADVIASLVELEEAL ******************:********::*.**********************:*:.* ENSP00000323926/1-1104 TSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAIS ENSMUSP00000108739/1-1104 TSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAIS ENSRNOP00000025879/1-1104 TSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAIS ENSCPOP00000004963/1-1104 TSSMVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAIS XP_004868422.1/1-1175 TSSMVKEKLVRFLPRTVSRLPEEEIENWIKWLKEILESSHLLTVIKMEEAGDEIVSSAIS *** ******************** *.**********..**************:**.*** ENSP00000323926/1-1104 YALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDRRWESADLQEVMFTALIKD ENSMUSP00000108739/1-1104 YALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKD ENSRNOP00000025879/1-1104 YALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKD ENSCPOP00000004963/1-1104 YALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESSDLQEVMFTALIKD XP_004868422.1/1-1175 YALYKAFSTNEQDKDNWSGQLRLLLEWNQLELASDEIFTNDRRWESADLQEVMFTALIKD *********.*******.***:********:**.************:************* ENSP00000323926/1-1104 RPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVA ENSMUSP00000108739/1-1104 RPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVA ENSRNOP00000025879/1-1104 RPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVA ENSCPOP00000004963/1-1104 RPKFVRLFLENGLNLQKFLTDDVLSELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVA XP_004868422.1/1-1175 RPKFVRLFLENGLNLQKFLTDDVLSELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVA ***************:****.:**:****.****************************** ENSP00000323926/1-1104 NFRRGFRKEDRNGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTL ENSMUSP00000108739/1-1104 NFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTL ENSRNOP00000025879/1-1104 NFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTL ENSCPOP00000004963/1-1104 NFRRSFWKEERSSRDDLDVEIHDPSSITRHPLQALFIWAILQNKRELSKVIWEQTRGCTL XP_004868422.1/1-1175 NFRRSFWKEERSSRDDLDVEIHDASSITRHPLQALFIWAILQNKKELSKVIWEQTRGCTL ****.* **:*..*:::*:*:** * *****************:**********:**** ENSP00000323926/1-1104 AALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCE ENSMUSP00000108739/1-1104 AALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCE ENSRNOP00000025879/1-1104 AALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCE ENSCPOP00000004963/1-1104 AALGASKLLKTLAKVKNDINAAGESDELANEYETRAVELFTECYSSDEDLAEQLLVYSCE XP_004868422.1/1-1175 AALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCE *************************:*******************.************** ENSP00000323926/1-1104 AWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGF ENSMUSP00000108739/1-1104 AWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGL ENSRNOP00000025879/1-1104 AWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGL ENSCPOP00000004963/1-1104 AWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGF XP_004868422.1/1-1175 AWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGF ***********************************************************: ENSP00000323926/1-1104 VSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPEL ENSMUSP00000108739/1-1104 VSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPEL ENSRNOP00000025879/1-1104 VSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPEL ENSCPOP00000004963/1-1104 VSFRKKPVDKHKKLLWNYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPEL XP_004868422.1/1-1175 VSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPEL *******:******** ***************************************.*** ENSP00000323926/1-1104 VLYSLVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGR ENSMUSP00000108739/1-1104 ILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGR ENSRNOP00000025879/1-1104 ILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGR ENSCPOP00000004963/1-1104 VLYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSANKSSLYCGR XP_004868422.1/1-1175 VLYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYCGR :**:**************:*******************************:******.** ENSP00000323926/1-1104 VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL ENSMUSP00000108739/1-1104 VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL ENSRNOP00000025879/1-1104 VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL ENSCPOP00000004963/1-1104 VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL XP_004868422.1/1-1175 VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGIL ************************************************************ ENSP00000323926/1-1104 RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLP ENSMUSP00000108739/1-1104 RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLP ENSRNOP00000025879/1-1104 RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLP ENSCPOP00000004963/1-1104 RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFARCTFTGNESKPLCVELDEHNLP XP_004868422.1/1-1175 RQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLP *******************************.*****::***:*************:*** ENSP00000323926/1-1104 RFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRL ENSMUSP00000108739/1-1104 RFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRL ENSRNOP00000025879/1-1104 RFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRL ENSCPOP00000004963/1-1104 RFPEWVTIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRL XP_004868422.1/1-1175 RFPEWVTIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSRL *****:***************************** *********************.** ENSP00000323926/1-1104 NIPFPFIVFAYFYMVVKKCFKCCCKEKNMESSVCCFKNEDNETLAWEGVMKENYLVKINT ENSMUSP00000108739/1-1104 NIPFPFVVFAYFYMVVKKCFKCCCKEKNMESNACCFRNEDNETLAWEGVMKENYLVKINT ENSRNOP00000025879/1-1104 NIPFPFVVFAYFYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINT ENSCPOP00000004963/1-1104 NIPFPFVVFAYFYMVVKKFFKCCCKEKKTESSACCFKNEDNETLAWEGVMKENYLVKINT XP_004868422.1/1-1175 NIPFPFVVFAYFYMVVKKFFKCCCKEKNTESSACCFKNEDNETLAWEGVMKENYLVKINT ******:*********** ********: **..***:*********************** ENSP00000323926/1-1104 KANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK ENSMUSP00000108739/1-1104 KANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK ENSRNOP00000025879/1-1104 KANDNAEEMRHRFRQLDTKLNDLKGLLKEIANKIK ENSCPOP00000004963/1-1104 KASDNSEEMRHRFRQLDTKLNDLKCLLKEIAAKIK XP_004868422.1/1-1175 KANDNSEEMRHRFRQLDTKLNDLKCLLKEIAMKIK **.*.:***********:****** ****** :**