CLUSTAL W(1.81) multiple sequence alignment ENSP00000376458/1-1287 MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGGPVVLHCSAQPVTTRIS ENSMUSP00000113977/1-1250 MHPDLGPLWTLLYV-LVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARIS ENSRNOP00000016247/1-1256 MHPDLGPLWKLLYV-LVILCSSVSSDLAPYFISEPLSAVQKLGRPVVLHCSAKPVTARIS ENSCPOP00000004916/1-1266 MHPDPGPLWTLLYVILKILCSSVSSDLAPYFISEPLSAIQKLGGPVTLHCSAKPVTAYIS XP_004862642.1/1-1262 MHPDLGPLQTLLYVILTILCSSVVSDLAPYFISEPLSTDQQLGGPVILHCSAKPLTAHIS **** *** .**** * ****** ******* *****: *:** ** *****:*:*: ** ENSP00000376458/1-1287 WLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNSIGAIVSGPATVSVAVLGD ENSMUSP00000113977/1-1250 WLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALGD ENSRNOP00000016247/1-1256 WLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSAAALAD ENSCPOP00000004916/1-1266 WLHNGKRLDKNTEQMELQRGTLTILSLNPSLSGYYQCIANNSIGAVVSSPAAVSIAVLGD XP_004862642.1/1-1262 WLHNGKRLGRNVEQIKIHQGTLTILSLNPSLSGYYQCIANNSIGAILSGPATVSIAVLGD ****** *. * *::::::*********.** * ***:****:**::*.**:** *.*.* ENSP00000376458/1-1287 FGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKWLEHSTENYLILPSGNLQILN ENSMUSP00000113977/1-1250 FDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLKHSTGNYIILPSGNLQVLN ENSRNOP00000016247/1-1256 FDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWLMYSTGNYIILPSGNLQILN ENSCPOP00000004916/1-1266 FDSSAKHIITAEENSTGFIGCQVPASNPKAEVRYKIRGRWLKHSTGKYVILPSGNLQILN XP_004862642.1/1-1262 FDSSAKHVITAEEKSTGFIGCQVPASNPKAEVRYKIRGRWLKHSTGNYVILPSGNLQILN *.**: *:*****:.:*****:** *************:** :** :*:********:** ENSP00000376458/1-1287 VSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSDDVHILHPTHSQALAVLSRSPVT ENSMUSP00000113977/1-1250 VSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNGFHILHPALSQALAVLPHSPVT ENSRNOP00000016247/1-1256 VSSKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDGFHILHPALSQALAVLPHSPVT ENSCPOP00000004916/1-1266 VSSEDQGSYKCAAYNPVTNELKVERISQKLLVSRPLADGFRILHPTLPQALAVPSHSPVT XP_004862642.1/1-1262 VSSEDKGVYKCAAYNPITNELKVEPVGQKLLVSRPSSDGFQILHPTLSQALAVLSHSPVT ** :*:* ********:* :**** .:******* ::..:****: .***** .:**** ENSP00000376458/1-1287 LECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLATDSVDPADSGNYSCMAG-NKSGDV ENSMUSP00000113977/1-1250 LECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLATASIDPADSGNYSCVVG-NKSGDV ENSRNOP00000016247/1-1256 LECVVSGVPASQVYWLKDGQDALSGSNWRRLYSHLATASIDPADSGNYSCVVGNNRSGDV ENSCPOP00000004916/1-1266 LECVVMGVPASQVQWLREGQGAVLGSHWRRLYSHLATASIHPADSGNYSCVVG-NKSGDI XP_004862642.1/1-1262 LECVVTGVPASQVYWLKEGQDAVLGSNWRRLYSHLATASIDPADSGNYSCVVG-NKSGDI ***** ****.** **::**. **:********** *:.*********:.* *:***: ENSP00000376458/1-1287 KYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCDVHGNPAPNCTWFHNAQPIHPSARHL ENSMUSP00000113977/1-1250 KHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDVHGNPAPNRTWFHNAQPIHPSSRHL ENSRNOP00000016247/1-1256 KHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCEVHGNPAPNRTWFHNAQPIRPSSRHL ENSCPOP00000004916/1-1266 KHVTYMVNVLEHASISKGLQDQRVSLGATVHFTCDVHGNPVPNCTWFHNAQPIRASPRHL XP_004862642.1/1-1262 KHVTYMVNVLEHASISKGLQDQRVSLGATVHFTCDVLGNPVPNRTWFHNAQPIHPSPRHL *:*** *************:** *******:***:* ***.** *********:.*.*** ENSP00000376458/1-1287 TAGNGLKISGVTVEDVGMYQCVADNGIGFMHSTGRLEIENDGGFKPVIITAPVSAKVADG ENSMUSP00000113977/1-1250 TEGNVLKITRVVMEDSGLYQCVADNGIGFMQSTGRLQIEQDSGWKPVIVTAPANIEVMDG ENSRNOP00000016247/1-1256 TEGSVLKITGVIMEDSGLYQCMADNGIGFMQSTGRLQIEQDSGQRPVIVTAPANVEVTDG ENSCPOP00000004916/1-1266 IAGKGLKITGVTMEDSGLYQCVADNGIGFMQSTGRLQVEQNNGFKPVIITAPTSAEVAAG XP_004862642.1/1-1262 TGGNELKITGVTMEDSGLYQCVADNRIGFMQSTGRLQIEQSNGFKPVIITAPTSAMVSDG *. ***: * :** *:***:*** ****:*****::*:..* :***:***.. * * ENSP00000376458/1-1287 DFVTLSCNASGLPVPVIRWYDSHGLITSHPSQVLRSKSRKSQLSRPEGLNLEPVYFVLSQ ENSMUSP00000113977/1-1250 DFVTLSCNATGVPVPVIHWYGRHGLITSHPSQVLRSKPRKSHLFRPGDLDLEPVYLIMSQ ENSRNOP00000016247/1-1256 DFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKSHLFRPGDLDPEPVYLIMSQ ENSCPOP00000004916/1-1266 DFVTLSCNATGVPVPAIRWYGSQGLITSHPSQVLRSKSRKSHLDRPGGLDLEPVYFIMSR XP_004862642.1/1-1262 DFVMLSCNATGVPVPVIRWYDSRGLITSHPSQVLRSKSRKSHLVRPGGLDPEPVYFIMSR *** *****:* ***.*:**. :**************.***:* ** .*: ****:::*: ENSP00000376458/1-1287 AGASSLHIQAVTQEHAGKYICEAANEHGTTQAEASLMVVPFETNTK-AETVTLPDAAQND ENSMUSP00000113977/1-1250 AGSSSLSIQAVTLEHAGKYTCEATNKHGSTQSEAFLTVVPFETNTK-AESVTPSEASQND ENSRNOP00000016247/1-1256 AGSSSLSIQAVTWEHAGKYTCEAVNKHGSTQSEAFLTVVPFETNTK-AEPVTPSEASQND ENSCPOP00000004916/1-1266 AGSSSLSIQAVTREHAGRYICEAANNHGTTQSEAFLTVVPSETDTKEGRAVTP-DAIQSD XP_004862642.1/1-1262 AGSSSLSIQAVTQERAGRYICEAINDYGTTRSEAFLTVVPFETNTK-AETLTP-DAIQSD **:*** ***** *:**:* *** *.:*:*::** * *** **:** ...:* :* *.* ENSP00000376458/1-1287 DRSKRDGSETGLLSSFPVKVHPSAVESAPEKNASGISVPDAPIILSPPQTHTPDTYNLVW ENSMUSP00000113977/1-1250 ERDPQDGSESSLLNLFPVKVHPSGVELPAERNA---SVPDAPNILSPPQTHMPDTYNLVW ENSRNOP00000016247/1-1256 ERDPRDGSESGLLNLFPVKVHSGGVELPAEKNA---SVPDAPNILSPPQTHMPDTYTLVW ENSCPOP00000004916/1-1266 ERDHRDSSESGLLSSFPGKGHPGAVQSSSEKNASGGSVPDAPIILSPPQTYTADTYHLVW XP_004862642.1/1-1262 ERDHRDSSESGLLSSFPGKGHPRAVE-SSEKNPSGTSVPDAPIILSPPQTHTADTYHLVW :*. :*.**:.**. ** * *. .*: ..*:*. ****** *******: .*** *** ENSP00000376458/1-1287 RAGKDGGLPINAYFVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVAR ENSMUSP00000113977/1-1250 RAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSENELHLTELEPSSLYEVLMVAR ENSRNOP00000016247/1-1256 RAGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVAR ENSCPOP00000004916/1-1266 RAGKDGGLPINAYFVKYRKLDDGAGAVGSWHTVRVPGSENELQLTELEPSSLYEVLMVAR XP_004862642.1/1-1262 RAGKDGGLPINAYFVKYRKLDDGAGAVGSWHTVRVPGSENELQLTELEPSSLYEVLMVAR ***:***:*************** * :************.**:*:*************** ENSP00000376458/1-1287 SAAGEGQPAMLTFRTSK-EKTASSKNTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRH ENSMUSP00000113977/1-1250 SAVGEGQPAMLTFRTSK-EKMASSKNTQASFPPVGVPKRPVTAEASNSNFGVVLTDSSRH ENSRNOP00000016247/1-1256 SAVGEGQPAMLTFRTSK-EKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRH ENSCPOP00000004916/1-1266 SAAGEGQPAMLTFRTSKVEKTASSKNTQASSPPAGIPKHPAVSEAANSNFGVVLTEASRH XP_004862642.1/1-1262 SAAGEGQPAMLTFRTSK-EKTASSKNTQASSPPLGIPKHPVVSEATNYNFGVVLTDSSRH **.************** ** ********* ** *:** *..:**:* *******::*** ENSP00000376458/1-1287 SGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSK ENSMUSP00000113977/1-1250 SGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSK ENSRNOP00000016247/1-1256 SGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMKSSDWLVAAEDIPPSK ENSCPOP00000004916/1-1266 SGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTGDWLVAAEDIPPSK XP_004862642.1/1-1262 SGVPEAPDRPTISTASETSVYVTWIPRANGGSPITAFKVEYKRMRTGDWLVAAEDIPPSK ************* ******************************::.:************ ENSP00000376458/1-1287 LSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEA ENSMUSP00000113977/1-1250 LSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEA ENSRNOP00000016247/1-1256 LSVEVRSLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEA ENSCPOP00000004916/1-1266 LSVEVRNLEPGSIYKFRVIAINHYGESFRSSASRPYQVAGFPKRFSSRPIAGPHIAYTEA XP_004862642.1/1-1262 LSVEVRNLEPGSIYKFRVIAVNHYGESFRSSASRPYQVAGFPKRFSSRPITGPHIAYTEA ******.***** *******:*****************.***:***.***:********* ENSP00000376458/1-1287 VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPE ENSMUSP00000113977/1-1250 VSDTQIMLKWTYVPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPE ENSRNOP00000016247/1-1256 VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPE ENSCPOP00000004916/1-1266 VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPE XP_004862642.1/1-1262 VSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPE ************:*************************************** ******* ENSP00000376458/1-1287 TSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATS ENSMUSP00000113977/1-1250 TSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATS ENSRNOP00000016247/1-1256 TSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATS ENSCPOP00000004916/1-1266 TSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPIKDLSTPPNSSGNGGNVGPAAS XP_004862642.1/1-1262 TSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPIKDLSTPPNSSGNGGNVGPATS ***********************************:**:*:*****.* *..******:* ENSP00000376458/1-1287 PARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMV ENSMUSP00000113977/1-1250 PARSSDMLYLIVGCVLGVMVLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMV ENSRNOP00000016247/1-1256 PARSSDMLYLIVGCVLGVMVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMV ENSCPOP00000004916/1-1266 STRSSDMLYLIVGCVLGVMVLILMVFIAMCLWKSRQQNAIQKYDPPRYLHQGSDISGQTV XP_004862642.1/1-1262 PARSSDMLYLIVGCVLGVMVLILMVFIAMCLWKSRQQNAIQKYDPPRYLYQGSDINGQMV .:*********************:****:****.***.:******* **:***::.** * ENSP00000376458/1-1287 DYTTLSGASQINGNVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSL ENSMUSP00000113977/1-1250 EYTTLSGAARINGSVHGGF-----LSNGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSL ENSRNOP00000016247/1-1256 EYTTLSGTARINGSVHGGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSL ENSCPOP00000004916/1-1266 ECAPLPGATRINGHIHTGFLGNSSLSNGCAHLHPKVPNGVSGLVNGSLNGGLYPAHSNSL XP_004862642.1/1-1262 ECATLPG-TQINGSVHAGFLGNSSLNNGCAHLHHKVPNGVNGMVNGSLTGGLYPAHTNSL : :.*.* ::*** :* ** *..* :*** * *..*.* :.*.:.****..*:.** ENSP00000376458/1-1287 TRTHVDFEHPHHLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVP ENSMUSP00000113977/1-1250 TRACVEFEHPHHLVNSGGVYTAVPQMDPLECINCRNCRNNNRCFTKTN-----SPLPVVP ENSRNOP00000016247/1-1256 TRTCVEFEHPHHLVNGGAVYTAVPQMDPLECINCRNCRNNNRCFTKTN-----SPLPVVP ENSCPOP00000004916/1-1266 SRTHVGFEHPHHLVNGSGVYTAVPQVEPLECVNCRNCRNNNRCFTKTNSAFSSSPLPLVP XP_004862642.1/1-1262 TRTHVEFEHPHHLVNGGGMYTAIPQIDPLECVNCRNCRNNNRCFTKTNGTFSSSSLPLVP :*: * *********...:***:**::****:**************** *. *:** ENSP00000376458/1-1287 VVAPYPQDGLEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDV ENSMUSP00000113977/1-1250 VVASYPQGGLEMKPLNAMKVPVCPASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDI ENSRNOP00000016247/1-1256 VVASYPQDGLEMKPLGVMKFPVCPVSTVPDGGQIPEECLKDSVAPAPTQRTCRQDNTSDI ENSCPOP00000004916/1-1266 VVAPCPQDGLEMKPLGAMKMPVCLAAMVPDCGQLPLESTKDGVVPASTPHPCCQDSVNGI XP_004862642.1/1-1262 VVAPCPQDGLEMKPLGAMKIPVCLASTVPDCGQLPEERTKDSVVPVPTPHTCCQDDINDI ***. **.*******. :*.*** .: *** **:* : **.* * .* :.* ** ..: ENSP00000376458/1-1287 SSDGSEDPAEFSRGQEGMINLRIPDHLQLAKSCVWEGDSCAHSETEINIVSWNALILPPV ENSMUSP00000113977/1-1250 NSDSTEDTAEFSR-----------------------GDSSGHSEAEDKVFSWNPLILSPV ENSRNOP00000016247/1-1256 NSDSTEDTAEFNR-----------------------GDSSGHSEAEDKVFSWSPLILSPV ENSCPOP00000004916/1-1266 NSDCTEDTTEFSR-----------------------GDSCGHLEMENKSLNWNPLSLPPT XP_004862642.1/1-1262 NSDCSEDTTECSR-----------------------GDSLGHLEMENRSLNWNPLILPPI .** :**.:* .* *** .* * * . ..*..* *.* ENSP00000376458/1-1287 PEGCAEKTM-WSPPGIPLDSPTEVLQQPRET ENSMUSP00000113977/1-1250 LEDCGEKTA-RSPPGPPLDGLSVVLQQAQET ENSRNOP00000016247/1-1256 LEDCSEKTA-WSPPGPPLDGLSVVLQQAQET ENSCPOP00000004916/1-1266 SGDCPGKMAVCSPPGIPLDSSSEVLQQPQET XP_004862642.1/1-1262 SEDCSGKMIVWSPPGIPLDSSSGVLQQPQET .* * **** ***. : ****.:**