CLUSTAL W(1.81) multiple sequence alignment ENSCPOP00000004899/1-1117 ------------------------------------------------------------ XP_004860219.1/1-1095 ------------------------------------------------------------ ENSP00000314505/1-1143 ------------------------------------------------------------ ENSMUSP00000074978/1-1290 MDQRTTRNGKYCDVEPVSRSNPAPCLRDPPLRRLVRPKPRLQLPESRLSPCSRLPLADSS ENSRNOP00000004499/1-1250 ----------------------------PPSNPLSRSNPALAPPESRPSLCARLPFADSS ENSCPOP00000004899/1-1117 ------------------------------------------------------------ XP_004860219.1/1-1095 ------------------------------------------------------------ ENSP00000314505/1-1143 ------------------------------------------------------------ ENSMUSP00000074978/1-1290 VRPGARPPASAPGRSPSGRKVEAVRGSGSAGSSSPSEAEREQREEACAPPRKAAPSSGRA ENSRNOP00000004499/1-1250 AGSGARPPASAPGRA-SGRKVEVVRGSGSAGSTGPSEARRKQLEEACAPSRK-APSSGRA ENSCPOP00000004899/1-1117 ------------------------------------MNTDQVALVGQVFESYVSEYHKSD XP_004860219.1/1-1095 ------------------------------------MNSDQVALVGQVFESYVSEYHKSD ENSP00000314505/1-1143 ------------------------------------MNSDQVTLVGQVFESYVSEYHKND ENSMUSP00000074978/1-1290 HAPPPPTPRGSGWGDHGRSAVPATKTVRVEPYPPFKMNSEQVTLVGQVFESYVSEYHKND ENSRNOP00000004499/1-1250 HAPPPPTPRGPGRVDYGSNAAPATKTVRVEPEPRLEMNSEQVTLVGQVFESYVSEYHKND **::**:***************.* ENSCPOP00000004899/1-1117 IILILKEDDEDAHYPVVVNAMTLFETNMEVGEYFTVFPNEVLTVFDSALRRSALTVFQSL XP_004860219.1/1-1095 IVQILKEDDEDAHYPVVVNAMTLFETNMEVGEYFTVFPDDVLTVFDSALRRSALAVFQSL ENSP00000314505/1-1143 ILLILKERDEDAHYPVVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRRSALTILQSL ENSMUSP00000074978/1-1290 ILLILKERDEDAHYPVVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAILQSL ENSRNOP00000004499/1-1250 ILLILKERDEDAHYPLVVNAMTLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAVLQSL *: **** *******:*****:*******:*:**.:**.:***:**********:::*** ENSCPOP00000004899/1-1117 SQHEAVSMKHNLHVRISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKLLEFERD XP_004860219.1/1-1095 SQLEGVSLKHNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLAKVLEFERD ENSP00000314505/1-1143 SQPEAVSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERD ENSMUSP00000074978/1-1290 PETEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERD ENSRNOP00000004499/1-1250 PEPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERD .: *.:*:*:***.*************************************.*:****** ENSCPOP00000004899/1-1117 YMCNKCKHTFVVKADFEQYYTFCRPSSCPSLESCDSSKFTCLSDLSSNPARCRDYQEIKI XP_004860219.1/1-1095 YMCTKCQHVFAVKADFEQYYTFCRPSSCPSVESCDSSKFTCLSDLSSHPARCRDYQEIKI ENSP00000314505/1-1143 YMCNKCKHVFVIKADFEQYYTFCRPSSCPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKI ENSMUSP00000074978/1-1290 YMCNKCKHVFMVEADFEQYYTFSRPSSCPSLASCDSSKFSCLSDLSSSPARCRDYQEIKI ENSRNOP00000004499/1-1250 YMCNKCKYVFTVKADFEQYYTFSRPSSCPSSDTCDSSKFTCLSDLSASPARCRDYQEIKI ***.**::.* ::*********.******* :******:***.**: *:********** ENSCPOP00000004899/1-1117 QEQVQKLSVGSIPRSMKIILEDDLVDSCKSGDDLTVYGVVMQRWKLFQQDVRCEVEIVLK XP_004860219.1/1-1095 QEQVQKLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVTQRWKPFQQDVRCEVEIVLK ENSP00000314505/1-1143 QEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLK ENSMUSP00000074978/1-1290 QEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDVRCEVEIVLK ENSRNOP00000004499/1-1250 QEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDMRCEVEIVLK *****:***********:*****************:**:* **** **:*:********* ENSCPOP00000004899/1-1117 ANYVQINNEQSSGIVVDEEVRKKFEDFWEYYRSDPFAGRNEILASLCPQVFGMYLVKLAV XP_004860219.1/1-1095 ANYVQINNEQSSGIVVAEEVRKEFEEFWKFYERDPFAGRNEILASLCPQVFGMYLVKLAV ENSP00000314505/1-1143 ANYIQVNNEQSSGIIMDEEVQKEFEDFWEYYKSDPFAGRNVILASLCPQVFGMYLVKLAV ENSMUSP00000074978/1-1290 ANYVQVNNEQSSGMVMDEDTRKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAV ENSRNOP00000004499/1-1250 ANYVQVNNEQSSGMVMDEDARKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAV ***:*:*******::: *:.:*:**:**:.*. ******* ******************* ENSCPOP00000004899/1-1117 AMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG XP_004860219.1/1-1095 AMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG ENSP00000314505/1-1143 AMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG ENSMUSP00000074978/1-1290 AMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG ENSRNOP00000004499/1-1250 AMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG *************:********************************************** ENSCPOP00000004899/1-1117 LTVTAVKDSGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLV XP_004860219.1/1-1095 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLV ENSP00000314505/1-1143 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLV ENSMUSP00000074978/1-1290 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLV ENSRNOP00000004499/1-1250 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLV ***********************.************************************ ENSCPOP00000004899/1-1117 CKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRVISSF XP_004860219.1/1-1095 CKLNTRTTILAATNPKGQYDPQESVAVNIALGSPLLSRFDLILVLLDTKNEDWDRVISSF ENSP00000314505/1-1143 CKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSF ENSMUSP00000074978/1-1290 CKLNTRTTILAATNPKGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSF ENSRNOP00000004499/1-1250 CKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTRNEDWDRIISSF *********************:***:***************:******:******:**** ENSCPOP00000004899/1-1117 ILENKGCPSRAKKLWSMEKMKTYFCLIRTLQPTLSDAGNQVLLRYYQMQRQSNARNAART XP_004860219.1/1-1095 ILENKGYPSKPEKLWNMEKMKTYFCLIRTLQPRLSEAGNQVLLRYYQMQRRSDARNAART ENSP00000314505/1-1143 ILENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAART ENSMUSP00000074978/1-1290 ILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQVLLRYYQMQRQSDSRNAART ENSRNOP00000004499/1-1250 ILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSDVSNQVLLRYYQMQRQSDSRNAART ****** **:.::**.************.*:* **:..************:*:.****** ENSCPOP00000004899/1-1117 TIRLLESLIRLAEAHARLMFRDTVTLEDAVTVVSVMESSMQGGALLGGVNALHTSFPENP XP_004860219.1/1-1095 TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVNALHTAFPEDP ENSP00000314505/1-1143 TIRLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPENP ENSMUSP00000074978/1-1290 TIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQGGALLGGVNALHTSFPENP ENSRNOP00000004499/1-1250 TIRLLESLIRLAEAHARLMFRSTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPESP *********************.:******:*.**********************:***.* ENSCPOP00000004899/1-1117 RAQYQQQCKLILERLELPSLLSEELQRLERLQNQNVHLSQPQAG----EVEAEAMPGFSR XP_004860219.1/1-1095 RAQYRQQCELILQRLELQGLLSEELQRLERLQNEGLHPSQPLEAEAEVEVEVETPPGSSG ENSP00000314505/1-1143 GEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPR------VLEVETTPGSLR ENSMUSP00000074978/1-1290 RAQYQRQCELILEKLELQGLLQEELRRLERLQNESVHQCQSH------SLEEEVAPGSCR ENSRNOP00000004499/1-1250 RAQYRRQCELILEKLELQSLLQEELRRLERLQNES-DQCQPH------SPEVEAAPGSCR **::**:***::*** .**.***:*******:. . .*. * *. ** ENSCPOP00000004899/1-1117 -DLGNKLELKTSTQQEQSCSPSSLL-PGGSPRENSAWESLPDLRSSRSM----------S XP_004860219.1/1-1095 DDPEDSLKLRTSTQQELSCSR--WALPGGRPWGSPVLDALADPGPSGSS-----GGHRGP ENSP00000314505/1-1143 NGPGEESNFRTSSQQEINYSTHIFS-PGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNN ENSMUSP00000074978/1-1290 NDPRDKPRLRTSTQQEQSCS---WS-STERSGA----DSPPGPGLNRPTSCNNSAENRDG ENSRNOP00000004499/1-1250 NDPRDRPGLRTPTQQEQSCS---WS-PAESSGG----DSPTGPGLSRPTSCNHKAEDGGG . : ::*.:*** . * . . :. . . . ENSCPOP00000004899/1-1117 RDHSQDQDDRMATQQTRPRNTTLASPGPQTAEENTALEVSDSRSRVQVKSQPGHWSP-LA XP_004860219.1/1-1095 RDDSRDWGDPVAAQRTAPRNTALVSPGSRAAEGDTALEIPDSRSRVKGVSWPGLRSP-SA ENSP00000314505/1-1143 RDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKISNSTSQGKEKSEPGQRSK-VD ENSMUSP00000074978/1-1290 RGDGLDWLDPTSSPEIAPEST-IVSPNVKTTEKNVNLKISNNKSQGKEKHGPQQRSKLLE ENSRNOP00000004499/1-1250 RGDCLAWADPTASPEIAQEST-IVSPGLKTMEEKEDLKISNNGAQGKGKHGLQKRSQLLK *.. * :: . ..* :.** :: . ::.:. :: : * ENSCPOP00000004899/1-1117 ASPLRSQEATIATLQSPGAQDRGAEREASRSEVATAEEEPDT---ASIPGRSHGWQQESV XP_004860219.1/1-1095 AAQLPSPEAASA-------EGKETKRGASGSEAAAGQGE-ELDLAPAVPGRPPRRLQEGA ENSP00000314505/1-1143 IGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERA ENSMUSP00000074978/1-1290 AGHLPSSGAMNAPLRSHGVKRTKASQAVVVSEAGRGDEE------DSVPRRLPKLLKEGS ENSRNOP00000004499/1-1250 PGRLPASGATDTSLRSRGSESTRARQAAVVSEAGRDDDQ------ESGPRRLPRLLKEGS . * : . : : . **.. : * . :* ENSCPOP00000004899/1-1117 LGLETLSGSAPAQLRAPSLLESTAAYGPEGTSETPARKRPKS--------PENTETPETP XP_004860219.1/1-1095 RRLGRLPSQAPAQPQGPGLLHSAPAHGPKGTLDLP---------------AAGAESPGRP ENSP00000314505/1-1143 QKLCRNSTRVPAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPGSP ENSMUSP00000074978/1-1290 QNVCRSTTRVRPLPPTVPLSLSIPSPGSGKRSGTPKRKRRKS-AQVEEPEPEGMET---P ENSRNOP00000004499/1-1250 QSVC--TTRVRTLPPTVPFPLSISPPGPGKKTGTPKRKRQKS-AQVEAPGPEGTETMSAP : . . . * . .. * . :. * ENSCPOP00000004899/1-1117 MAKLAKFTFKQKSKLTHFPKDHGLVSCDPTEMAGPGLGAPQQGTRIEAVIPVKGPERLVS XP_004860219.1/1-1095 EVKLAKFTFKQKSRLTHSPG-----PPGTSEVPGPRWAAPQQGSGRRA---VKSPKEPAP ENSP00000314505/1-1143 VAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKISQRRTRRDAALPVKRPGKLTS ENSMUSP00000074978/1-1290 TVKLAKFTFKQKTKLTHSPEGQGPIPPSASEIAVDSSKIPQQRTRREAAVPVVAPGKSTS ENSRNOP00000004499/1-1250 VVKLAKFTFKQKSKLTHSPEGQGPMPPSASKVAVDSSKIPRQRTRREAGVPAAGPGQSTS .**********::* * . ..:::. .:: : * . * . .. ENSCPOP00000004899/1-1117 TLASRDFTQPQGKLKQWSQQPCREDVCREERD-------LDPELESGTHAGTAHPSRERA XP_004860219.1/1-1095 TSAGRGCQQPQGELEQRPQQPCPEDACREERSPGP-----GPEPEPTNQAGPARLCRERA ENSP00000314505/1-1143 TPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAHLTCEGD ENSMUSP00000074978/1-1290 TSGDRCSDQLHGKTKELSRQPPDSNPPREEREQGPKRRVIQPKPELGNQAGHSHLACEKD ENSRNOP00000004499/1-1250 TSGDRCSEQLQGQTKALSRQPPESHRPREEKEQGPERRVIQSELELGSQAGHSHPACKKD * ..: * :*: : .:** .. **: .: * ..:* :: : ENSCPOP00000004899/1-1117 PEEG-PCRAKGSKVHAGTLATLARFSFTPPVESPSESPPACGGK---------TWTHHGP XP_004860219.1/1-1095 RREEAPCSSKGSKVHSGTLAALARFSFTPPAESQAE--PP-GRA---------------- ENSP00000314505/1-1143 KKEEVSGSNKSGKVHACTLARLANFCFTPPSESKSKSPPP-ERK---------NRGERGP ENSMUSP00000074978/1-1290 RKEGVSCGNKSSKVHAGTIARLASFSFTSPSESKSESLPP-ERKDSRDSRDSRDSRDRC- ENSRNOP00000004499/1-1250 RKEGASCSNK-SKVHAGTMARLANFSFTSPPESKSESLPP-ERK---------ESRDRS- .* . * .***: *:* ** *.**.* ** :: *. ENSCPOP00000004899/1-1117 SPPHASSVPGLGSRRKSFQLQASSAEKPNLSKNALFTLPELNDDVLDFDWDEEMRRKP XP_004860219.1/1-1095 ---HAPSAPGLGSKRKSFQLQA-SAEKPTLSKNSLFTLPELDDEVLDFDWDEEMRKKP ENSP00000314505/1-1143 SSPPTTTAPMRVSKRKSFQLRG-STEKLIVSKESLFTLPELGDEAFDCDWDEEMRKKS ENSMUSP00000074978/1-1290 HSPPATTAPVLGQQRQTFQLQQ-PTERANLSTLSLFTLSELDDEALDFDWEEEMRKKP ENSRNOP00000004499/1-1250 HNPPATTAPVLGQQRQSFQLQQ-PPERVNLSTLSLFTLSELDDEALDFDWDEEMRKKP :.:.* .:*::***: ..*: :*. :****.**.*:.:* **:****:*.